Symbol:
Lox
Name:
lysyl oxidase
RGD ID:
3015
Description:
Enables copper ion binding activity and protein-lysine 6-oxidase activity. Involved in extracellular matrix organization; response to steroid hormone; and response to xenobiotic stimulus. Acts upstream of or within cell chemotaxis; platelet-derived growth factor receptor-beta signaling pathway; and protein oxidation. Located in extracellular matrix. Used to study abdominal aortic aneurysm; arteriosclerosis; coronary artery disease; coronary restenosis; and hypertension. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; colon adenocarcinoma; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase); PARTICIPATES IN hypertension pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
H-rev142; Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts); protein-lysine 6-oxidase; Rrg1
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
LOX (lysyl oxidase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Lox (lysyl oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Lox (lysyl oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
LOX (lysyl oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
LOX (lysyl oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Lox (lysyl oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
LOX (lysyl oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
LOX (lysyl oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Lox (lysyl oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Lox (lysyl oxidase)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
LOX (lysyl oxidase)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
loxa (lysyl oxidase a)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
lox
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 18 48,162,889 - 48,175,640 (-) NCBI GRCr8 mRatBN7.2 18 45,964,544 - 45,977,431 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 18 45,967,343 - 46,041,477 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 18 48,017,910 - 48,092,296 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 18 48,730,134 - 48,804,144 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 18 46,523,816 - 46,598,201 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 18 47,500,320 - 47,577,819 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 18 47,500,330 - 47,577,819 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 18 46,713,533 - 46,791,367 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 18 47,896,674 - 47,970,829 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 18 47,931,499 - 47,944,296 (-) NCBI Celera 18 44,155,712 - 44,229,997 (-) NCBI Celera Cytogenetic Map 18 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Lox Rat (-)-epigallocatechin 3-gallate multiple interactions ISO LOX (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LOX mRNA CTD PMID:22079256 Lox Rat 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of LOX mRNA CTD PMID:25380136 Lox Rat 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of LOX mRNA CTD PMID:16079270 Lox Rat 17alpha-ethynylestradiol multiple interactions ISO Lox (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of LOX mRNA CTD PMID:17942748 Lox Rat 17beta-estradiol affects expression ISO LOX (Homo sapiens) 6480464 Estradiol affects the expression of LOX mRNA CTD PMID:14699072 Lox Rat 17beta-estradiol increases expression ISO LOX (Homo sapiens) 6480464 Estradiol results in increased expression of LOX mRNA CTD PMID:36142876 Lox Rat 17beta-estradiol increases expression ISO Lox (Mus musculus) 6480464 Estradiol results in increased expression of LOX mRNA CTD PMID:19484750 Lox Rat 17beta-estradiol multiple interactions ISO LOX (Homo sapiens) 6480464 [Estradiol binds to ESR2 protein] which results in increased expression of LOX mRNA more ... CTD PMID:20404318 more ... Lox Rat 17beta-estradiol decreases expression ISO LOX (Homo sapiens) 6480464 Estradiol results in decreased expression of LOX mRNA CTD PMID:20106945 and PMID:21632981 Lox Rat 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO LOX (Homo sapiens) 6480464 Dihydrotestosterone results in increased expression of LOX mRNA CTD PMID:29581250 Lox Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Lox (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of LOX mRNA CTD PMID:17942748 Lox Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Lox (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of LOX mRNA CTD PMID:16922920 and PMID:27562557 Lox Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Lox (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of LOX mRNA CTD PMID:26377647 Lox Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of LOX mRNA CTD PMID:16054898 more ... Lox Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO LOX (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of LOX mRNA CTD PMID:20106945 and PMID:21632981 Lox Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of LOX mRNA CTD PMID:22298810 and PMID:34747641 Lox Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Lox (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of LOX mRNA CTD PMID:19770486 Lox Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:21724226 Lox Rat 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO Lox (Mus musculus) 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA] CTD PMID:18200517 Lox Rat 2,4,6-trinitrobenzenesulfonic acid increases expression ISO Lox (Mus musculus) 6480464 Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA CTD PMID:17982090 and PMID:18200517 Lox Rat 2-butoxyethanol decreases expression ISO Lox (Mus musculus) 6480464 n-butoxyethanol results in decreased expression of LOX mRNA CTD PMID:19812364 Lox Rat 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 Lox Rat 3,3',5,5'-tetrabromobisphenol A decreases expression ISO Lox (Mus musculus) 6480464 tetrabromobisphenol A results in decreased expression of LOX mRNA CTD PMID:25172293 Lox Rat 3-methylcholanthrene decreases expression ISO Lox (Mus musculus) 6480464 Methylcholanthrene results in decreased expression of LOX mRNA CTD PMID:20713471 Lox Rat 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1 and 2-dithiol-3-thione results in increased expression of LOX mRNA CTD PMID:19162173 Lox Rat 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of LOX mRNA CTD PMID:25380136 Lox Rat 4,4'-sulfonyldiphenol increases expression ISO Lox (Mus musculus) 6480464 bisphenol S results in increased expression of LOX mRNA CTD PMID:30951980 Lox Rat 4,4'-sulfonyldiphenol multiple interactions ISO Lox (Mus musculus) 6480464 [bisphenol S co-treated with Tretinoin] results in decreased expression of LOX mRNA CTD PMID:30951980 Lox Rat 4-hydroxyphenyl retinamide increases expression ISO Lox (Mus musculus) 6480464 Fenretinide results in increased expression of LOX mRNA CTD PMID:28973697 Lox Rat 5-aza-2'-deoxycytidine increases expression ISO LOX (Homo sapiens) 6480464 Decitabine results in increased expression of LOX mRNA CTD PMID:17908484 Lox Rat 5-aza-2'-deoxycytidine affects expression ISO LOX (Homo sapiens) 6480464 Decitabine affects the expression of LOX mRNA CTD PMID:17194187 Lox Rat 5-chloro-7-iodoquinolin-8-ol increases expression ISO LOX (Homo sapiens) 6480464 Clioquinol results in increased expression of LOX mRNA CTD PMID:33034664 Lox Rat 5-chloro-7-iodoquinolin-8-ol decreases secretion ISO LOX (Homo sapiens) 6480464 Clioquinol results in decreased secretion of LOX protein CTD PMID:33034664 Lox Rat 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of LOX mRNA CTD PMID:19483382 Lox Rat 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of LOX mRNA CTD PMID:19483382 and PMID:24780913 Lox Rat acetamide decreases expression EXP 6480464 acetamide results in decreased expression of LOX mRNA CTD PMID:31881176 Lox Rat acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of LOX mRNA CTD PMID:28959563 Lox Rat aflatoxin B1 affects expression ISO LOX (Homo sapiens) 6480464 Aflatoxin B1 affects the expression of LOX protein CTD PMID:20106945 Lox Rat aflatoxin B1 decreases methylation ISO LOX (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of LOX gene CTD PMID:27153756 Lox Rat aflatoxin B1 decreases expression ISO LOX (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of LOX mRNA CTD PMID:21632981 and PMID:21641981 Lox Rat alendronic acid affects expression EXP 6480464 Alendronate affects the expression of LOX mRNA CTD PMID:16079270 Lox Rat Alisol A multiple interactions EXP 6480464 [alisol A co-treated with alisol A 24-acetate co-treated with alisol B co-treated with alisol B 23-acetate co-treated with alisol C 23-acetate co-treated with alisol F co-treated with alisol F 24-acetate] results in decreased expression of LOX mRNA CTD PMID:33035272 Lox Rat Alisol B multiple interactions EXP 6480464 [alisol A co-treated with alisol A 24-acetate co-treated with alisol B co-treated with alisol B 23-acetate co-treated with alisol C 23-acetate co-treated with alisol F co-treated with alisol F 24-acetate] results in decreased expression of LOX mRNA CTD PMID:33035272 Lox Rat Alisol C 23-acetate multiple interactions EXP 6480464 [alisol A co-treated with alisol A 24-acetate co-treated with alisol B co-treated with alisol B 23-acetate co-treated with alisol C 23-acetate co-treated with alisol F co-treated with alisol F 24-acetate] results in decreased expression of LOX mRNA CTD PMID:33035272 Lox Rat all-trans-retinoic acid decreases expression ISO LOX (Homo sapiens) 6480464 Tretinoin results in decreased expression of LOX mRNA CTD PMID:23724009 Lox Rat all-trans-retinoic acid multiple interactions ISO Lox (Mus musculus) 6480464 [bisphenol A co-treated with Tretinoin] results in decreased expression of LOX mRNA more ... CTD PMID:30951980 Lox Rat alpha-Zearalanol multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of LOX mRNA CTD PMID:35163327 Lox Rat amiodarone affects expression EXP 6480464 Amiodarone affects the expression of LOX mRNA CTD PMID:18355885 and PMID:19483382 Lox Rat amitriptyline affects expression EXP 6480464 Amitriptyline affects the expression of LOX mRNA CTD PMID:18355885 Lox Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of LOX mRNA CTD PMID:16483693 Lox Rat ampicillin increases expression ISO LOX (Homo sapiens) 6480464 Ampicillin results in increased expression of LOX mRNA CTD PMID:21632981 Lox Rat antirheumatic drug increases expression ISO LOX (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of LOX mRNA CTD PMID:24449571 Lox Rat aristolochic acid A decreases expression ISO LOX (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of LOX mRNA and aristolochic acid I results in decreased expression of LOX protein CTD PMID:33212167 Lox Rat arsane multiple interactions ISO LOX (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LOX mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of LOX mRNA CTD PMID:32525701 and PMID:39836092 Lox Rat arsane decreases ubiquitination ISO LOX (Homo sapiens) 6480464 Arsenic results in decreased ubiquitination of LOX protein CTD PMID:35994080 Lox Rat arsenic atom multiple interactions ISO LOX (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LOX mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of LOX mRNA CTD PMID:32525701 and PMID:39836092 Lox Rat arsenic atom decreases ubiquitination ISO LOX (Homo sapiens) 6480464 Arsenic results in decreased ubiquitination of LOX protein CTD PMID:35994080 Lox Rat arsenite(3-) increases expression ISO LOX (Homo sapiens) 6480464 arsenite results in increased expression of LOX mRNA CTD PMID:23974009 Lox Rat Azoxymethane multiple interactions ISO Lox (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of LOX mRNA CTD PMID:29950665 Lox Rat benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of LOX mRNA CTD PMID:19483382 Lox Rat benzo[a]pyrene decreases expression ISO Lox (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of LOX mRNA CTD PMID:19770486 Lox Rat benzo[a]pyrene increases methylation ISO LOX (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of LOX exon CTD PMID:27901495 Lox Rat benzo[a]pyrene decreases methylation ISO LOX (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of LOX 5' UTR and Benzo(a)pyrene results in decreased methylation of LOX promoter CTD PMID:27901495 Lox Rat benzo[a]pyrene affects expression ISO Lox (Mus musculus) 6480464 Benzo(a)pyrene affects the expression of LOX mRNA CTD PMID:22342234 Lox Rat benzo[a]pyrene decreases expression ISO LOX (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of LOX mRNA CTD PMID:20106945 more ... Lox Rat benzo[a]pyrene increases expression ISO Lox (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of LOX mRNA CTD PMID:21569818 Lox Rat beta-aminopropionitrile decreases activity EXP 6480464 Aminopropionitrile results in decreased activity of LOX protein CTD PMID:19524603 Lox Rat beta-aminopropionitrile multiple interactions ISO LOX (Homo sapiens) 6480464 Aminopropionitrile inhibits the reaction [cupric chloride results in increased activity of LOX protein] CTD PMID:25044713 Lox Rat beta-aminopropionitrile decreases activity ISO Lox (Mus musculus) 6480464 Aminopropionitrile results in decreased activity of LOX protein CTD PMID:22367676 Lox Rat beta-aminopropionitrile decreases activity ISO LOX (Homo sapiens) 6480464 Aminopropionitrile results in decreased activity of LOX protein CTD PMID:16023247 Lox Rat beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LOX mRNA CTD PMID:18164116 Lox Rat bexarotene decreases expression EXP 6480464 bexarotene results in decreased expression of LOX mRNA CTD PMID:16648578 Lox Rat bis(2-ethylhexyl) phthalate decreases expression ISO LOX (Homo sapiens) 6480464 Diethylhexyl Phthalate results in decreased expression of LOX mRNA CTD PMID:28412506 Lox Rat bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of LOX mRNA CTD PMID:32533902 Lox Rat bis(2-ethylhexyl) phthalate increases expression ISO LOX (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of LOX mRNA CTD PMID:31163220 Lox Rat bisphenol A decreases expression ISO LOX (Homo sapiens) 6480464 bisphenol A results in decreased expression of LOX mRNA CTD PMID:22576693 Lox Rat bisphenol A increases methylation ISO LOX (Homo sapiens) 6480464 bisphenol A results in increased methylation of LOX promoter CTD PMID:31610501 Lox Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LOX mRNA CTD PMID:30816183 more ... Lox Rat bisphenol A increases expression ISO Lox (Mus musculus) 6480464 bisphenol A results in increased expression of LOX mRNA CTD PMID:30951980 more ... Lox Rat bisphenol A multiple interactions ISO Lox (Mus musculus) 6480464 [bisphenol A co-treated with Tretinoin] results in decreased expression of LOX mRNA CTD PMID:30951980 Lox Rat bisphenol A affects expression ISO LOX (Homo sapiens) 6480464 bisphenol A affects the expression of LOX mRNA CTD PMID:30903817 Lox Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of LOX mRNA CTD PMID:25181051 and PMID:33296240 Lox Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of LOX mRNA CTD PMID:26496021 Lox Rat bisphenol AF increases expression ISO LOX (Homo sapiens) 6480464 bisphenol AF results in increased expression of LOX protein CTD PMID:34186270 Lox Rat Bisphenol B increases expression ISO LOX (Homo sapiens) 6480464 bisphenol B results in increased expression of LOX protein CTD PMID:34186270 Lox Rat bisphenol F multiple interactions ISO Lox (Mus musculus) 6480464 [bisphenol F co-treated with Tretinoin] results in decreased expression of LOX mRNA CTD PMID:30951980 Lox Rat bisphenol F increases expression ISO LOX (Homo sapiens) 6480464 bisphenol F results in increased expression of LOX protein CTD PMID:34186270 Lox Rat bisphenol F increases expression ISO Lox (Mus musculus) 6480464 bisphenol F results in increased expression of LOX mRNA CTD PMID:30951980 Lox Rat bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of LOX mRNA CTD PMID:32479839 Lox Rat brucine decreases expression ISO Lox (Mus musculus) 6480464 brucine results in decreased expression of LOX mRNA and brucine results in decreased expression of LOX protein CTD PMID:23933019 Lox Rat brucine decreases expression ISO LOX (Homo sapiens) 6480464 brucine results in decreased expression of LOX mRNA CTD PMID:23933019 Lox Rat cadmium atom affects methylation EXP 6480464 Cadmium affects the methylation of LOX promoter CTD PMID:25741534 Lox Rat cadmium atom decreases expression EXP 6480464 Cadmium results in decreased expression of LOX CTD PMID:19879314 Lox Rat cadmium atom affects expression EXP 6480464 Cadmium affects the expression of LOX CTD PMID:25741534 Lox Rat cadmium dichloride decreases activity EXP 6480464 Cadmium Chloride results in decreased activity of LOX CTD PMID:19879314 Lox Rat cadmium dichloride decreases expression ISO LOX (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of LOX mRNA CTD PMID:38568856 Lox Rat cadmium dichloride increases expression ISO LOX (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of LOX mRNA CTD PMID:38382870 Lox Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of LOX mRNA CTD PMID:25993096 Lox Rat cadmium dichloride multiple interactions EXP 6480464 Cadmium Chloride inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to LOX promoter]] CTD PMID:23161664 Lox Rat cadmium dichloride multiple interactions ISO Lox (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of LOX mRNA CTD PMID:19840844 Lox Rat calcitriol increases expression ISO LOX (Homo sapiens) 6480464 Calcitriol results in increased expression of LOX mRNA CTD PMID:16002434 Lox Rat carbon nanotube increases expression ISO Lox (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 Lox Rat carvedilol decreases expression EXP 6480464 carvedilol results in decreased expression of LOX mRNA CTD PMID:21216836 Lox Rat chlorohydrocarbon multiple interactions EXP 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in increased expression of LOX mRNA CTD PMID:30744511 Lox Rat chloroprene increases expression ISO Lox (Mus musculus) 6480464 Chloroprene results in increased expression of LOX mRNA CTD PMID:23125180 Lox Rat chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of LOX mRNA CTD PMID:23125180 Lox Rat ciglitazone multiple interactions ISO LOX (Homo sapiens) 6480464 [ciglitazone binds to PPARG protein alternative form] which results in increased expression of LOX mRNA CTD PMID:16197558 Lox Rat cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of LOX mRNA CTD PMID:22023808 Lox Rat cisplatin multiple interactions ISO LOX (Homo sapiens) 6480464 [Cisplatin co-treated with Paclitaxel] results in decreased expression of LOX mRNA CTD PMID:20705681 Lox Rat clofibrate affects expression EXP 6480464 Clofibrate affects the expression of LOX mRNA CTD PMID:19483382 Lox Rat clofibrate increases expression ISO Lox (Mus musculus) 6480464 Clofibrate results in increased expression of LOX mRNA CTD PMID:17585979 Lox Rat clomipramine affects expression EXP 6480464 Clomipramine affects the expression of LOX mRNA CTD PMID:18355885 Lox Rat clothianidin increases expression ISO LOX (Homo sapiens) 6480464 clothianidin results in increased expression of LOX mRNA CTD PMID:29044138 Lox Rat cobalt dichloride increases expression ISO LOX (Homo sapiens) 6480464 cobaltous chloride results in increased expression of LOX mRNA and cobaltous chloride results in increased expression of LOX protein CTD PMID:24614111 Lox Rat cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of LOX mRNA CTD PMID:23161664 Lox Rat cobalt dichloride multiple interactions EXP 6480464 Cadmium Chloride inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to LOX promoter]] more ... CTD PMID:23161664 Lox Rat cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of LOX mRNA CTD PMID:17898221 Lox Rat copper atom multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA and [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein CTD PMID:22276220 Lox Rat copper atom decreases expression EXP 6480464 Copper results in decreased expression of LOX mRNA CTD PMID:30556269 Lox Rat copper atom multiple interactions ISO Lox (Mus musculus) 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of LOX mRNA CTD PMID:15467011 Lox Rat copper(0) multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA and [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein CTD PMID:22276220 Lox Rat copper(0) decreases expression EXP 6480464 Copper results in decreased expression of LOX mRNA CTD PMID:30556269 Lox Rat copper(0) multiple interactions ISO Lox (Mus musculus) 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of LOX mRNA CTD PMID:15467011 Lox Rat copper(II) chloride increases activity ISO Lox (Mus musculus) 6480464 cupric chloride results in increased activity of LOX protein CTD PMID:22367676 Lox Rat copper(II) chloride decreases expression ISO LOX (Homo sapiens) 6480464 cupric chloride results in decreased expression of LOX mRNA CTD PMID:38568856 Lox Rat copper(II) chloride multiple interactions ISO LOX (Homo sapiens) 6480464 Aminopropionitrile inhibits the reaction [cupric chloride results in increased activity of LOX protein] CTD PMID:25044713 Lox Rat copper(II) chloride increases activity ISO LOX (Homo sapiens) 6480464 cupric chloride results in increased activity of LOX protein CTD PMID:25044713 Lox Rat copper(II) sulfate increases expression ISO LOX (Homo sapiens) 6480464 Copper Sulfate results in increased expression of LOX mRNA CTD PMID:20599845 Lox Rat copper(II) sulfate decreases expression ISO LOX (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of LOX mRNA CTD PMID:19549813 and PMID:20599845 Lox Rat corn oil multiple interactions ISO Lox (Mus musculus) 6480464 Corn Oil results in increased activity of and results in increased cleavage of LOX protein CTD PMID:26240151 Lox Rat crocidolite asbestos decreases expression ISO Lox (Mus musculus) 6480464 Asbestos and Crocidolite results in decreased expression of LOX mRNA CTD PMID:29279043 Lox Rat curcumin multiple interactions ISO Lox (Mus musculus) 6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA] CTD PMID:18200517 Lox Rat cyclosporin A decreases expression ISO LOX (Homo sapiens) 6480464 Cyclosporine results in decreased expression of LOX mRNA CTD PMID:20106945 more ... Lox Rat cytarabine decreases expression ISO LOX (Homo sapiens) 6480464 Cytarabine results in decreased expression of LOX mRNA CTD PMID:21198554 Lox Rat DDT decreases expression EXP 6480464 DDT results in decreased expression of LOX mRNA CTD PMID:30207508 Lox Rat decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of LOX mRNA CTD PMID:23640034 Lox Rat deguelin multiple interactions ISO LOX (Homo sapiens) 6480464 deguelin inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA] CTD PMID:22745725 Lox Rat desferrioxamine B multiple interactions ISO LOX (Homo sapiens) 6480464 [Deferoxamine results in decreased abundance of Iron] which results in increased expression of LOX mRNA CTD PMID:12393473 Lox Rat dexamethasone increases expression ISO Lox (Mus musculus) 6480464 Dexamethasone results in increased expression of LOX mRNA CTD PMID:10926554 and PMID:22733784 Lox Rat dextran sulfate multiple interactions ISO Lox (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of LOX mRNA and Qingdai compound inhibits the reaction [Dextran Sulfate results in increased expression of LOX mRNA] CTD PMID:29950665 and PMID:32033881 Lox Rat dextran sulfate increases expression ISO Lox (Mus musculus) 6480464 Dextran Sulfate results in increased expression of LOX mRNA CTD PMID:32033881 and PMID:35093514 Lox Rat diallyl trisulfide multiple interactions ISO LOX (Homo sapiens) 6480464 diallyl trisulfide inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA] CTD PMID:28574600 Lox Rat dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of LOX mRNA CTD PMID:21266533 Lox Rat dicrotophos increases expression ISO LOX (Homo sapiens) 6480464 dicrotophos results in increased expression of LOX mRNA CTD PMID:28302478 Lox Rat dioxygen multiple interactions ISO LOX (Homo sapiens) 6480464 (+)-JQ1 compound inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA] more ... CTD PMID:22745725 more ... Lox Rat dioxygen multiple interactions ISO Lox (Mus musculus) 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of LOX mRNA CTD PMID:30529165 Lox Rat dioxygen increases expression ISO LOX (Homo sapiens) 6480464 Oxygen deficiency results in increased expression of LOX mRNA and Oxygen deficiency results in increased expression of LOX protein CTD PMID:18924134 more ... Lox Rat dioxygen increases activity ISO LOX (Homo sapiens) 6480464 Oxygen deficiency results in increased activity of LOX protein CTD PMID:25044713 Lox Rat dioxygen increases expression ISO Lox (Mus musculus) 6480464 Oxygen deficiency results in increased expression of LOX mRNA and Oxygen deficiency results in increased expression of LOX protein CTD PMID:24614111 Lox Rat diuron decreases expression EXP 6480464 Diuron results in decreased expression of LOX mRNA CTD PMID:25152437 Lox Rat dorsomorphin multiple interactions ISO LOX (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LOX mRNA CTD PMID:27188386 Lox Rat doxorubicin affects response to substance ISO LOX (Homo sapiens) 6480464 LOX protein affects the susceptibility to Doxorubicin CTD PMID:16217747 Lox Rat doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of LOX mRNA CTD PMID:32289291 Lox Rat doxorubicin increases expression ISO LOX (Homo sapiens) 6480464 Doxorubicin results in increased expression of LOX mRNA CTD PMID:29803840 Lox Rat doxorubicin decreases expression ISO LOX (Homo sapiens) 6480464 Doxorubicin results in decreased expression of LOX mRNA CTD PMID:22908232 Lox Rat doxorubicin multiple interactions ISO Lox (Mus musculus) 6480464 [[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of LOX mRNA CTD PMID:21040762 Lox Rat doxorubicin increases expression ISO Lox (Mus musculus) 6480464 Doxorubicin results in increased expression of LOX mRNA CTD PMID:21040762 Lox Rat doxorubicin affects expression ISO Lox (Mus musculus) 6480464 Doxorubicin affects the expression of LOX mRNA CTD PMID:15033991 Lox Rat endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of LOX mRNA CTD PMID:29391264 Lox Rat ethanol multiple interactions ISO Lox (Mus musculus) 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LOX mRNA CTD PMID:30517762 Lox Rat ethanol decreases expression ISO Lox (Mus musculus) 6480464 Ethanol results in decreased expression of LOX mRNA CTD PMID:34755883 Lox Rat ethanol increases expression ISO LOX (Homo sapiens) 6480464 Ethanol results in increased expression of LOX mRNA CTD PMID:23378141 Lox Rat ethanol multiple interactions ISO LOX (Homo sapiens) 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of LOX mRNA CTD PMID:23378141 Lox Rat ethylparaben increases expression ISO LOX (Homo sapiens) 6480464 ethyl-p-hydroxybenzoate results in increased expression of LOX mRNA CTD PMID:37690743 Lox Rat fentanyl decreases expression EXP 6480464 Fentanyl results in decreased expression of LOX mRNA CTD PMID:36032789 Lox Rat fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of LOX mRNA CTD PMID:30307764 Lox Rat flutamide increases expression EXP 6480464 Flutamide results in increased expression of LOX mRNA CTD PMID:21525395 Lox Rat folic acid multiple interactions ISO LOX (Homo sapiens) 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of LOX mRNA CTD PMID:23378141 Lox Rat furan increases expression EXP 6480464 furan results in increased expression of LOX mRNA CTD PMID:27387713 Lox Rat genistein multiple interactions EXP 6480464 [Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of LOX mRNA CTD PMID:32533902 Lox Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of LOX mRNA CTD PMID:33387578 Lox Rat Glutathione ethyl ester decreases expression EXP 6480464 S-ethyl glutathione results in decreased expression of LOX mRNA CTD PMID:19879314 Lox Rat Glutathione ethyl ester decreases activity EXP 6480464 S-ethyl glutathione results in decreased activity of LOX protein CTD PMID:19879314 Lox Rat glycidol increases expression EXP 6480464 glycidol results in increased expression of LOX mRNA CTD PMID:24395379 Lox Rat hemin multiple interactions ISO LOX (Homo sapiens) 6480464 [Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA CTD PMID:12393473 Lox Rat hydrogen peroxide affects expression ISO LOX (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of LOX mRNA CTD PMID:23410634 Lox Rat hydrogen peroxide increases expression ISO LOX (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of LOX mRNA CTD PMID:32949572 Lox Rat hydrogen sulfide increases expression ISO Lox (Mus musculus) 6480464 Hydrogen Sulfide results in increased expression of LOX mRNA CTD PMID:31843631 Lox Rat imipramine affects expression EXP 6480464 Imipramine affects the expression of LOX mRNA CTD PMID:18355885 Lox Rat inulin multiple interactions ISO Lox (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of LOX mRNA CTD PMID:36331819 Lox Rat iron atom multiple interactions ISO LOX (Homo sapiens) 6480464 [Deferoxamine results in decreased abundance of Iron] which results in increased expression of LOX mRNA and [Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA CTD PMID:12393473 Lox Rat iron(0) multiple interactions ISO LOX (Homo sapiens) 6480464 [Deferoxamine results in decreased abundance of Iron] which results in increased expression of LOX mRNA and [Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA CTD PMID:12393473 Lox Rat isoprenaline increases expression ISO Lox (Mus musculus) 6480464 Isoproterenol results in increased expression of LOX mRNA CTD PMID:20003209 Lox Rat ketoconazole affects expression EXP 6480464 Ketoconazole affects the expression of LOX mRNA CTD PMID:18355885 Lox Rat L-ethionine affects expression EXP 6480464 Ethionine affects the expression of LOX mRNA CTD PMID:19483382 Lox Rat lead diacetate decreases expression ISO LOX (Homo sapiens) 6480464 lead acetate results in decreased expression of LOX mRNA CTD PMID:38568856 Lox Rat lead(0) affects expression ISO LOX (Homo sapiens) 6480464 Lead affects the expression of LOX mRNA CTD PMID:28903495 Lox Rat linoleic acid multiple interactions ISO Lox (Mus musculus) 6480464 FADS2 protein inhibits the reaction [Linoleic Acid results in increased activity of LOX protein] and TGFB1 protein promotes the reaction [Linoleic Acid results in increased activity of LOX protein] CTD PMID:26240151 Lox Rat linoleic acid increases activity ISO Lox (Mus musculus) 6480464 Linoleic Acid results in increased activity of LOX protein CTD PMID:26240151 Lox Rat losartan decreases expression EXP 6480464 Losartan results in decreased expression of LOX mRNA CTD PMID:15100363 Lox Rat manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of LOX mRNA CTD PMID:28801915 Lox Rat menadione affects expression ISO LOX (Homo sapiens) 6480464 Vitamin K 3 affects the expression of LOX mRNA CTD PMID:23410634 Lox Rat metformin affects expression EXP 6480464 Metformin affects the expression of LOX mRNA CTD PMID:31324951 Lox Rat methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of LOX mRNA CTD PMID:30467583 Lox Rat methylmercury chloride multiple interactions EXP 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in increased expression of LOX mRNA CTD PMID:30744511 Lox Rat mifepristone decreases expression EXP 6480464 Mifepristone results in decreased expression of LOX mRNA CTD PMID:25972201 Lox Rat molibresib multiple interactions ISO LOX (Homo sapiens) 6480464 molibresib inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA] CTD PMID:27292261 Lox Rat molibresib decreases expression ISO LOX (Homo sapiens) 6480464 molibresib results in decreased expression of LOX mRNA CTD PMID:27292261 Lox Rat N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of LOX gene CTD PMID:33148267 Lox Rat N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of LOX mRNA CTD PMID:28801915 Lox Rat N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO Lox (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of LOX mRNA more ... CTD PMID:19840844 Lox Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LOX mRNA CTD PMID:18164116 Lox Rat N-nitrosodiethylamine increases expression ISO LOX (Homo sapiens) 6480464 Diethylnitrosamine results in increased expression of LOX mRNA CTD PMID:21527772 Lox Rat N-nitrosomorpholine affects expression EXP 6480464 N-nitrosomorpholine affects the expression of LOX mRNA CTD PMID:19716841 Lox Rat naphthalene increases expression ISO Lox (Mus musculus) 6480464 naphthalene results in increased expression of LOX mRNA CTD PMID:18978301 Lox Rat nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of LOX mRNA CTD PMID:24136188 Lox Rat nickel atom increases expression ISO Lox (Mus musculus) 6480464 Nickel results in increased expression of LOX mRNA CTD PMID:12540486 Lox Rat nickel dichloride increases expression ISO LOX (Homo sapiens) 6480464 nickel chloride results in increased expression of LOX mRNA CTD PMID:17312168 and PMID:21455298 Lox Rat nickel sulfate increases expression ISO LOX (Homo sapiens) 6480464 nickel sulfate results in increased expression of LOX mRNA CTD PMID:17382205 Lox Rat nickel sulfate decreases expression ISO LOX (Homo sapiens) 6480464 nickel sulfate results in decreased expression of LOX mRNA CTD PMID:22714537 Lox Rat nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of LOX mRNA and nitrofen results in decreased expression of LOX protein CTD PMID:25111273 Lox Rat okadaic acid multiple interactions ISO Lox (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of LOX mRNA CTD PMID:19840844 Lox Rat okadaic acid decreases expression ISO LOX (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of LOX mRNA CTD PMID:38832940 Lox Rat oleic acid increases activity ISO Lox (Mus musculus) 6480464 Oleic Acid results in increased activity of LOX protein CTD PMID:26240151 Lox Rat omeprazole affects expression EXP 6480464 Omeprazole affects the expression of LOX mRNA CTD PMID:19483382 Lox Rat orotic acid decreases expression EXP 6480464 Orotic Acid results in decreased expression of LOX mRNA CTD PMID:17203948 Lox Rat oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of LOX mRNA CTD PMID:25729387 Lox Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of LOX mRNA CTD PMID:25729387 Lox Rat ozone increases expression ISO Lox (Mus musculus) 6480464 Ozone results in increased expression of LOX mRNA CTD PMID:17095637 Lox Rat ozone multiple interactions ISO Lox (Mus musculus) 6480464 [Air Pollutants results in increased abundance of Ozone] which results in increased expression of LOX mRNA CTD PMID:34911549 Lox Rat ozone increases expression ISO LOX (Homo sapiens) 6480464 Ozone results in increased expression of LOX mRNA CTD PMID:23033980 Lox Rat paclitaxel multiple interactions ISO LOX (Homo sapiens) 6480464 [Cisplatin co-treated with Paclitaxel] results in decreased expression of LOX mRNA CTD PMID:20705681 Lox Rat paracetamol affects expression ISO Lox (Mus musculus) 6480464 Acetaminophen affects the expression of LOX mRNA CTD PMID:17562736 Lox Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of LOX mRNA CTD PMID:17202762 more ... Lox Rat paraquat increases expression EXP 6480464 Paraquat results in increased expression of LOX mRNA CTD PMID:32680482 Lox Rat paraquat decreases expression ISO LOX (Homo sapiens) 6480464 Paraquat results in decreased expression of LOX protein CTD PMID:34064677 Lox Rat pentane-2,3-dione increases expression EXP 6480464 2 and 3-pentanedione results in increased expression of LOX mRNA CTD PMID:25710175 Lox Rat perfluorohexanesulfonic acid increases expression ISO LOX (Homo sapiens) 6480464 perfluorohexanesulfonic acid results in increased expression of LOX mRNA CTD PMID:25812627 Lox Rat perfluorononanoic acid increases expression ISO LOX (Homo sapiens) 6480464 perfluoro-n-nonanoic acid results in increased expression of LOX mRNA CTD PMID:25812627 Lox Rat perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of LOX mRNA CTD PMID:19162173 Lox Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Lox (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of LOX mRNA CTD PMID:36331819 Lox Rat perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of LOX mRNA CTD PMID:16221955 and PMID:19162173 Lox Rat perfluorooctanoic acid increases expression ISO LOX (Homo sapiens) 6480464 perfluorooctanoic acid results in increased expression of LOX mRNA CTD PMID:25812627 Lox Rat perfluorooctanoic acid multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of LOX mRNA CTD PMID:35163327 Lox Rat permethrin multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of LOX gene CTD PMID:33148267 Lox Rat phenylmercury acetate increases expression ISO LOX (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of LOX mRNA CTD PMID:26272509 Lox Rat phenylmercury acetate multiple interactions ISO LOX (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LOX mRNA CTD PMID:27188386 Lox Rat phorbol 13-acetate 12-myristate multiple interactions ISO Lox (Mus musculus) 6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LOX mRNA CTD PMID:19840844 Lox Rat pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of LOX mRNA CTD PMID:19483382 Lox Rat potassium chromate increases expression ISO LOX (Homo sapiens) 6480464 potassium chromate(VI) results in increased expression of LOX mRNA CTD PMID:22079256 Lox Rat potassium chromate multiple interactions ISO LOX (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LOX mRNA CTD PMID:22079256 Lox Rat potassium dichromate decreases expression ISO Lox (Mus musculus) 6480464 Potassium Dichromate results in decreased expression of LOX mRNA CTD PMID:23608068 Lox Rat progesterone increases expression ISO Lox (Mus musculus) 6480464 Progesterone results in increased expression of LOX mRNA CTD PMID:22238285 Lox Rat quercetin decreases expression ISO LOX (Homo sapiens) 6480464 Quercetin results in decreased expression of LOX mRNA CTD PMID:21632981 Lox Rat quinolin-8-ol decreases expression ISO LOX (Homo sapiens) 6480464 Oxyquinoline results in decreased expression of LOX mRNA CTD PMID:21632981 Lox Rat raloxifene affects expression EXP 6480464 Raloxifene Hydrochloride affects the expression of LOX mRNA CTD PMID:16079270 Lox Rat rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of LOX mRNA CTD PMID:28374803 Lox Rat SB 431542 multiple interactions ISO LOX (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LOX mRNA CTD PMID:27188386 Lox Rat semicarbazide decreases activity EXP 6480464 carbamylhydrazine results in decreased activity of LOX protein CTD PMID:19524603 Lox Rat sevoflurane affects expression EXP 6480464 sevoflurane affects the expression of LOX mRNA CTD PMID:15967596 Lox Rat silicon dioxide decreases expression ISO LOX (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of LOX mRNA CTD PMID:25895662 Lox Rat silver atom decreases expression ISO Lox (Mus musculus) 6480464 Silver results in decreased expression of LOX mRNA CTD PMID:27131904 Lox Rat silver(0) decreases expression ISO Lox (Mus musculus) 6480464 Silver results in decreased expression of LOX mRNA CTD PMID:27131904 Lox Rat simvastatin decreases expression EXP 6480464 Simvastatin results in decreased expression of LOX mRNA CTD PMID:16414398 Lox Rat sodium arsenate increases expression ISO Lox (Mus musculus) 6480464 sodium arsenate results in increased expression of LOX mRNA CTD PMID:21795629 Lox Rat sodium arsenate multiple interactions ISO LOX (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LOX mRNA CTD PMID:32525701 Lox Rat sodium arsenite decreases expression ISO Lox (Mus musculus) 6480464 sodium arsenite results in decreased expression of LOX mRNA CTD PMID:32068019 and PMID:37682722 Lox Rat sodium arsenite multiple interactions ISO LOX (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of LOX mRNA CTD PMID:39836092 Lox Rat sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of LOX mRNA CTD PMID:25993096 Lox Rat sotorasib multiple interactions ISO LOX (Homo sapiens) 6480464 [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LOX mRNA CTD PMID:36139627 Lox Rat sulforaphane decreases expression ISO Lox (Mus musculus) 6480464 sulforaphane results in decreased expression of LOX mRNA CTD PMID:30529165 Lox Rat sulindac decreases expression ISO LOX (Homo sapiens) 6480464 Sulindac analog results in decreased expression of LOX mRNA CTD PMID:18924134 Lox Rat sunitinib decreases expression ISO LOX (Homo sapiens) 6480464 Sunitinib results in decreased expression of LOX mRNA CTD PMID:31533062 Lox Rat tauroursodeoxycholic acid decreases expression EXP 6480464 ursodoxicoltaurine results in decreased expression of LOX mRNA CTD PMID:15885361 Lox Rat tert-butyl hydroperoxide affects expression ISO LOX (Homo sapiens) 6480464 tert-Butylhydroperoxide affects the expression of LOX mRNA CTD PMID:23410634 Lox Rat testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of LOX mRNA CTD PMID:26496021 Lox Rat tetrachloromethane affects expression ISO Lox (Mus musculus) 6480464 Carbon Tetrachloride affects the expression of LOX mRNA CTD PMID:17484886 Lox Rat tetrachloromethane multiple interactions ISO Lox (Mus musculus) 6480464 [Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of LOX mRNA and [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LOX mRNA CTD PMID:25827057 and PMID:30517762 Lox Rat tetrachloromethane increases expression ISO Lox (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of LOX mRNA CTD PMID:15056808 and PMID:25827057 Lox Rat tetrathiomolybdate(2-) multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA and [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein CTD PMID:22276220 Lox Rat thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of LOX mRNA CTD PMID:19483382 Lox Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of LOX mRNA CTD PMID:23411599 Lox Rat thiram decreases expression ISO LOX (Homo sapiens) 6480464 Thiram results in decreased expression of LOX mRNA CTD PMID:38568856 Lox Rat titanium dioxide increases expression ISO Lox (Mus musculus) 6480464 titanium dioxide results in increased expression of LOX mRNA CTD PMID:27760801 Lox Rat titanium dioxide increases methylation ISO Lox (Mus musculus) 6480464 titanium dioxide results in increased methylation of LOX gene CTD PMID:35295148 Lox Rat titanium dioxide decreases methylation ISO Lox (Mus musculus) 6480464 titanium dioxide results in decreased methylation of LOX gene CTD PMID:35295148 Lox