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Gene: LOX (lysyl oxidase) Homo sapiens
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Symbol: LOX
Name: lysyl oxidase
Description: Exhibits collagen binding activity and protein-lysine 6-oxidase activity. Involved in peptidyl-lysine oxidation. Localizes to extracellular space. Implicated in Ehlers-Danlos syndrome; Menkes disease; hypertension; and thoracic aortic aneurysm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAT10; MGC105112; protein-lysine 6-oxidase
Orthologs:
Mus musculus (house mouse) : Lox (lysyl oxidase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lox (lysyl oxidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lox (lysyl oxidase)
Pan paniscus (bonobo/pygmy chimpanzee) : LOX (lysyl oxidase)
Canis lupus familiaris (dog) : LOX (lysyl oxidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lox (lysyl oxidase)
Sus scrofa (pig) : LOX (lysyl oxidase)
Chlorocebus sabaeus (African green monkey) : LOX (lysyl oxidase)
Heterocephalus glaber (naked mole-rat) : Lox (lysyl oxidase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl5122,063,195 - 122,078,360 (-)EnsemblGRCh38hg38GRCh38
GRCh385122,063,195 - 122,078,259 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375121,398,890 - 121,414,206 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365121,429,918 - 121,441,853 (-)NCBINCBI36hg18NCBI36
Build 345121,429,917 - 121,441,853NCBI
Celera5117,353,346 - 117,368,512 (-)NCBI
Cytogenetic Map5q23.1NCBI
HuRef5116,590,466 - 116,605,632 (-)NCBIHuRef
CHM1_15120,831,494 - 120,846,800 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on LOX
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736846
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.