Niddm26 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Niddm26 (Non-insulin dependent diabetes mellitus QTL 26) Rattus norvegicus

Symbol: Niddm26
Name: Non-insulin dependent diabetes mellitus QTL 26
RGD ID: 70186
Previously known as: Nidd8/of
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level area under curve (AUC)   (CMO:0000350)    
LOD Score: 3.87
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8929,567,664 - 83,835,942RGD_MAPPER_PIPELINE
mRatBN7.2922,071,169 - 86,369,743RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0925,692,342 - 92,741,406RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0924,554,173 - 92,471,992RGDRnor5.0
RGSC_v3.4918,347,567 - 84,432,994RGDRGSC3.4
RGSC_v3.1918,344,890 - 84,616,413RGD
Cross Type: F2
Strains Crossed: F344/DuCrlCrlj OLETF/Got 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm26Rattype 2 diabetes mellitus  IDA 69696 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm26Ratimpaired glucose tolerance  QTM 69696 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm26Ratblood glucose level area under curve (AUC)  IDA 625760 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm26Ratfasting  IDA 625760 RGD 
Niddm26Ratglucose solution, 2.8M  IDA 625760 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm26Ratoral glucose tolerance test  IDA 625760 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm26RatF344/DuCrlCrlj  IEA 625760 RGD 
Niddm26RatOLETF/Got  IEA 625760 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm26Ratblood glucose amount  IDA 625760 RGD 


#
Reference Title
Reference Citation
1. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
2. QTL Data Transfer QTL data import from the RatMap database
3. Identification of genetic loci involved in diabetes using a rat model of depression. Solberg Woods LC, etal., Mamm Genome. 2009 Aug 22.
4. Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method. Sugiura K, etal., Mamm Genome 1999 Dec;10(12):1126-31.
5. Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat. Yamada T, etal., Exp Diabetes Res. 2012;2012:582546. doi: 10.1155/2012/582546. Epub 2012 Oct 15.
PMID:NIddm26  


Related QTL Description Reference
Gluco54 maps to same region RGD:2312611



1 to 20 of 700 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1308476Pkhd1PKHD1 ciliary IPT domain containing fibrocystin/polyductin92254739623037443Rat
41204456Rpl19-ps12ribosomal protein L19, pseudogene 1292292760822932930Rat
41309300LOC120094648uncharacterized LOC12009464892308610723099478Rat
2325550Mir206microRNA 20692309424923094332Rat
2325527Mir133bmicroRNA 133b92309813423098217Rat
2888Il17ainterleukin 17A92314440223147889Rat
1584090Ppig-ps1peptidylprolyl isomerase G, pseudogene 192315970023162455Rat
41327487LOC120094868U6 spliceosomal RNA92317884423178936Rat
1311398Il17finterleukin 17F92319009423201482Rat
1305168Mcm3minichromosome maintenance complex component 392321916923237314Rat
2318314Cct7-ps4chaperonin containing TCP1 subunit 7, pseudogene 492323722223241597Rat
41151456LOC120094940small nucleolar RNA SNORA1792326215223262285Rat
1311710Paqr8progestin and adipoQ receptor family member 892331252123362175Rat
40980684LOC120094937small nucleolar RNA SNORA1792333872223338803Rat
7567345LOC102549795uncharacterized LOC10254979592334850723376276Rat
1587365Efhc1EF-hand domain containing 192337581523414283Rat
1589151Tram2translocation associated membrane protein 292341920423498745Rat
7706003LOC102549948uncharacterized LOC10254994892351713023522234Rat
7743195LOC102550123uncharacterized LOC10255012392361424323645208Rat
1562107Gsta3l1glutathione S-transferase alpha 3 like 192361969123628517Rat

1 to 20 of 700 rows
1 to 20 of 1099 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10252D7Mit1213693513366635133728Ratregion
10403D9Wox812196647532866475449Ratregion
10404D9Mit219096643705266437242Ratregion
10411D9Mgh413996745134667451485Ratregion
10658D9Wox1518494941569249415876Ratregion
10807D9Wox1012397699412376994246Ratregion
33979D9Mit420494243579742436001Ratregion
33999D9Mit514697781389477814038Ratregion
34013D9Mit317095816286358163035Ratregion
34088D9Mgh211098636963186369743Ratregion
34090D9Mgh822393684038536840608Ratregion
34286D9Mgh614393145248931452632Ratregion
34413D9Mgh314894077390540774051Ratregion
11296D9Arb312497594962675949750Ratregion
11312D9Bro111097702634377026453Ratregion
33583D9Mit927192315912623159388Ratregion
36009D9Rat5414998131436481314513Ratregion
36059D15Rat3018697450771274507902Ratregion
36147D9Rat1514596538378965383934Ratregion
36155D9Rat913697739687677397012Ratregion
1 to 20 of 1099 rows

Flank 1: (D9Wox19)
Rat AssemblyChrPosition (strand)Source
GRCr8929,567,664 - 29,567,840 (+)Marker Load Pipeline
mRatBN7.2922,071,169 - 22,071,345 (+)MAPPER
Rnor_6.0925,692,342 - 25,692,517NCBI
Rnor_5.0924,554,173 - 24,554,348UniSTS
RGSC_v3.4918,347,567 - 18,347,743RGD
RGSC_v3.4918,347,568 - 18,347,743UniSTS
RGSC_v3.1918,344,890 - 18,345,065RGD
Celera919,655,621 - 19,655,796UniSTS
RH 3.4 Map9194.1RGD
RH 3.4 Map9194.1UniSTS
RH 2.0 Map9162.0RGD
Cytogenetic Map9 RGD
Peak: (D9Rat21)
Rat AssemblyChrPosition (strand)Source
GRCr8956,701,714 - 56,701,893 (+)Marker Load Pipeline
mRatBN7.2949,209,741 - 49,209,920 (+)MAPPER
Rnor_6.0954,077,675 - 54,077,853NCBI
Rnor_5.0953,742,163 - 53,742,341UniSTS
RGSC_v3.4946,242,537 - 46,242,833RGD
RGSC_v3.4946,242,608 - 46,242,786UniSTS
RGSC_v3.1946,243,951 - 46,244,247RGD
Celera946,875,660 - 46,875,838UniSTS
SHRSP x BN Map941.0298UniSTS
SHRSP x BN Map941.0298RGD
FHH x ACI Map934.58RGD
Flank 2: (D9Mgh2)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2986,369,631 - 86,369,743 (+)MAPPER
Rnor_6.0992,741,297 - 92,741,406NCBI
Rnor_5.0992,471,883 - 92,471,992UniSTS
RGSC_v3.4984,432,884 - 84,432,994RGD
RGSC_v3.4984,432,885 - 84,432,994UniSTS
RGSC_v3.1984,616,303 - 84,616,413RGD
Celera983,792,714 - 83,792,823UniSTS
RH 2.0 Map9848.3RGD
Cytogenetic Map9 RGD


1 to 10 of 62 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat

1 to 10 of 62 rows


Database
Acc Id
Source(s)
NCBI Gene Niddm26

Note Type Note Reference
qtl_general LOD reported to be 4.92 when glucose was measured at 90 min in males which was confirmed in another experiment using the same strains 61021
qtl_general corresponds to 2q32-q34 in humans 61021
qtl_general locus confirmed by the generation of F344.OLETF-(D9Mgh8-D9Rat15)/Tj congenic strain 625760
qtl_general syntenic region in human has NEUROD1 as candidate gene 7207431