Advanced Search (OLGA)

Gene: Stradb (STE20 related adaptor beta) Rattus norvegicus

Analyze

Symbol:

Stradb

Name:

STE20 related adaptor beta

RGD ID:

1559449

Description:

Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in activation of protein kinase activity and protein export from nucleus. Predicted to act upstream of or within JNK cascade; cell morphogenesis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in aggresome; cytosol; and nucleus. Predicted to be part of serine/threonine protein kinase complex. Orthologous to human STRADB (STE20 related adaptor beta); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Als2cr2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 (human); LOC501146; polyploidy associated protein kinase PAPK-A; RGD1559449; similar to polyploidy associated protein kinase PAPK-A; STE20-related kinase adapter protein beta; STE20-related kinase adaptor beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	STRADB (STE20 related adaptor beta)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Stradb (STE20-related kinase adaptor beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Stradb (STE20 related adaptor beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	STRADB (STE20 related adaptor beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	STRADB (STE20 related adaptor beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Stradb (STE20 related adaptor beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	STRADB (STE20 related adaptor beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	STRADB (STE20 related adaptor beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Stradb (STE20 related adaptor beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	STRADB (STE20 related adaptor beta)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Stradb (STE20-related kinase adaptor beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Stlk	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	strd-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PhylomeDB)
Danio rerio (zebrafish):	stradb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	stradb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	67,908,277 - 67,927,224 (+)	NCBI		GRCr8
mRatBN7.2	9	60,414,182 - 60,433,084 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	60,414,182 - 60,433,084 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	68,909,965 - 68,928,356 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	74,025,925 - 74,044,316 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	72,344,201 - 72,362,592 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	65,763,437 - 65,782,513 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	65,763,437 - 65,782,513 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	65,570,181 - 65,589,257 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	57,540,915 - 57,559,817 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	57,853,259 - 57,871,982 (+)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune lymphoproliferative syndrome type 2B (ISO)

Autoimmune Lymphoproliferative Syndrome, Type V (ISO)

common variable immunodeficiency 1 (ISO)

Joubert syndrome 14 (ISO)

Neurodevelopmental Disorders (ISO)

Pulmonary Arterial Hypertension (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4-hydroxynon-2-enal (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

cannabidiol (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

diethylstilbestrol (EXP)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

folic acid (ISO)

gentamycin (EXP)

glafenine (EXP)

hydrogen peroxide (ISO)

L-methionine (ISO)

leflunomide (ISO)

methylmercury chloride (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

sunitinib (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

thiram (ISO)

topotecan (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of protein kinase activity (ISO)

cell morphogenesis (IEA,ISO)

JNK cascade (IEA,ISO)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (IEA,ISO)

protein export from nucleus (IBA,IEA,ISO)

protein phosphorylation (ISO)

Cellular Component

aggresome (IEA,ISO)

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

nucleus (IEA,ISO)

serine/threonine protein kinase complex (IBA)

Molecular Function

ATP binding (IEA)

protein binding (ISO)

protein kinase activity (ISO)

protein serine/threonine kinase activator activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12574163	PMID:14517248

Genomics

Comparative Map Data

Stradb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	67,908,277 - 67,927,224 (+)	NCBI		GRCr8
mRatBN7.2	9	60,414,182 - 60,433,084 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	60,414,182 - 60,433,084 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	68,909,965 - 68,928,356 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	74,025,925 - 74,044,316 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	72,344,201 - 72,362,592 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	65,763,437 - 65,782,513 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	65,763,437 - 65,782,513 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	65,570,181 - 65,589,257 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	57,540,915 - 57,559,817 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	9	57,853,259 - 57,871,982 (+)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

STRADB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	201,451,740 - 201,480,846 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	201,387,858 - 201,480,846 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	202,316,463 - 202,345,569 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	202,024,637 - 202,053,819 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	202,141,897 - 202,170,956	NCBI
Celera	2	196,068,337 - 196,097,512 (+)	NCBI		Celera
Cytogenetic Map	2	q33.1	NCBI
HuRef	2	194,164,497 - 194,193,482 (+)	NCBI		HuRef
CHM1_1	2	202,322,488 - 202,351,676 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	201,932,523 - 201,961,624 (+)	NCBI		T2T-CHM13v2.0

Stradb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	59,012,681 - 59,034,281 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	59,012,681 - 59,034,874 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	58,973,522 - 58,995,122 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	58,973,522 - 58,995,715 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	59,030,415 - 59,051,966 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	58,918,117 - 58,939,668 (+)	NCBI		MGSCv36	mm8
Celera	1	59,489,295 - 59,510,821 (+)	NCBI		Celera
Cytogenetic Map	1	C1.3	NCBI
cM Map	1	29.2	NCBI

