RGD Reference Report - Landscape of the hnRNP K protein-protein interactome. - Rat Genome Database

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Landscape of the hnRNP K protein-protein interactome.

Authors: Mikula, M  Dzwonek, A  Karczmarski, J  Rubel, T  Dadlez, M  Wyrwicz, LS  Bomsztyk, K  Ostrowski, J 
Citation: Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
RGD ID: 10054427
Pubmed: PMID:16518874   (View Abstract at PubMed)
DOI: DOI:10.1002/pmic.200500632   (Journal Full-text)

The heterogeneous nuclear ribonucleoprotein K is an ancient RNA/DNA-binding protein that is involved in multiple processes that compose gene expression. The pleiotropic action of K protein reflects its ability to interact with different classes of factors, interactions that are regulated by extracellular signals. We used affinity purification and MS to better define the repertoire of K protein partners. We identified a large number of new K protein partners, some typically found in subcellular compartments, such as plasma membrane, where K protein has not previously been seen. Electron microscopy showed K protein in the nucleus, cytoplasm, mitochondria, and in vicinity of plasma membrane. These observations greatly expanded the view of the landscape of K protein-protein interaction and provide new opportunities to explore signal transduction and gene expression in several subcellular compartments.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HnrnpkRatcell cortex  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HnrnpkRatactinin binding  IPIActn4 (Rattus norvegicus) RGD 
HnrnpkRatheat shock protein binding  IPIHspa2 (Rattus norvegicus) RGD 
HnrnpkRatheat shock protein binding  IPIHspa9 (Rattus norvegicus) RGD 
HnrnpkRatlamin binding  IPILmna (Rattus norvegicus) RGD 
Actn4Ratprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
Hnrnpa1Ratprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
Hnrnpa2b1Ratprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
HnrnpabRatprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
HnrnpdRatprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
HnrnpkRatprotein binding  IPIRtraf (Rattus norvegicus) RGD 
HnrnpkRatprotein binding  IPIHnrnpab (Rattus norvegicus) RGD 
HnrnpkRatprotein binding  IPIHnrnpa1 (Rattus norvegicus) RGD 
HnrnpkRatprotein binding  IPIRps28 (Rattus norvegicus) RGD 
HnrnpkRatprotein binding  IPIHnrnpd (Rattus norvegicus) RGD 
HnrnpkRatprotein binding  IPIRps5 (Rattus norvegicus) RGD 
HnrnpkRatprotein binding  IPIHnrnpa2b1 (Rattus norvegicus) RGD 
Hspa2Ratprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
Hspa9Ratprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
LmnaRatprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
Rps28Ratprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
Rps5Ratprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
RtrafRatprotein binding  IPIHnrnpk (Rattus norvegicus) RGD 
HnrnpkRatribonucleoprotein complex binding  IPIRplp2 (Rattus norvegicus) RGD 
HnrnpkRatribonucleoprotein complex binding  IPIRplp1 (Rattus norvegicus) RGD 
Rplp1Ratribonucleoprotein complex binding  IPIHnrnpk (Rattus norvegicus) RGD 
Rplp2Ratribonucleoprotein complex binding  IPIHnrnpk (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Actn4  (actinin alpha 4)
Hnrnpa1  (heterogeneous nuclear ribonucleoprotein A1)
Hnrnpa2b1  (heterogeneous nuclear ribonucleoprotein A2/B1)
Hnrnpab  (heterogeneous nuclear ribonucleoprotein A/B)
Hnrnpd  (heterogeneous nuclear ribonucleoprotein D)
Hnrnpk  (heterogeneous nuclear ribonucleoprotein K)
Hspa2  (heat shock protein family A (Hsp70) member 2)
Hspa9  (heat shock protein family A (Hsp70) member 9)
Lmna  (lamin A/C)
Rplp1  (ribosomal protein lateral stalk subunit P1)
Rplp2  (ribosomal protein lateral stalk subunit P2)
Rps28  (ribosomal protein S28)
Rps5  (ribosomal protein S5)
Rtraf  (RNA transcription, translation and transport factor)


Additional Information