Lox (lysyl oxidase) - Rat Genome Database

Name: Lox
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Lox (lysyl oxidase) Heterocephalus glaber

Analyze

Symbol:

Lox

Name:

lysyl oxidase

RGD ID:

18919791

Description:

ENCODES a protein that exhibits collagen binding (ortholog); copper ion binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN aorta development (ortholog); ascending aorta development (ortholog); blood vessel development (ortholog); PARTICIPATES IN hypertension pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); aortic aneurysm (ortholog); aortic dissection (ortholog); FOUND IN collagen trimer (ortholog); extracellular matrix (ortholog); extracellular region (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protein-lysine 6-oxidase

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LOX (lysyl oxidase)	NCBI	Ortholog
Mus musculus (house mouse):	Lox (lysyl oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Lox (lysyl oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lox (lysyl oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOX (lysyl oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOX (lysyl oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lox (lysyl oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOX (lysyl oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOX (lysyl oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	20,116,970 - 20,134,355 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624774	20,116,625 - 20,137,767 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

abdominal aortic aneurysm (ISO)

aortic aneurysm (ISO)

aortic dissection (ISO)

aortic valve insufficiency (ISO)

arteriosclerosis (ISO)

colon adenocarcinoma (ISO)

colorectal cancer (ISO)

connective tissue disease (ISO)

coronary artery disease (ISO)

coronary restenosis (ISO)

cutis laxa (ISO)

Ehlers-Danlos syndrome (ISO)

Emphysema (ISO)

Experimental Liver Cirrhosis (ISO)

familial adenomatous polyposis 1 (ISO)

Familial Thoracic Aortic Aneurysm 1 (ISO)

Familial Thoracic Aortic Aneurysm 10 (ISO)

genetic disease (ISO)

hepatitis B (ISO)

hepatitis C (ISO)

Hereditary Neoplastic Syndromes (ISO)

hypertension (ISO)

liver cirrhosis (ISO)

Menkes disease (ISO)

myocardial infarction (ISO)

Neurodevelopmental Disorders (ISO)

oral submucous fibrosis (ISO)

osteosarcoma (ISO)

Pleural Effusion (ISO)

Prenatal Injuries (ISO)

primary biliary cholangitis (ISO)

pulmonary emphysema (ISO)

pulmonary hypertension (ISO)

thoracic aortic aneurysm (ISO)

Williams-Beuren syndrome (ISO)

Wilson disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aorta development (ISO)

ascending aorta development (ISO)

blood vessel development (ISO)

blood vessel morphogenesis (ISO)

bone mineralization (ISO)

cell chemotaxis (ISO)

cellular response to chemokine (ISO)

cellular response to organic substance (ISO)

collagen fibril organization (ISO)

connective tissue development (ISO)

descending aorta development (ISO)

DNA biosynthetic process (ISO)

elastic fiber assembly (ISO)

heart development (ISO)

lung development (ISO)

muscle cell cellular homeostasis (ISO)

muscle cell development (ISO)

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

osteoblast differentiation (ISO)

platelet-derived growth factor receptor-beta signaling pathway (ISO)

regulation of apoptotic process (ISO)

regulation of bone development (ISO)

regulation of gene expression (ISO)

regulation of megakaryocyte differentiation (ISO)

regulation of platelet-derived growth factor receptor-beta signaling pathway (ISO)

regulation of protein phosphorylation (ISO)

regulation of striated muscle tissue development (ISO)

regulation of transforming growth factor beta receptor signaling pathway (ISO)

response to hormone (ISO)

response to steroid hormone (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

collagen trimer (ISO)

extracellular matrix (ISO)

extracellular region (ISO)

extracellular space (ISO)

Molecular Function

collagen binding (ISO)

copper ion binding (ISO)

molecular adaptor activity (ISO)

protein binding (ISO)

protein-lysine 6-oxidase activity (ISO)

small molecule binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

hypertension pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Lox
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	20,116,970 - 20,134,355 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624774	20,116,625 - 20,137,767 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

LOX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	122,063,195 - 122,078,259 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	122,063,195 - 122,078,413 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	121,398,890 - 121,413,954 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	121,429,918 - 121,441,853 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	121,429,917 - 121,441,853	NCBI
Celera	5	117,353,346 - 117,368,512 (-)	NCBI		Celera
Cytogenetic Map	5	q23.1	NCBI
HuRef	5	116,590,466 - 116,605,632 (-)	NCBI		HuRef
CHM1_1	5	120,831,494 - 120,846,659 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	122,579,951 - 122,595,014 (-)	NCBI		T2T-CHM13v2.0

Lox
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	52,649,132 - 52,662,939 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	52,649,139 - 52,662,939 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	52,516,060 - 52,529,867 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	52,516,067 - 52,529,867 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	52,676,892 - 52,689,362 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	52,641,436 - 52,655,072 (-)	NCBI		MGSCv36	mm8
Celera	18	53,829,941 - 53,842,352 (-)	NCBI		Celera
Cytogenetic Map	18	D1	NCBI
cM Map	18	28.22	NCBI

Lox
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	48,162,889 - 48,175,640 (-)	NCBI		GRCr8
mRatBN7.2	18	45,964,544 - 45,977,431 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	45,967,343 - 46,041,477 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	48,017,910 - 48,092,296 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	48,730,134 - 48,804,144 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	46,523,816 - 46,598,201 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	47,500,320 - 47,577,819 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	47,500,330 - 47,577,819 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	46,713,533 - 46,791,367 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	47,896,674 - 47,970,829 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	47,931,499 - 47,944,296 (-)	NCBI
Celera	18	44,155,712 - 44,229,997 (-)	NCBI		Celera
Cytogenetic Map	18	q11	NCBI

Lox
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955521	185,792 - 193,926 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955521	178,290 - 193,926 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	117,339,359 - 117,353,228 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	115,491,718 - 115,506,516 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	117,450,833 - 117,464,957 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	123,233,359 - 123,248,658 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	123,234,662 - 123,248,717 (-)	Ensembl	panpan1.1		panPan2

LOX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	12,023,645 - 12,040,015 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	12,027,250 - 12,039,819 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	10,807,698 - 10,821,728 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	12,730,282 - 12,744,862 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	12,732,124 - 12,744,691 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	11,471,714 - 11,486,299 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	11,289,217 - 11,303,248 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	11,920,314 - 11,934,905 (-)	NCBI		UU_Cfam_GSD_1.0

Lox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	134,444,800 - 134,452,726 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936575	2,524,342 - 2,533,559 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936575	2,526,067 - 2,533,996 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	125,591,789 - 125,607,594 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	125,595,115 - 125,607,026 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	130,888,135 - 130,900,048 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	25,158,458 - 25,172,763 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	25,157,269 - 25,172,757 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	53,042,867 - 53,057,523 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004854490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021266284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021266285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01053442	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSHGLT00000009788 ⟹ ENSHGLP00000009680

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624774	20,116,970 - 20,134,355 (+)	Ensembl

RefSeq Acc Id:

XM_004854490 ⟹ XP_004854547

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624774	20,116,625 - 20,130,849 (+)	NCBI

RefSeq Acc Id:

XM_021266284 ⟹ XP_021121943

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624774	20,116,627 - 20,137,767 (+)	NCBI

RefSeq Acc Id:

XM_021266285 ⟹ XP_021121944

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624774	20,116,625 - 20,137,767 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_004854547	(Get FASTA)	NCBI Sequence Viewer
	XP_021121943	(Get FASTA)	NCBI Sequence Viewer
	XP_021121944	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000009680

RefSeq Acc Id:	XP_021121944 ⟸ XM_021266285
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_004854547 ⟸ XM_004854490
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_021121943 ⟸ XM_021266284
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSHGLP00000009680 ⟸ ENSHGLT00000009788

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000006947	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000009788	ENTREZGENE
NCBI Gene	Lox	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM

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