Camk4 (calcium/calmodulin-dependent protein kinase IV)

Gene: Camk4 (calcium/calmodulin-dependent protein kinase IV) Rattus norvegicus

Analyze

Symbol:

Camk4

Name:

calcium/calmodulin-dependent protein kinase IV

RGD ID:

2264

Description:

Enables calmodulin-dependent protein kinase activity. Predicted to be involved in several processes, including long-term memory; myeloid dendritic cell differentiation; and postsynapse to nucleus signaling pathway. Predicted to act upstream of or within several processes, including neuron-neuron synaptic transmission; nucleocytoplasmic transport; and positive regulation of protein export from nucleus. Is active in glutamatergic synapse and postsynapse. Biomarker of alcohol use disorder and withdrawal disorder. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV); PARTICIPATES IN calcium/calcium-mediated signaling pathway; long term potentiation; neurotrophic factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

calcium/calmodulin-dependent protein kinase type IV; Calmodulin-dependent protein kinase IV; calspermin; CAM kinase-GR; caMK IV; Ccdpk; RATCCDPK

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	24,857,152 - 25,076,054 (+)	NCBI		GRCr8
mRatBN7.2	18	24,582,988 - 24,811,918 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	24,585,269 - 24,802,487 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	24,711,029 - 24,929,241 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	25,476,377 - 25,693,513 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	24,806,056 - 25,024,906 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	25,746,878 - 25,975,962 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	25,749,098 - 25,965,957 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	25,461,935 - 25,690,666 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	25,404,123 - 25,625,785 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	25,434,889 - 25,652,443 (+)	NCBI
Celera	18	24,329,977 - 24,549,475 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (IEP)

cocaine dependence (ISO)

Cocaine-Related Disorders (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

intellectual disability (ISO)

male infertility (ISO)

Neurodevelopmental Disorders (ISO)

withdrawal disorder (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,4,5-Tetrachloro-4'-biphenylol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile (EXP)

3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

9-cis-retinoic acid (EXP)

acrolein (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

amosite asbestos (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

Butylbenzyl phthalate (EXP)

C60 fullerene (EXP)

cadmium atom (ISO)

casticin (ISO)

clozapine (EXP)

cocaine (ISO)

crocidolite asbestos (ISO)

cyclosporin A (EXP)

dexamethasone (EXP)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diethylstilbestrol (ISO)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dimethylarsinous acid (ISO)

dizocilpine maleate (EXP)

dorsomorphin (ISO)

ethanol (ISO)

fenamidone (ISO)

fluoxetine (EXP)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

glycidol (EXP)

haloperidol (EXP)

hydrogen peroxide (ISO)

kainic acid (ISO)

KN-93 (EXP)

lanthanum atom (EXP)

lipopolysaccharide (ISO)

lithium atom (EXP)

lithium hydride (EXP)

maneb (ISO)

methapyrilene (ISO)

methylseleninic acid (ISO)

N-Nitrosopyrrolidine (ISO)

nicardipine (EXP)

nickel atom (ISO)

nicotine (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

PCB138 (ISO)

perchlorate (EXP)

perfluorooctane-1-sulfonic acid (ISO)

resveratrol (EXP)

risperidone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

testosterone (EXP)

tetrodotoxin (EXP)

thapsigargin (EXP)

titanium dioxide (ISO)

toluene (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (EXP,ISO)

verapamil (EXP)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IEA)

inflammatory response (IEA)

intracellular signal transduction (IBA)

long-term memory (IEA,ISO,ISS)

myeloid dendritic cell differentiation (IEA,ISO,ISS)

neuron-neuron synaptic transmission (ISO)

nucleocytoplasmic transport (ISO)

positive regulation of DNA-templated transcription (IEA,ISO,ISS)

positive regulation of myeloid dendritic cell cytokine production (ISO)

positive regulation of protein export from nucleus (ISO)

postsynapse to nucleus signaling pathway (ISO)

postsynaptic modulation of chemical synaptic transmission (ISO)

protein phosphorylation (IDA)

signal transduction (ISO)

Cellular Component

cytoplasm (IBA,ISO)

fibrillar center (IEA,ISO)

GABA-ergic synapse (ISO)

glutamatergic synapse (IDA,ISO)

nucleoplasm (IEA,ISO,TAS)

nucleus (IBA,ISO)

postsynapse (IDA)

Molecular Function

ATP binding (IEA)

calcium-dependent protein serine/threonine kinase activity (IBA)

calmodulin binding (IBA,IEA)

calmodulin-dependent protein kinase activity (IBA,IDA,IEA,ISO)

protein binding (ISO)

protein serine kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium/calcium-mediated signaling pathway (IEA)

long term potentiation (IEA)

neurotrophic factor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.	Bilbao A, etal., Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17549-54. doi: 10.1073/pnas.0803959105. Epub 2008 Nov 10.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory.	Kang H, etal., Cell 2001 Sep 21;106(6):771-83.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	An immunohistochemical study of Ca2+/calmodulin-dependent protein kinase IV in the rat central nervous system: light and electron microscopic observations.	Nakamura Y, etal., Neuroscience. 1995 Sep;68(1):181-94.
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Ca2+/calmodulin-dependent protein kinase enriched in cerebellar granule cells. Identification of a novel neuronal calmodulin-dependent protein kinase.	Ohmstede CA, etal., J Biol Chem 1989 Apr 5;264(10):5866-75.
9.	Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene.	Ohmstede CA, etal., Proc Natl Acad Sci U S A 1991 Jul 1;88(13):5784-8.
10.	Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex.	Pandey SC, etal., J Pharmacol Exp Ther. 2001 Mar;296(3):857-68.
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Cloning and sequencing of a gene encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV and its expression confined to the mature cerebellar granule cells.	Sakagami H and Kondo H, Brain Res Mol Brain Res 1993 Aug;19(3):215-8.
15.	Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene.	Sun Z, etal., J Biol Chem 1995 Dec 8;270(49):29507-14.
16.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17.	Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4.	Wu JY, etal., Nat Genet 2000 Aug;25(4):448-52.

Additional References at PubMed

PMID:1646483	PMID:1649385	PMID:2914893	PMID:7592527	PMID:7615569	PMID:7961813	PMID:8065343	PMID:8107230	PMID:8299971	PMID:8621702	PMID:8631893	PMID:8636117
PMID:8855261	PMID:9596578	PMID:9822657	PMID:10336483	PMID:10964952	PMID:11081517	PMID:12086646	PMID:12130539	PMID:12403833	PMID:12477932	PMID:14701808	PMID:15262966
PMID:15308608	PMID:15537635	PMID:15719015	PMID:15748849	PMID:15919723	PMID:16822951	PMID:16923323	PMID:17273866	PMID:17909078	PMID:18029144	PMID:18381242	PMID:18559891
PMID:18829949	PMID:19056867	PMID:19292454	PMID:19506079	PMID:19711354	PMID:19874424	PMID:20056827	PMID:20423744	PMID:20799369	PMID:21762679	PMID:21989476	PMID:23680840
PMID:23817991	PMID:27216039	PMID:28592691	PMID:30053369	PMID:34586897

Genomics

Comparative Map Data

Camk4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	24,857,152 - 25,076,054 (+)	NCBI		GRCr8
mRatBN7.2	18	24,582,988 - 24,811,918 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	24,585,269 - 24,802,487 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	24,711,029 - 24,929,241 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	25,476,377 - 25,693,513 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	24,806,056 - 25,024,906 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	25,746,878 - 25,975,962 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	25,749,098 - 25,965,957 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	25,461,935 - 25,690,666 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	25,404,123 - 25,625,785 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	25,434,889 - 25,652,443 (+)	NCBI
Celera	18	24,329,977 - 24,549,475 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

CAMK4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	111,223,583 - 111,494,886 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	111,223,653 - 111,494,886 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	110,559,281 - 110,830,584 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	110,587,981 - 110,848,648 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	110,587,980 - 110,848,645	NCBI
Celera	5	106,506,012 - 106,766,350 (+)	NCBI		Celera
Cytogenetic Map	5	q22.1	NCBI
HuRef	5	105,739,000 - 105,999,500 (+)	NCBI		HuRef
CHM1_1	5	109,993,303 - 110,254,043 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	111,734,219 - 112,005,186 (+)	NCBI		T2T-CHM13v2.0

Camk4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	33,067,995 - 33,328,820 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	33,067,984 - 33,324,281 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	32,934,941 - 33,195,767 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	32,934,931 - 33,191,228 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	33,098,695 - 33,355,421 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	33,082,366 - 33,311,737 (+)	NCBI		MGSCv36	mm8
Celera	18	33,410,258 - 33,643,822 (+)	NCBI		Celera
Cytogenetic Map	18	B1	NCBI
cM Map	18	18.15	NCBI

Camk4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	3,664,479 - 3,887,175 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	3,664,352 - 3,887,175 (-)	NCBI	ChiLan1.0	ChiLan1.0

CAMK4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	106,415,303 - 106,751,790 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	104,568,958 - 104,905,445 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	106,590,803 - 106,855,592 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	112,393,674 - 112,657,593 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	112,393,211 - 112,647,203 (+)	Ensembl	panpan1.1		panPan2

CAMK4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	1,174,975 - 1,369,640 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	1,180,401 - 1,369,803 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	2,578,244 - 2,850,336 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	1,020,594 - 1,293,824 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	1,020,667 - 1,218,126 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	1,010,019 - 1,282,970 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	1,006,461 - 1,284,714 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	1,170,193 - 1,449,448 (-)	NCBI		UU_Cfam_GSD_1.0

Camk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	155,752,531 - 155,995,704 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	5,616,746 - 5,849,088 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	5,615,442 - 5,858,968 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CAMK4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	116,000,791 - 116,229,758 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	115,910,403 - 116,234,835 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	120,705,517 - 120,814,660 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CAMK4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	14,563,476 - 14,828,128 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	14,563,034 - 14,826,821 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	63,642,472 - 63,910,617 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Camk4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	29,047,004 - 29,266,685 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	29,045,998 - 29,276,801 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Camk4
1862 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	134
Count of miRNA genes:	100
Interacting mature miRNAs:	106
Transcripts:	ENSRNOT00000027771
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552968	Pigfal19	Plasma insulin-like growth factor 1 level QTL 19	11.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	18	1	25758124	Rat
9590248	Scort10	Serum corticosterone level QTL 10	19.71	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	1	25758124	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
12904690	Cm129	Cardiac mass QTL 129		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	11944273	26548295	Rat
12904689	Cm128	Cardiac mass QTL 128		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	11944273	26548295	Rat
12904693	Am20	Aortic mass QTL 20		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	11944273	26548295	Rat
12904695	Kidm73	Kidney mass QTL 73		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	11944273	26548295	Rat
12904691	Cm130	Cardiac mass QTL 130		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	11944273	26548295	Rat
12904680	Bw189	Body weight QTL 189		0.019	body mass (VT:0001259)	body weight (CMO:0000012)	18	11944273	26548295	Rat
2301410	Bp317	Blood pressure QTL 317		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944273	26548295	Rat
1331781	Scl28	Serum cholesterol level QTL 28	3.995		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	11944299	24797117	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat

Markers in Region

D18Wox14

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,586,534 - 24,586,682 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,750,364 - 25,750,511	NCBI	Rnor6.0
Rnor_5.0	18	25,465,421 - 25,465,568	UniSTS	Rnor5.0
RGSC_v3.4	18	25,407,670 - 25,407,817	UniSTS	RGSC3.4
Celera	18	24,333,528 - 24,333,675	UniSTS
Cytogenetic Map	18	p12	UniSTS

D18Mgh9

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,796,977 - 24,797,117 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,961,026 - 25,961,165	NCBI	Rnor6.0
Rnor_5.0	18	25,675,732 - 25,675,871	UniSTS	Rnor5.0
RGSC_v3.4	18	25,620,884 - 25,621,024	RGD	RGSC3.4
RGSC_v3.4	18	25,620,885 - 25,621,024	UniSTS	RGSC3.4
RGSC_v3.1	18	25,647,530 - 25,647,670	RGD
Celera	18	24,544,575 - 24,544,714	UniSTS
RH 3.4 Map	18	338.4	UniSTS
RH 3.4 Map	18	338.4	RGD
RH 2.0 Map	18	571.8	RGD
Cytogenetic Map	18	p12	UniSTS

D18Rat66

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,768,796 - 24,769,009 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,932,986 - 25,933,198	NCBI	Rnor6.0
Rnor_5.0	18	25,647,692 - 25,647,904	UniSTS	Rnor5.0
RGSC_v3.4	18	25,592,835 - 25,593,048	RGD	RGSC3.4
RGSC_v3.4	18	25,592,836 - 25,593,048	UniSTS	RGSC3.4
RGSC_v3.1	18	25,619,401 - 25,619,957	RGD
Celera	18	24,516,452 - 24,516,664	UniSTS
SHRSP x BN Map	18	11.4999	UniSTS
SHRSP x BN Map	18	11.4999	RGD
FHH x ACI Map	18	14.96	RGD
Cytogenetic Map	18	p12	UniSTS

D18Rat132

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,732,271 - 24,732,519 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,896,100 - 25,896,347	NCBI	Rnor6.0
Rnor_5.0	18	25,610,723 - 25,610,970	UniSTS	Rnor5.0
RGSC_v3.4	18	25,556,340 - 25,556,586	RGD	RGSC3.4
RGSC_v3.4	18	25,556,341 - 25,556,586	UniSTS	RGSC3.4
RGSC_v3.1	18	25,582,986 - 25,583,232	RGD
Celera	18	24,479,152 - 24,479,397	UniSTS
SHRSP x BN Map	18	11.4999	UniSTS
SHRSP x BN Map	18	11.4999	RGD
FHH x ACI Map	18	14.96	RGD
Cytogenetic Map	18	p12	UniSTS

D18Got37

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,630,802 - 24,631,052 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,794,805 - 25,795,052	NCBI	Rnor6.0
Rnor_5.0	18	25,509,862 - 25,510,109	UniSTS	Rnor5.0
RGSC_v3.4	18	25,451,941 - 25,452,189	RGD	RGSC3.4
RGSC_v3.4	18	25,451,942 - 25,452,189	UniSTS	RGSC3.4
RGSC_v3.1	18	25,478,588 - 25,478,835	RGD
Celera	18	24,377,826 - 24,378,073	UniSTS
RH 3.4 Map	18	324.4	UniSTS
RH 3.4 Map	18	324.4	RGD
RH 2.0 Map	18	581.7	RGD
Cytogenetic Map	18	p12	UniSTS

D18Chm2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,735,261 - 24,735,488 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,899,090 - 25,899,314	NCBI	Rnor6.0
Rnor_5.0	18	25,613,713 - 25,613,937	UniSTS	Rnor5.0
RGSC_v3.4	18	25,559,329 - 25,559,553	UniSTS	RGSC3.4
Celera	18	24,482,140 - 24,482,364	UniSTS
Cytogenetic Map	18	p12	UniSTS

BF400657

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,619,029 - 24,619,134 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,783,028 - 25,783,132	NCBI	Rnor6.0
Rnor_5.0	18	25,498,085 - 25,498,189	UniSTS	Rnor5.0
RGSC_v3.4	18	25,440,165 - 25,440,269	UniSTS	RGSC3.4
Celera	18	24,366,044 - 24,366,148	UniSTS
RH 3.4 Map	18	333.0	UniSTS
Cytogenetic Map	18	p12	UniSTS

BE107932

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,682,558 - 24,682,711 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,845,932 - 25,846,084	NCBI	Rnor6.0
Rnor_5.0	18	25,560,989 - 25,561,141	UniSTS	Rnor5.0
RGSC_v3.4	18	25,505,193 - 25,505,345	UniSTS	RGSC3.4
Celera	18	24,429,493 - 24,429,645	UniSTS
RH 3.4 Map	18	334.6	UniSTS
Cytogenetic Map	18	p12	UniSTS

AU047213

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,621,756 - 24,621,933 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,785,755 - 25,785,931	NCBI	Rnor6.0
Rnor_5.0	18	25,500,812 - 25,500,988	UniSTS	Rnor5.0
RGSC_v3.4	18	25,442,892 - 25,443,068	UniSTS	RGSC3.4
Celera	18	24,368,771 - 24,368,947	UniSTS
Cytogenetic Map	18	p12	UniSTS

RH137597

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,792,955 - 24,793,148 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,957,005 - 25,957,197	NCBI	Rnor6.0
Rnor_5.0	18	25,671,711 - 25,671,903	UniSTS	Rnor5.0
RGSC_v3.4	18	25,616,864 - 25,617,056	UniSTS	RGSC3.4
Celera	18	24,540,554 - 24,540,746	UniSTS
Cytogenetic Map	18	p12	UniSTS

RH138191

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,801,575 - 24,801,824 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,965,623 - 25,965,871	NCBI	Rnor6.0
Rnor_5.0	18	25,680,329 - 25,680,577	UniSTS	Rnor5.0
RGSC_v3.4	18	25,625,482 - 25,625,730	UniSTS	RGSC3.4
Celera	18	24,549,172 - 24,549,420	UniSTS
RH 3.4 Map	18	336.1	UniSTS
Cytogenetic Map	18	p12	UniSTS

BE119628

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,620,602 - 24,620,776 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,784,601 - 25,784,774	NCBI	Rnor6.0
Rnor_5.0	18	25,499,658 - 25,499,831	UniSTS	Rnor5.0
RGSC_v3.4	18	25,441,738 - 25,441,911	UniSTS	RGSC3.4
Celera	18	24,367,617 - 24,367,790	UniSTS
RH 3.4 Map	18	316.2	UniSTS
Cytogenetic Map	18	p12	UniSTS

STS-Z40708

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	24,732,046 - 24,733,183 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,895,875 - 25,897,011	NCBI	Rnor6.0
Rnor_5.0	18	25,610,498 - 25,611,634	UniSTS	Rnor5.0
RGSC_v3.4	18	25,556,116 - 25,557,250	UniSTS	RGSC3.4
Celera	18	24,478,927 - 24,480,061	UniSTS
Cytogenetic Map	18	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			8		13				48		7
Low	3	24	9	1	6	1	4	4	24	6	22	11	4
Below cutoff		19	14	14		14	4	7	2	29	11		4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC128706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J04446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J04600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L16999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M63334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M64757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M74488	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S65840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X91964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000027771 ⟹ ENSRNOP00000027771

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	24,585,269 - 24,801,869 (+)	Ensembl
Rnor_6.0 Ensembl	18	25,749,098 - 25,965,916 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000078822 ⟹ ENSRNOP00000072926

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	24,587,103 - 24,802,487 (+)	Ensembl
Rnor_6.0 Ensembl	18	25,962,855 - 25,965,957 (+)	Ensembl

RefSeq Acc Id:

NM_012727 ⟹ NP_036859

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	24,857,152 - 25,076,027 (+)	NCBI
mRatBN7.2	18	24,582,988 - 24,801,879 (+)	NCBI
Rnor_6.0	18	25,746,878 - 25,965,926 (+)	NCBI
Rnor_5.0	18	25,461,935 - 25,690,666 (+)	NCBI
RGSC_v3.4	18	25,404,123 - 25,625,785 (+)	RGD
Celera	18	24,329,977 - 24,549,475 (+)	RGD

