Mff (mitochondrial fission factor) - Rat Genome Database
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Gene: Mff (mitochondrial fission factor) Rattus norvegicus
Analyze
Symbol: Mff
Name: mitochondrial fission factor
RGD ID: 1310230
Description: Exhibits GTPase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of cellular component organization. Localizes to synaptic vesicle. Colocalizes with mitochondrial membrane and synaptic vesicle membrane. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human MFF (mitochondrial fission factor); PARTICIPATES IN mitochondria fission pathway; INTERACTS WITH bisphenol A; chloroprene; cocaine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC301563; MGC112646; mitochondrial fission factor-like; RGD1310230; similar to RIKEN cDNA 5230400G24; uncharacterized protein LOC100911613
Orthologs:
Homo sapiens (human) : MFF (mitochondrial fission factor)  HGNC  Alliance
Mus musculus (house mouse) : Mff (mitochondrial fission factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mff (mitochondrial fission factor)
Pan paniscus (bonobo/pygmy chimpanzee) : MFF (mitochondrial fission factor)
Canis lupus familiaris (dog) : MFF (mitochondrial fission factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mff (mitochondrial fission factor)
Sus scrofa (pig) : MFF (mitochondrial fission factor)
Chlorocebus sabaeus (African green monkey) : MFF (mitochondrial fission factor)
Heterocephalus glaber (naked mole-rat) : Mff (mitochondrial fission factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0988,490,280 - 88,518,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl988,493,593 - 88,517,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0988,237,923 - 88,266,173 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4982,045,236 - 82,071,135 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1982,226,339 - 82,254,116 (+)NCBI
Celera981,449,284 - 81,477,522 (+)NCBICelera
Cytogenetic Map9q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12477932   PMID:15057822   PMID:18353969   PMID:20451243   PMID:21149567   PMID:21700703   PMID:23283981   PMID:23530241   PMID:23921378   PMID:30059978  


Genomics

Comparative Map Data
Mff
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0988,490,280 - 88,518,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl988,493,593 - 88,517,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0988,237,923 - 88,266,173 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4982,045,236 - 82,071,135 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1982,226,339 - 82,254,116 (+)NCBI
Celera981,449,284 - 81,477,522 (+)NCBICelera
Cytogenetic Map9q34NCBI
MFF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2227,325,151 - 227,357,836 (+)EnsemblGRCh38hg38GRCh38
GRCh382227,325,233 - 227,357,836 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372228,189,867 - 228,222,552 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,900,472 - 227,930,793 (+)NCBINCBI36hg18NCBI36
Build 342228,017,732 - 228,048,052NCBI
Celera2221,961,362 - 221,991,712 (+)NCBI
Cytogenetic Map2q36.3NCBI
HuRef2220,033,273 - 220,065,950 (+)NCBIHuRef
CHM1_12228,195,676 - 228,228,351 (+)NCBICHM1_1
Mff
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39182,702,599 - 82,730,111 (+)NCBI
GRCm38182,724,890 - 82,752,390 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl182,724,890 - 82,752,394 (+)EnsemblGRCm38mm10GRCm38
MGSCv37182,721,493 - 82,748,965 (+)NCBIGRCm37mm9NCBIm37
MGSCv36182,603,942 - 82,631,414 (+)NCBImm8
Celera182,791,317 - 82,818,740 (+)NCBICelera
Cytogenetic Map1C5NCBI
Mff
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554537,221,244 - 7,256,029 (-)NCBIChiLan1.0ChiLan1.0
MFF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B233,381,466 - 233,413,784 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B233,381,466 - 233,413,778 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B114,569,893 - 114,602,158 (+)NCBIMhudiblu_PPA_v0panPan3
MFF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2540,111,894 - 40,141,776 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12540,111,860 - 40,142,246 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mff
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365258,604,478 - 8,636,352 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15128,768,348 - 128,799,345 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115128,768,441 - 128,799,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215142,603,384 - 142,605,459 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFF
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl10113,348,446 - 113,381,162 (+)Ensembl
ChlSab1.110113,348,330 - 113,381,875 (+)NCBI
Mff
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248431,626,800 - 1,664,906 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92569234292741406Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)929075079122095297Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)929466970107878528Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)94126103490024806Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94126103498606834Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)941261034102531865Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94657976991579769Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94657976991579769Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94724896594124663Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95417754299177542Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)961186278106186278Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)963270073107878387Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)966757444112943287Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96745166499920892Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96745166499920892Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)970241351115241351Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)970942881115942881Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)981411073119983851Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98368615398164303Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)98368615398164303Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)98368615398164303Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)983686153111609081Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:72
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000020705, ENSRNOT00000020712
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff 2 2 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07068185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM107137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN804971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020712   ⟹   ENSRNOP00000020712
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl988,493,593 - 88,517,827 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089451   ⟹   ENSRNOP00000075445
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl988,494,676 - 88,517,827 (+)Ensembl
RefSeq Acc Id: NM_001039015   ⟹   NP_001034104
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,280 - 88,518,517 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
RGSC_v3.4982,045,236 - 82,071,135 (+)RGD
Celera981,449,284 - 81,477,522 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271284   ⟹   NP_001258213
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,280 - 88,518,517 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Celera981,449,284 - 81,477,522 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001276401   ⟹   NP_001263330
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,280 - 88,518,517 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Celera981,449,284 - 81,477,522 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245195   ⟹   XP_006245257
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,284 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245197   ⟹   XP_006245259
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,285 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245198   ⟹   XP_006245260
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,285 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245200   ⟹   XP_006245262
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,286 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245201   ⟹   XP_006245263
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,285 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245204   ⟹   XP_006245266
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,285 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245205   ⟹   XP_006245267
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,286 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245206   ⟹   XP_006245268
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,345 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245208   ⟹   XP_006245270
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,286 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245209   ⟹   XP_006245271
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,287 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245211   ⟹   XP_006245273
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,288 - 88,518,513 (+)NCBI
Rnor_5.0988,237,923 - 88,266,173 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767230   ⟹   XP_008765452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,285 - 88,518,513 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767231   ⟹   XP_008765453
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,345 - 88,518,513 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767232   ⟹   XP_008765454
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,280 - 88,518,513 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767233   ⟹   XP_008765455
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,280 - 88,518,513 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596377   ⟹   XP_017451866
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0988,490,280 - 88,518,513 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001034104   ⟸   NM_001039015
- Peptide Label: isoform 2
- UniProtKB: Q4KM98 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001263330   ⟸   NM_001276401
- Peptide Label: isoform 3
- UniProtKB: Q4KM98 (UniProtKB/Swiss-Prot),   A0A0H2UHM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258213   ⟸   NM_001271284
- Peptide Label: isoform 1
- UniProtKB: Q4KM98 (UniProtKB/Swiss-Prot),   A0A0G2KAL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245257   ⟸   XM_006245195
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006245259   ⟸   XM_006245197
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006245263   ⟸   XM_006245201
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006245267   ⟸   XM_006245205
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_006245270   ⟸   XM_006245208
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_006245260   ⟸   XM_006245198
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006245262   ⟸   XM_006245200
- Peptide Label: isoform X5
- UniProtKB: A0A0G2KAL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245266   ⟸   XM_006245204
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006245271   ⟸   XM_006245209
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_006245273   ⟸   XM_006245211
- Peptide Label: isoform X13
- UniProtKB: Q4KM98 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245268   ⟸   XM_006245206
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_008765452   ⟸   XM_008767230
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008765454   ⟸   XM_008767232
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008765455   ⟸   XM_008767233
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_008765453   ⟸   XM_008767231
- Peptide Label: isoform X8
- UniProtKB: A0A0G2K2M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451866   ⟸   XM_017596377
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000075445   ⟸   ENSRNOT00000089451
RefSeq Acc Id: ENSRNOP00000020712   ⟸   ENSRNOT00000020712
Protein Domains
Miff

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310230 AgrOrtholog
Ensembl Genes ENSRNOG00000015428 UniProtKB/TrEMBL
  ENSRNOG00000048016 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020705 UniProtKB/TrEMBL
  ENSRNOP00000020712 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072300 UniProtKB/TrEMBL
  ENSRNOP00000074586 UniProtKB/TrEMBL
  ENSRNOP00000075445 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020705 UniProtKB/TrEMBL
  ENSRNOT00000020712 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000077859 UniProtKB/TrEMBL
  ENSRNOT00000089142 UniProtKB/TrEMBL
  ENSRNOT00000089451 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7385142 IMAGE-MGC_LOAD
InterPro Mff-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mff/Tango-11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:102556337 UniProtKB/Swiss-Prot
  rno:301563 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112646 IMAGE-MGC_LOAD
NCBI Gene 301563 ENTREZGENE
PANTHER PTHR16501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Miff UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mff PhenoGen
UniGene Rn.229030 ENTREZGENE
  Rn.93479 ENTREZGENE
UniProt A0A0G2K2M2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAL9 ENTREZGENE, UniProtKB/TrEMBL
  A0A0H2UHM6 ENTREZGENE, UniProtKB/TrEMBL
  MFF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Mff  mitochondrial fission factor  LOC100911613  mitochondrial fission factor-like  Data Merged 1643240 APPROVED
2012-07-05 LOC100911613  mitochondrial fission factor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-12-10 Mff  mitochondrial fission factor  RGD1310230  similar to RIKEN cDNA 5230400G24  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310230  similar to RIKEN cDNA 5230400G24  RGD1310230_predicted  similar to RIKEN cDNA 5230400G24 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310230_predicted  similar to RIKEN cDNA 5230400G24 (predicted)  LOC301563_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC301563_predicted  similar to RIKEN cDNA 5230400G24 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL