Actr1b (actin related protein 1B) - Rat Genome Database

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Gene: Actr1b (actin related protein 1B) Rattus norvegicus
Analyze
Symbol: Actr1b
Name: actin related protein 1B
RGD ID: 1307380
Description: Predicted to be located in centrosome and cytoplasm. Orthologous to human ACTR1B (actin related protein 1B); INTERACTS WITH bisphenol A; fipronil; flutamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ARP1 actin related protein 1 homolog B; ARP1 actin-related protein 1 homolog B; ARP1 actin-related protein 1 homolog B (yeast); ARP1 actin-related protein 1 homolog B, centractin beta; ARP1 actin-related protein 1 homolog B, centractin beta (yeast); beta-centractin; LOC316333; MGC116310
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2938,928,819 - 38,938,483 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl938,929,912 - 38,938,507 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx947,431,851 - 47,441,470 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0952,547,613 - 52,557,279 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0950,829,511 - 50,839,177 (-)NCBIRnor_WKY
Rnor_6.0943,267,053 - 43,276,717 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl943,267,057 - 43,276,685 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0942,919,561 - 42,929,225 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4935,632,318 - 35,641,982 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1935,635,671 - 35,643,387 (-)NCBI
Celera936,695,198 - 36,704,862 (-)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:19946888   PMID:21399614   PMID:22871113   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Actr1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2938,928,819 - 38,938,483 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl938,929,912 - 38,938,507 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx947,431,851 - 47,441,470 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0952,547,613 - 52,557,279 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0950,829,511 - 50,839,177 (-)NCBIRnor_WKY
Rnor_6.0943,267,053 - 43,276,717 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl943,267,057 - 43,276,685 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0942,919,561 - 42,929,225 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4935,632,318 - 35,641,982 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1935,635,671 - 35,643,387 (-)NCBI
Celera936,695,198 - 36,704,862 (-)NCBICelera
Cytogenetic Map9q21NCBI
ACTR1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38297,655,939 - 97,664,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl297,655,939 - 97,664,044 (-)EnsemblGRCh38hg38GRCh38
GRCh37298,272,402 - 98,280,507 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36297,638,863 - 97,646,816 (-)NCBINCBI36Build 36hg18NCBI36
Build 34297,730,948 - 97,738,902NCBI
Celera292,476,403 - 92,484,541 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef292,038,099 - 92,046,237 (-)NCBIHuRef
CHM1_1298,276,759 - 98,284,918 (-)NCBICHM1_1
T2T-CHM13v2.0298,114,160 - 98,122,265 (-)NCBIT2T-CHM13v2.0
Actr1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,737,195 - 36,749,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl136,737,195 - 36,753,503 (-)EnsemblGRCm39 Ensembl
GRCm38136,698,114 - 36,710,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,698,114 - 36,714,422 (-)EnsemblGRCm38mm10GRCm38
MGSCv37136,756,047 - 36,766,770 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36136,643,748 - 36,654,471 (-)NCBIMGSCv36mm8
Celera136,485,914 - 36,496,820 (-)NCBICelera
Cytogenetic Map1BNCBI
Actr1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554704,326,096 - 4,336,441 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554704,328,895 - 4,336,441 (-)NCBIChiLan1.0ChiLan1.0
ACTR1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A98,555,298 - 98,563,389 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A98,555,298 - 98,563,389 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A101,659,316 - 101,667,402 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACTR1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11044,964,979 - 44,972,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1044,899,103 - 44,972,613 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1044,891,846 - 44,899,863 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01045,840,987 - 45,849,007 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1045,841,006 - 45,850,553 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11045,552,752 - 45,560,767 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01045,838,842 - 45,846,851 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01046,022,193 - 46,030,210 (+)NCBIUU_Cfam_GSD_1.0
Actr1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629283,675,139 - 83,682,983 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936744928,073 - 936,043 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936744928,075 - 935,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTR1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl356,610,304 - 56,620,164 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1356,610,356 - 56,619,171 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2359,388,416 - 59,395,936 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTR1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1141,342,290 - 1,350,496 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl141,342,100 - 1,350,197 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041168,783,466 - 168,791,549 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actr1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,844,063 - 2,852,290 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247492,844,295 - 2,851,805 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Actr1b
63 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:157
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000022779
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat

Markers in Region
RH132454  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2938,928,944 - 38,929,156 (+)MAPPERmRatBN7.2
Rnor_6.0943,267,179 - 43,267,390NCBIRnor6.0
Rnor_5.0942,919,687 - 42,919,898UniSTSRnor5.0
RGSC_v3.4935,632,444 - 35,632,655UniSTSRGSC3.4
Celera936,695,324 - 36,695,535UniSTS
RH 3.4 Map9368.2UniSTS
Cytogenetic Map9q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 37 11 8
Low 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022779   ⟹   ENSRNOP00000022779
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl938,930,759 - 38,937,089 (-)Ensembl
Rnor_6.0 Ensembl943,267,057 - 43,276,685 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076692
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl938,929,912 - 38,938,507 (-)Ensembl
Rnor_6.0 Ensembl943,268,146 - 43,271,043 (-)Ensembl
RefSeq Acc Id: NM_001039028   ⟹   NP_001034117
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2938,928,819 - 38,938,483 (-)NCBI
Rnor_6.0943,267,053 - 43,276,717 (-)NCBI
Rnor_5.0942,919,561 - 42,929,225 (-)NCBI
RGSC_v3.4935,632,318 - 35,641,982 (-)RGD
Celera936,695,198 - 36,704,862 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001034117 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66803 (Get FASTA)   NCBI Sequence Viewer  
  EDL99257 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001034117   ⟸   NM_001039028
- UniProtKB: B2RYJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022779   ⟸   ENSRNOT00000022779

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYJ7-F1-model_v2 AlphaFold B2RYJ7 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696609
Promoter ID:EPDNEW_R7134
Type:initiation region
Name:Actr1b_1
Description:ARP1 actin related protein 1 homolog B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0943,276,698 - 43,276,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307380 AgrOrtholog
BioCyc Gene G2FUF-27800 BioCyc
Ensembl Genes ENSRNOG00000016789 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022779 ENTREZGENE
  ENSRNOP00000022779.5 UniProtKB/TrEMBL
  ENSRNOP00000093915.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022779 ENTREZGENE
  ENSRNOT00000022779.7 UniProtKB/TrEMBL
  ENSRNOT00000076692.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7380320 IMAGE-MGC_LOAD
  IMAGE:7938869 IMAGE-MGC_LOAD
InterPro Actin-like UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/TrEMBL
  Actin_CS UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
KEGG Report rno:316333 UniProtKB/TrEMBL
MGC_CLONE MGC:116310 IMAGE-MGC_LOAD
  MGC:188605 IMAGE-MGC_LOAD
NCBI Gene 316333 ENTREZGENE
PANTHER Actin_like UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PhenoGen Actr1b PhenoGen
PRINTS ACTIN UniProtKB/TrEMBL
PROSITE ACTINS_2 UniProtKB/TrEMBL
  ACTINS_ACT_LIKE UniProtKB/TrEMBL
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A8I6AKZ9_RAT UniProtKB/TrEMBL
  B2RYJ7 ENTREZGENE, UniProtKB/TrEMBL
  F7F067_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-25 Actr1b  actin related protein 1B  Actr1b  ARP1 actin related protein 1 homolog B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-05-05 Actr1b  ARP1 actin related protein 1 homolog B  Actr1b  ARP1 actin-related protein 1 homolog B, centractin beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-20 Actr1b  ARP1 actin-related protein 1 homolog B, centractin beta  Actr1b  ARP1 actin-related protein 1 homolog B, centractin beta (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-13 Actr1b  ARP1 actin-related protein 1 homolog B, centractin beta (yeast)  Actr1b  ARP1 actin-related protein 1 homolog B (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Actr1b  ARP1 actin-related protein 1 homolog B (yeast)  Actr1b_predicted  ARP1 actin-related protein 1 homolog B (yeast) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Actr1b_predicted  ARP1 actin-related protein 1 homolog B (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED