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Gene: Isoc1 (isochorismatase domain containing 1) Rattus norvegicus

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Symbol:

Isoc1

Name:

isochorismatase domain containing 1

RGD ID:

1307632

Description:

Located in peroxisome. Orthologous to human ISOC1 (isochorismatase domain containing 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Down-regulated in nephrectomized rat kidney #1; down-regulated in nephrectomized rat kidney protein 1; DR-NR#1; DR-NR1; isochorismatase domain-containing protein 1; LOC103694869; LOC364879; RGD1307632; similar to tumor-related protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ISOC1 (isochorismatase domain containing 1)	HGNC	HomoloGene, NCBI, Panther
Mus musculus (house mouse):	Isoc1 (isochorismatase domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Isoc1 (isochorismatase domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ISOC1 (isochorismatase domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ISOC1 (isochorismatase domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Isoc1 (isochorismatase domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ISOC1 (isochorismatase domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ISOC1 (isochorismatase domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Isoc1 (isochorismatase domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ISOC1 (isochorismatase domain containing 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Isoc1 (isochorismatase domain containing 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	isoc1 (isochorismatase domain containing 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11333	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3663	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	isoc1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	54,356,757 - 54,377,170 (+)	NCBI		GRCr8
mRatBN7.2	18	52,158,790 - 52,179,206 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	52,158,790 - 52,178,703 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	54,182,706 - 54,203,140 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	54,897,271 - 54,917,718 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	52,709,462 - 52,729,877 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	53,727,203 - 53,747,612 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	53,727,209 - 53,745,200 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	53,008,359 - 53,028,768 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	54,471,690 - 54,492,099 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	54,535,657 - 54,556,067 (+)	NCBI
Celera	18	50,269,258 - 50,289,538 (+)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial adenomatous polyposis 1 (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP,ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

doxorubicin (ISO)

ethanol (ISO)

fipronil (EXP)

folic acid (ISO)

genistein (EXP)

gentamycin (EXP)

glafenine (EXP)

isotretinoin (ISO)

ivermectin (ISO)

L-methionine (ISO)

methimazole (EXP)

methoxychlor (EXP)

nefazodone (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

progesterone (ISO)

propiconazole (EXP,ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (EXP)

trichloroethene (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IBA)

peroxisome (IDA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.	Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15200410	PMID:23376485

Genomics

Comparative Map Data

Isoc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	54,356,757 - 54,377,170 (+)	NCBI		GRCr8
mRatBN7.2	18	52,158,790 - 52,179,206 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	52,158,790 - 52,178,703 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	54,182,706 - 54,203,140 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	54,897,271 - 54,917,718 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	52,709,462 - 52,729,877 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	53,727,203 - 53,747,612 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	53,727,209 - 53,745,200 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	53,008,359 - 53,028,768 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	54,471,690 - 54,492,099 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	54,535,657 - 54,556,067 (+)	NCBI
Celera	18	50,269,258 - 50,289,538 (+)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI

ISOC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	129,094,749 - 129,114,028 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	129,094,749 - 129,114,028 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	128,430,442 - 128,449,721 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	128,458,341 - 128,477,620 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	128,458,338 - 128,477,730	NCBI
Celera	5	124,561,590 - 124,580,869 (+)	NCBI		Celera
Cytogenetic Map	5	q23.3	NCBI
HuRef	5	123,621,725 - 123,641,469 (+)	NCBI		HuRef
CHM1_1	5	127,863,093 - 127,882,374 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	129,597,478 - 129,632,738 (+)	NCBI		T2T-CHM13v2.0

Isoc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	58,792,554 - 58,812,642 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	58,792,538 - 58,813,440 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	58,659,482 - 58,679,570 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	58,659,466 - 58,680,368 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	58,819,136 - 58,839,224 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	58,784,851 - 58,804,939 (+)	NCBI		MGSCv36	mm8
Celera	18	59,962,819 - 59,982,937 (+)	NCBI		Celera
Cytogenetic Map	18	D3	NCBI
cM Map	18	33.71	NCBI

Isoc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	2,091,857 - 2,110,374 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	2,091,857 - 2,110,313 (+)	NCBI	ChiLan1.0	ChiLan1.0

ISOC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	124,402,367 - 124,421,758 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	122,541,929 - 122,561,338 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	124,508,166 - 124,527,560 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	130,270,416 - 130,289,582 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	130,270,123 - 130,289,570 (+)	Ensembl	panpan1.1		panPan2

ISOC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	18,011,330 - 18,029,330 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	18,012,333 - 18,028,489 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	16,807,451 - 16,825,469 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	18,760,942 - 18,778,889 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	18,760,942 - 18,778,934 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	17,480,530 - 17,498,517 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	17,319,280 - 17,337,261 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	17,931,905 - 17,950,287 (+)	NCBI		UU_Cfam_GSD_1.0

Isoc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	140,681,736 - 140,704,138 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936504	2,255,177 - 2,278,113 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936504	2,255,702 - 2,276,356 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ISOC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	131,857,168 - 131,877,631 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	131,857,126 - 131,877,873 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	137,198,549 - 137,219,688 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ISOC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	32,039,732 - 32,059,821 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	32,039,811 - 32,059,848 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	45,976,316 - 45,996,444 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Isoc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624774	12,220,031 - 12,244,746 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Isoc1
159 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	199
Count of miRNA genes:	149
Interacting mature miRNAs:	169
Transcripts:	ENSRNOT00000026706
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	59796643	Rat
1331736	Bp227	Blood pressure QTL 227	2.791		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	46718763	59796643	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	43345022	83828827	Rat
1331727	Bp237	Blood pressure QTL 237	3.053		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	61698465	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	46640675	83828827	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	46640675	83828827	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	29792965	74792965	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	59796643	Rat
61360	Eaey	Experimental allergic encephalomyelitis QTL y	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	18	46988939	60377753	Rat
2300177	Bmd65	Bone mineral density QTL 65	19.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31359408	83218561	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	38192455	83192455	Rat
2293658	Bmd23	Bone mineral density QTL 23	7.3	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	18	51464733	63636873	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	29792965	74792965	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	29792965	74792965	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	59796643	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	48520044	83828827	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31271681	60377755	Rat
1331806	Bp229	Blood pressure QTL 229	4.36484		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	46718763	57867167	Rat
1331780	Bp238	Blood pressure QTL 238	3.269		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	46718763	59796643	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	51464733	83218561	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31359408	59796643	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	35870723	80870723	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	46718935	59796478	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
6903347	Bp350	Blood pressure QTL 350	4.4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359530	59796478	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	46640675	83828827	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	46718935	59796478	Rat
2300157	Bmd66	Bone mineral density QTL 66	13.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
738005	Anxrr11	Anxiety related response QTL 11	3.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	18	30039813	75039813	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	46718935	59796478	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31393320	77209694	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
2293704	Bss35	Bone structure and strength QTL 35	4.59	0.0002	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	18	28964853	73964853	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	29792965	74792965	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	48520044	83828827	Rat
1598826	Anxrr20	Anxiety related response QTL 20	3.04		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	18	41432971	83828827	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31359408	70263868	Rat
7411719	Strs5	Sensitivity to stroke QTL 5	9.4		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	18	49999958	65845095	Rat

Markers in Region

RH132613

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	52,177,519 - 52,177,701 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	53,745,926 - 53,746,107	NCBI	Rnor6.0
Rnor_5.0	18	53,009,864 - 53,010,045	UniSTS	Rnor5.0
RGSC_v3.4	18	54,490,413 - 54,490,594	UniSTS	RGSC3.4
Celera	18	50,287,852 - 50,288,033	UniSTS
RH 3.4 Map	18	505.8	UniSTS
Cytogenetic Map	18	q12.1	UniSTS

RH134325

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	52,178,697 - 52,178,895 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	53,747,104 - 53,747,301	NCBI	Rnor6.0
Rnor_5.0	18	53,008,670 - 53,008,867	UniSTS	Rnor5.0
RGSC_v3.4	18	54,491,591 - 54,491,788	UniSTS	RGSC3.4
Celera	18	50,289,030 - 50,289,227	UniSTS
RH 3.4 Map	18	508.5	UniSTS
Cytogenetic Map	18	q12.1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB108669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC109037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC111220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026706 ⟹ ENSRNOP00000026706

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	52,158,790 - 52,178,703 (+)	Ensembl
Rnor_6.0 Ensembl	18	53,727,209 - 53,745,200 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099120 ⟹ ENSRNOP00000086734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	52,158,796 - 52,178,703 (+)	Ensembl

RefSeq Acc Id:

NM_001014242 ⟹ NP_001014264

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	54,356,757 - 54,377,170 (+)	NCBI
mRatBN7.2	18	52,158,790 - 52,179,206 (+)	NCBI
Rnor_6.0	18	53,727,203 - 53,747,612 (+)	NCBI
Rnor_5.0	18	53,008,359 - 53,028,768 (-)	NCBI
RGSC_v3.4	18	54,471,690 - 54,492,099 (+)	RGD
Celera	18	50,269,258 - 50,289,538 (+)	NCBI

Sequence:

show sequence

GGGAACATGGCGGCGGCGGAGCCCTCGGTGGCCGCGCTGGCGGGCGGCGGTGTGGGCGCGGGGG
CGCCGTCGGGCGGCGTGCCGGTGCTCTTCTGCTTCTCGGTGTTCGCGCGGCCCGCGTCGGTGCC
CCACGGCGCGGGCTACGACGTGCTCATCCAGAAGTTCCTGAGCCTGTACGGCGACCAGGTCGAC
ATGCACCGCAAATTCGTGGTGCAGCTCTTCGCCGAGGAGTGGGGCCAGTACGTGGACCTGCCCA
AGGGCTTCGCGGTGAGCGAGCGCTGCAAGCTGCGCCTGGTGCCGCTGCAGATCCAGCTCACGAC
CCTGGGGAATCTCACGCCTCCCAGCACTGTGTTCTTCTGTTGTGACATGCAGGAAAGGTTCCGT
CCAGCCATCAAGTATTTTGGAGACATCATTAGTGTGGGACAGAGACTGTTGCAAGGAGCTCGGA
TACTAGGGATCCCAGTTATCATAACAGAACAGTACCCGAAAGGACTCGGCAGCACCGTTCAGGA
AATTGACTTAACAGGTGTAAAACTGGTTCTTCCGAAGACCAAGTTTTCTATGGTGTTACCCGAA
GTCGAAGCTGCCTTGGCTGAGATTCCTGGCGTCCGGAGCGTTGTGCTGTTTGGAGTAGAAACAC
ACGTCTGTATCCAGCAGACTGCCCTAGAGCTGGTGGGCCGAGGTATTGAGGTCCACATCGTTGC
TGACGCCACATCCTCGAGAAGCATGATGGACAGGATGTTCGCTCTTGAGCGTCTTGCTCGAACT
GGGATCATCGTGACCACTAGTGAGGCTGTCCCCCTACAGCTGGTGGCAGACAAAGACCACCCGA
AGTTCAAGGAAATCCAGAACCTAATTAAGGCCAGTGCCCCGGAGTCTGGTCTGCTTTCCAAAGT
GTAGGAGTCTCGGAGGATGAGGATCCTCCTTCCCCCCAGGCGACGGGACTGCAAGCCAGACAAG
CCGTTGTCTCTTAGAACTAATATGTTAAGTCAACAACAGTTCCTTCTTTGCAGTTCTTAGTAAC
ACTGAACTGGCTAGACCATTGGGTGTTGTGTACAAGTGTTTAGTTCCAATGTCGAGGCTTCAGG
TGCTGCTTCTCTTCTTCTTAACGAGCTTTTAGTTATTAAGACAAATTACCATGGAGGTGCCTGT
CTCGTCTATACTGCATACTCTGACCATATCTTTCCCGAAGTGCACCCTCTGGTGAAGTTTTCTT
CAACTGTGCACTTTAAAGGGGAAAAAAACAAAAAACCCACCTACCACAGTGATTTGACTTTTCT
ATTGTTGTGAAACATCCGTTGTAATGTCAGTGTGTACCCAGTGGTTTCGCTTCCCAGGCTGACT
GGCCAATGATCCTGGATTGACAAGCAGGACTCTGGATCCAGTATCTGCTCCTCTCACAGTGTTG
AGGTTACTGACTGAGTGACATGCACTGACTTAACCACAGCAAATTATCTTAAATATTGTGTATC
TGTCTTGATTGCCCTAATTTCCTTATTCCCGTTAGCATCTTTGTGGATTTTCTTCCTCTGGCTA
ACAGTCTACGTTAACGTTTTTTTCTTCCACTGAATGTTCTACTTCCTCCTTGGTTATTTCAGAC
TTGTAAACAGGTGGGAGTGGTTTGCAGTGTCTGGGTAATGGACAGAGGCACACTGTAACATAAT
GCCTTTACAGTCTTTTTAAGTGCATCTTTTACTGTACACCGGAGTTGGTAGAGAAAGAAACTCT
AGGTAAAATGGAGTTTAAAATGCCCATATTCCCCTTCAAACATTGTTATGGCTGACATCATCAA
CAGGACTCTTAGCGGTAATACTGTGGTCATTGTTAATCCGTCAAGAAACTTACTTTCATTTCAT
ACTGATTAGTGCTTAAAAAACATTTTAATGTATGTTGTGATCAGTGGAACATCACTCTCTTTGT
ATAAAATTAAAGAAAATGTATTATGTAAGTGAAATTGTTTTGTTTCCCATGACTCCATGAATAT
TAGTCAGTGAATTGTAATAAGTTTTCAAAGGCAACAGATTTGATATTTATAATCTTATAACTTA
TCAGAACTTACAAAGGAGCAGAATCCGGTGCAGGCCCAGACCGATAGAGTTCCCGCAGAGTTTT
CCTGTTAGCACTATCGAAATGTGTTTTGTTGTTTGAGCCTTGGTAAGGCACCACAGCATAGACT
TCTTGATGTGCTCAGTGGTTCTCAACCTCTGGGCAGTGTCCACAGGGGTTGCAGATCAGATATC
TTTCCTATCAGGTATTTACGTTAAGATTCATGACAGTAGCAAAGTTACGGTTATGAAGTAGCGA
TGAAAATAATTGTATGGTTGGGTTGGGTCACCACCACATGAATAACTGTATTAAAGGGTTGCAG
CATTAGGAAGGTTGAGAGCTCCTGCTTAGAAGATGAGTCTAGAAAGAAGCATCATATAGATATC
CACGTTTTAAGAAAATTTCTAATAAGTGTAATCTAGTGTTTTTCAAATGTTTATTATCTGTAGT
GCTTGTTAAAATACTAGCCCCGCCCCTCTTCAGCATTGCCCCTGGCAAAGGAAGGATTTATGGT
AGGAAGGTTTCCCTCTCTTGTACCCATGCCTCTTCCACAGCTGAAGCCAGCTCTGGGACGCTGG
ATTAGTGTCCTGTAGCTGCACTAACAAAACGCCATAGACGCCATGTCTCAAGACAACAGACTGT
TTCATCTCAATTCTGTAGAGTTCTAGGGCTTACTGTGCTGACAGCAAAGCTCGTGTTGCTAAGG
CTGCGATGTATTCTGGGGCCCGTATAAGGGATGACTTCTATCCTGCCGTCCCATGATGCTAGAG
TCTGCTCGTGTGGGTTTTTATGTTTGGTTTGTTTTGGTTTATTTGATTGTTTTGTCCCTTATTT
CATCTTCTCAGGCAACAAGTGTGGGTCCTTAGGTCCCTTCTGACTCCCTTCTTCTGCCTGGCCT
AAGCTCTCATGGGATTTAAGGTTCCTAATTAGCATCCTTATTCCACCTCCAGCCTTAACACCGT
TAGGCCATGTATCTCTTTCCCAGGATCTAGGGATTAGGATGTGGGTGTCTTCACACAGTCATCA
GCTAGTAAGTGAATTGAATTAAATTGTATCAGGTCCAGGAATGTAAATACATGGAAGCTCAGAA
CAATTGTGAGCTCTGCCTTCTCTTTTCTGTTTTGTTAATCATGCCAAGAAGGTGACAAGGCTTT
TACTTTATGATTATAGGAAAACTGGTTGATTGTAATACTTTGAAGTGGAAGTGTCTGTGACTTT
ATAGGATAATGAAATTCTTTTCATTGACATAAATAAAGAACTTCAGAATGT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001014264	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAD23894	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026706.4
	ENSRNOP00000086734.1
GenBank Protein	Q6I7R3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001014264 ⟸ NM_001014242

- UniProtKB:

Q6I7R3 (UniProtKB/Swiss-Prot), F2Z3T7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAAEPSVAALAGGGVGAGAPSGGVPVLFCFSVFARPASVPHGAGYDVLIQKFLSLYGDQVDMH
RKFVVQLFAEEWGQYVDLPKGFAVSERCKLRLVPLQIQLTTLGNLTPPSTVFFCCDMQERFRPA
IKYFGDIISVGQRLLQGARILGIPVIITEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVE
AALAEIPGVRSVVLFGVETHVCIQQTALELVGRGIEVHIVADATSSRSMMDRMFALERLARTGI
IVTTSEAVPLQLVADKDHPKFKEIQNLIKASAPESGLLSKV

hide sequence

Ensembl Acc Id:

ENSRNOP00000026706 ⟸ ENSRNOT00000026706

Ensembl Acc Id:

ENSRNOP00000086734 ⟸ ENSRNOT00000099120

Protein Domains

Isochorismatase-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F2Z3T7-F1-model_v2	AlphaFold	F2Z3T7	1-297	view protein structure
AF-Q6I7R3-F1-model_v2	AlphaFold	Q6I7R3	1-297	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700798

Promoter ID:

EPDNEW_R11321

Type:

multiple initiation site

Name:

Isoc1_1

Description:

isochorismatase domain containing 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	53,727,196 - 53,727,256	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307632	AgrOrtholog
Ensembl Genes	ENSRNOG00000019711	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026706.6	UniProtKB/TrEMBL
	ENSRNOT00000099120.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.850	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Isochorismatase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Isochorismatase-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Isochorismatase_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:364879	UniProtKB/Swiss-Prot
NCBI Gene	364879	ENTREZGENE
PANTHER	HYDROLASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Isochorismatase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Isoc1	PhenoGen
RatGTEx	ENSRNOG00000019711	RatGTEx
Superfamily-SCOP	SSF52499	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6GF98_RAT	UniProtKB/TrEMBL
	F2Z3T7	ENTREZGENE, UniProtKB/TrEMBL
	ISOC1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Isoc1	isochorismatase domain containing 1	LOC103694869	isochorismatase domain-containing protein 1	Data merged from RGD:9465707	737654	PROVISIONAL
2014-08-25	LOC103694869	isochorismatase domain-containing protein 1			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-03-30	Isoc1	isochorismatase domain containing 1	RGD1307632	similar to tumor-related protein	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1307632	similar to tumor-related protein	RGD1307632_predicted	similar to tumor-related protein (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1307632_predicted	similar to tumor-related protein (predicted)	LOC364879_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC364879_predicted	similar to tumor-related protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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