Wdr55 (WD repeat domain 55) - Rat Genome Database

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Gene: Wdr55 (WD repeat domain 55) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Wdr55
Name: WD repeat domain 55
RGD ID: 1305640
Description: Predicted to be involved in rRNA processing. Predicted to be located in nucleolus. Orthologous to human WDR55 (WD repeat domain 55); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC307494; LRRG00133; RGD1305640; similar to RIKEN cDNA 2410080P20; WD repeat-containing protein 55
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81828,649,386 - 28,652,854 (+)NCBIGRCr8
mRatBN7.21828,375,366 - 28,378,834 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1828,502,515 - 28,505,983 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01829,264,589 - 29,268,057 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01828,599,817 - 28,603,285 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01829,605,217 - 29,608,730 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01829,309,024 - 29,312,537 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,461,320 - 29,464,833 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11829,474,359 - 29,491,087 (+)NCBI
Celera1828,095,873 - 28,099,386 (+)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleolus  (ISS)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15489334   PMID:18769712   PMID:31505169  


Genomics

Variants

.
Variants in Wdr55
2 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001017932   ⟹   NP_001017932
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81828,649,386 - 28,652,854 (+)NCBI
mRatBN7.21828,375,366 - 28,378,834 (+)NCBI
Rnor_6.01829,605,217 - 29,608,730 (+)NCBI
Rnor_5.01829,309,024 - 29,312,537 (+)NCBI
RGSC_v3.41829,461,320 - 29,464,833 (+)RGD
Celera1828,095,873 - 28,099,386 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001017932 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A1L112 (Get FASTA)   NCBI Sequence Viewer  
  AAI27461 (Get FASTA)   NCBI Sequence Viewer  
  EDL76316 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044213.4
  ENSRNOP00065002334
Reference Protein Sequences
RefSeq Acc Id: NP_001017932   ⟸   NM_001017932
- UniProtKB: A1L112 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
Anaphase-promoting complex subunit 4-like WD40   Protein RED C-terminal   RED-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1L112-F1-model_v2 AlphaFold A1L112 1-384 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305640 AgrOrtholog
BioCyc Gene G2FUF-7860 BioCyc
Ensembl Genes ENSRNOG00000017251 UniProtKB/TrEMBL
  ENSRNOG00065002572 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000043271.4 UniProtKB/TrEMBL
  ENSRNOT00065003399 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8367400 IMAGE-MGC_LOAD
InterPro Apc4_WD40_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Red-like UniProtKB/TrEMBL
  RED_C UniProtKB/TrEMBL
  RED_N UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WDR55 UniProtKB/Swiss-Prot
KEGG Report rno:307494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156524 IMAGE-MGC_LOAD
NCBI Gene 307494 ENTREZGENE
PANTHER PROTEIN RED UniProtKB/TrEMBL
  PTHR12765 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 55 UniProtKB/Swiss-Prot
  WD REPEAT-CONTAINING PROTEIN 55 UniProtKB/Swiss-Prot
Pfam ANAPC4_WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RED_C UniProtKB/TrEMBL
  RED_N UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wdr55 PhenoGen
PIRSF WD_repeat_p55 UniProtKB/Swiss-Prot
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017251 RatGTEx
  ENSRNOG00065002572 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1L112 ENTREZGENE
  Q6QI75_RAT UniProtKB/TrEMBL
  WDR55_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Wdr55  WD repeat domain 55  RGD1305640_predicted  similar to RIKEN cDNA 2410080P20 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305640_predicted  similar to RIKEN cDNA 2410080P20 (predicted)  LOC307494_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC307494_predicted  similar to RIKEN cDNA 2410080P20 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL