Lox (lysyl oxidase) - Rat Genome Database

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Gene: Lox (lysyl oxidase) Rattus norvegicus
Analyze
Symbol: Lox
Name: lysyl oxidase
RGD ID: 3015
Description: Enables copper ion binding activity and protein-lysine 6-oxidase activity. Involved in extracellular matrix organization; response to steroid hormone; and response to xenobiotic stimulus. Acts upstream of or within cell chemotaxis and platelet-derived growth factor receptor-beta signaling pathway. Located in extracellular matrix. Used to study abdominal aortic aneurysm; arteriosclerosis; coronary artery disease; coronary restenosis; and hypertension. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; colon adenocarcinoma; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase); PARTICIPATES IN hypertension pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H-rev142; Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts); protein-lysine 6-oxidase; Rrg1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81848,162,889 - 48,175,640 (-)NCBIGRCr8
mRatBN7.21845,964,544 - 45,977,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1845,967,343 - 46,041,477 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1848,017,910 - 48,092,296 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01848,730,134 - 48,804,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01846,523,816 - 46,598,201 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01847,500,320 - 47,577,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1847,500,330 - 47,577,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01846,713,533 - 46,791,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41847,896,674 - 47,970,829 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11847,931,499 - 47,944,296 (-)NCBI
Celera1844,155,712 - 44,229,997 (-)NCBICelera
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
Alisol A  (EXP)
Alisol B  (EXP)
Alisol C 23-acetate  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-aminopropionitrile  (EXP,ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
brucine  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
chlorohydrocarbon  (EXP)
chloroprene  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clomipramine  (EXP)
clothianidin  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
Glutathione ethyl ester  (EXP)
glycidol  (EXP)
hemin  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
imipramine  (EXP)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
lead(0)  (ISO)
linoleic acid  (ISO)
losartan  (EXP)
manganese(II) chloride  (EXP)
menadione  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methylmercury chloride  (EXP)
mifepristone  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentane-2,3-dione  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
raloxifene  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
semicarbazide  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trametinib  (ISO)
Trapidil  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. Baker AM, etal., J Natl Cancer Inst. 2011 Mar 2;103(5):407-24. doi: 10.1093/jnci/djq569. Epub 2011 Jan 31.
2. Effect of nifedipine and amlodipine on dead space wound healing in rats. Bhaskar HN, etal., Indian J Exp Biol. 2005 Mar;43(3):294-6.
3. Downregulation of lysyl oxidase and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate. Chen LJ, etal., Toxicol Sci. 2005 Feb;83(2):372-9. Epub 2004 Oct 27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Lysyl oxidase gene expression and enzyme activity in the rat ovary: regulation by follicle-stimulating hormone, androgen, and transforming growth factor-beta superfamily members in vitro. Harlow CR, etal., Endocrinology 2003 Jan;144(1):154-62.
7. Differential regulation of functional gene clusters in overt coronary artery disease in a transgenic atherosclerosis-hypertensive rat model. Herrera VM, etal., Mol Med. 2002 Jul;8(7):367-75.
8. Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms. Huffman MD, etal., Surgery. 2000 Sep;128(3):429-38.
9. Expression of mRNAs for lysyl oxidase and type III procollagen in cultured fibroblasts from patients with the Menkes and occipital horn syndromes as determined by quantitative polymerase chain reaction. Kemppainen R, etal., Arch Biochem Biophys. 1996 Apr 1;328(1):101-6.
10. Overexpression of lysyl oxidase to increase matrix crosslinking and improve tissue strength in dermal wound healing. Lau YK, etal., Ann Biomed Eng. 2006 Aug;34(8):1239-46. Epub 2006 Jun 28.
11. Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells. Lucero HA, etal., J Biol Chem. 2008 Aug 29;283(35):24103-17. doi: 10.1074/jbc.M709897200. Epub 2008 Jun 27.
12. Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Maki JM, etal., Circulation. 2002 Nov 5;106(19):2503-9.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth-muscle cells. Nellaiappan K, etal., J Cell Biochem. 2000 Sep 14;79(4):576-82.
16. Lysyl oxidase expression in a rat model of arterial balloon injury. Nuthakki VK, etal., J Vasc Surg. 2004 Jul;40(1):123-9.
17. Increased lysyl oxidase activity in blood vessels of hypertensive rats and effect of beta-aminopropionitrile on arteriosclerosis. Ooshima A and Midorikawa O, Jpn Circ J. 1977 Dec;41(12):1337-40.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. PKC-MEK-MAPK-dependent signal transduction pathway mediates the stimulation of lysyl oxidase expression by serum and PDGF in rat aortic smooth muscle cells. Smith-Mungo L and Kagan HM, J Cell Biochem 2002;85(4):775-84.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. Thomassin L, etal., J Biol Chem. 2005 Dec 30;280(52):42848-55. Epub 2005 Oct 26.
23. Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence. Trackman PC, etal., Biochemistry 1990 May 22;29(20):4863-70.
24. Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence. Trackman PC, etal., Biochemistry 1991 Aug 20;30(33):8282.
25. Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes. Tsuda T, etal., Cardiovasc Res. 2003 Oct 1;59(4):926-33.
26. Zinc, copper, and zinc- or copper-dependent enzymes in human hypertension. Vivoli G, etal., Biol Trace Elem Res. 1995 Aug-Sep;49(2-3):97-106.
27. Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat fetal lung fibroblasts. Zhao Y, etal., Toxicol Sci. 2006 Apr;90(2):478-89. Epub 2006 Jan 23.
Additional References at PubMed
PMID:14140   PMID:20889   PMID:7873615   PMID:7901452   PMID:9382709   PMID:12577300   PMID:12686140   PMID:14741400   PMID:15489334   PMID:16126250   PMID:16192629   PMID:17584760  
PMID:17673218   PMID:18060869   PMID:18803461   PMID:18835815   PMID:19359664   PMID:19458888   PMID:19683237   PMID:20048148   PMID:20192271   PMID:20484295   PMID:20606470   PMID:20888776  
PMID:21215756   PMID:21498085   PMID:21665949   PMID:21893029   PMID:22205540   PMID:23006535   PMID:23413430   PMID:24006456   PMID:24120383   PMID:24440697   PMID:24650661   PMID:24971753  
PMID:25111273   PMID:25715398   PMID:25807483   PMID:26670953   PMID:26700732   PMID:26755713   PMID:26780438   PMID:26804196   PMID:27169768   PMID:27432961   PMID:28285904   PMID:28538980  
PMID:28550176   PMID:28668305   PMID:28711328   PMID:28800626   PMID:29146187   PMID:29278308   PMID:29502979   PMID:31152061   PMID:32979358   PMID:35011567   PMID:37095518  


Genomics

Comparative Map Data
Lox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81848,162,889 - 48,175,640 (-)NCBIGRCr8
mRatBN7.21845,964,544 - 45,977,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1845,967,343 - 46,041,477 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1848,017,910 - 48,092,296 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01848,730,134 - 48,804,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01846,523,816 - 46,598,201 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01847,500,320 - 47,577,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1847,500,330 - 47,577,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01846,713,533 - 46,791,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41847,896,674 - 47,970,829 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11847,931,499 - 47,944,296 (-)NCBI
Celera1844,155,712 - 44,229,997 (-)NCBICelera
Cytogenetic Map18q11NCBI
LOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385122,063,195 - 122,078,259 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5122,063,195 - 122,078,413 (-)EnsemblGRCh38hg38GRCh38
GRCh375121,398,890 - 121,413,954 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365121,429,918 - 121,441,853 (-)NCBINCBI36Build 36hg18NCBI36
Build 345121,429,917 - 121,441,853NCBI
Celera5117,353,346 - 117,368,512 (-)NCBICelera
Cytogenetic Map5q23.1NCBI
HuRef5116,590,466 - 116,605,632 (-)NCBIHuRef
CHM1_15120,831,494 - 120,846,659 (-)NCBICHM1_1
T2T-CHM13v2.05122,579,951 - 122,595,014 (-)NCBIT2T-CHM13v2.0
Lox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391852,649,132 - 52,662,939 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1852,649,139 - 52,662,939 (-)EnsemblGRCm39 Ensembl
GRCm381852,516,060 - 52,529,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1852,516,067 - 52,529,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv371852,676,892 - 52,689,362 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361852,641,436 - 52,655,072 (-)NCBIMGSCv36mm8
Celera1853,829,941 - 53,842,352 (-)NCBICelera
Cytogenetic Map18D1NCBI
cM Map1828.22NCBI
Lox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955521185,792 - 193,926 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955521178,290 - 193,926 (-)NCBIChiLan1.0ChiLan1.0
LOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24117,339,359 - 117,353,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15115,491,718 - 115,506,516 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05117,450,833 - 117,464,957 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15123,233,359 - 123,248,658 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5123,234,662 - 123,248,717 (-)Ensemblpanpan1.1panPan2
LOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,023,645 - 12,040,015 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,027,250 - 12,039,819 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,807,698 - 10,821,728 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,730,282 - 12,744,862 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,732,124 - 12,744,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11111,471,714 - 11,486,299 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,289,217 - 11,303,248 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,920,314 - 11,934,905 (-)NCBIUU_Cfam_GSD_1.0
Lox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213134,444,800 - 134,452,726 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365752,524,342 - 2,533,559 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365752,526,067 - 2,533,996 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2125,591,789 - 125,607,594 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12125,595,115 - 125,607,026 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22130,888,135 - 130,900,048 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12325,158,458 - 25,172,763 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2325,157,269 - 25,172,757 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603453,042,867 - 53,057,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477420,116,970 - 20,134,355 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477420,116,625 - 20,137,767 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lox
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:412
Count of miRNA genes:232
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000019844, ENSRNOT00000074226
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat

Markers in Region
D18Got43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21845,988,320 - 45,988,509 (+)MAPPERmRatBN7.2
Rnor_6.01847,524,323 - 47,524,511NCBIRnor6.0
Rnor_5.01846,737,398 - 46,737,586UniSTSRnor5.0
RGSC_v3.41847,917,682 - 47,917,868RGDRGSC3.4
RGSC_v3.41847,917,680 - 47,917,868UniSTSRGSC3.4
RGSC_v3.11847,955,305 - 47,955,491RGD
Celera1844,176,590 - 44,176,778UniSTS
Cytogenetic Map18q11UniSTS
D18Got44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21846,039,149 - 46,039,354 (+)MAPPERmRatBN7.2
Rnor_6.01847,575,494 - 47,575,696NCBIRnor6.0
Rnor_5.01846,789,042 - 46,789,244UniSTSRnor5.0
RGSC_v3.41847,968,503 - 47,968,706RGDRGSC3.4
RGSC_v3.41847,968,504 - 47,968,706UniSTSRGSC3.4
RGSC_v3.11848,006,126 - 48,006,329RGD
Celera1844,227,672 - 44,227,874UniSTS
Cytogenetic Map18q11UniSTS
D18Chm55  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21846,039,157 - 46,039,364 (+)MAPPERmRatBN7.2
Rnor_6.01847,575,502 - 47,575,706NCBIRnor6.0
Rnor_5.01846,789,050 - 46,789,254UniSTSRnor5.0
RGSC_v3.41847,968,512 - 47,968,716UniSTSRGSC3.4
Celera1844,227,680 - 44,227,884UniSTS
Cytogenetic Map18q11UniSTS
RH134457  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21845,964,574 - 45,964,754 (+)MAPPERmRatBN7.2
Rnor_6.01847,500,582 - 47,500,761NCBIRnor6.0
Rnor_5.01846,713,795 - 46,713,974UniSTSRnor5.0
RGSC_v3.41847,893,908 - 47,894,087UniSTSRGSC3.4
Celera1844,152,946 - 44,153,125UniSTS
Cytogenetic Map18q11UniSTS
RH139210  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21845,965,564 - 45,965,716 (+)MAPPERmRatBN7.2
Rnor_6.01847,501,572 - 47,501,723NCBIRnor6.0
Rnor_5.01846,714,785 - 46,714,936UniSTSRnor5.0
RGSC_v3.41847,894,898 - 47,895,049UniSTSRGSC3.4
Celera1844,153,936 - 44,154,087UniSTS
Cytogenetic Map18q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 9 1 11 1 4 4 11 20 29 11 4
Low 3 17 46 38 8 38 4 7 62 15 12 4
Below cutoff 2 2 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019844   ⟹   ENSRNOP00000019844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1845,967,343 - 46,041,477 (-)Ensembl
Rnor_6.0 Ensembl1847,503,350 - 47,577,819 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000074226   ⟹   ENSRNOP00000065314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1847,500,330 - 47,513,065 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083881   ⟹   ENSRNOP00000068687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1847,504,284 - 47,513,030 (-)Ensembl
RefSeq Acc Id: NM_001414003   ⟹   NP_001400932
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81848,162,889 - 48,175,640 (-)NCBI
mRatBN7.21845,964,544 - 45,977,295 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001400932 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52176 (Get FASTA)   NCBI Sequence Viewer  
  AAH78861 (Get FASTA)   NCBI Sequence Viewer  
  EDM14445 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019844
  ENSRNOP00000019844.3
  ENSRNOP00055024718
  ENSRNOP00060016498
  ENSRNOP00065004350
GenBank Protein P16636 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000019844   ⟸   ENSRNOT00000019844
RefSeq Acc Id: ENSRNOP00000068687   ⟸   ENSRNOT00000083881
RefSeq Acc Id: ENSRNOP00000065314   ⟸   ENSRNOT00000074226
RefSeq Acc Id: NP_001400932   ⟸   NM_001414003
- Peptide Label: precursor
- UniProtKB: P16636 (UniProtKB/Swiss-Prot),   A6IX14 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16636-F1-model_v2 AlphaFold P16636 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700788
Promoter ID:EPDNEW_R11303
Type:initiation region
Name:Lox_1
Description:lysyl oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01847,513,095 - 47,513,155EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3015 AgrOrtholog
BioCyc Gene G2FUF-7518 BioCyc
Ensembl Genes ENSRNOG00000014426 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055018147 UniProtKB/Swiss-Prot
  ENSRNOG00060012348 UniProtKB/Swiss-Prot
  ENSRNOG00065004171 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019844 ENTREZGENE
  ENSRNOT00000019844.7 UniProtKB/Swiss-Prot
  ENSRNOT00055030727 UniProtKB/Swiss-Prot
  ENSRNOT00060020923 UniProtKB/Swiss-Prot
  ENSRNOT00065006090 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7113042 IMAGE-MGC_LOAD
InterPro Lysyl_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lysyl_oxidase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24914 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93522 IMAGE-MGC_LOAD
NCBI Gene 24914 ENTREZGENE
PANTHER LYSYL OXIDASE-LIKE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN-LYSINE 6-OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lysyl_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lox PhenoGen
PRINTS LYSYLOXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LYSYL_OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014426 RatGTEx
  ENSRNOG00055018147 RatGTEx
  ENSRNOG00060012348 RatGTEx
  ENSRNOG00065004171 RatGTEx
UniProt A6IX14 ENTREZGENE, UniProtKB/TrEMBL
  LYOX_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lox  lysyl oxidase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process important for regulating the formation and maintenance of extracellular matrix in the ovary 729248