RGD Reference Report - Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. - Rat Genome Database

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Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats.

Authors: Kose, H  Moralejo, DH  Ogino, T  Mizuno, A  Yamada, T  Matsumoto, K 
Citation: Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
RGD ID: 625760
Pubmed: PMID:12420133   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-002-2199-y   (Journal Full-text)

The Otuska Long-Evans Tokushima Fatty (OLETF) rat is one of the well-characterized animal models for the study of type 2 diabetes. Our previous QTL mapping identified 11 loci responsible for non-insulin-dependent diabetes mellitus (NIDDM) susceptibility in the OLETF rat. Here we generated a series of congenic animals by individually introgressing all 11 OLETF-derived NIDDM loci into a normoglycemic F344 background. Subsequent oral glucose tolerance test revealed that the congenic strains for Nidd1/of, Nidd2/of, Nidd3/of Nidd4/of, Nidd7/of, and Nidd10/of showed significantly higher levels of blood glucose in comparison with parental host strain F344. Furthermore, simultaneously made heterozygote animals for Nidd1/of and Nidd2/of did not increase blood glucose levels, indicating that these loci are recessively inherited as predicted by the QTL analysis. Congenic strains for the other five loci-Nidd5/of, Nidd6/of, Nidd8/of, Nidd9/of, and Nidd11/of-were apparently normoglycemic, presumably owing to heterosis or because the effect of these loci may not be detected unless interactions with other OLETF genes exist. We believe that these congenic strains should provide useful agents for decomposing complex diabetic traits and for positional cloning.



Disease Annotations    
hyperglycemia  (IAGP)

Phenotype Annotations    

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table  |  Show All Strains Clinical Measurement

Strains with Phenominer Data Strains with phenominer dataStrains with phenominer data
F344.OLETF-(D11Mgh4-D11Mgh1)/2Tj F344.OLETF-(D1Mit20-D1Mgh26)/2Tj F344.OLETF-(D1Rat166-D1Rat90)/Tj
F344.OLETF-(D5Mgh4-D5Rat21)/Tj F344.OLETF-(D9Mgh8-D9Mit2)/2Tj F344.OLETF-(D12Wox5-D12Rat21)/Tj
F344.OLETF-(D14Rat8-D14Rat26)/Tj F344.OLETF-(D16Wox4-D16Rat13)/Tj F344.OLETF-(D10Wox7-D10Wox6)/Tj
F344/NSlc F344.OLETF-(D7Mgh16-D7Mgh20)/Tj F344.OLETF-(D14Rat8-D14Rat26)/2Tj
F344.OLETF-(D8Rat54-D8Mgh17)/2Tj

Objects Annotated

QTLs
Niddm19  (Non-insulin dependent diabetes mellitus QTL 19)
Niddm20  (Non-insulin dependent diabetes mellitus QTL 20)
Niddm22  (Non-insulin dependent diabetes mellitus QTL 22)
Niddm23  (Non-insulin dependent diabetes mellitus QTL 23)
Niddm24  (Non-insulin dependent diabetes mellitus QTL 24)
Niddm25  (Non-insulin dependent diabetes mellitus QTL 25)
Niddm26  (Non-insulin dependent diabetes mellitus QTL 26)
Niddm27  (Non-insulin dependent diabetes mellitus QTL 27)
Niddm28  (Non-insulin dependent diabetes mellitus QTL 28)
Niddm29  (Non-insulin dependent diabetes mellitus QTL 29)

Objects referenced in this article
QTL Bw21 Body weight QTL 21 Rattus norvegicus
Strain F344.OLETF-(D11Mgh4-D11Mgh1)/Tj null Rattus norvegicus
Strain F344.OLETF-(D12Rat8-D12Rat16)/Tj null Rattus norvegicus
Strain F344.OLETF-(D12Wox5-D12Rat21)/Tj null Rattus norvegicus
Strain F344.OLETF-(D14Rat23-D14Rat12)/Tj null Rattus norvegicus
Strain F344.OLETF-(D14Rat8-D14Rat26)(D14Rat18-D14Rat22)/Tj null Rattus norvegicus
Strain F344.OLETF-(D16Rat19-D16Rat13)/Tj null Rattus norvegicus
Strain F344.OLETF-(D16Wox4-D16Rat13)/Tj null Rattus norvegicus
Strain F344.OLETF-(D1Mit20-D1Mgh26)/Tj null Rattus norvegicus
Strain F344.OLETF-(D5Mgh4-D5Rat21)/Tj null Rattus norvegicus
Strain F344.OLETF-(D5Rat32-D5Rat26)/Tj null Rattus norvegicus
Strain F344.OLETF-(D7Mgh16-D7Mgh20)(D14Rat23-D14Rat12)/Tj null Rattus norvegicus
Strain F344.OLETF-(D7Mgh16-D7Mgh20)(D14Rat8-D14Rat26)/Tj null Rattus norvegicus
Strain F344.OLETF-(D8Rat54-D8Mgh17)/Tj null Rattus norvegicus
Strain F344.OLETF-(D9Mgh8-D9Mit2)/Tj null Rattus norvegicus
Strain F344.OLETF-(D9Mgh8-D9Rat15)/Tj null Rattus norvegicus
Strain KND/Tky komeda non-diabetic rat Rattus norvegicus
QTL Niddm21 Non-insulin dependent diabetes mellitus QTL 21 Rattus norvegicus

Additional Information