RGD Reference Report - IL-17 in cutaneous lupus erythematosus. - Rat Genome Database

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IL-17 in cutaneous lupus erythematosus.

Authors: Tanasescu, C  Balanescu, E  Balanescu, P  Olteanu, R  Badea, C  Grancea, C  Vagu, C  Bleotu, C  Ardeleanu, C  Georgescu, A 
Citation: Tanasescu C, etal., Eur J Intern Med. 2010 Jun;21(3):202-7. doi: 10.1016/j.ejim.2010.03.004. Epub 2010 Apr 8.
RGD ID: 8698667
Pubmed: PMID:20493423   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejim.2010.03.004   (Journal Full-text)

BACKGROUND: Lupus erythematosus (LE) is a heterogeneous disease with broad clinical spectrum from cutaneous to visceral and systemic inflammation. IL-17 isoforms (IL-17A and IL-17F) are proinflammatory cytokines with unclear implications in lupus erythematosus pathogenesis. In this study we focused upon IL-17 in normal and modified lupus skin with a correlative study between local and serological expression. MATERIAL AND METHODS: 89 subjects were recruited and divided in 5 groups-10 patients with psoriasis (disease control group), 13 healthy controls, 26 with discoid chronic lupus (DLE), 23 with systemic lupus erythematosus (SLE) and 17 with subacute lupus erythematosus (SCLE). Blood samples and skin punched-biopsy specimens were performed. Serum IL-17A, IL-17F, and IL-23 concentrations were determined by ELISA. Skin IL-17A and CD4 expression were evaluated by immunohistochemistry. RESULTS: Immunohistochemical expression of IL-17A was higher in DLE, SCLE and SLE patients than in negative control subjects (all p<0.05). Serum IL-17A concentrations were higher in DLE and SLE patients than in negative controls (p<0.05). Serum IL-17A levels were similar in SCLE and negative controls (p>0.05). Serum IL-17F concentrations were higher in DLE, SCLE and SLE patients than in healthy controls (all p<0.05). In DLE, SCLE, SLE patients and healthy controls we observed comparable levels of IL-23 (p>0.05). Serum anti Ro antibodies correlate with IL-17A+ lymphocytes from SCLE lesion and SLE normal skin (all p<0.05). CONCLUSION: IL-17 isoforms (IL-17A and IL-17F) are implicated in SLE but also in DLE and SCLE immunopathogenesis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL17AHumancutaneous lupus erythematosus  IEP protein:increased expression:epidermis (human)RGD 
Il17aRatcutaneous lupus erythematosus  ISOIL17A (Homo sapiens)protein:increased expression:epidermis (human)RGD 
Il17aMousecutaneous lupus erythematosus  ISOIL17A (Homo sapiens)protein:increased expression:epidermis (human)RGD 
IL17AHumanDiscoid Lupus Erythematosus  IEP protein:increased expression:epidermis (human)RGD 
Il17aRatDiscoid Lupus Erythematosus  ISOIL17A (Homo sapiens)protein:increased expression:epidermis (human)RGD 
Il17aMouseDiscoid Lupus Erythematosus  ISOIL17A (Homo sapiens)protein:increased expression:epidermis (human)RGD 
IL17AHumansystemic lupus erythematosus  IEP protein:increased expression:epidermis (human)RGD 
Il17aRatsystemic lupus erythematosus  ISOIL17A (Homo sapiens)protein:increased expression:epidermis (human)RGD 
Il17aMousesystemic lupus erythematosus  ISOIL17A (Homo sapiens)protein:increased expression:epidermis (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il17a  (interleukin 17A)

Genes (Mus musculus)
Il17a  (interleukin 17A)

Genes (Homo sapiens)
IL17A  (interleukin 17A)


Additional Information