Creb1 (cAMP responsive element binding protein 1) - Rat Genome Database

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Gene: Creb1 (cAMP responsive element binding protein 1) Rattus norvegicus
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Symbol: Creb1
Name: cAMP responsive element binding protein 1
RGD ID: 620218
Description: Enables several functions, including Hsp70 protein binding activity; arrestin family protein binding activity; and histone acetyltransferase binding activity. Involved in several processes, including learning or memory; regulation of apoptotic process; and regulation of gene expression. Located in axon; mitochondrial matrix; and nucleus. Part of chromatin and transcription regulator complex. Used to study several diseases, including alcohol use disorder; cerebrovascular disease (multiple); cocaine abuse; obsessive-compulsive disorder; and substance dependence (multiple). Biomarker of several diseases, including Huntington's disease; alcohol dependence; alcohol use disorder; amphetamine abuse; and drug dependence (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human CREB1 (cAMP responsive element binding protein 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; adenosine signaling pathway; follicle-stimulating hormone signaling pathway; INTERACTS WITH (R)-adrenaline; (R)-lipoic acid; (R)-salsolinol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP response element binding protein 1; cAMP-responsive element-binding protein 1; Creb; CREB-1; cyclic AMP-responsive element-binding protein 1; Y protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Memor11
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,397,333 - 73,466,339 (+)NCBIGRCr8
mRatBN7.2965,903,511 - 65,972,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,903,547 - 65,970,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,423,783 - 74,487,123 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0979,554,383 - 79,617,717 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0977,958,854 - 78,022,149 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,229,753 - 71,298,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,230,108 - 71,293,435 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0971,277,171 - 71,346,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,170,785 - 63,234,727 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,317,766 - 63,381,709 (+)NCBI
Celera963,310,784 - 63,374,139 (+)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol dependence  (IDA,IEP,ISO)
alcohol use disorder  (IDA,IEP)
amnestic disorder  (IDA,ISO)
amphetamine abuse  (IEP,ISO)
Angiomatoid Fibrous Histiocytoma  (ISO)
anxiety disorder  (IEP,ISO)
autism spectrum disorder  (IDA)
brain ischemia  (IEP)
cocaine abuse  (IDA,ISO)
cocaine dependence  (IDA,IEP,ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (IDA)
depressive disorder  (IDA,IEP)
Diabetic Nephropathies  (IEP)
dilated cardiomyopathy  (ISO)
drug dependence  (IEP)
Experimental Liver Cirrhosis  (IMP)
genetic disease  (ISO)
heroin dependence  (IDA,ISO)
holoprosencephaly  (ISO)
Huntington's disease  (IEP,ISO)
hypertension  (IDA)
hypoglycemia  (ISO)
Memory Disorders  (IDA,IEP,ISO)
middle cerebral artery infarction  (IDA)
morphine dependence  (IDA,IEP,ISO)
morphine withdrawal syndrome  (IDA)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
Neurodevelopmental Disorders  (ISO)
nicotine dependence  (ISO)
non-alcoholic fatty liver  (ISO)
obsessive-compulsive disorder  (IDA)
opioid abuse  (IEP,ISO)
Parkinson's disease  (ISO)
Pick's disease  (ISO)
Postoperative Cognitive Dysfunction  (IDA,ISO)
Prenatal Exposure Delayed Effects  (IDA)
primary pulmonary hypertension  (ISO)
Pulmonary Arterial Hypertension  (IDA)
schizophrenia  (ISO)
sciatic neuropathy  (IDA,IEP)
Spinal Cord Reperfusion Injury  (IEP)
steatotic liver disease  (ISO)
substance dependence  (IDA)
transient cerebral ischemia  (IDA)
vascular dementia  (IDA)
Ventricular Dysfunction, Right  (IEP)
withdrawal disorder  (IDA,IEP,IMP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (EXP)
(R)-salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-3,5-dihydroxyphenylglycine  (EXP,ISO)
(S)-AMPA  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dichloroethane  (ISO)
1,2-naphthoquinone  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
2-naphthylamine  (ISO)
23-epi-26-deoxyactein  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methoxynobiletin  (EXP)
3-methylcholanthrene  (EXP)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-aminobenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP)
