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Gene: Lox (lysyl oxidase) Rattus norvegicus
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Symbol: Lox
Name: lysyl oxidase
Description: Exhibits copper ion binding activity and protein-lysine 6-oxidase activity. Involved in several processes, including collagen fibril organization; elastic fiber assembly; and platelet-derived growth factor receptor-beta signaling pathway. Localizes to the extracellular matrix and nucleus. Used to study abdominal aortic aneurysm; arteriosclerosis; coronary artery disease; coronary restenosis; and hypertension. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Menkes disease; hypertension; and thoracic aortic aneurysm. Orthologous to human LOX (lysyl oxidase); PARTICIPATES IN hypertension pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: H-rev142; Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts); protein-lysine 6-oxidase; Rrg1
Orthologs:
Homo sapiens (human) : LOX (lysyl oxidase)  HGNC  Alliance
Mus musculus (house mouse) : Lox (lysyl oxidase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lox (lysyl oxidase)
Pan paniscus (bonobo/pygmy chimpanzee) : LOX (lysyl oxidase)
Canis lupus familiaris (dog) : LOX (lysyl oxidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lox (lysyl oxidase)
Sus scrofa (pig) : LOX (lysyl oxidase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01847,500,320 - 47,577,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1847,500,330 - 47,577,819 (-)Ensembl
Rnor_5.01846,713,533 - 46,791,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41847,896,674 - 47,970,829 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11847,931,499 - 47,944,296 (-)NCBI
Celera1844,155,712 - 44,229,997 (-)NCBICelera
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lox
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3015
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.