Stradb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	181,120 - 198,885 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	181,120 - 198,882 (-)	NCBI	ChiLan1.0	ChiLan1.0

STRADB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	104,075,176 - 104,104,917 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	104,090,176 - 104,119,917 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	88,705,840 - 88,735,511 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	206,861,151 - 206,890,868 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	206,864,319 - 206,890,868 (+)	Ensembl	panpan1.1		panPan2

STRADB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	10,521,643 - 10,557,611 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	10,521,574 - 10,557,231 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	11,405,300 - 11,441,314 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	10,426,375 - 10,462,454 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	10,426,315 - 10,462,454 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	10,407,001 - 10,442,996 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	10,386,018 - 10,422,012 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	10,379,447 - 10,415,449 (+)	NCBI		UU_Cfam_GSD_1.0

Stradb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	158,738,725 - 158,758,405 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936726	709,038 - 731,338 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936726	709,037 - 728,696 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STRADB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	105,055,274 - 105,126,927 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	105,055,218 - 105,083,429 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	116,465,665 - 116,493,729 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STRADB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	87,096,768 - 87,127,131 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	87,096,838 - 87,127,209 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	112,293,201 - 112,322,783 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stradb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624899	255,042 - 275,235 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624899	255,042 - 275,258 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Stradb
94 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	583
Count of miRNA genes:	262
Interacting mature miRNAs:	316
Transcripts:	ENSRNOT00000043558
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	32535505	77535505	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	23754024	61381613	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
631680	Cm11	Cardiac mass QTL 11	3.1	0.00089	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	9	20430519	65430519	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	25268044	79271759	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
631643	Bp120	Blood pressure QTL 120	3	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	22071200	67071200	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
1598849	Memor17	Memory QTL 17	2.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	49968546	71098346	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	55847841	77026453	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	42495343	79271511	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	36962359	77814038	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	22071169	86369743	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	23754144	83851531	Rat
6903941	Pur31	Proteinuria QTL 31		0.036	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	9	40194188	85194188	Rat
2303180	Bp333	Blood pressure QTL 333		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56627713	78595166	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
11353949	Bp393	Blood pressure QTL 393			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	40194188	85194188	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	32535505	77535505	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	27468639	72468639	Rat

Markers in Region

AA792893

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	9	67,926,686 - 67,926,932 (+)	Marker Load Pipeline
mRatBN7.2	9	60,432,545 - 60,432,792 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	65,781,975 - 65,782,221	NCBI	Rnor6.0
Rnor_5.0	9	65,588,719 - 65,588,965	UniSTS	Rnor5.0
RGSC_v3.4	9	57,559,279 - 57,559,525	UniSTS	RGSC3.4
Celera	9	57,871,444 - 57,871,690	UniSTS
Cytogenetic Map	9	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000043558 ⟹ ENSRNOP00000049160

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	60,414,182 - 60,433,084 (+)	Ensembl
Rnor_6.0 Ensembl	9	65,763,437 - 65,782,513 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096296 ⟹ ENSRNOP00000095704

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	60,414,210 - 60,432,814 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109430 ⟹ ENSRNOP00000083664

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	60,414,182 - 60,433,045 (+)	Ensembl

RefSeq Acc Id:

NM_001109307 ⟹ NP_001102777

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	67,908,322 - 67,927,224 (+)	NCBI
mRatBN7.2	9	60,414,182 - 60,433,084 (+)	NCBI
Rnor_6.0	9	65,763,437 - 65,782,513 (+)	NCBI
Rnor_5.0	9	65,570,181 - 65,589,257 (+)	NCBI
RGSC_v3.4	9	57,540,915 - 57,559,817 (+)	RGD
Celera	9	57,853,259 - 57,871,982 (+)	RGD

Sequence:

show sequence

AAGCTGGAGGCGCGGTGGGGCGGAGCGGCGGGTCCCGACCCCGCTGGGGTGGGGCGAATCCCGT
CCCAGCCGGTTGCCCCGGACTAGGGCAGAGGTCCAGGCCGACAGGCCTTCTGCGGCGGTGCTGC
ACTTCTGTGCCTTGAGGCTCGCCCTGGAAGCAGGCCTAGTGTTCTCGCCTCGCCGCTCCGCGAG
GCAGGTCCCGGGTCTCGCGCGTGTCGCCTCCCCCCAGCGCCCGCCGCCTGGAGAGTCGCTGGCC
TTGATCGCTGCCTAGTGGGATATATCTGCAACTTGAAGGGAAGATAAAGGAAAAAATCTTTGGA
ATAGATGGGATTTTGTCACTTTCTGTGAACTAAAGCGATTCAATGTCTCTTTTGGATTGTTTCT
GTGCTTCACGTACACGAGTTGAATCACTCAGACCTGAAAAGCAATCTGAAACCAGTATCCATCA
ATACTCGGTTGATGAGCCAGCTATTTCCTGGTCCCCTCCATGTGCTACAACCAATGAAGTGCTG
TGCTCCACGGATGCCACTCACTATGAACTGCATGTGGAGATAGGAAGAGGGTTCGACAACTTGA
CCTCTGTTCATCTCGCACGGCACACTCCTACAGGAACACTGGTAACTATAAAAATTACAAACCT
GGAGACCTGCACTGACGAGCGTCTGAGAGCTTTACAGAGAGCGGTGATTCTATCTCACTTTTTC
CAACATCCCAATATTACAACTTACTGGACAGTTTTCACTGTTGGCAGCTGGCTTTGGGTTATTT
ATCCATTCATGGCCTACGGTTCAGCAAGTCAGCTCCTAAGGACCTACTTTCCTGATGGAATGAG
TGAAACTTTAATAAGAAACATTCTCTTTGGAGCAGTACGAGGGTTGAACTATCTGCACCAAAAT
GGCTGCATCCATAGGAGTTTTAAAGCCAGCCATATCCTCATTTCTGGTGATGGCCTGGTGACCC
TCTCTGGCCTGTCCCATCTGCATAGTTTGGTTAAGCACGGACAAAGGCATAGGGCTGTGTTTGA
TTTCCCACAGTTCAGCACCTCAGTGCAGCCGTGGCTGAGTCCAGAACTACTGAGACAGGATTTA
CATGGATATAATGTGAAGTCTGATATTTACAGTGTTGGGATCACAGCCTGTGAATTGGCCAGCG
GGCAGGTTCCTTTCCAGGACATGCATAGTACTCAGATGCTACTACAGAAACTGAAAGGTCCTCC
ATATAGCCCACTGGATGTCAGTATTTTTCCTCAGTCAGACTCTAGAATGAGAAATTCCCAGTCA
GGAGTAGACTCTGGGATTGGAGAGAGCGTGCTTGTCTCCACTGGAACTCACACAGTCAATAGTG
ACCGGCTCCACACGCCATCCACAAGAACATTCTCTCCTGCCTTTTTTAGCTTGGTGCAGCTGTG
TTTGCAGCAAGATCCTGAGAAAAGGCCATCAGCAAGCAGTTTGTTGTCCCATGTTTTCTTCAAG
CAGATGAAAGAAGAAAGCCAAGACTCCATACTCTCCCTGCTGCCACCTGCTTATAACAGGCCAG
CAGCGTCACTGCCACCAGTGTCACCGTGGAGCGAGCTGGAATTCCAGTTTCCTGATGACAAAGA
CCCAGACTGGGAATTCTAGGGTTCCAAATCATTTCATGTCCTCTATACTTGACAGCCTCTCCTT
GCTGCTTGTCTTCTGTCTTGTTAGGTACAAATGACAAATCTATACTTGAAAATACAGTTGGTGC
ACTGGAGAATGATCAGTTAAACCACTCTGTTCATGGGGCACGAATTGACCCTCTCTGCCCAGAT
CAGAACACCCGCACGACCAACGTCAGTTATGCCCAGCTCAGCCAGTGTTGGCTCTCCTTTCCCT
TCCTTTCCTTCTCTCTTCTTTCCCACCTTCTAAACTGTGACTGGTACTTTCTGGATCTCAGTGA
GCTTTTGACCTGGTTAATTTTCTTCTACATTTTACTGTGCTCTGGGGAATGAATCCTTCTCAGG
ACAGTGCTTCCAGAGCATCTTTTCTTCCAGATTCACTAGCCTTTTTGACCAGCTGTTGTTAGAT
GAACAGGCTGGTTTACTCTGGTACAAAGCCCTTTTTTGGAGAAGGGAAAATGTTTGTACTGTCC
CTTTTACCTATGGCAACATCAGACTGAGCCTTGCTCACATTGAATAATTCACTCGAACTATAAA
GAGAAGATGCAGTTTGCATTTCAAAAGAGAAGGGGCTAACATATCACTTTTCTACCTGTGTAAA
TTATAAATCATTAATTCATGCACCCTGTGGGAGCTCAATAAAAATGTATTAAATTGAACGTTCC
TTTTATTTATTTTGTGTGGCTTAATAAAGCTAGTACACAGATTTTAA

hide sequence

RefSeq Acc Id:

