Slc6a7 (solute carrier family 6 member 7) - Rat Genome Database

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Gene: Slc6a7 (solute carrier family 6 member 7) Rattus norvegicus
Analyze
Symbol: Slc6a7
Name: solute carrier family 6 member 7
RGD ID: 620928
Description: Enables L-proline transmembrane transporter activity and proline:sodium symporter activity. Involved in proline transport and protein catabolic process. Is active in several cellular components, including Schaffer collateral - CA1 synapse; presynaptic membrane; and synaptic vesicle membrane. Orthologous to human SLC6A7 (solute carrier family 6 member 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: L-proline transporter; LOC103690061; proline transporter; Prot; sodium-dependent proline transporter; sodium-dependent proline transporter-like; solute carrier family 6 (neurotransmitter transporter L-proline) member 7; solute carrier family 6 (neurotransmitter transporter), member 7; solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,718,849 - 56,737,702 (-)NCBIGRCr8
mRatBN7.21854,448,464 - 54,467,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,448,464 - 54,467,319 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,536,530 - 56,555,331 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,251,136 - 57,269,935 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,072,309 - 55,091,168 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,305,765 - 56,325,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,305,735 - 56,331,991 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,557,703 - 55,564,493 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01855,539,473 - 55,557,682 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,958,965 - 56,977,159 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,031,196 - 57,049,391 (-)NCBI
Celera1852,602,558 - 52,620,980 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of a high affinity L-proline transporter expressed in putative glutamatergic pathways of rat brain. Fremeau RT Jr, etal., Neuron 1992 May;8(5):915-26.
2. L-proline and L-pipecolate induce enkephalin-sensitive currents in human embryonic kidney 293 cells transfected with the high-affinity mammalian brain L-proline transporter. Galli A, etal., J Neurosci. 1999 Aug 1;19(15):6290-7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. "On" and "off" responses of K+-induced synaptosomal proline release: involvement of the sodium pump. Nickolson VJ, J Neurochem. 1982 Jan;38(1):289-92. doi: 10.1111/j.1471-4159.1982.tb10885.x.
7. The mammalian brain high-affinity L-proline transporter is enriched preferentially in synaptic vesicles in a subpopulation of excitatory nerve terminals in rat forebrain. Renick SE, etal., J Neurosci. 1999 Jan 1;19(1):21-33.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16458270   PMID:19029042  


Genomics

Comparative Map Data
Slc6a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,718,849 - 56,737,702 (-)NCBIGRCr8
mRatBN7.21854,448,464 - 54,467,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,448,464 - 54,467,319 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,536,530 - 56,555,331 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,251,136 - 57,269,935 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,072,309 - 55,091,168 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,305,765 - 56,325,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,305,735 - 56,331,991 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,557,703 - 55,564,493 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01855,539,473 - 55,557,682 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41856,958,965 - 56,977,159 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,031,196 - 57,049,391 (-)NCBI
Celera1852,602,558 - 52,620,980 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
SLC6A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,190,062 - 150,211,063 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,190,062 - 150,222,788 (+)EnsemblGRCh38hg38GRCh38
GRCh375149,569,625 - 149,590,626 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,549,713 - 149,570,828 (+)NCBINCBI36Build 36hg18NCBI36
Build 345149,549,712 - 149,570,827NCBI
Celera5145,650,900 - 145,672,027 (+)NCBICelera
Cytogenetic Map5q32ENTREZGENE
HuRef5144,717,577 - 144,738,751 (+)NCBIHuRef
CHM1_15149,002,105 - 149,023,228 (+)NCBICHM1_1
T2T-CHM13v2.05150,721,251 - 150,747,665 (+)NCBIT2T-CHM13v2.0
Slc6a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,128,448 - 61,147,484 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,128,452 - 61,147,294 (-)EnsemblGRCm39 Ensembl
GRCm381860,995,376 - 61,014,416 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1860,995,380 - 61,014,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv371861,155,034 - 61,173,853 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,120,749 - 61,139,568 (-)NCBIMGSCv36mm8
Celera1862,282,370 - 62,301,212 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
Slc6a7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,314,067 - 4,332,665 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,314,090 - 4,332,659 (-)NCBIChiLan1.0ChiLan1.0
SLC6A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,418,619 - 145,439,644 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,558,179 - 143,579,193 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,614,286 - 145,635,345 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,619,466 - 151,640,609 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,619,288 - 151,652,149 (+)Ensemblpanpan1.1panPan2
SLC6A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,873,547 - 58,892,357 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,874,137 - 58,887,129 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,638,808 - 58,658,424 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,353,446 - 59,373,028 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,353,457 - 59,373,409 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,142,170 - 59,161,799 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,256,627 - 59,276,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,787,700 - 59,807,346 (-)NCBIUU_Cfam_GSD_1.0
Slc6a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,135,063 - 143,156,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,709,583 - 4,730,219 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,709,539 - 4,730,583 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,223,028 - 151,241,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,221,542 - 151,241,983 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22158,310,108 - 158,329,390 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,799,847 - 52,820,745 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,800,358 - 52,820,732 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603424,896,351 - 24,917,248 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc6a7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,499,450 - 9,519,583 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,499,697 - 9,519,522 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc6a7
134 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:68
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000025209
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876357867167Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat

Markers in Region
AW455934  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,448,076 - 54,448,203 (+)MAPPERmRatBN7.2
Rnor_6.01856,305,910 - 56,306,036NCBIRnor6.0
Rnor_5.01855,539,086 - 55,539,212UniSTSRnor5.0
RGSC_v3.41856,958,578 - 56,958,704UniSTSRGSC3.4
Celera1852,602,171 - 52,602,297UniSTS
Cytogenetic Map18q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 38 3
Low 3 6 2 1 2 26 16 3
Below cutoff 39 13 4 13 4 5 8 4 28 21 8 5

Sequence


RefSeq Acc Id: ENSRNOT00000025209   ⟹   ENSRNOP00000025209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,449,049 - 54,463,268 (-)Ensembl
Rnor_6.0 Ensembl1856,307,020 - 56,325,095 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085841   ⟹   ENSRNOP00000070592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,448,464 - 54,467,319 (-)Ensembl
Rnor_6.0 Ensembl1856,306,297 - 56,331,991 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086464   ⟹   ENSRNOP00000070137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1856,305,735 - 56,326,389 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091220   ⟹   ENSRNOP00000074128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,448,464 - 54,463,268 (-)Ensembl
Rnor_6.0 Ensembl1856,306,297 - 56,331,991 (-)Ensembl
RefSeq Acc Id: NM_053996   ⟹   NP_446448
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,718,849 - 56,737,702 (-)NCBI
mRatBN7.21854,448,464 - 54,467,319 (-)NCBI
Rnor_6.01856,306,297 - 56,325,179 (-)NCBI
Rnor_5.01855,539,473 - 55,557,682 (-)NCBI
RGSC_v3.41856,958,965 - 56,977,159 (-)RGD
Celera1852,602,558 - 52,620,980 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446448 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41541 (Get FASTA)   NCBI Sequence Viewer  
  EDM14583 (Get FASTA)   NCBI Sequence Viewer  
  EDM14584 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025209.4
  ENSRNOP00000070592
  ENSRNOP00000070592.1
  ENSRNOP00000074128.2
GenBank Protein P28573 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446448   ⟸   NM_053996
- UniProtKB: P28573 (UniProtKB/Swiss-Prot),   A0A0G2JYB6 (UniProtKB/TrEMBL),   A6IXF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074128   ⟸   ENSRNOT00000091220
RefSeq Acc Id: ENSRNOP00000070592   ⟸   ENSRNOT00000085841
RefSeq Acc Id: ENSRNOP00000070137   ⟸   ENSRNOT00000086464
RefSeq Acc Id: ENSRNOP00000025209   ⟸   ENSRNOT00000025209

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28573-F1-model_v2 AlphaFold P28573 1-637 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620928 AgrOrtholog
BioCyc Gene G2FUF-7350 BioCyc
Ensembl Genes ENSRNOG00000018644 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025209.6 UniProtKB/TrEMBL
  ENSRNOT00000085841 ENTREZGENE
  ENSRNOT00000085841.2 UniProtKB/TrEMBL
  ENSRNOT00000091220.2 UniProtKB/TrEMBL
InterPro Na/ntran_symport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117100 ENTREZGENE
PANTHER PTHR11616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM-DEPENDENT PROLINE TRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc6a7 PhenoGen
PRINTS NANEUSMPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018644 RatGTEx
Superfamily-SCOP SSF161070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K7A6_RAT UniProtKB/TrEMBL
  A6IXF2_RAT UniProtKB/TrEMBL
  A6IXF3 ENTREZGENE, UniProtKB/TrEMBL
  G3V8F1_RAT UniProtKB/TrEMBL
  P28573 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Slc6a7  solute carrier family 6 member 7  LOC103690061  sodium-dependent proline transporter-like  Data merged from RGD:9125619 737654 PROVISIONAL
2016-02-24 Slc6a7  solute carrier family 6 member 7  Slc6a7  solute carrier family 6 (neurotransmitter transporter), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690061  sodium-dependent proline transporter-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-08-02 Slc6a7  solute carrier family 6 (neurotransmitter transporter), member 7  Slc6a7  solute carrier family 6 (neurotransmitter transporter, L-proline), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-01-30 Slc6a7  solute carrier family 6 (neurotransmitter transporter, L-proline), member 7  Prot  proline transporter  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Prot  proline transporter      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression in mitral cells of the olfactory bulb, pyramidal cells of layer V of the cerebral cortex, pyramidal cells of the piriform cortex, and pyramidal cells of field CA3 of the hippocampus 633816