Bp355 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bp355 (Blood pressure QTL 355) Rattus norvegicus

Symbol: Bp355
Name: Blood pressure QTL 355
RGD ID: 6903359
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: systolic blood pressure   (CMO:0000004)    
LOD Score: 3.6
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,944,544 - 59,796,478RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01815,539,671 - 61,985,648RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01815,314,271 - 61,176,840RGDRnor5.0
RGSC_v3.41862,228,896 - 80,277,631RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: BN/NHsdMcwi SS/JrHsdMcwi 




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp355Rathypertension  IAGP 69700 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp355Ratdecreased systemic arterial systolic blood pressure  IDA 69700 RGD 
Bp355Ratsalt-sensitive hypertension  IDA 69700 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp355Ratsystolic blood pressure  IDA 69700 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp355Ratcontrolled exposure to ambient light  IDA 69700 RGD 
Bp355Ratcontrolled sodium content diet  IDA 69700 RGD 
Bp355Ratfurosemide  IDA 69700 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp355Ratvascular indwelling catheter method  IDA 69700 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp355RatBN/NHsdMcwi  IEA 69700 RGD 
Bp355RatSS/JrHsdMcwi  IEA 69700 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp355Ratarterial blood pressure trait  IDA 69700 RGD 


#
Reference Title
Reference Citation
1. Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats. Cowley AW Jr, etal., Physiol Genomics 2000 Apr 27;2(3):107-15.

Related QTL Description Reference
Bp54 sub_region RGD:69700



1 to 20 of 635 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
3916Ttrtransthyretin181194179111951008Rat
71046B4galt6beta-1,4-galactosyltransferase 6181195838212015247Rat
7733249LOC102551486uncharacterized LOC102551486181201461012021819Rat
6502448Ipo5-ps1importin 5, pseudogene 1181203772312039781Rat
41193066LOC120098272uncharacterized LOC120098272181208142912093465Rat
1309102Trappc8trafficking protein particle complex subunit 8181210387412180422Rat
1560045Vom2r52l1vomeronasal 2 receptor, 52 like 1181219476712207125Rat
1592104Eef2-ps4eukaryotic translation elongation factor 2, pseudogene 4181223437412236924Rat
1306757Rnf125ring finger protein 125181225406612275719Rat
621485Rnf138ring finger protein 138181229155712315931Rat
3081Mep1bmeprin A subunit beta181236612612392840Rat
1591842Garem1GRB2 associated regulator of MAPK1 subtype 1181242016912585323Rat
41250271LOC120098265uncharacterized LOC120098265181249349512509604Rat
41219354LOC120098431U6 spliceosomal RNA181268326212683364Rat
1566178Klhl14kelch-like family member 14181280425312917828Rat
75277674930426D05RiklRIKEN cDNA 4930426D05 gene like181291489212918657Rat
1308160Ccdc178coiled-coil domain containing 178181307483413472732Rat
1305869Asxl3ASXL transcriptional regulator 3181359352913766324Rat
1310663Nol4nucleolar protein 4181393249914294873Rat
40980709LOC120098415U2 spliceosomal RNA181402922314029406Rat

1 to 20 of 635 rows
1 to 20 of 829 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10108D18Mgh11341185564260755642948Ratregion
10287D18Wox14148182458653424586682Ratregion
10689D18Mit5122183135940831359530Ratregion
33884D18Mit8147185979647859796643Ratregion
33949D18Mit1496181527559715275693Ratregion
33971D18Mit7204181287462012874824Ratregion
34059D18Mit2100181495133714951437Ratregion
34156D18Mgh1114184698893946989053Ratregion
34218D18Mgh2183185971223459712417Ratregion
34296D3Mgh24116181499676814996831Ratregion
34550D18Mgh9140182479697724797117Ratregion
11337D18Wox9242183586942035869662Ratregion
11461D18Mit1245181194429911944544Ratregion
33577D18Mit1585182730725627307341Ratregion
33606D18Mit395181963384219633937Ratregion
33766D18Mit4117182653319226533309Ratregion
37412D18Rat40154185933040959330563Ratregion
37524D18Rat63251182754179827542049Ratregion
37548D18Rat52195185853611658536311Ratregion
37568D18Rat55100185253976352539863Ratregion
1 to 20 of 829 rows

Flank 1: (D18Mit8)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21859,796,478 - 59,796,643 (+)MAPPER
Rnor_6.01861,985,648 - 61,985,812NCBI
Rnor_5.01861,176,840 - 61,177,004UniSTS
RGSC_v3.41862,228,896 - 62,229,060UniSTS
RGSC_v3.11862,301,978 - 62,302,324RGD
Celera1857,917,062 - 57,917,198UniSTS
RH 3.4 Map18604.6RGD
RH 3.4 Map18604.6UniSTS
RH 2.0 Map18307.7RGD
SHRSP x BN Map1832.1699RGD
Cytogenetic Map18q12.1UniSTS
Flank 2: (D18Mit1)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21811,944,299 - 11,944,544 (-)MAPPER
Rnor_6.01815,539,427 - 15,539,671NCBI
Rnor_5.01815,314,027 - 15,314,271UniSTS
RGSC_v3.41880,277,473 - 80,277,631RGD
RGSC_v3.41812,406,975 - 12,407,219UniSTS
RGSC_v3.11812,433,620 - 12,433,865RGD
Celera1811,951,912 - 11,952,156UniSTS
RH 3.4 Map18134.2UniSTS
RH 3.4 Map18134.2RGD
RH 2.0 Map18760.7RGD
SHRSP x BN Map183.6099RGD
FHH x ACI Map186.08RGD
Cytogenetic Map18pUniSTS


1 to 10 of 109 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)185880568763636873Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat

1 to 10 of 109 rows


Note Type Note Reference
qtl_general number of animals used: 113 F2 male rats 69700
qtl_general measurement method: at weaning rats were on 0.4% NaCl diet till 5 wks of age; then 0.1% NaCl diet until 9 wks of age; then on 8% NaCl diet for 4 wks; then injected with furosemide and given 0.4% NaCl diet; arterial pressure was recorded after 36 hours on low diet by solid-state pressure transducer 69700
qtl_general software used: MAPMAKER/QTL 69700
qtl_general SAP recorded during salt depletion after 4 wks on high salt then on low-salt diet 69700
qtl_general phenotypes passed the normality test; mapped using a parametric linkage analysis 69700