XM_039084089 ⟹ XP_038940017

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	67,908,277 - 67,927,224 (+)	NCBI
mRatBN7.2	9	60,414,183 - 60,432,341 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102777	(Get FASTA)	NCBI Sequence Viewer
	XP_038940017	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL98970	(Get FASTA)	NCBI Sequence Viewer
	EDL98971	(Get FASTA)	NCBI Sequence Viewer
	EDL98972	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000049160
	ENSRNOP00000049160.2
	ENSRNOP00000083664.1
	ENSRNOP00000095704.1

RefSeq Acc Id:

NP_001102777 ⟸ NM_001109307

- UniProtKB:

D3ZVH0 (UniProtKB/TrEMBL), A6IP88 (UniProtKB/TrEMBL), A0A8I6AK98 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSLLDCFCASRTRVESLRPEKQSETSIHQYSVDEPAISWSPPCATTNEVLCSTDATHYELHVEI
GRGFDNLTSVHLARHTPTGTLVTIKITNLETCTDERLRALQRAVILSHFFQHPNITTYWTVFTV
GSWLWVIYPFMAYGSASQLLRTYFPDGMSETLIRNILFGAVRGLNYLHQNGCIHRSFKASHILI
SGDGLVTLSGLSHLHSLVKHGQRHRAVFDFPQFSTSVQPWLSPELLRQDLHGYNVKSDIYSVGI
TACELASGQVPFQDMHSTQMLLQKLKGPPYSPLDVSIFPQSDSRMRNSQSGVDSGIGESVLVST
GTHTVNSDRLHTPSTRTFSPAFFSLVQLCLQQDPEKRPSASSLLSHVFFKQMKEESQDSILSLL
PPAYNRPAASLPPVSPWSELEFQFPDDKDPDWEF

hide sequence

Ensembl Acc Id:

ENSRNOP00000049160 ⟸ ENSRNOT00000043558

RefSeq Acc Id:	XP_038940017 ⟸ XM_039084089
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AK98 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000083664 ⟸ ENSRNOT00000109430

Ensembl Acc Id:

ENSRNOP00000095704 ⟸ ENSRNOT00000096296

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZVH0-F1-model_v2	AlphaFold	D3ZVH0	1-418	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696696

Promoter ID:

EPDNEW_R7221

Type:

initiation region

Name:

Stradb_1

Description:

STE20-related kinase adaptor beta

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	65,763,527 - 65,763,587	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1559449	AgrOrtholog
BioCyc Gene	G2FUF-27428	BioCyc
Ensembl Genes	ENSRNOG00000010728	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000043558	ENTREZGENE
	ENSRNOT00000043558.3	UniProtKB/TrEMBL
	ENSRNOT00000096296.1	UniProtKB/TrEMBL
	ENSRNOT00000109430.1	UniProtKB/TrEMBL
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	STRAD_A/B-like	UniProtKB/TrEMBL
KEGG Report	rno:501146	UniProtKB/TrEMBL
NCBI Gene	501146	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN KINASE FRAY2	UniProtKB/TrEMBL
	STE20-RELATED KINASE ADAPTER PROTEIN BETA	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PhenoGen	Stradb	PhenoGen
PROSITE	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010728	RatGTEx
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZXN6_RAT	UniProtKB/TrEMBL
	A0A8I6AK98	ENTREZGENE, UniProtKB/TrEMBL
	A6IP88	ENTREZGENE, UniProtKB/TrEMBL
	D3ZVH0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-12-04	Stradb	STE20 related adaptor beta	Stradb	STE20-related kinase adaptor beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-11-05	Stradb	STE20-related kinase adaptor beta	Als2cr2	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-15	Als2cr2	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 (human)	Als2cr2	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Als2cr2	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2	RGD1559449_predicted	similar to polyploidy associated protein kinase PAPK-A (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1559449_predicted	similar to polyploidy associated protein kinase PAPK-A (predicted)	LOC501146	similar to polyploidy associated protein kinase PAPK-A	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC501146	similar to polyploidy associated protein kinase PAPK-A			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar