Hspa9 (heat shock protein family A (Hsp70) member 9) - Rat Genome Database

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Gene: Hspa9 (heat shock protein family A (Hsp70) member 9) Rattus norvegicus
Analyze
Symbol: Hspa9
Name: heat shock protein family A (Hsp70) member 9
RGD ID: 1311806
Description: Enables fibroblast growth factor binding activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Involved in several processes, including cellular response to interleukin-1; response to folic acid; and response to thyroxine. Predicted to be located in mitochondrial nucleoid and nucleus. Predicted to be active in mitochondrion. Biomarker of Parkinsonism and brain ischemia. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (Hsp70) member 9); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; presequence pathway of mitochondrial protein import; RNA degradation pathway; INTERACTS WITH (+)-schisandrin B; (-)-anisomycin; (R)-adrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 75 kDa glucose-regulated protein; catecholamine regulated protein 40; Crp40; GRP 75; GRP-75; heat shock 70 kDa protein 9; heat shock 70kDa protein 9A; heat shock protein 9; heat shock protein family A member 9; heat shock protein, A; Hspa9a; LOC100912578; LOC291671; mortalin; mtHSP70; PBP74; peptide-binding protein 74; stress-70 protein, mitochondrial; stress-70 protein, mitochondrial-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Hspa9-ps2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,810,004 - 26,832,958 (-)NCBIGRCr8
mRatBN7.21826,536,131 - 26,554,294 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,535,798 - 26,554,292 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,663,496 - 26,681,657 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,427,270 - 27,445,422 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,762,158 - 26,780,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,731,072 - 27,749,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,731,072 - 27,749,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,441,164 - 27,459,327 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,419,614 - 27,437,031 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,445,403 - 27,463,728 (-)NCBI
Celera1826,272,806 - 26,290,966 (-)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-anisomycin  (EXP)
(1->4)-beta-D-glucan  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,2,2-tetramine  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
26-hydroxycholesterol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
ferric ammonium citrate  (ISO)
finasteride  (EXP)
flufenoxuron  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hemin  (ISO)
homocysteine  (ISO)
hydrazine  (EXP)
indirubin-3'-monoxime  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lead nitrate  (EXP)
lead(II) chloride  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
melatonin  (EXP)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mevinphos  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
ochratoxin A  (EXP,ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium dichromate  (EXP)
pterostilbene  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sarin  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanillic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
withaferin A  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Mitochondrial HSP60 (P1 protein) and a HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced nephrotoxicity. Bruschi SA, etal., J Biol Chem. 1993 Nov 5;268(31):23157-61.
2. Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis. Burbulla LF, etal., Hum Mol Genet. 2010 Nov 15;19(22):4437-52. Epub 2010 Sep 2.
3. Proteomic analysis reveals changes in the liver protein pattern of rats exposed to dietary folate deficiency. Chanson A, etal., J Nutr. 2005 Nov;135(11):2524-9.
4. Mortalin inhibition in experimental Parkinson's disease. Chiasserini D, etal., Mov Disord. 2011 Aug 1;26(9):1639-47. doi: 10.1002/mds.23647. Epub 2011 May 3.
5. Mutational screening of the mortalin gene (HSPA9) in Parkinson's disease. De Mena L, etal., J Neural Transm. 2009 Oct;116(10):1289-93. Epub 2009 Aug 6.
6. Identification of rTid-1, the rat homologue of the drosophila tumor suppressor l(2)tid gene. Fujita M, etal., Mol Cell Biochem. 2004 Mar;258(1-2):183-9.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Glucose-regulated protein 75 overexpression attenuates ionizing radiation-mediated injury in PC12 cells by inducing the expression of topoisomerase IIa. Guo W, etal., Mol Med Rep. 2012 Dec;6(6):1423-7. doi: 10.3892/mmr.2012.1070. Epub 2012 Sep 10.
10. Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. Ishihara N and Mihara K, J Biochem (Tokyo) 1998 Apr;123(4):722-32.
11. Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease. Jin J, etal., Mol Cell Proteomics. 2006 Jul;5(7):1193-204. Epub 2006 Mar 24.
12. Is mortalin a candidate gene for T1DM ? Johannesen J, etal., Autoimmunity. 2004 Sep-Nov;37(6-7):423-30.
13. Angiotensin II induces phosphorylation of glucose-regulated protein-75 in WB rat liver cells. Krishna SB, etal., Arch Biochem Biophys. 2007 Jan 1;457(1):16-28. Epub 2006 Nov 2.
14. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. Lee J, etal., J Biol Chem. 2005 Dec 9;280(49):40398-401. Epub 2005 Oct 5.
15. Proteomic analysis of synovial fibroblast-like synoviocytes from rheumatoid arthritis. Li XJ, etal., Clin Exp Rheumatol. 2013 Jul-Aug;31(4):552-8. Epub 2013 Jun 5.
16. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
17. Cloning of rat grp75, an hsp70-family member, and its expression in normal and ischemic brain. Massa SM, etal., J Neurosci Res. 1995 Apr 15;40(6):807-19.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Landscape of the hnRNP K protein-protein interactome. Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
20. Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin. Mizukoshi E, etal., Biochem J. 1999 Oct 15;343 Pt 2:461-6.
21. Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members. Naylor DJ, etal., J Biol Chem. 1998 Aug 14;273(33):21169-77.
22. Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice. Osorio C, etal., Neurobiol Aging. 2007 Dec;28(12):1853-62. Epub 2006 Oct 16.
23. Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria. Ozaki T, etal., Biochim Biophys Acta. 2009 Dec;1793(12):1848-59. doi: 10.1016/j.bbamcr.2009.10.002. Epub 2009 Oct 13.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
29. Proteomic characterization of early changes induced by triiodothyronine in rat liver. Severino V, etal., J Proteome Res. 2011 Jul 1;10(7):3212-24. Epub 2011 Jun 1.
30. Mortalin: a protein associated with progression of Parkinson disease? Shi M, etal., J Neuropathol Exp Neurol. 2008 Feb;67(2):117-24.
31. cDNA cloning and efficient mitochondrial import of pre-mtHSP70 from rat liver. Webster TJ, etal., DNA Cell Biol. 1994 Dec;13(12):1213-20. doi: 10.1089/dna.1994.13.1213.
Additional References at PubMed
PMID:2372296   PMID:7896880   PMID:11092755   PMID:11900485   PMID:12084410   PMID:12646231   PMID:12931191   PMID:14651853   PMID:14993262   PMID:16854843   PMID:17634366   PMID:18063578  
PMID:18614015   PMID:19725078   PMID:20340173   PMID:20458337   PMID:21123823   PMID:21423176   PMID:21753002   PMID:21964438   PMID:22658674   PMID:22681889   PMID:23106098   PMID:23376485  
PMID:23979707   PMID:24030972   PMID:24625528   PMID:25600835   PMID:26702583   PMID:28098881   PMID:28376086   PMID:31904090   PMID:32357304   PMID:34489498   PMID:35352799  


Genomics

Comparative Map Data
Hspa9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,810,004 - 26,832,958 (-)NCBIGRCr8
mRatBN7.21826,536,131 - 26,554,294 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,535,798 - 26,554,292 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,663,496 - 26,681,657 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,427,270 - 27,445,422 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,762,158 - 26,780,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,731,072 - 27,749,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,731,072 - 27,749,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,441,164 - 27,459,327 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,419,614 - 27,437,031 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,445,403 - 27,463,728 (-)NCBI
Celera1826,272,806 - 26,290,966 (-)NCBICelera
Cytogenetic Map18p12NCBI
HSPA9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,553,756 - 138,575,401 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,553,756 - 138,575,675 (-)EnsemblGRCh38hg38GRCh38
GRCh375137,889,445 - 137,911,090 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,918,923 - 137,939,014 (-)NCBINCBI36Build 36hg18NCBI36
Build 345137,918,923 - 137,939,014NCBI
Celera5134,012,432 - 134,033,183 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5133,080,998 - 133,101,775 (-)NCBIHuRef
CHM1_15137,322,949 - 137,343,701 (-)NCBICHM1_1
T2T-CHM13v2.05139,080,003 - 139,101,647 (-)NCBIT2T-CHM13v2.0
Hspa9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391835,070,467 - 35,087,404 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1835,070,467 - 35,087,410 (-)EnsemblGRCm39 Ensembl
GRCm381834,937,414 - 34,954,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,937,414 - 34,954,357 (-)EnsemblGRCm38mm10GRCm38
MGSCv371835,097,068 - 35,114,005 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361835,063,405 - 35,080,297 (-)NCBIMGSCv36mm8
Celera1835,391,734 - 35,408,655 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.8NCBI
Hspa9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554181,915,985 - 1,931,017 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554181,915,985 - 1,931,017 (+)NCBIChiLan1.0ChiLan1.0
HSPA9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,830,305 - 133,851,364 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,969,859 - 131,990,917 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,934,859 - 133,955,048 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15140,064,207 - 140,084,551 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5140,064,207 - 140,084,551 (-)Ensemblpanpan1.1panPan2
HSPA9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,122,917 - 26,142,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,121,499 - 26,142,434 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,890,286 - 24,911,642 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,977,471 - 26,998,872 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,978,054 - 26,998,797 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,684,920 - 25,708,764 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,507,197 - 25,528,814 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01126,171,421 - 26,192,815 (-)NCBIUU_Cfam_GSD_1.0
Hspa9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,895,035 - 153,908,810 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,702,695 - 7,716,380 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,702,186 - 7,716,428 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,515,253 - 140,531,857 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,515,239 - 140,532,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,230,077 - 146,246,697 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,230,675 - 41,251,177 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2341,231,364 - 41,251,150 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603436,634,038 - 36,655,489 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474331,324,085 - 31,345,695 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474331,324,085 - 31,345,681 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hspa9
58 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:40
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000026696
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat

Markers in Region
D18Rat101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,548,082 - 26,548,295 (+)MAPPERmRatBN7.2
Rnor_6.01827,743,024 - 27,743,236NCBIRnor6.0
Rnor_5.01827,453,116 - 27,453,328UniSTSRnor5.0
RGSC_v3.41827,430,874 - 27,431,087RGDRGSC3.4
RGSC_v3.41827,430,875 - 27,431,087UniSTSRGSC3.4
RGSC_v3.11827,457,520 - 27,457,733RGD
Celera1826,284,754 - 26,284,966UniSTS
RH 2.0 Map18543.4RGD
SHRSP x BN Map1811.4999RGD
Cytogenetic Map18p12UniSTS
D18Chm4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,538,058 - 26,538,225 (+)MAPPERmRatBN7.2
Rnor_6.01827,733,000 - 27,733,166NCBIRnor6.0
Rnor_5.01827,443,092 - 27,443,258UniSTSRnor5.0
RGSC_v3.41827,420,851 - 27,421,017UniSTSRGSC3.4
Celera1826,274,734 - 26,274,919UniSTS
Cytogenetic Map18p12UniSTS
BE120145  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,541,802 - 26,541,965 (+)MAPPERmRatBN7.2
Rnor_6.01827,736,744 - 27,736,906NCBIRnor6.0
Rnor_5.01827,446,836 - 27,446,998UniSTSRnor5.0
RGSC_v3.41827,424,595 - 27,424,757UniSTSRGSC3.4
Celera1826,278,497 - 26,278,659UniSTS
RH 3.4 Map18372.8UniSTS
Cytogenetic Map18p12UniSTS
RH139216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21826,554,351 - 26,554,489 (+)MAPPERmRatBN7.2
Rnor_6.01827,749,293 - 27,749,430NCBIRnor6.0
Rnor_5.01827,459,385 - 27,459,522UniSTSRnor5.0
RGSC_v3.41827,437,144 - 27,437,281UniSTSRGSC3.4
Celera1826,291,024 - 26,291,161UniSTS
Cytogenetic Map18p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000026696   ⟹   ENSRNOP00000026696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1826,535,798 - 26,554,292 (-)Ensembl
Rnor_6.0 Ensembl1827,731,072 - 27,749,235 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1826,535,798 - 26,553,056 (-)Ensembl
Rnor_6.0 Ensembl374,226,407 - 74,229,066 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl374,226,407 - 74,229,066 (-)Ensembl
RefSeq Acc Id: NM_001100658   ⟹   NP_001094128
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,810,235 - 26,828,398 (-)NCBI
mRatBN7.21826,536,131 - 26,554,294 (-)NCBI
Rnor_6.01827,731,072 - 27,749,235 (-)NCBI
Rnor_5.01827,441,164 - 27,459,327 (-)NCBI
RGSC_v3.41827,419,614 - 27,437,031 (-)RGD
Celera1826,272,806 - 26,290,966 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063277217   ⟹   XP_063133287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,810,004 - 26,832,958 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094128 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133287 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB33049 (Get FASTA)   NCBI Sequence Viewer  
  EDL76251 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026696
  ENSRNOP00000026696.4
  ENSRNOP00000080615.1
GenBank Protein P48721 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001094128   ⟸   NM_001100658
- UniProtKB: P48721 (UniProtKB/Swiss-Prot),   F1M953 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026696   ⟸   ENSRNOT00000026696
RefSeq Acc Id: XP_063133287   ⟸   XM_063277217
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48721-F1-model_v2 AlphaFold P48721 1-679 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700704
Promoter ID:EPDNEW_R11228
Type:initiation region
Name:Hspa9_1
Description:heat shock protein family A member 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01827,749,214 - 27,749,274EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311806 AgrOrtholog
BioCyc Gene G2FUF-7932 BioCyc
Ensembl Genes ENSRNOG00000019525 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000059883 Ensembl
Ensembl Transcript ENSRNOT00000026696 ENTREZGENE
  ENSRNOT00000026696.7 UniProtKB/TrEMBL
  ENSRNOT00000079460.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chaperone_DnaK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291671 UniProtKB/TrEMBL
NCBI Gene 291671 ENTREZGENE
PANTHER PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRESS-70 PROTEIN, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspa9 PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019525 RatGTEx
  ENSRNOG00000059883 RatGTEx
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZR52_RAT UniProtKB/TrEMBL
  F1M953 ENTREZGENE, UniProtKB/TrEMBL
  GRP75_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hspa9  heat shock protein family A (Hsp70) member 9  LOC100912578  stress-70 protein, mitochondrial-like  Data merged from RGD:6486342 737654 PROVISIONAL
2019-04-10 Hspa9  heat shock protein family A (Hsp70) member 9  Hspa9  heat shock protein family A member 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Hspa9  heat shock protein family A member 9  Hspa9  heat shock protein 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912578  stress-70 protein, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-04 Hspa9  heat shock protein 9  Hspa9a_predicted  heat shock 70kDa protein 9A (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hspa9a_predicted  heat shock 70kDa protein 9A (predicted)    heat shock protein, A (predicted)  Name updated 1299863 APPROVED
2005-01-12 Hspa9a_predicted  heat shock protein, A (predicted)      Symbol and Name status set to approved 70820 APPROVED