Igfbp5 (insulin-like growth factor binding protein 5) - Rat Genome Database

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Gene: Igfbp5 (insulin-like growth factor binding protein 5) Rattus norvegicus
Symbol: Igfbp5
Name: insulin-like growth factor binding protein 5
RGD ID: 2876
Description: Enables insulin-like growth factor binding activity. Involved in intracellular signal transduction and response to organic cyclic compound. Predicted to be part of insulin-like growth factor ternary complex. Predicted to be active in extracellular space. Biomarker of congenital diaphragmatic hernia. Orthologous to human IGFBP5 (insulin like growth factor binding protein 5); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,10-phenanthroline.
Type: protein-coding
Previously known as: IBP-5; IGF-binding protein 5; IGF-BP5; IGFBP-5; insulin-like growth factor-binding protein 5
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2974,452,371 - 74,464,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,448,382 - 74,465,156 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx982,907,194 - 82,919,768 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0988,036,079 - 88,048,653 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0986,422,859 - 86,435,462 (-)NCBIRnor_WKY
Rnor_6.0980,154,230 - 80,166,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl980,150,211 - 80,167,033 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0979,924,622 - 79,937,205 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4972,003,637 - 72,016,263 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1972,150,618 - 72,163,245 (-)NCBI
Celera972,045,541 - 72,058,122 (-)NCBICelera
RH 3.4 Map9679.1RGD
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,10-phenanthroline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
aluminium trifluoride  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzamidine  (EXP)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP)
bicalutamide  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
cytarabine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
disodium selenite  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (EXP)
flavonoids  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (EXP,ISO)
hydrazines  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
isoflavones  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP,ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nitrofen  (EXP)
Nonylphenol  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmethanesulfonyl fluoride  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
Thiorphan  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Regulation of granulosa cell-derived insulin-like growth factor binding proteins (IGFBPs): role for protein kinase-C in the pre- and posttranslational modulation of IGFBP-4 and IGFBP-5. Chamoun D, etal., Biol Reprod 2002 Sep;67(3):1003-12.
2. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
3. Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease. Fischer F, etal., Clin Endocrinol (Oxf). 2004 Nov;61(5):595-602.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Inverse correlation between insulin-like growth factor (IGF)-binding protein-5 and IGF-I and II during postnatal development of the anterior pituitary gland. Gonzalez-Parra S, etal., Horm Res 2002;57(1-2):10-4.
7. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes. Landau D, etal., Endocrinology. 1995 May;136(5):1835-42. doi: 10.1210/endo.136.5.7536658.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition. Pilewski JM, etal., Am J Pathol. 2005 Feb;166(2):399-407.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Downregulation of insulin-like growth factor binding protein 3 and 5 in nitrofen-induced pulmonary hypoplasia. Ruttenstock E, etal., Pediatr Surg Int. 2010 Jan;26(1):59-63. doi: 10.1007/s00383-009-2509-5.
16. Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. Shimasaki S, etal., J Biol Chem 1991 Jun 5;266(16):10646-53.
17. Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent. Spangenburg EE, etal., Am J Physiol Endocrinol Metab 2003 Feb;284(2):E340-50.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Cloning of the rat insulin- like growth factor binding protein-5 gene and DNA sequence analysis of its promoter region. Zhu X, etal., Biochem Biophys Res Commun 1993 Feb 15;190(3):1045-52.
Additional References at PubMed
PMID:7559606   PMID:9497324   PMID:10766744   PMID:12477932   PMID:12626499   PMID:14566968   PMID:15010534   PMID:15589207   PMID:15700281   PMID:15845624   PMID:16024235   PMID:16204335  
PMID:16311053   PMID:16339387   PMID:16672690   PMID:16675541   PMID:17255210   PMID:18762576   PMID:19208758   PMID:19236847   PMID:19864299   PMID:19897600   PMID:20167606   PMID:21598309  
PMID:23417767   PMID:25127757   PMID:25230843   PMID:28077319   PMID:29016699   PMID:31310371   PMID:31926246   PMID:33035436   PMID:35821045  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2974,452,371 - 74,464,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl974,448,382 - 74,465,156 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx982,907,194 - 82,919,768 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0988,036,079 - 88,048,653 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0986,422,859 - 86,435,462 (-)NCBIRnor_WKY
Rnor_6.0980,154,230 - 80,166,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl980,150,211 - 80,167,033 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0979,924,622 - 79,937,205 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4972,003,637 - 72,016,263 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1972,150,618 - 72,163,245 (-)NCBI
Celera972,045,541 - 72,058,122 (-)NCBICelera
RH 3.4 Map9679.1RGD
Cytogenetic Map9q33NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382216,672,105 - 216,695,549 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2216,672,105 - 216,695,549 (-)EnsemblGRCh38hg38GRCh38
GRCh372217,536,828 - 217,560,272 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,245,073 - 217,268,516 (-)NCBINCBI36Build 36hg18NCBI36
Build 342217,362,334 - 217,385,777NCBI
Celera2211,304,716 - 211,328,161 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2209,391,205 - 209,414,636 (-)NCBIHuRef
CHM1_12217,543,006 - 217,566,425 (-)NCBICHM1_1
T2T-CHM13v2.02217,154,530 - 217,177,979 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39172,897,224 - 72,914,024 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,897,091 - 72,914,043 (-)EnsemblGRCm39 Ensembl
GRCm38172,858,065 - 72,874,865 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,857,932 - 72,874,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv37172,904,639 - 72,921,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36172,791,272 - 72,808,072 (-)NCBIMGSCv36mm8
Celera173,426,251 - 73,443,205 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.94NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545316,530,110 - 16,550,733 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545316,530,110 - 16,550,733 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12B119,315,416 - 119,339,017 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B103,932,983 - 103,956,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B222,534,967 - 222,558,432 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B222,534,967 - 222,558,432 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13723,575,265 - 23,596,970 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3723,579,841 - 23,596,870 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3724,403,819 - 24,425,502 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03723,603,056 - 23,624,922 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3723,603,193 - 23,624,698 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13723,486,557 - 23,508,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03723,439,644 - 23,461,314 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03723,458,321 - 23,480,088 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303171,959,265 - 171,978,245 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936586647,493 - 666,621 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936586647,553 - 666,595 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl15118,857,625 - 118,878,120 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115118,861,816 - 118,877,787 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215131,682,267 - 131,684,608 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.110102,510,939 - 102,531,710 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10102,510,897 - 102,531,724 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604096,877,547 - 96,898,347 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248238,434,635 - 8,454,747 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248238,434,614 - 8,454,879 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Igfbp5
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:611
Count of miRNA genes:263
Interacting mature miRNAs:364
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0979,937,995 - 79,938,109NCBIRnor5.0
RGSC_v3.4972,017,507 - 72,017,728UniSTSRGSC3.4
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,448,393 - 74,448,601 (+)MAPPERmRatBN7.2
Rnor_6.0980,150,253 - 80,150,460NCBIRnor6.0
Rnor_5.0979,920,645 - 79,920,852UniSTSRnor5.0
RGSC_v3.4971,999,660 - 71,999,867UniSTSRGSC3.4
Celera972,041,564 - 72,041,771UniSTS
RH 3.4 Map9679.4UniSTS
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,464,690 - 74,464,989 (+)MAPPERmRatBN7.2
Rnor_6.0980,166,551 - 80,166,849NCBIRnor6.0
Rnor_5.0979,936,943 - 79,937,241UniSTSRnor5.0
RGSC_v3.4972,016,001 - 72,016,299UniSTSRGSC3.4
Celera972,057,860 - 72,058,158UniSTS
RH 3.4 Map9679.1UniSTS
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,448,392 - 74,448,603 (+)MAPPERmRatBN7.2
Rnor_6.0980,150,252 - 80,150,462NCBIRnor6.0
Rnor_5.0979,920,644 - 79,920,854UniSTSRnor5.0
RGSC_v3.4971,999,659 - 71,999,869UniSTSRGSC3.4
Celera972,041,563 - 72,041,773UniSTS
RH 3.4 Map9679.4UniSTS
Cytogenetic Map9q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,452,653 - 74,453,508 (+)MAPPERmRatBN7.2
Rnor_6.0980,154,513 - 80,155,367NCBIRnor6.0
Rnor_5.0979,924,905 - 79,925,759UniSTSRnor5.0
RGSC_v3.4972,003,920 - 72,004,774UniSTSRGSC3.4
Celera972,045,824 - 72,046,678UniSTS
Cytogenetic Map9q33UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 8
Medium 3 43 21 6 8 6 8 11 74 35 26 11 8
Low 35 34 11 34 7
Below cutoff 1 1 1


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023530   ⟹   ENSRNOP00000023530
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl974,448,382 - 74,465,156 (-)Ensembl
Rnor_6.0 Ensembl980,150,211 - 80,167,033 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079493   ⟹   ENSRNOP00000069640
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl980,154,230 - 80,166,807 (-)Ensembl
RefSeq Acc Id: NM_012817   ⟹   NP_036949
Rat AssemblyChrPosition (strand)Source
mRatBN7.2974,452,371 - 74,464,953 (-)NCBI
Rnor_6.0980,154,230 - 80,166,813 (-)NCBI
Rnor_5.0979,924,622 - 79,937,205 (-)NCBI
RGSC_v3.4972,003,637 - 72,016,263 (-)RGD
Celera972,045,541 - 72,058,122 (-)RGD
Protein Sequences
Protein RefSeqs NP_036949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA53533 (Get FASTA)   NCBI Sequence Viewer  
  AAN87105 (Get FASTA)   NCBI Sequence Viewer  
  EDL75317 (Get FASTA)   NCBI Sequence Viewer  
  P24594 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036949   ⟸   NM_012817
- Peptide Label: precursor
- UniProtKB: P24594 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069640   ⟸   ENSRNOT00000079493
RefSeq Acc Id: ENSRNOP00000023530   ⟸   ENSRNOT00000023530
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24594-F1-model_v2 AlphaFold P24594 1-271 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696740
Promoter ID:EPDNEW_R7265
Type:single initiation site
Description:insulin-like growth factor binding protein 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0980,167,035 - 80,167,095EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2876 AgrOrtholog
BioCyc Gene G2FUF-27190 BioCyc
Ensembl Genes ENSRNOG00000017206 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000023530 ENTREZGENE
  ENSRNOP00000023530.3 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023530 ENTREZGENE
  ENSRNOT00000023530.7 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot
  4.10.800.10 UniProtKB/Swiss-Prot
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-5 UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot
KEGG Report rno:25285 UniProtKB/Swiss-Prot
  PTHR11551:SF4 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  Thyroglobulin_1 UniProtKB/Swiss-Prot
PhenoGen Igfbp5 PhenoGen
  IGFBPFAMILY5 UniProtKB/Swiss-Prot
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot
  IGFBP_N_2 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot
SMART SM00121 UniProtKB/Swiss-Prot
  SM00211 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57610 UniProtKB/Swiss-Prot
TIGR TC217713
UniProt IBP5_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Igfbp5  insulin-like growth factor binding protein 5    insulin-like growth factor-binding protein 5  Name updated 1299863 APPROVED
2002-06-10 Igfbp5  insulin-like growth factor-binding protein 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in soleus muscle 729113
gene_regulation expression is decreased in soleus muscle by aging 729113