Rat titanium dioxide multiple interactions ISO Lox (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of LOX mRNA CTD PMID:29950665 Lox Rat toluene increases expression EXP 6480464 Toluene results in increased expression of LOX mRNA CTD PMID:22967744 Lox Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of LOX mRNA CTD PMID:25729387 Lox Rat topotecan increases expression EXP 6480464 Topotecan results in increased expression of LOX mRNA CTD PMID:25729387 Lox Rat trametinib multiple interactions ISO LOX (Homo sapiens) 6480464 [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of LOX mRNA CTD PMID:36139627 Lox Rat Trapidil multiple interactions EXP 6480464 Trapidil affects the reaction [PTH protein affects the expression of LOX mRNA] CTD PMID:18635661 Lox Rat tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of LOX mRNA CTD PMID:21683754 Lox Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of LOX mRNA CTD PMID:33387578 Lox Rat trimellitic anhydride increases expression ISO Lox (Mus musculus) 6480464 trimellitic anhydride results in increased expression of LOX mRNA CTD PMID:19042947 Lox Rat triphenyl phosphate affects expression EXP 6480464 triphenyl phosphate affects the expression of LOX mRNA CTD PMID:30589522 Lox Rat tris(2-butoxyethyl) phosphate affects expression ISO LOX (Homo sapiens) 6480464 tris(2-butoxyethyl) phosphate affects the expression of LOX mRNA CTD PMID:29024780 Lox Rat troglitazone increases expression ISO Lox (Mus musculus) 6480464 troglitazone results in increased expression of LOX mRNA CTD PMID:28973697 Lox Rat urethane decreases expression ISO LOX (Homo sapiens) 6480464 Urethane results in decreased expression of LOX mRNA CTD PMID:28818685 Lox Rat ursodeoxycholic acid decreases expression EXP 6480464 Ursodeoxycholic Acid results in decreased expression of LOX mRNA CTD PMID:15885361 Lox Rat valproic acid increases expression ISO LOX (Homo sapiens) 6480464 Valproic Acid results in increased expression of LOX mRNA CTD PMID:19101580 and PMID:28001369 Lox Rat valproic acid decreases expression ISO LOX (Homo sapiens) 6480464 Valproic Acid results in decreased expression of LOX mRNA CTD PMID:23179753 and PMID:29154799 Lox Rat valproic acid increases expression ISO Lox (Mus musculus) 6480464 Valproic Acid results in increased expression of LOX mRNA CTD PMID:24896083 Lox Rat vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of LOX mRNA CTD PMID:23034163
(-)-epigallocatechin 3-gallate (ISO) 1-naphthyl isothiocyanate (EXP) 17alpha-ethynylestradiol (EXP,ISO) 17beta-estradiol (ISO) 17beta-hydroxy-5alpha-androstan-3-one (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2,3,7,8-Tetrachlorodibenzofuran (EXP) 2,4,6-trinitrobenzenesulfonic acid (ISO) 2-butoxyethanol (ISO) 3,3',4,4',5-pentachlorobiphenyl (EXP) 3,3',5,5'-tetrabromobisphenol A (ISO) 3-methylcholanthrene (ISO) 3H-1,2-dithiole-3-thione (EXP) 4,4'-diaminodiphenylmethane (EXP) 4,4'-sulfonyldiphenol (ISO) 4-hydroxyphenyl retinamide (ISO) 5-aza-2'-deoxycytidine (ISO) 5-chloro-7-iodoquinolin-8-ol (ISO) 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP) 6-propyl-2-thiouracil (EXP) acetamide (EXP) acrylamide (EXP) aflatoxin B1 (ISO) alendronic acid (EXP) Alisol A (EXP) Alisol B (EXP) Alisol C 23-acetate (EXP) all-trans-retinoic acid (ISO) alpha-Zearalanol (EXP) amiodarone (EXP) amitriptyline (EXP) ammonium chloride (EXP) ampicillin (ISO) antirheumatic drug (ISO) aristolochic acid A (ISO) arsane (ISO) arsenic atom (ISO) arsenite(3-) (ISO) Azoxymethane (ISO) benzbromarone (EXP) benzo[a]pyrene (ISO) beta-aminopropionitrile (EXP,ISO) beta-naphthoflavone (EXP) bexarotene (EXP) bis(2-ethylhexyl) phthalate (EXP,ISO) bisphenol A (EXP,ISO) bisphenol AF (ISO) Bisphenol B (ISO) bisphenol F (ISO) bromobenzene (EXP) brucine (ISO) cadmium atom (EXP) cadmium dichloride (EXP,ISO) calcitriol (ISO) carbon nanotube (ISO) carvedilol (EXP) chlorohydrocarbon (EXP) chloroprene (EXP,ISO) ciglitazone (ISO) cisplatin (EXP,ISO) clofibrate (EXP,ISO) clomipramine (EXP) clothianidin (ISO) cobalt dichloride (EXP,ISO) cocaine (EXP) copper atom (EXP,ISO) copper(0) (EXP,ISO) copper(II) chloride (ISO) copper(II) sulfate (ISO) corn oil (ISO) crocidolite asbestos (ISO) curcumin (ISO) cyclosporin A (ISO) cytarabine (ISO) DDT (EXP) decabromodiphenyl ether (EXP) deguelin (ISO) desferrioxamine B (ISO) dexamethasone (ISO) dextran sulfate (ISO) diallyl trisulfide (ISO) dibutyl phthalate (EXP) dicrotophos (ISO) dioxygen (ISO) diuron (EXP) dorsomorphin (ISO) doxorubicin (EXP,ISO) endosulfan (EXP) ethanol (ISO) ethylparaben (ISO) fentanyl (EXP) fenvalerate (EXP) flutamide (EXP) folic acid (ISO) furan (EXP) genistein (EXP) gentamycin (EXP) Glutathione ethyl ester (EXP) glycidol (EXP) hemin (ISO) hydrogen peroxide (ISO) hydrogen sulfide (ISO) imipramine (EXP) inulin (ISO) iron atom (ISO) iron(0) (ISO) isoprenaline (ISO) ketoconazole (EXP) L-ethionine (EXP) lead diacetate (ISO) lead(0) (ISO) linoleic acid (ISO) losartan (EXP) manganese(II) chloride (EXP) menadione (ISO) metformin (EXP) methapyrilene (EXP) methylmercury chloride (EXP) mifepristone (EXP) molibresib (ISO) N,N-diethyl-m-toluamide (EXP) N-methyl-4-phenylpyridinium (EXP) N-methyl-N'-nitro-N-nitrosoguanidine (ISO) N-nitrosodiethylamine (EXP,ISO) N-nitrosomorpholine (EXP) naphthalene (ISO) nefazodone (EXP) nickel atom (ISO) nickel dichloride (ISO) nickel sulfate (ISO) nitrofen (EXP) okadaic acid (ISO) oleic acid (ISO) omeprazole (EXP) orotic acid (EXP) oxaliplatin (EXP) ozone (ISO) paclitaxel (ISO) paracetamol (EXP,ISO) paraquat (EXP,ISO) pentane-2,3-dione (EXP) perfluorohexanesulfonic acid (ISO) perfluorononanoic acid (ISO) perfluorooctane-1-sulfonic acid (EXP,ISO) perfluorooctanoic acid (EXP,ISO) permethrin (EXP) phenylmercury acetate (ISO) phorbol 13-acetate 12-myristate (ISO) pirinixic acid (EXP) potassium chromate (ISO) potassium dichromate (ISO) progesterone (ISO) quercetin (ISO) quinolin-8-ol (ISO) raloxifene (EXP) rotenone (EXP) SB 431542 (ISO) semicarbazide (EXP) sevoflurane (EXP) silicon dioxide (ISO) silver atom (ISO) silver(0) (ISO) simvastatin (EXP) sodium arsenate (ISO) sodium arsenite (ISO) sodium dichromate (EXP) sotorasib (ISO) sulforaphane (ISO) sulindac (ISO) sunitinib (ISO) tauroursodeoxycholic acid (EXP) tert-butyl hydroperoxide (ISO) testosterone (EXP) tetrachloromethane (ISO) tetrathiomolybdate(2-) (EXP) thioacetamide (EXP) thiram (ISO) titanium dioxide (ISO) toluene (EXP) topotecan (EXP) trametinib (ISO) Trapidil (EXP) tributylstannane (EXP) trichloroethene (EXP) trimellitic anhydride (ISO) triphenyl phosphate (EXP) tris(2-butoxyethyl) phosphate (ISO) troglitazone (ISO) urethane (ISO) ursodeoxycholic acid (EXP) valproic acid (ISO) vinclozolin (EXP)
Biological Process
aorta development (IEA,ISO) ascending aorta development (IEA,ISO) blood vessel development (IEA,ISO) blood vessel morphogenesis (IEA,ISO,ISS) bone mineralization (IEA,ISO) cell chemotaxis (IEA,IMP,ISO) cellular response to chemokine (IEA,ISO) collagen fibril organization (IBA,IDA,IEA,IMP,ISO) connective tissue development (IEA,ISO) descending aorta development (IEA,ISO) DNA biosynthetic process (IEA,ISO) elastic fiber assembly (IEA,IMP,ISO) heart development (IEA,ISO) lung development (IEA,ISO) muscle cell cellular homeostasis (IEA,ISO) muscle cell development (IEA,ISO) negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO) osteoblast differentiation (IEA,ISO) peptidyl-lysine oxidation (ISO,ISS) platelet-derived growth factor receptor-beta signaling pathway (IBA,IEA,IMP,ISO) protein oxidation (IMP) regulation of apoptotic process (IEA,ISO) regulation of bone development (IEA,ISO) regulation of gene expression (IEA,ISO) regulation of megakaryocyte differentiation (IEA,ISO) regulation of platelet-derived growth factor receptor-beta signaling pathway (IEA,ISO) regulation of protein phosphorylation (ISO) regulation of striated muscle tissue development (IEA,ISO) regulation of transforming growth factor beta receptor signaling pathway (IEA,ISO) response to hormone (IDA) response to steroid hormone (IDA) response to xenobiotic stimulus (IEP)
Molecular Function
collagen binding (IEA,ISO,ISS) copper ion binding (IEA,IMP) metal ion binding (IEA) molecular adaptor activity (IEA,ISO) oxidoreductase activity (IEA) oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor (IEA) protein binding (ISO) protein-lysine 6-oxidase activity (IBA,IDA,IEA,IMP,ISO) small molecule binding (IEA,ISO)
1.
The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer.
Baker AM, etal., J Natl Cancer Inst. 2011 Mar 2;103(5):407-24. doi: 10.1093/jnci/djq569. Epub 2011 Jan 31.
2.
Effect of nifedipine and amlodipine on dead space wound healing in rats.
Bhaskar HN, etal., Indian J Exp Biol. 2005 Mar;43(3):294-6.
3.
Downregulation of lysyl oxidase and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate.
Chen LJ, etal., Toxicol Sci. 2005 Feb;83(2):372-9. Epub 2004 Oct 27.
4.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.
Rat ISS GO annotations from GOA human gene data--August 2006
GOA data from the GO Consortium
6.
Lysyl oxidase gene expression and enzyme activity in the rat ovary: regulation by follicle-stimulating hormone, androgen, and transforming growth factor-beta superfamily members in vitro.
Harlow CR, etal., Endocrinology 2003 Jan;144(1):154-62.
7.
Differential regulation of functional gene clusters in overt coronary artery disease in a transgenic atherosclerosis-hypertensive rat model.
Herrera VM, etal., Mol Med. 2002 Jul;8(7):367-75.
8.
Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms.
Huffman MD, etal., Surgery. 2000 Sep;128(3):429-38.
9.
Expression of mRNAs for lysyl oxidase and type III procollagen in cultured fibroblasts from patients with the Menkes and occipital horn syndromes as determined by quantitative polymerase chain reaction.
Kemppainen R, etal., Arch Biochem Biophys. 1996 Apr 1;328(1):101-6.
10.
Overexpression of lysyl oxidase to increase matrix crosslinking and improve tissue strength in dermal wound healing.
Lau YK, etal., Ann Biomed Eng. 2006 Aug;34(8):1239-46. Epub 2006 Jun 28.
11.
Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells.
Lucero HA, etal., J Biol Chem. 2008 Aug 29;283(35):24103-17. doi: 10.1074/jbc.M709897200. Epub 2008 Jun 27.
12.
Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.
Maki JM, etal., Circulation. 2002 Nov 5;106(19):2503-9.
13.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
14.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.
Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth-muscle cells.
Nellaiappan K, etal., J Cell Biochem. 2000 Sep 14;79(4):576-82.
16.
Lysyl oxidase expression in a rat model of arterial balloon injury.
Nuthakki VK, etal., J Vasc Surg. 2004 Jul;40(1):123-9.
17.
Increased lysyl oxidase activity in blood vessels of hypertensive rats and effect of beta-aminopropionitrile on arteriosclerosis.
Ooshima A and Midorikawa O, Jpn Circ J. 1977 Dec;41(12):1337-40.
18.
GOA pipeline
RGD automated data pipeline
19.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
20.
PKC-MEK-MAPK-dependent signal transduction pathway mediates the stimulation of lysyl oxidase expression by serum and PDGF in rat aortic smooth muscle cells.
Smith-Mungo L and Kagan HM, J Cell Biochem 2002;85(4):775-84.
21.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22.
The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers.
Thomassin L, etal., J Biol Chem. 2005 Dec 30;280(52):42848-55. Epub 2005 Oct 26.
23.
Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence.
Trackman PC, etal., Biochemistry 1990 May 22;29(20):4863-70.
24.
Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence.
Trackman PC, etal., Biochemistry 1991 Aug 20;30(33):8282.
25.
Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes.
Tsuda T, etal., Cardiovasc Res. 2003 Oct 1;59(4):926-33.
26.
Zinc, copper, and zinc- or copper-dependent enzymes in human hypertension.
Vivoli G, etal., Biol Trace Elem Res. 1995 Aug-Sep;49(2-3):97-106.
27.
Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat fetal lung fibroblasts.
Zhao Y, etal., Toxicol Sci. 2006 Apr;90(2):478-89. Epub 2006 Jan 23.
Lox Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 18 48,162,889 - 48,175,640 (-) NCBI GRCr8 mRatBN7.2 18 45,964,544 - 45,977,431 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 18 45,967,343 - 46,041,477 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 18 48,017,910 - 48,092,296 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 18 48,730,134 - 48,804,144 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 18 46,523,816 - 46,598,201 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 18 47,500,320 - 47,577,819 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 18 47,500,330 - 47,577,819 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 18 46,713,533 - 46,791,367 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 18 47,896,674 - 47,970,829 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 18 47,931,499 - 47,944,296 (-) NCBI Celera 18 44,155,712 - 44,229,997 (-) NCBI Celera Cytogenetic Map 18 q11 NCBI
LOX Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 5 122,063,195 - 122,078,259 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 5 122,063,195 - 122,078,413 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 5 121,398,890 - 121,413,954 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 5 121,429,918 - 121,441,853 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 5 121,429,917 - 121,441,853 NCBI Celera 5 117,353,346 - 117,368,512 (-) NCBI Celera Cytogenetic Map 5 q23.1 NCBI HuRef 5 116,590,466 - 116,605,632 (-) NCBI HuRef CHM1_1 5 120,831,494 - 120,846,659 (-) NCBI CHM1_1 T2T-CHM13v2.0 5 122,579,951 - 122,595,014 (-) NCBI T2T-CHM13v2.0
Lox Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 18 52,649,132 - 52,662,939 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 18 52,649,139 - 52,662,939 (-) Ensembl GRCm39 Ensembl GRCm38 18 52,516,060 - 52,529,867 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 18 52,516,067 - 52,529,867 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 18 52,676,892 - 52,689,362 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 18 52,641,436 - 52,655,072 (-) NCBI MGSCv36 mm8 Celera 18 53,829,941 - 53,842,352 (-) NCBI Celera Cytogenetic Map 18 D1 NCBI cM Map 18 28.22 NCBI
Lox Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955521 185,792 - 193,926 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955521 178,290 - 193,926 (-) NCBI ChiLan1.0 ChiLan1.0
LOX Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 4 117,339,359 - 117,353,228 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 5 115,491,718 - 115,506,516 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 5 117,450,833 - 117,464,957 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 5 123,233,359 - 123,248,658 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 5 123,234,662 - 123,248,717 (-) Ensembl panpan1.1 panPan2
LOX Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 11 12,023,645 - 12,040,015 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 11 12,027,250 - 12,039,819 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 11 10,807,698 - 10,821,728 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 11 12,730,282 - 12,744,862 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 11 12,732,124 - 12,744,691 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 11 11,471,714 - 11,486,299 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 11 11,289,217 - 11,303,248 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 11 11,920,314 - 11,934,905 (-) NCBI UU_Cfam_GSD_1.0
Lox Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024407213 134,444,800 - 134,452,726 (-) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936575 2,524,342 - 2,533,559 (-) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936575 2,526,067 - 2,533,996 (-) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
LOX Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 2 125,591,789 - 125,607,594 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 2 125,595,115 - 125,607,026 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 2 130,888,135 - 130,900,048 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
LOX Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 23 25,158,458 - 25,172,763 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 23 25,157,269 - 25,172,757 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666034 53,042,867 - 53,057,523 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Lox
.
Predicted Target Of
Count of predictions: 412 Count of miRNA genes: 232 Interacting mature miRNAs: 270 Transcripts: ENSRNOT00000019844, ENSRNOT00000074226 Prediction methods: Microtar, Miranda, Targetscan Result types: miRGate_prediction
1331733 Bp233 Blood pressure QTL 233 3.97196 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 24796977 79788953 Rat 1358358 Sradr6 Stress Responsive Adrenal Weight QTL 6 2.49 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 18 11944299 59330563 Rat 1331798 Bp224 Blood pressure QTL 224 3.53873 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 31359408 59796643 Rat 2301413 Bp318 Blood pressure QTL 318 0.002 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 26548082 46969551 Rat 61383 Bp47 Blood pressure QTL 47 17.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 18 31271681 60377755 Rat 1331741 Bp232 Blood pressure QTL 232 3.59112 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 18 21372893 83213037 Rat 1331742 Bp228 Blood pressure QTL 228 3.88752 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 31359408 59796643 Rat 1331776 Bp225 Blood pressure QTL 225 2.829 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 18 31359408 59796643 Rat 6903359 Bp355 Blood pressure QTL 355 3.6 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 18 11944544 59796478 Rat 631518 Bw11 Body weight QTL 11 2.8 body mass (VT:0001259) body weight (CMO:0000012) 18 35870723 80870723 Rat 12904668 Bw188 Body weight QTL 188 0.03 body mass (VT:0001259) body weight (CMO:0000012) 18 26548082 46969551 Rat 2313082 Bss85 Bone structure and strength QTL 85 0.8 0.0001 long bone metaphysis morphology trait (VT:0000133) tibia midshaft total cross-sectional area (CMO:0001715) 18 14951337 59951337 Rat 12904669 Cm125 Cardiac mass QTL 125 0.001 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) 18 26548082 46969551 Rat 1641923 Colcr8 Colorectal carcinoma resistance QTL 8 3.1 0.0014 intestine integrity trait (VT:0010554) poorly differentiated malignant colorectal tumor number (CMO:0002076) 18 22066242 52293055 Rat 12904670 Cm126 Cardiac mass QTL 126 0.001 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 18 26548082 46969551 Rat 6903347 Bp350 Blood pressure QTL 350 4.4 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 31359530 59796478 Rat 6893683 Bw110 Body weight QTL 110 2.7 0.002 body mass (VT:0001259) body weight (CMO:0000012) 18 43345022 83828827 Rat 1331727 Bp237 Blood pressure QTL 237 3.053 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 31359408 61698465 Rat 2300157 Bmd66 Bone mineral density QTL 66 13.1 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 18 28964853 73964853 Rat 738005 Anxrr11 Anxiety related response QTL 11 3.4 exploratory behavior trait (VT:0010471) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 18 30039813 75039813 Rat 12904677 Kidm72 Kidney mass QTL 72 0.001 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 18 26548082 46969551 Rat 631274 Sprol1 Serum protein level QTL 1 5.3 blood total protein amount (VT:0005567) serum total protein level (CMO:0000661) 18 31393320 77209694 Rat 1358193 Emca2 Estrogen-induced mammary cancer QTL 2 1.6 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 18 18007599 63571040 Rat 12904673 Cm127 Cardiac mass QTL 127 0.005 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) 18 26548082 46969551 Rat 12904675 Am19 Aortic mass QTL 19 0.001 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) 18 26548082 46969551 Rat 2293704 Bss35 Bone structure and strength QTL 35 4.59 0.0002 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) 18 28964853 73964853 Rat 9589816 Gluco68 Glucose level QTL 68 7.25 0.001 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 18 29792965 74792965 Rat 1331774 Bp226 Blood pressure QTL 226 4.41065 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 31359408 59796643 Rat 2325839 Bp348 Blood pressure QTL 348 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 25570985 70570985 Rat 1600373 Mamtr6 Mammary tumor resistance QTL 6 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 18 19278901 83218561 Rat 2293708 Bss46 Bone structure and strength QTL 46 8.8 0.0001 lumbar vertebra morphology trait (VT:0010494) lumbar vertebra cortical cross-sectional area (CMO:0001690) 18 11791518 63636873 Rat 8694378 Bw157 Body weight QTL 157 3.59 0.001 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) 18 29792965 74792965 Rat 2300177 Bmd65 Bone mineral density QTL 65 19.7 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 18 28964853 73964853 Rat 1598826 Anxrr20 Anxiety related response QTL 20 3.04 body movement coordination trait (VT:0005424) number of rearing movements in an experimental apparatus (CMO:0001752) 18 41432971 83828827 Rat 1578667 Bss21 Bone structure and strength QTL 21 3.5 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) 18 11791518 83218561 Rat 2303120 Mamtr8 Mammary tumor resistance QTL 8 0.001 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) 18 31359408 83218561 Rat 61429 Cia17 Collagen induced arthritis QTL 17 4.6 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 18 31359408 70263868 Rat 61367 Iddm4 Insulin dependent diabetes mellitus QTL 4 2.33 0.0074 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 18 38192455 83192455 Rat 2299160 Iddm35 Insulin dependent diabetes mellitus QTL 35 2.79 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) 18 4207941 60377792 Rat 9590318 Scort22 Serum corticosterone level QTL 22 7.64 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 18 29792965 74792965 Rat 1578661 Bss20 Bone structure and strength QTL 20 3.7 femur morphology trait (VT:0000559) femoral neck cross-sectional area (CMO:0001697) 18 11791518 83218561 Rat 1331753 Bp231 Blood pressure QTL 231 3.643 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 18 11944299 52293055 Rat 1331754 Bp230 Blood pressure QTL 230 4.61609 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 29792965 74792965 Rat
D18Got43
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 18 45,988,320 - 45,988,509 (+) MAPPER mRatBN7.2 Rnor_6.0 18 47,524,323 - 47,524,511 NCBI Rnor6.0 Rnor_5.0 18 46,737,398 - 46,737,586 UniSTS Rnor5.0 RGSC_v3.4 18 47,917,682 - 47,917,868 RGD RGSC3.4 RGSC_v3.4 18 47,917,680 - 47,917,868 UniSTS RGSC3.4 RGSC_v3.1 18 47,955,305 - 47,955,491 RGD Celera 18 44,176,590 - 44,176,778 UniSTS Cytogenetic Map 18 q11 UniSTS
D18Got44
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 18 46,039,149 - 46,039,354 (+) MAPPER mRatBN7.2 Rnor_6.0 18 47,575,494 - 47,575,696 NCBI Rnor6.0 Rnor_5.0 18 46,789,042 - 46,789,244 UniSTS Rnor5.0 RGSC_v3.4 18 47,968,503 - 47,968,706 RGD RGSC3.4 RGSC_v3.4 18 47,968,504 - 47,968,706 UniSTS RGSC3.4 RGSC_v3.1 18 48,006,126 - 48,006,329 RGD Celera 18 44,227,672 - 44,227,874 UniSTS Cytogenetic Map 18 q11 UniSTS
D18Chm55
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 18 46,039,157 - 46,039,364 (+) MAPPER mRatBN7.2 Rnor_6.0 18 47,575,502 - 47,575,706 NCBI Rnor6.0 Rnor_5.0 18 46,789,050 - 46,789,254 UniSTS Rnor5.0 RGSC_v3.4 18 47,968,512 - 47,968,716 UniSTS RGSC3.4 Celera 18 44,227,680 - 44,227,884 UniSTS Cytogenetic Map 18 q11 UniSTS
RH134457
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 18 45,964,574 - 45,964,754 (+) MAPPER mRatBN7.2 Rnor_6.0 18 47,500,582 - 47,500,761 NCBI Rnor6.0 Rnor_5.0 18 46,713,795 - 46,713,974 UniSTS Rnor5.0 RGSC_v3.4 18 47,893,908 - 47,894,087 UniSTS RGSC3.4 Celera 18 44,152,946 - 44,153,125 UniSTS Cytogenetic Map 18 q11 UniSTS
RH139210
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 18 45,965,564 - 45,965,716 (+) MAPPER mRatBN7.2 Rnor_6.0 18 47,501,572 - 47,501,723 NCBI Rnor6.0 Rnor_5.0 18 46,714,785 - 46,714,936 UniSTS Rnor5.0 RGSC_v3.4 18 47,894,898 - 47,895,049 UniSTS RGSC3.4 Celera 18 44,153,936 - 44,154,087 UniSTS Cytogenetic Map 18 q11 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
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Ensembl Acc Id:
ENSRNOT00000019844 ⟹ ENSRNOP00000019844
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 18 45,967,343 - 46,041,477 (-) Ensembl Rnor_6.0 Ensembl 18 47,503,350 - 47,577,819 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000074226 ⟹ ENSRNOP00000065314
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source Rnor_6.0 Ensembl 18 47,500,330 - 47,513,065 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000083881 ⟹ ENSRNOP00000068687
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source Rnor_6.0 Ensembl 18 47,504,284 - 47,513,030 (-) Ensembl
RefSeq Acc Id:
NM_001414003 ⟹ NP_001400932
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 18 48,162,889 - 48,175,640 (-) NCBI mRatBN7.2 18 45,964,544 - 45,977,295 (-) NCBI
Ensembl Acc Id:
ENSRNOP00000019844 ⟸ ENSRNOT00000019844
Ensembl Acc Id:
ENSRNOP00000068687 ⟸ ENSRNOT00000083881
Ensembl Acc Id:
ENSRNOP00000065314 ⟸ ENSRNOT00000074226
RefSeq Acc Id:
NP_001400932 ⟸ NM_001414003
- Peptide Label:
precursor
- UniProtKB:
P16636 (UniProtKB/Swiss-Prot), A6IX14 (UniProtKB/TrEMBL)
RGD ID: 13700788 Promoter ID: EPDNEW_R11303 Type: initiation region Name: Lox_1 Description: lysyl oxidase SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 18 47,513,095 - 47,513,155 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2002-06-10
Lox
lysyl oxidase
Symbol and Name status set to approved
70586 APPROVED
Note Type
Note
Reference
gene_process
important for regulating the formation and maintenance of extracellular matrix in the ovary
729248
