Gene: Ctnna1 (catenin alpha 1) Rattus norvegicus
Analyze
Symbol:
Ctnna1
Name:
catenin alpha 1
Description:
Predicted to have several functions, including beta-catenin binding activity; cytoskeletal protein binding activity; and gamma-catenin binding activity. Involved in several processes, including axon regeneration; gap junction assembly; and gonad development. Localizes to the acrosomal vesicle; cell-cell adherens junction; and plasma membrane. Biomarker of esophageal cancer and lung carcinoma. Human ortholog(s) of this gene implicated in patterned macular dystrophy 2. Orthologous to human CTNNA1 (catenin alpha 1); PARTICIPATES IN E-cadherin signaling pathway; N-cadherin signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha-1; catenin, alpha 1; Catna1; MGC93767
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CTNNA1 (catenin alpha 1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Ctnna1 (catenin (cadherin associated protein), alpha 1) HGNC
Treefam, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ctnna1 (catenin alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CTNNA1 (catenin alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CTNNA1 (catenin alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ctnna1 (catenin alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CTNNA1 (catenin alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
CTNNA1 (catenin alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ctnna1 (catenin alpha 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
CTNNA2 (catenin alpha 2) HGNC
EggNOG, OrthoMCL
Homo sapiens (human):
CTNNA3 (catenin alpha 3) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
CTNNA1 (catenin alpha 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Ctnna1 (catenin (cadherin associated protein), alpha 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
ctnna1 (catenin (cadherin-associated protein), alpha 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
alpha-Cat
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
hmp-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 18 27,923,229 - 28,055,972 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 18 27,923,572 - 28,055,960 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 18 27,633,009 - 27,766,069 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 18 27,629,915 - 27,769,360 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 18 27,656,560 - 27,796,004 (+) NCBI Celera 18 26,463,736 - 26,596,152 (+) NCBI Celera Cytogenetic Map 18 p11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
fundus dystrophy ISO RGD:1348842 8554872 ClinVar Annotator: match by term: Retinal dystrophy ClinVar PMID:28041643 , PMID:28492532 Hereditary Neoplastic Syndromes ISO RGD:1348842 8554872 ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary ClinVar Hereditary Neoplastic Syndromes ISO RGD:1348842 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:26845104 , PMID:28492532 Hereditary Neoplastic Syndromes ISO RGD:1348842 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:28492532 Hereditary Neoplastic Syndromes ISO RGD:1348842 8554872 ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary ClinVar PMID:26845104 Neurodevelopmental Disorders ISO RGD:1348842 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 patterned macular dystrophy 2 ISO RGD:1348842 8554872 ClinVar Annotator: match by term: Macular dystrophy, patterned, 2 ClinVar PMID:26691986 patterned macular dystrophy 2 ISO RGD:1348842 8554872 ClinVar Annotator: match by term: Macular dystrophy, patterned, 2 ClinVar PMID:26691986 , PMID:5442145
Imported Annotations - CTD
acute myeloid leukemia ISO RGD:1348842 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17330099 gastrointestinal stromal tumor ISO RGD:1348842 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27793025 myelodysplastic syndrome ISO RGD:1348842 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17330099 patterned macular dystrophy ISO RGD:1348842 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26691986 Imported Annotations - OMIM
patterned macular dystrophy 2 ISO RGD:1348842 7240710 OMIM
1,3-dinitrobenzene increases expression EXP 6480464 3-dinitrobenzene results in increased expression of CTNNA1 mRNA CTD PMID:21983209 , PMID:24140754 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO RGD:1553700 6480464 Dihydrotestosterone results in decreased expression of CTNNA1 mRNA CTD PMID:17023530 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1553700 6480464 Tetrachlorodibenzodioxin affects the expression of CTNNA1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1348842 6480464 Tetrachlorodibenzodioxin results in increased expression of CTNNA1 mRNA CTD PMID:20106945 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1348842 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTNNA1 mRNA] CTD PMID:23625689 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1553700 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of CTNNA1 mRNA CTD PMID:20188158 3-methylcholanthrene multiple interactions ISO RGD:1348842 6480464 Methylcholanthrene promotes the reaction [AHR protein binds to CTNNA1 promoter] CTD PMID:20348232 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1348842 6480464 [Decitabine co-treated with Vorinostat] affects the expression of CTNNA1 mRNA CTD PMID:17330099 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of CTNNA1 mRNA CTD PMID:19483382 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of CTNNA1 mRNA CTD PMID:19483382 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of CTNNA1 mRNA CTD PMID:28959563 all-trans-retinoic acid decreases expression ISO RGD:1348842 6480464 Tretinoin results in decreased expression of CTNNA1 mRNA CTD PMID:12875902 all-trans-retinoic acid increases expression ISO RGD:1553700 6480464 Tretinoin results in increased expression of CTNNA1 mRNA CTD PMID:16236135 amiodarone affects expression EXP 6480464 Amiodarone affects the expression of CTNNA1 mRNA CTD PMID:19483382 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of CTNNA1 protein CTD PMID:16483693 arsane increases expression ISO RGD:1553700 6480464 Arsenic results in increased expression of CTNNA1 protein CTD PMID:23942117 arsenic atom increases expression ISO RGD:1553700 6480464 Arsenic results in increased expression of CTNNA1 protein CTD PMID:23942117 arsenous acid decreases expression ISO RGD:1348842 6480464 Arsenic Trioxide results in decreased expression of CTNNA1 mRNA CTD PMID:15761015 atrazine multiple interactions ISO RGD:1348842 6480464 [Atrazine co-treated with Arsenates] results in increased expression of CTNNA1 mRNA CTD PMID:18585445 benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of CTNNA1 mRNA CTD PMID:19483382 benzo[a]pyrene increases expression ISO RGD:1348842 6480464 Benzo(a)pyrene metabolite results in increased expression of CTNNA1 mRNA CTD PMID:26314263 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1348842 6480464 7 more ... CTD PMID:20018196 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:1348842 6480464 Mustard Gas results in increased phosphorylation of CTNNA1 protein CTD PMID:19845377 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of CTNNA1 mRNA, Diethylhexyl Phthalate results in increased expression of CTNNA1 protein CTD PMID:16678996 , PMID:20920545 bisphenol A increases expression ISO RGD:1553700 6480464 bisphenol A results in increased expression of CTNNA1 mRNA CTD PMID:26063408 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CTNNA1 mRNA CTD PMID:30816183 bisphenol A affects expression ISO RGD:1348842 6480464 bisphenol A affects the expression of CTNNA1 mRNA CTD PMID:30903817 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CTNNA1 mRNA CTD PMID:25181051 cadmium dichloride multiple interactions EXP 6480464 Cadmium Chloride inhibits the reaction [CTNNB1 protein binds to CDH1 protein binds to CTNNA1 protein] CTD PMID:20459685 cadmium dichloride decreases expression ISO RGD:1348842 6480464 Cadmium Chloride results in decreased expression of CTNNA1 mRNA, Cadmium Chloride results in decreased expression of CTNNA1 protein CTD PMID:24527689 , PMID:27510461 cadmium dichloride affects localization EXP 6480464 Cadmium Chloride affects the localization of CTNNA1 protein CTD PMID:20459685 calcitriol decreases expression ISO RGD:1348842 6480464 Calcitriol results in decreased expression of CTNNA1 mRNA CTD PMID:12875902 cisplatin affects response to substance EXP 6480464 CTNNA1 gene affects the susceptibility to Cisplatin, CTNNA1 protein affects the susceptibility to Cisplatin CTD PMID:24973089 , PMID:27989596 cisplatin multiple interactions EXP 6480464 [CTNNA1 protein affects the susceptibility to Cisplatin] which results in decreased expression of BCL2 protein more ... CTD PMID:24973089 , PMID:27989596 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of CTNNA1 mRNA, Cisplatin results in decreased expression of CTNNA1 protein CTD PMID:22023808 , PMID:24973089 clofibrate affects expression EXP 6480464 Clofibrate affects the expression of CTNNA1 mRNA CTD PMID:19483382 cobalt dichloride increases expression ISO RGD:1348842 6480464 cobaltous chloride results in increased expression of CTNNA1 mRNA CTD PMID:26314263 copper(II) sulfate increases expression ISO RGD:1348842 6480464 Copper Sulfate results in increased expression of CTNNA1 mRNA CTD PMID:19549813 corticosterone multiple interactions ISO RGD:1553700 6480464 [Corticosterone results in increased phosphorylation of NDRG1 protein] which results in increased expression of and results in increased localization of CTNNA1 protein CTD PMID:21655274 cyclosporin A increases expression ISO RGD:1348842 6480464 Cyclosporine results in increased expression of CTNNA1 mRNA CTD PMID:25562108 diarsenic trioxide decreases expression ISO RGD:1348842 6480464 Arsenic Trioxide results in decreased expression of CTNNA1 mRNA CTD PMID:15761015 dibutyl phthalate increases expression ISO RGD:1553700 6480464 Dibutyl Phthalate results in increased expression of CTNNA1 mRNA CTD PMID:21266533 doxorubicin increases expression ISO RGD:1553700 6480464 Doxorubicin results in increased expression of CTNNA1 mRNA CTD PMID:25896364 doxorubicin increases expression ISO RGD:1348842 6480464 Doxorubicin results in increased expression of CTNNA1 mRNA CTD PMID:29803840 elemental selenium increases expression ISO RGD:1348842 6480464 Selenium results in increased expression of CTNNA1 mRNA CTD PMID:19244175 ethanol increases expression ISO RGD:1553700 6480464 Ethanol results in increased expression of CTNNA1 mRNA CTD PMID:30319688 fenamidone increases expression ISO RGD:1553700 6480464 fenamidone results in increased expression of CTNNA1 mRNA CTD PMID:27029645 fumonisin B1 increases expression ISO RGD:1553700 6480464 fumonisin B1 results in increased expression of CTNNA1 mRNA CTD PMID:16221962 geldanamycin increases expression ISO RGD:1348842 6480464 geldanamycin results in increased expression of CTNNA1 mRNA CTD PMID:26705709 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of CTNNA1 mRNA CTD PMID:24136188 hydrogen peroxide decreases expression ISO RGD:1348842 6480464 Hydrogen Peroxide results in decreased expression of CTNNA1 mRNA CTD PMID:12419474 hydrogen peroxide decreases secretion ISO RGD:1553700 6480464 Hydrogen Peroxide results in decreased secretion of CTNNA1 mRNA CTD PMID:21179422 jaspamide multiple interactions EXP 6480464 jasplakinolide affects the reaction [CTNNA1 protein affects the susceptibility to Cisplatin] CTD PMID:27989596 L-ethionine affects expression EXP 6480464 Ethionine affects the expression of CTNNA1 mRNA CTD PMID:19483382 latrunculin A multiple interactions EXP 6480464 latrunculin A affects the reaction [FSCN1 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]], latrunculin A affects the reaction [FSCN2 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]] CTD PMID:27989596 lead nitrate multiple interactions ISO RGD:1553700 6480464 lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA], lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA] CTD PMID:11891201 manganese atom decreases expression ISO RGD:1348842 6480464 Manganese results in decreased expression of CTNNA1 mRNA CTD PMID:17175027 manganese(0) decreases expression ISO RGD:1348842 6480464 Manganese results in decreased expression of CTNNA1 mRNA CTD PMID:17175027 manganese(II) chloride decreases expression ISO RGD:1348842 6480464 manganese chloride results in decreased expression of CTNNA1 mRNA CTD PMID:17175027 methotrexate increases expression ISO RGD:1348842 6480464 Methotrexate results in increased expression of CTNNA1 mRNA CTD PMID:21678067 methotrexate decreases expression ISO RGD:1348842 6480464 Methotrexate results in decreased expression of CTNNA1 mRNA CTD PMID:24449571 methylazoxymethanol increases expression ISO RGD:1553700 6480464 methylazoxymethanol results in increased expression of CTNNA1 mRNA CTD PMID:17107856 methylmercury(1+) increases expression ISO RGD:1348842 6480464 methylmercury II results in increased expression of CTNNA1 mRNA CTD PMID:26314263 mitomycin C affects response to substance ISO RGD:1348842 6480464 CTNNA1 protein affects the susceptibility to Mitomycin CTD PMID:16217747 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:1553700 6480464 Ethylnitrosourea results in increased mutagenesis of CTNNA1 intron CTD PMID:27776689 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of CTNNA1 mRNA CTD PMID:22124623 ochratoxin A increases expression ISO RGD:1348842 6480464 ochratoxin A metabolite results in increased expression of CTNNA1 mRNA, ochratoxin A results in increased expression of CTNNA1 mRNA CTD PMID:22124623 , PMID:26314263 omeprazole affects expression EXP 6480464 Omeprazole affects the expression of CTNNA1 mRNA CTD PMID:19483382 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CTNNA1 mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:1553700 6480464 Acetaminophen affects the expression of CTNNA1 mRNA CTD PMID:17562736 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of CTNNA1 mRNA CTD PMID:12082028 phenobarbital affects expression ISO RGD:1553700 6480464 Phenobarbital affects the expression of CTNNA1 mRNA CTD PMID:23091169 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of CTNNA1 mRNA CTD PMID:19483382 pirinixic acid increases expression ISO RGD:1553700 6480464 pirinixic acid results in increased expression of CTNNA1 mRNA CTD PMID:16221962 quercetin increases expression ISO RGD:1348842 6480464 Quercetin results in increased expression of CTNNA1 mRNA CTD PMID:15309432 SB 431542 increases expression ISO RGD:1348842 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of CTNNA1 protein CTD PMID:25670856 selenium atom increases expression ISO RGD:1348842 6480464 Selenium results in increased expression of CTNNA1 mRNA CTD PMID:19244175 sodium dichromate decreases expression ISO RGD:1348842 6480464 sodium bichromate results in decreased expression of CTNNA1 mRNA CTD PMID:12760830 , PMID:17685462 sodium fluoride multiple interactions ISO RGD:1553700 6480464 [Sodium Fluoride co-treated with Sulfur Dioxide] results in decreased expression of CTNNA1 protein CTD PMID:27237588 sodium fluoride decreases expression ISO RGD:1553700 6480464 Sodium Fluoride results in decreased expression of CTNNA1 mRNA, Sodium Fluoride results in decreased expression of CTNNA1 protein CTD PMID:27237588 Soman increases expression EXP 6480464 Soman results in increased expression of CTNNA1 mRNA CTD PMID:19281266 sulfur dioxide decreases expression ISO RGD:1553700 6480464 Sulfur Dioxide results in decreased expression of CTNNA1 protein CTD PMID:27237588 sulfur dioxide multiple interactions ISO RGD:1553700 6480464 [Sodium Fluoride co-treated with Sulfur Dioxide] results in decreased expression of CTNNA1 protein CTD PMID:27237588 sunitinib increases expression ISO RGD:1348842 6480464 Sunitinib results in increased expression of CTNNA1 mRNA CTD PMID:31533062 tert-butyl hydroperoxide decreases expression ISO RGD:1348842 6480464 tert-Butylhydroperoxide results in decreased expression of CTNNA1 mRNA CTD PMID:12419474 thimerosal decreases expression ISO RGD:1348842 6480464 Thimerosal results in decreased expression of CTNNA1 mRNA CTD PMID:27188386 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of CTNNA1 mRNA CTD PMID:19483382 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CTNNA1 mRNA CTD PMID:25729387 tributylstannane increases expression ISO RGD:1348842 6480464 tributyltin results in increased expression of CTNNA1 mRNA CTD PMID:26314263 Tributyltin oxide increases expression ISO RGD:1348842 6480464 bis(tri-n-butyltin)oxide results in increased expression of CTNNA1 mRNA CTD PMID:26314263 trimellitic anhydride decreases expression ISO RGD:1553700 6480464 trimellitic anhydride results in decreased expression of CTNNA1 mRNA CTD PMID:19042947 tungsten decreases expression ISO RGD:1553700 6480464 Tungsten results in decreased expression of CTNNA1 mRNA CTD PMID:30912803 tunicamycin decreases expression ISO RGD:1553700 6480464 Tunicamycin results in decreased expression of CTNNA1 mRNA CTD PMID:17127020 valproic acid affects expression ISO RGD:1348842 6480464 Valproic Acid affects the expression of CTNNA1 mRNA CTD PMID:25979313 vorinostat multiple interactions ISO RGD:1348842 6480464 [decitabine co-treated with vorinostat] affects the expression of CTNNA1 mRNA CTD PMID:17330099
Biological Process aging IEP 2289805 RGD apical junction assembly ISO RGD:1553700 1624291 MGI:MGI:2176173 more ... RGD MGI:MGI:3619284 more ... axon regeneration IEP 632464 RGD cellular protein localization ISO RGD:1553700 1624291 MGI:MGI:2677796 (MGI:MGI:5315030 , PMID:22411810) RGD MGI:MGI:5315030 , PMID:22411810 cellular response to indole-3-methanol ISO RGD:1348842 1624291 (PMID:10868478) RGD PMID:10868478 epithelial cell-cell adhesion ISO RGD:1553700 1624291 MGI:MGI:2677796 (MGI:MGI:5315030 , PMID:22411810) RGD MGI:MGI:5315030 , PMID:22411810 establishment or maintenance of cell polarity ISO RGD:1553700 1624291 MGI:MGI:2176173 more ... RGD MGI:MGI:3619284 , PMID:16543460 gap junction assembly IMP 2289808 RGD male gonad development IEP 2289812 RGD negative regulation of apoptotic process ISO RGD:1553700 1624291 MGI:MGI:2176173 more ... RGD MGI:MGI:3619284 , PMID:16543460 negative regulation of cell motility ISO RGD:1553700 1624291 MGI:MGI:2677796 (MGI:MGI:5315030 , PMID:22411810) RGD MGI:MGI:5315030 , PMID:22411810 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO RGD:1553700 1624291 MGI:MGI:2677796 (MGI:MGI:5315030 , PMID:22411810) RGD MGI:MGI:5315030 , PMID:22411810 negative regulation of integrin-mediated signaling pathway ISO RGD:1553700 1624291 MGI:MGI:2677796 (MGI:MGI:5315030 , PMID:22411810) RGD MGI:MGI:5315030 , PMID:22411810 negative regulation of neuroblast proliferation ISO RGD:1553700 1624291 MGI:MGI:108075 more ... RGD MGI:MGI:3619284 , PMID:16543460 odontogenesis of dentin-containing tooth IEP 2289810 RGD ovarian follicle development IEP 2289809 RGD positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO RGD:1553700 1624291 MGI:MGI:2677796 (MGI:MGI:5315030 , PMID:22411810) RGD MGI:MGI:5315030 , PMID:22411810 positive regulation of smoothened signaling pathway ISO RGD:1553700 1624291 MGI:MGI:108075 (MGI:MGI:3619284 , PMID:16543460) RGD MGI:MGI:3619284 , PMID:16543460 regulation of cell population proliferation ISO RGD:1553700 1624291 MGI:MGI:88039 (MGI:MGI:3763775 , PMID:17989230) RGD MGI:MGI:3763775 , PMID:17989230 response to estrogen IEP 2289809 RGD response to organic cyclic compound IEP 2289802 RGD Cellular Component acrosomal vesicle IDA 2289801 RGD actin cytoskeleton IEA InterPro:IPR000633 1600115 GO_REF:0000002 InterPro GO_REF:0000002 adherens junction IDA 2291902 RGD adherens junction ISO RGD:1553700 1624291 (MGI:MGI:2656687 more ... RGD MGI:MGI:2656687 more ... catenin complex ISO RGD:1348842 1624291 (PMID:28051089), (PMID:7650039) RGD PMID:28051089 , PMID:7650039 cell junction ISO RGD:1348842 1624291 RGD GO_REF:0000052 cell-cell junction IDA 2289803 RGD cell-cell junction ISO RGD:1348842 1624291 (PMID:10460003), (PMID:7650039) RGD PMID:10460003 , PMID:7650039 cytoplasm IDA 2289801 RGD flotillin complex ISO RGD:1553700 1624291 (MGI:MGI:5634880, PMID:24046456) RGD MGI:MGI:5634880 , PMID:24046456 intercalated disc ISO RGD:1553700 1624291 (MGI:MGI:3720394, PMID:17535849) RGD MGI:MGI:3720394 , PMID:17535849 intracellular membrane-bounded organelle ISO RGD:1348842 1624291 RGD GO_REF:0000052 intracellular membrane-bounded organelle IEA UniProtKB:P35221 , ensembl:ENSP000003046691600115 GO_REF:0000107 Ensembl GO_REF:0000107 lamellipodium ISO RGD:1553700 1624291 (MGI:MGI:3028451, PMID:14657280) RGD MGI:MGI:3028451 , PMID:14657280 plasma membrane IDA 2289800 RGD plasma membrane ISO RGD:1553700 1624291 (MGI:MGI:82531, PMID:8853988) RGD MGI:MGI:82531 , PMID:8853988 plasma membrane ISO RGD:1348842 1624291 RGD GO_REF:0000052 zonula adherens ISO RGD:1553700 1624291 (MGI:MGI:1926537, PMID:11025210) RGD MGI:MGI:1926537 , PMID:11025210 Molecular Function actin filament binding ISO RGD:1553700 1624291 (MGI:MGI:2159085, PMID:11795944) RGD MGI:MGI:2159085 , PMID:11795944 beta-catenin binding ISO RGD:1348842 1624291 UniProtKB:P35222 (PMID:7650039), (PMID:7890674) RGD PMID:7650039 , PMID:7890674 cadherin binding ISO RGD:1348842 1624291 UniProtKB:P19022 more ... RGD PMID:12734196 , PMID:7650039 gamma-catenin binding ISO RGD:1348842 1624291 UniProtKB:P14923 (PMID:7650039), (PMID:7890674) RGD PMID:7650039 , PMID:7890674 identical protein binding ISO RGD:1553700 1624291 UniProtKB:P26231 (MGI:MGI:5476862 , PMID:23417122) RGD MGI:MGI:5476862 , PMID:23417122 identical protein binding ISO RGD:1348842 1624291 UniProtKB:P35221 (PMID:23292143) RGD PMID:23292143 protein binding IPI RGD:70487 2289806 RGD protein binding ISO RGD:1553700 1624291 UniProtKB:O35889 more ... RGD MGI:MGI:1355058 more ... protein binding ISO RGD:1348842 1624291 UniProtKB:O60716 more ... RGD PMID:12477722 more ... protein-containing complex binding IPI RGD:69280 , RGD:70487 2291902 heterooligomerization RGD protein-containing complex binding IPI RGD:69280 , RGD:620412 2291902 heterooligomerization RGD structural molecule activity IEA InterPro:IPR000633 1600115 GO_REF:0000002 InterPro GO_REF:0000002 vinculin binding ISO RGD:1348842 1624291 UniProtKB:P18206 (PMID:9700171) RGD PMID:9700171
Gene-Chemical Interaction Annotations
