LOX (lysyl oxidase) - Rat Genome Database

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Gene: LOX (lysyl oxidase) Chlorocebus sabaeus
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Symbol: LOX
Name: lysyl oxidase
RGD ID: 18498954
Description: ENCODES a protein that exhibits collagen binding (ortholog); copper ion binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN aorta development (ortholog); ascending aorta development (ortholog); blood vessel development (ortholog); PARTICIPATES IN hypertension pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); aortic aneurysm (ortholog); aortic dissection (ortholog); FOUND IN collagen trimer (ortholog); extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein-lysine 6-oxidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12325,158,458 - 25,172,763 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2325,157,269 - 25,172,757 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603453,042,867 - 53,057,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12325,158,458 - 25,172,763 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2325,157,269 - 25,172,757 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603453,042,867 - 53,057,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385122,063,195 - 122,078,259 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5122,063,195 - 122,078,413 (-)EnsemblGRCh38hg38GRCh38
GRCh375121,398,890 - 121,413,954 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365121,429,918 - 121,441,853 (-)NCBINCBI36Build 36hg18NCBI36
Build 345121,429,917 - 121,441,853NCBI
Celera5117,353,346 - 117,368,512 (-)NCBICelera
Cytogenetic Map5q23.1NCBI
HuRef5116,590,466 - 116,605,632 (-)NCBIHuRef
CHM1_15120,831,494 - 120,846,659 (-)NCBICHM1_1
T2T-CHM13v2.05122,579,951 - 122,595,014 (-)NCBIT2T-CHM13v2.0
Lox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391852,649,132 - 52,662,939 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1852,649,139 - 52,662,939 (-)EnsemblGRCm39 Ensembl
GRCm381852,516,060 - 52,529,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1852,516,067 - 52,529,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv371852,676,892 - 52,689,362 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361852,641,436 - 52,655,072 (-)NCBIMGSCv36mm8
Celera1853,829,941 - 53,842,352 (-)NCBICelera
Cytogenetic Map18D1NCBI
cM Map1828.22NCBI
Lox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81848,162,889 - 48,175,640 (-)NCBIGRCr8
mRatBN7.21845,964,544 - 45,977,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1845,967,343 - 46,041,477 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1848,017,910 - 48,092,296 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01848,730,134 - 48,804,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01846,523,816 - 46,598,201 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01847,500,320 - 47,577,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1847,500,330 - 47,577,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01846,713,533 - 46,791,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41847,896,674 - 47,970,829 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11847,931,499 - 47,944,296 (-)NCBI
Celera1844,155,712 - 44,229,997 (-)NCBICelera
Cytogenetic Map18q11NCBI
Lox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955521185,792 - 193,926 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955521178,290 - 193,926 (-)NCBIChiLan1.0ChiLan1.0
LOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24117,339,359 - 117,353,228 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15115,491,718 - 115,506,516 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05117,450,833 - 117,464,957 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15123,233,359 - 123,248,658 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5123,234,662 - 123,248,717 (-)Ensemblpanpan1.1panPan2
LOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,023,645 - 12,040,015 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,027,250 - 12,039,819 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,807,698 - 10,821,728 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,730,282 - 12,744,862 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,732,124 - 12,744,691 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11111,471,714 - 11,486,299 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,289,217 - 11,303,248 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,920,314 - 11,934,905 (-)NCBIUU_Cfam_GSD_1.0
Lox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213134,444,800 - 134,452,726 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365752,524,342 - 2,533,559 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365752,526,067 - 2,533,996 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2125,591,789 - 125,607,594 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12125,595,115 - 125,607,026 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22130,888,135 - 130,900,048 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Lox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477420,116,970 - 20,134,355 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477420,116,625 - 20,137,767 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 36 13 43
Below cutoff 7 17

Sequence


RefSeq Acc Id: ENSCSAT00000012728   ⟹   ENSCSAP00000010758
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2325,157,269 - 25,172,757 (-)Ensembl
RefSeq Acc Id: XM_038008649   ⟹   XP_037864577
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603453,042,867 - 53,057,523 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037864577 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010758.1
RefSeq Acc Id: ENSCSAP00000010758   ⟸   ENSCSAT00000012728
RefSeq Acc Id: XP_037864577   ⟸   XM_038008649
- UniProtKB: A0A0D9RQ69 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014633 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012728.1 UniProtKB/TrEMBL
InterPro Lysyl_oxidase UniProtKB/TrEMBL
  Lysyl_oxidase_CS UniProtKB/TrEMBL
KEGG Report csab:103244411 UniProtKB/TrEMBL
NCBI Gene LOX ENTREZGENE
PANTHER LYSYL OXIDASE-LIKE-RELATED UniProtKB/TrEMBL
  PROTEIN-LYSINE 6-OXIDASE UniProtKB/TrEMBL
Pfam Lysyl_oxidase UniProtKB/TrEMBL
PRINTS LYSYLOXIDASE UniProtKB/TrEMBL
PROSITE LYSYL_OXIDASE UniProtKB/TrEMBL
UniProt A0A0D9RQ69 ENTREZGENE, UniProtKB/TrEMBL