Igfbp5 (insulin-like growth factor binding protein 5) - Rat Genome Database
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Gene: Igfbp5 (insulin-like growth factor binding protein 5) Rattus norvegicus
Analyze
Symbol: Igfbp5
Name: insulin-like growth factor binding protein 5
RGD ID: 2876
Description: Exhibits insulin-like growth factor binding activity. Involved in aging and intracellular signal transduction. Predicted to localize to insulin-like growth factor ternary complex. Biomarker of congenital diaphragmatic hernia. Orthologous to human IGFBP5 (insulin like growth factor binding protein 5); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,10-phenanthroline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IBP-5; IGF-binding protein 5; IGF-BP5; IGFBP-5; insulin-like growth factor-binding protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2974,452,371 - 74,464,953 (-)NCBI
Rnor_6.0 Ensembl980,150,211 - 80,167,033 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0980,154,230 - 80,166,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0979,924,622 - 79,937,205 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4972,003,637 - 72,016,263 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1972,150,618 - 72,163,245 (-)NCBI
Celera972,045,541 - 72,058,122 (-)NCBICelera
RH 3.4 Map9679.1RGD
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(+)-catechin  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,10-phenanthroline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
aluminium trifluoride  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzamidine  (EXP)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP)
bicalutamide  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
cytarabine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
disodium selenite  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (EXP)
flavonoids  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
gentamycin  (EXP,ISO)
hydrazines  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
isoflavones  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (EXP)
linuron  (EXP)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP,ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nitrofen  (EXP)
Nonylphenol  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentane-2,3-dione  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmethanesulfonyl fluoride  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
Thiorphan  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7559606   PMID:9497324   PMID:10766744   PMID:12477932   PMID:12626499   PMID:14566968   PMID:15010534   PMID:15589207   PMID:15700281   PMID:15845624   PMID:16024235   PMID:16204335  
PMID:16311053   PMID:16339387   PMID:16672690   PMID:16675541   PMID:17255210   PMID:18762576   PMID:19208758   PMID:19236847   PMID:19864299   PMID:19897600   PMID:20167606   PMID:21598309  
PMID:23417767   PMID:25127757   PMID:25230843   PMID:28077319   PMID:29016699   PMID:31310371   PMID:31926246   PMID:33035436  


Genomics

Comparative Map Data
Igfbp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2974,452,371 - 74,464,953 (-)NCBI
Rnor_6.0 Ensembl980,150,211 - 80,167,033 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0980,154,230 - 80,166,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0979,924,622 - 79,937,205 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4972,003,637 - 72,016,263 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1972,150,618 - 72,163,245 (-)NCBI
Celera972,045,541 - 72,058,122 (-)NCBICelera
RH 3.4 Map9679.1RGD
Cytogenetic Map9q33NCBI
IGFBP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2216,672,105 - 216,695,549 (-)EnsemblGRCh38hg38GRCh38
GRCh382216,672,105 - 216,695,549 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372217,536,828 - 217,560,272 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,245,073 - 217,268,516 (-)NCBINCBI36hg18NCBI36
Build 342217,362,334 - 217,385,777NCBI
Celera2211,304,716 - 211,328,161 (-)NCBI
Cytogenetic Map2q35NCBI
HuRef2209,391,205 - 209,414,636 (-)NCBIHuRef
CHM1_12217,543,006 - 217,566,425 (-)NCBICHM1_1
Igfbp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,897,224 - 72,914,024 (-)NCBIGRCm39mm39
GRCm39 Ensembl172,897,091 - 72,914,043 (-)Ensembl
GRCm38172,858,065 - 72,874,865 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,857,932 - 72,874,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv37172,904,639 - 72,921,439 (-)NCBIGRCm37mm9NCBIm37
MGSCv36172,791,272 - 72,808,072 (-)NCBImm8
Celera173,426,251 - 73,443,205 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.94NCBI
Igfbp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545316,530,110 - 16,550,733 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545316,530,110 - 16,550,733 (+)NCBIChiLan1.0ChiLan1.0
IGFBP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B222,534,967 - 222,558,432 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B222,534,967 - 222,558,432 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B103,932,983 - 103,956,475 (-)NCBIMhudiblu_PPA_v0panPan3
IGFBP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3723,579,841 - 23,596,870 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13723,575,265 - 23,596,970 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Igfbp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936586647,553 - 666,595 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15118,857,479 - 118,878,522 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115118,861,816 - 118,877,787 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215131,682,267 - 131,684,608 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110102,510,939 - 102,531,710 (-)NCBI
ChlSab1.1 Ensembl10102,510,897 - 102,531,724 (-)Ensembl
Igfbp5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248238,434,614 - 8,454,879 (+)NCBI

Position Markers
D9Wox32  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0979,937,995 - 79,938,109NCBIRnor5.0
RGSC_v3.4972,017,507 - 72,017,728UniSTSRGSC3.4
Cytogenetic Map9q33UniSTS
RH127562  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0980,150,253 - 80,150,460NCBIRnor6.0
Rnor_5.0979,920,645 - 79,920,852UniSTSRnor5.0
RGSC_v3.4971,999,660 - 71,999,867UniSTSRGSC3.4
Celera972,041,564 - 72,041,771UniSTS
RH 3.4 Map9679.4UniSTS
Cytogenetic Map9q33UniSTS
RH94791  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0980,166,551 - 80,166,849NCBIRnor6.0
Rnor_5.0979,936,943 - 79,937,241UniSTSRnor5.0
RGSC_v3.4972,016,001 - 72,016,299UniSTSRGSC3.4
Celera972,057,860 - 72,058,158UniSTS
RH 3.4 Map9679.1UniSTS
Cytogenetic Map9q33UniSTS
AA963598  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0980,150,252 - 80,150,462NCBIRnor6.0
Rnor_5.0979,920,644 - 79,920,854UniSTSRnor5.0
RGSC_v3.4971,999,659 - 71,999,869UniSTSRGSC3.4
Celera972,041,563 - 72,041,773UniSTS
RH 3.4 Map9679.4UniSTS
Cytogenetic Map9q33UniSTS
Igfbp5  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0980,154,513 - 80,155,367NCBIRnor6.0
Rnor_5.0979,924,905 - 79,925,759UniSTSRnor5.0
RGSC_v3.4972,003,920 - 72,004,774UniSTSRGSC3.4
Celera972,045,824 - 72,046,678UniSTS
Cytogenetic Map9q33UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9105522293442944Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92569234292741406Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92748615588333183Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92907507983686404Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)929075079122095297Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)929466970107878528Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93764235182642351Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93764235182642351Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)94126103490024806Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94126103498606834Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)941261034102531865Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94657976991579769Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94657976991579769Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94695242783686153Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94724896594124663Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95417754299177542Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)96081029882732466Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)961186278106186278Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)96173092382890620Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)96173092382890620Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)96173092382890620Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)963270073107878387Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)966757444112943287Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96745166499920892Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96745166499920892Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)970241351115241351Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)970942881115942881Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:611
Count of miRNA genes:263
Interacting mature miRNAs:364
Transcripts:ENSRNOT00000023530
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 8
Medium 3 43 21 6 8 6 8 11 74 35 26 11 8
Low 35 34 11 34 7
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023530   ⟹   ENSRNOP00000023530
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl980,150,211 - 80,167,033 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079493   ⟹   ENSRNOP00000069640
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl980,154,230 - 80,166,807 (-)Ensembl
RefSeq Acc Id: NM_012817   ⟹   NP_036949
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2974,452,371 - 74,464,953 (-)NCBI
Rnor_6.0980,154,230 - 80,166,813 (-)NCBI
Rnor_5.0979,924,622 - 79,937,205 (-)NCBI
RGSC_v3.4972,003,637 - 72,016,263 (-)RGD
Celera972,045,541 - 72,058,122 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA53533 (Get FASTA)   NCBI Sequence Viewer  
  AAN87105 (Get FASTA)   NCBI Sequence Viewer  
  EDL75317 (Get FASTA)   NCBI Sequence Viewer  
  P24594 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036949   ⟸   NM_012817
- Peptide Label: precursor
- UniProtKB: P24594 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069640   ⟸   ENSRNOT00000079493
RefSeq Acc Id: ENSRNOP00000023530   ⟸   ENSRNOT00000023530
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696740
Promoter ID:EPDNEW_R7265
Type:single initiation site
Name:Igfbp5_1
Description:insulin-like growth factor binding protein 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0980,167,035 - 80,167,095EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2876 AgrOrtholog
Ensembl Genes ENSRNOG00000017206 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023530 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000069640 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023530 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000079493 UniProtKB/TrEMBL
Gene3D-CATH 4.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110383 IMAGE-MGC_LOAD
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25285 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93594 IMAGE-MGC_LOAD
NCBI Gene 25285 ENTREZGENE
PANTHER PTHR11551:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igfbp5 PhenoGen
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBPFAMILY5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217713
UniProt A0A0G2JVW1_RAT UniProtKB/TrEMBL
  IBP5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Igfbp5  insulin-like growth factor binding protein 5    insulin-like growth factor-binding protein 5  Name updated 1299863 APPROVED
2002-06-10 Igfbp5  insulin-like growth factor-binding protein 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in soleus muscle 729113
gene_regulation expression is decreased in soleus muscle by aging 729113