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Gene: Atic (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) Rattus norvegicus
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Symbol: Atic
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Description: Exhibits IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in several processes, including animal organ development; folic acid-containing compound metabolic process; and nucleobase-containing small molecule metabolic process. Predicted to localize to the cytosol and plasma membrane. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase); PARTICIPATES IN folate mediated one-carbon metabolic pathway; folate metabolic pathway; purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP; bifunctional purine biosynthesis protein PURH
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0978,862,013 - 78,882,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,862,013 - 78,882,060 (+)Ensembl
Rnor_5.0978,636,339 - 78,656,387 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,676,744 - 70,696,865 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1970,823,725 - 70,843,846 (+)NCBI
Celera970,582,456 - 70,602,475 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Atic
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70879
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.