adenosine  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP,ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
alpha-Solamarine  (ISO)
alternariol  (ISO)
AM-251  (ISO)
amino acid  (ISO)
aminoguanidine  (ISO)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP,ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (EXP,ISO)
antimycin A  (ISO)
apocynin  (ISO)
arachidonic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atenolol  (ISO)
atosiban  (ISO)
Atractylone  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
baclofen  (ISO)
BAPTA  (ISO)
bathocuproine disulfonic acid  (ISO)
Bay-K-8644  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP)
beryllium difluoride  (ISO)
beryllium sulfate  (ISO)
beta-naphthoflavone  (ISO)
betaxolol  (EXP)
bicuculline  (EXP)
bilobalide  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bortezomib  (EXP)
brimonidine tartrate  (EXP)
bucladesine  (ISO)
buprenorphine  (EXP)
butan-1-ol  (EXP)
cabergoline  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
Calphostin C  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
capsaicin  (EXP)
carbon dioxide  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
celecoxib  (ISO)
CGS-21680  (EXP)
chaetocin  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
cilostazol  (EXP,ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
daidzein  (EXP)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
desipramine  (EXP)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
diazepam  (EXP,ISO)
diazinon  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorvos  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinous acid  (ISO)
diosmin  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
disulfiram  (ISO)
dizocilpine maleate  (EXP,ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxycycline  (ISO)
elemental selenium  (EXP,ISO)
emetine  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
Erythropoietin  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
eticlopride(1+)  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenvalerate  (EXP)
fisetin  (ISO)
fluoxetine  (EXP,ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
furan  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
Geniposide  (ISO)
genistein  (EXP)
Ginkgolide C  (ISO)
ginsenoside Rg1  (ISO)
glucagon  (EXP)
glucose  (EXP,ISO)
glycidol  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
GW 1929  (ISO)
GYKI 52466  (EXP)
haloperidol  (EXP,ISO)
heroin  (EXP)
hexadecanoic acid  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
icariin  (ISO)
imipramine  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
ketoconazole  (EXP,ISO)
KN-93  (EXP)
kojic acid  (ISO)
KT 5823  (ISO)
Kukoamine B  (ISO)
L-methionine  (ISO)
L-mimosine  (EXP)
lanthanum atom  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lipoteichoic acid  (ISO)
liraglutide  (EXP)
lithium chloride  (EXP,ISO)
lithocholic acid  (ISO)
loliolide  (ISO)
losartan  (EXP)
lovastatin  (EXP)
LY294002  (EXP,ISO)
lycopene  (EXP)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
Mecamylamine  (EXP)
melatonin  (ISO)
melittin  (ISO)
memantine  (EXP)
menadione  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
Mitotane  (ISO)
MK-2206  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (EXP,ISO)
mycophenolic acid  (ISO)
N(6)-butyryl-cAMP  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nimodipine  (ISO)
nitroprusside  (EXP)
Nonylphenol  (EXP,ISO)
o-anisidine  (ISO)
okadaic acid  (EXP,ISO)
olanzapine  (EXP)
oleuropein  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (EXP)
Panaxynol  (EXP)
papaverine  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paxilline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
peroxynitrous acid  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylpropanolamine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium atom  (EXP)
potassium chloride  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prasugrel hydrochloride  (EXP)
prazosin  (EXP)
proanthocyanidin  (ISO)
progesterone  (EXP)
propranolol  (EXP)
prostaglandin E2  (ISO)
puerarin  (ISO)
pyrethrins  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (EXP,ISO)
Ro 31-8220  (EXP,ISO)
roflumilast  (EXP)
rolipram  (EXP)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
ryanodine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 203580  (EXP,ISO)
SB 415286  (EXP,ISO)
SCH 23390  (EXP)
SCH772984  (EXP)
scopolamine  (ISO)
selenium atom  (EXP,ISO)
selumetinib  (ISO)
serotonin  (ISO)
sertraline  (EXP)
sevoflurane  (EXP,ISO)
sildenafil citrate  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
SKF 38393  (EXP)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sphingosine 1-phosphate  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
suramin  (ISO)
suvorexant  (ISO)
T-2 toxin  (EXP)
tacrine  (ISO)
tadalafil  (ISO)
tamibarotene  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (EXP)
Tetrachlorobisphenol A  (EXP)
tetrachloromethane  (EXP)
tetrodotoxin  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
toluene  (ISO)
topiramate  (EXP)
tramadol  (EXP)
tranylcypromine  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP,ISO)
umbelliferone  (EXP)
urethane  (ISO)
Ursonic acid  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (EXP)
wortmannin  (ISO)
Xamoterol  (ISO)
xanthohumol  (ISO)
xenon atom  (EXP)
xenon(0)  (EXP)
XL147  (ISO)
Yessotoxin  (ISO)
zebularine  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axonogenesis  (ISO)
cAMP-mediated signaling  (ISO)
cell differentiation  (IMP)
cellular response to fatty acid  (IEP)
cellular response to forskolin  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (IEP)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to retinoic acid  (ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to zinc ion  (ISO)
chemotaxis to arachidonic acid  (IMP)
circadian rhythm  (IEP,ISO)
hormone secretion  (ISO)
lactation  (ISO)
lung epithelium development  (ISO)
lung saccule development  (ISO)
mammary gland development  (ISO)
memory  (IMP,ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of gene expression  (IMP)
negative regulation of transcription by competitive promoter binding  (ISO)
osteoclast differentiation  (ISO)
pituitary gland development  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of cardiac muscle tissue development  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of fat cell differentiation  (ISO,ISS)
positive regulation of hormone secretion  (ISO)
positive regulation of lipid biosynthetic process  (ISO,ISS)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of membrane depolarization  (IMP)
positive regulation of multicellular organism growth  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transforming growth factor beta3 production  (IMP)
protein stabilization  (ISO,ISS)
regulation of apoptotic process  (IDA)
regulation of cell size  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of fibroblast proliferation  (IMP)
regulation of glial cell proliferation  (IMP)
regulation of testosterone biosynthetic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to activity  (IEP)
response to cocaine  (IEP)
response to dehydroepiandrosterone  (IEP)
response to erythropoietin  (IDA)
response to ethanol  (IDA,IEP)
response to glucagon  (ISO,ISS)
response to hypobaric hypoxia  (IEP)
response to hypoxia  (IEP)
response to inorganic substance  (ISO)
response to L-glutamate  (IEP)
response to nicotine  (IEP)
response to organic substance  (ISO)
response to purine-containing compound  (ISO)
response to xenobiotic stimulus  (IEP,ISO)
secretory granule organization  (ISO)
transcription by RNA polymerase II  (IMP)
transforming growth factor beta receptor signaling pathway  (IMP)
type I pneumocyte differentiation  (ISO)
visual learning  (IMP)

Cellular Component

References

References - curated
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99. Parental morphine exposure affects repetitive grooming actions and marble burying behavior in the offspring: Potential relevance for obsessive-compulsive like behavior. Rohbani K, etal., Eur J Pharmacol. 2019 Dec 15;865:172757. doi: 10.1016/j.ejphar.2019.172757. Epub 2019 Nov 3.
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101. Tramadol induces changes in Δ-FosB, µ-opioid receptor, and p-CREB level in the nucleus accumbens and prefrontal cortex of male Wistar rat. Sadat-Shirazi MS, etal., Am J Drug Alcohol Abuse. 2019;45(1):84-89. doi: 10.1080/00952990.2018.1529182. Epub 2019 Jan 11.
102. Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation. Saifudeen Z, etal., Am J Physiol Renal Physiol. 2005 May;288(5):F899-909. Epub 2005 Jan 4.
103. Calcium-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein (CREB). Schuh RA, etal., J Neurochem 2005 Jan;92(2):388-94.
104. Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells. Short ML, etal., Nucleic Acids Res 1991 Aug 11;19(15):4290.
105. Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles. Shukla SD, etal., J Pharmacol Exp Ther. 2019 Sep;370(3):390-398. doi: 10.1124/jpet.119.258871. Epub 2019 Jul 1.
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107. Decrease of phosphorylated CREB and ERK in nucleus accumbens is associated with the incubation of heroin seeking induced by cues after withdrawal. Sun A, etal., Neurosci Lett. 2015 Mar 30;591:166-170. doi: 10.1016/j.neulet.2015.02.048. Epub 2015 Feb 21.
108. Erythropoietin attenuates neuronal injury and potentiates the expression of pCREB in anterior horn after transient spinal cord ischemia in rats. Sönmez A, etal., Surg Neurol. 2007 Sep;68(3):297-303; discussion 303. doi: 10.1016/j.surneu.2006.11.045. Epub 2007 Mar 21.
109. Endogenous prolactin-releasing peptide regulates food intake in rodents. Takayanagi Y, etal., J Clin Invest. 2008 Dec;118(12):4014-24. doi: 10.1172/JCI34682. Epub 2008 Nov 3.
110. Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock. Tischkau SA, etal., J Biol Chem 2003 Jan 10;278(2):718-23.
111. Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells. Tokunou T, etal., Circulation 2003 Sep 9;108(10):1246-52.
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119. Dexmedetomidine promotes the recovery of neurogenesis in aged mouse with postoperative cognitive dysfunction. Wang WX, etal., Neurosci Lett. 2018 Jun 11;677:110-116. doi: 10.1016/j.neulet.2018.03.043. Epub 2018 Mar 20.
120. Sinomenine alleviates dorsal root ganglia inflammation to inhibit neuropathic pain via the p38 MAPK/CREB signalling pathway. Wang X, etal., Eur J Pharmacol. 2021 Apr 15;897:173945. doi: 10.1016/j.ejphar.2021.173945. Epub 2021 Feb 14.
121. MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Wang Y, etal., Autophagy. 2013 Dec;9(12):2069-86. doi: 10.4161/auto.26447. Epub 2013 Nov 1.
122. cAMP responsive element-binding protein phosphorylation is necessary for perirhinal long-term potentiation and recognition memory. Warburton EC, etal., J Neurosci. 2005 Jul 6;25(27):6296-303.
123. Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth muscles. Watson PA, etal., Endocrinology 2002 Aug;143(8):2922-9.
124. Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism. Wu H, etal., Psychopharmacology (Berl). 2018 Mar;235(3):873-886. doi: 10.1007/s00213-017-4805-4. Epub 2017 Dec 7.
125. κ Opioid Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO-1 Pathway and Regulating Ca2+-SERCA2a. Wu T, etal., Oxid Med Cell Longev. 2021 Jul 30;2021:7328437. doi: 10.1155/2021/7328437. eCollection 2021.
126. CREB down-regulation in the laterodorsal thalamic nucleus deteriorates memory consolidation in rats. Xiang W, etal., Learn Mem. 2019 May 15;26(6):182-186. doi: 10.1101/lm.049742.119. Print 2019 Jun.
127. Transcriptional regulation of the promoter of the rat frizzled related protein gene by CREB. Yam JW, etal., Oncogene 2003 Jun 19;22(25):3901-10.
128. Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin. Yan D, etal., Brain Behav Immun. 2018 Jul;71:66-80. doi: 10.1016/j.bbi.2018.04.014. Epub 2018 Apr 26.
129. The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line. Yang GM, etal., Neurotox Res. 2020 Apr;37(4):926-935. doi: 10.1007/s12640-019-00150-7. Epub 2020 Jan 4.
130. Alterations of postsynaptic density proteins in the hippocampus of rat offspring from the morphine-addicted mother: Beneficial effect of dextromethorphan. Yang SN, etal., Hippocampus. 2006;16(6):521-30. doi: 10.1002/hipo.20179.
131. Chronic ethanol exposure impairs phosphorylation of CREB and CRE-binding activity in rat striatum. Yang X, etal., Alcohol Clin Exp Res. 1998 Apr;22(2):382-90.
132. Involvement of cyclic adenosine 5'-monophosphate response element-binding protein, steroidogenic factor 1, and Dax-1 in the regulation of gonadotropin-inducible ovarian transcription factor 1 gene expression by follicle-stimulating hormone in ovarian granulosa cells. Yazawa T, etal., Endocrinology. 2003 May;144(5):1920-30.
133. TOX3 regulates calcium-dependent transcription in neurons. Yuan SH, etal., Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2909-14. doi: 10.1073/pnas.0805555106. Epub 2009 Feb 5.
134. Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala. Zhang H, etal., Sci Rep. 2018 Jul 10;8(1):10376. doi: 10.1038/s41598-018-28415-9.
135. Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus. Zhang J, etal., Neurosci Lett. 2016 Sep 6;630:70-76. doi: 10.1016/j.neulet.2016.07.047. Epub 2016 Jul 25.
136. Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat. Zhang L, etal., Brain Res Bull. 2013 Jul;96:45-53. doi: 10.1016/j.brainresbull.2013.04.009. Epub 2013 May 2.
137. Effects of morphine-dependent and withdrawal on activation of the distal cerebrospinal fluid contacting neurons' phosphorylation CREB in rat brain. Zhang L, etal., Neurol Res. 2009 Sep;31(7):738-42. doi: 10.1179/174313209X382386. Epub 2008 Dec 23.
138. [Effect of manual acupuncture on expression of BDNF/TrkB/ERK/CREB signaling in infarcted tissue of cerebral ischemia rats]. Zhong LY, etal., Zhen Ci Yan Jiu. 2022 Feb 25;47(2):135-40. doi: 10.13702/j.1000-0607.20210048.
Additional References at PubMed
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Genomics

Comparative Map Data
Creb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,397,333 - 73,466,339 (+)NCBIGRCr8
mRatBN7.2965,903,511 - 65,972,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,903,547 - 65,970,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,423,783 - 74,487,123 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0979,554,383 - 79,617,717 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0977,958,854 - 78,022,149 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,229,753 - 71,298,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,230,108 - 71,293,435 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0971,277,171 - 71,346,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,170,785 - 63,234,727 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,317,766 - 63,381,709 (+)NCBI
Celera963,310,784 - 63,374,139 (+)NCBICelera
Cytogenetic Map9q32NCBI
CREB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382207,529,962 - 207,605,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2207,529,737 - 207,605,988 (+)EnsemblGRCh38hg38GRCh38
GRCh372208,394,686 - 208,470,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,102,931 - 208,171,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 342208,220,191 - 208,289,074NCBI
Celera2202,156,105 - 202,231,803 (+)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2200,237,266 - 200,313,048 (+)NCBIHuRef
CHM1_12208,400,466 - 208,476,105 (+)NCBICHM1_1
T2T-CHM13v2.02208,003,958 - 208,080,006 (+)NCBIT2T-CHM13v2.0
Creb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,571,963 - 64,643,707 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,571,804 - 64,643,707 (+)EnsemblGRCm39 Ensembl
GRCm38164,532,794 - 64,604,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,532,645 - 64,604,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv37164,579,378 - 64,651,122 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,467,080 - 64,538,824 (+)NCBIMGSCv36mm8
Celera165,034,311 - 65,105,954 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.74NCBI
Creb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554577,431,736 - 7,491,149 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554577,424,403 - 7,490,630 (-)NCBIChiLan1.0ChiLan1.0
CREB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,136,747 - 110,210,159 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,151,726 - 110,225,138 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B94,762,796 - 94,836,304 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B212,891,261 - 212,963,584 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B212,891,261 - 212,958,130 (+)Ensemblpanpan1.1panPan2
CREB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13715,921,214 - 15,978,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3715,939,138 - 15,977,556 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3716,804,994 - 16,867,966 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03715,856,953 - 15,919,649 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3715,856,946 - 15,919,150 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13715,802,749 - 15,865,587 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03715,775,840 - 15,838,520 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03715,785,052 - 15,847,761 (+)NCBIUU_Cfam_GSD_1.0
Creb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,086,248 - 164,150,269 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366313,721,313 - 3,780,892 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366313,721,307 - 3,785,346 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CREB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15110,705,496 - 110,771,728 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115110,705,548 - 110,773,037 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,245,218 - 122,278,060 (+)NCBISscrofa10.2Sscrofa10.2susScr3