Stk32a (serine/threonine kinase 32A) - Rat Genome Database

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Gene: Stk32a (serine/threonine kinase 32A) Rattus norvegicus
Analyze
Symbol: Stk32a
Name: serine/threonine kinase 32A
RGD ID: 1308338
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Orthologous to human STK32A (serine/threonine kinase 32A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC364858; serine/threonine-protein kinase 32A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21835,258,865 - 35,374,985 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1835,259,052 - 35,369,451 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1835,363,088 - 35,472,487 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01836,081,399 - 36,190,804 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01835,458,355 - 35,567,752 (+)NCBIRnor_WKY
Rnor_6.01837,597,305 - 37,706,884 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1837,597,156 - 37,710,306 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01837,253,122 - 37,366,281 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41836,501,876 - 36,611,248 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11836,537,033 - 36,646,846 (+)NCBI
Celera1834,848,008 - 34,957,385 (+)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Stk32a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21835,258,865 - 35,374,985 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1835,259,052 - 35,369,451 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1835,363,088 - 35,472,487 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01836,081,399 - 36,190,804 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01835,458,355 - 35,567,752 (+)NCBIRnor_WKY
Rnor_6.01837,597,305 - 37,706,884 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1837,597,156 - 37,710,306 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01837,253,122 - 37,366,281 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41836,501,876 - 36,611,248 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11836,537,033 - 36,646,846 (+)NCBI
Celera1834,848,008 - 34,957,385 (+)NCBICelera
Cytogenetic Map18p11NCBI
STK32A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385147,235,026 - 147,401,990 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5147,234,963 - 147,387,855 (+)EnsemblGRCh38hg38GRCh38
GRCh375146,614,589 - 146,767,418 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365146,594,862 - 146,708,586 (+)NCBINCBI36Build 36hg18NCBI36
Build 345146,594,861 - 146,708,581NCBI
Celera5142,696,707 - 142,845,791 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5141,761,757 - 141,910,943 (+)NCBIHuRef
CHM1_15146,046,999 - 146,196,079 (+)NCBICHM1_1
T2T-CHM13v2.05147,770,995 - 147,923,633 (+)NCBIT2T-CHM13v2.0
Stk32a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391843,340,762 - 43,450,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1843,340,648 - 43,451,747 (+)EnsemblGRCm39 Ensembl
GRCm381843,207,697 - 43,317,481 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1843,207,583 - 43,318,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv371843,367,351 - 43,477,135 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361843,333,028 - 43,442,812 (+)NCBIMGSCv36mm8
Celera1844,582,297 - 44,700,893 (+)NCBICelera
Cytogenetic Map18B3NCBI
Stk32a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554156,815,852 - 6,948,232 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554156,817,152 - 6,948,180 (-)NCBIChiLan1.0ChiLan1.0
STK32A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15148,694,879 - 148,848,227 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5148,694,879 - 148,844,508 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05142,683,261 - 142,868,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
STK32A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1241,555,314 - 41,686,016 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl241,559,019 - 41,683,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,597,167 - 38,727,788 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,010,369 - 42,141,271 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,010,123 - 42,138,189 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,086,862 - 39,217,202 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0239,893,973 - 40,027,318 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0240,718,283 - 40,849,352 (+)NCBIUU_Cfam_GSD_1.0
Stk32a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213145,797,205 - 145,936,117 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365047,370,332 - 7,510,562 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365047,369,180 - 7,510,016 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK32A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2148,519,679 - 148,659,461 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12148,519,808 - 148,663,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22155,283,793 - 155,320,647 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STK32A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12349,786,215 - 49,935,407 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2349,786,283 - 49,939,332 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603427,827,660 - 27,980,790 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk32a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247746,703,443 - 6,834,553 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247746,703,983 - 6,833,226 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stk32a
529 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000031370
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 2 1 16 18 8 10 50 29 17 11 8
Below cutoff 1 22 13 13 1 13 1 18 6 19

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031370   ⟹   ENSRNOP00000036737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1835,259,052 - 35,369,451 (+)Ensembl
Rnor_6.0 Ensembl1837,597,156 - 37,710,306 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115603   ⟹   ENSRNOP00000079735
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1835,259,052 - 35,369,451 (+)Ensembl
RefSeq Acc Id: NM_001191894   ⟹   NP_001178823
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21835,259,052 - 35,368,451 (+)NCBI
Rnor_6.01837,597,305 - 37,706,884 (+)NCBI
Rnor_5.01837,253,122 - 37,366,281 (+)NCBI
Celera1834,848,008 - 34,957,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097002   ⟹   XP_038952930
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21835,258,865 - 35,374,985 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178823 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952930 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76496 (Get FASTA)   NCBI Sequence Viewer  
  EDL76497 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178823   ⟸   NM_001191894
- UniProtKB: D3ZD18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036737   ⟸   ENSRNOT00000031370
RefSeq Acc Id: XP_038952930   ⟸   XM_039097002
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000079735   ⟸   ENSRNOT00000115603
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZD18-F1-model_v2 AlphaFold D3ZD18 1-397 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308338 AgrOrtholog
BioCyc Gene G2FUF-7686 BioCyc
Ensembl Genes ENSRNOG00000027066 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000036737 ENTREZGENE
  ENSRNOP00000036737.4 UniProtKB/TrEMBL
  ENSRNOP00000079735.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031370 ENTREZGENE
  ENSRNOT00000031370.7 UniProtKB/TrEMBL
  ENSRNOT00000115603.1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:364858 UniProtKB/TrEMBL
NCBI Gene 364858 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Stk32a PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZNQ1_RAT UniProtKB/TrEMBL
  D3ZD18 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Stk32a  serine/threonine kinase 32A   Stk32a_predicted  serine/threonine kinase 32A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Stk32a_predicted  serine/threonine kinase 32A (predicted)      Symbol and Name status set to approved 70820 APPROVED