Sequence:

show sequence

GTGAGGAGAAAGCTTCATGGATTAAATAAAATACATCACCTCCCCCTTGCCTTCCACAAGACAT
ACATCTCAAGACTTCCAGTGGATGCATGACGCTGAGGAGCTCCAGCAGAGCCAGAGGCGACAGG
GCCACCAGCAGAGATGACAAATTGAAGACTTCAATCAAAGGCGGCGGCCAGCGGTTCCAGCTCG
GGCAGCGGCGGCATCTTCCGGAGTCCCGCGGCGAAGATGCTCAAAGTCACGGTGCCCTCCTGTC
CCTCCTCGCCCTGCTCCTCGGTCACCTCCAGTACTGAGAACCTCGTCCCGGATTACTGGATCGA
CGGCTCTAAACGGGATCCTCTGAGCGATTTCTTCGAGGTGGAGTCAGAGCTGGGACGGGGTGCT
ACATCCATTGTGTACAGATGCAAACAGAAGGGGACCCAGAAGCCCTATGCTCTCAAAGTGTTAA
AGAAAACAGTGGACAAGAAGATCGTGAGAACTGAAATAGGAGTTCTCCTGAGACTCTCACACCC
GAACATCATAAAACTCAAGGAAATATTTGAAACCCCCACAGAAATCAGCCTGGTTCTTGAGCTA
GTCACAGGAGGAGAACTGTTTGACAGGATTGTGGAGAAAGGCTATTACAGTGAACGCGACGCGG
CCGATGCTGTGAAGCAGATCCTGGAGGCAGTTGCTTACCTGCACGAAAATGGAATCGTCCATCG
CGACCTCAAACCAGAGAATCTTCTTTATGCAACGCCAGCCCCTGATGCACCACTCAAAATTGCT
GATTTTGGACTTTCTAAAATCGTGGAACATCAAGTGCTCATGAAGACGGTGTGTGGAACCCCGG
GGTACTGTGCACCTGAGATTCTCCGAGGCTGTGCCTATGGCCCCGAGGTGGACATGTGGTCTGT
AGGAATAATTACCTACATCCTACTTTGTGGATTTGAACCATTCTATGATGAGAGAGGTGATCAG
TTCATGTTCAGGAGAATTCTGAATTGTGAATATTACTTTATCTCCCCCTGGTGGGATGAAGTTT
CTTTAAATGCCAAGGACTTGGTCAAGAAACTCATTGTTTTGGACCCTAAGAAGCGGCTGACTAC
ATTCCAAGCCCTCCAACACCCGTGGGTCACAGGAAAAGCAGCCAACTTTGTCCACATGGATACC
GCTCAGAAAAAGCTTCAAGAATTCAATGCTAGGCGCAAGCTTAAGGCGGCAGTGAAGGCTGTGG
TGGCCTCTTCTCGGCTGGGAAGTGCCAGCAGCAGTCACACCAACATCCAAGAAAGCAACAAAGC
CAGCTCGGAGGCACAGCCCGCCCAAGACGGCAAGGACAAGACAGATCCTCTGGAAAACAAAATG
CAAGCGGGGGACCACGAGGCAGCCAAGGCTGCAGCCGATGAGACGATGAAGCTACAGTCCGAGG
AGGTGGAGGAAGAGGAAGGTGTAAAAGAAGAGGAGGAAGAGGAAGAAGAGGAAGAGGAGACCTC
CAGGATGGTACCTCAGGAGCCAGAGGACAGGCTGGAGACAGATGACCAGGAAATGAAGAGAAAT
TCAGAGGAGACGTTGAAGAGTGTGGAGGAAGAAATGGACCCGAAAGCTGAGGAGGAAGCCGCTG
CCGTGGGACTTGGGGTCCCTCCACAGCAGGATGCTATTCTGCCAGAGTACTAACCCGGCTTCCT
TTAGGGCCCCAGGCCAACCCCAGCATTTTATGCACTTTGTCCTTCAGCAAGGTGGGGAAGCATG
ATAAGCACTATAGTGATTCTGTTTTGAGGTGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006254523 ⟹ XP_006254585

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	24,861,253 - 25,076,054 (+)	NCBI
mRatBN7.2	18	24,587,187 - 24,811,918 (+)	NCBI
Rnor_6.0	18	25,750,924 - 25,975,962 (+)	NCBI
Rnor_5.0	18	25,461,935 - 25,690,666 (+)	NCBI

Sequence:

show sequence

GACATAGGGACCAACAAGGGCTGCCTGTTTAGCTGGTGCAAGGTGGAAGGGACTCGCCTGCTTG
GAGCCTCGCTCCAGGAAACATGAGTTGCGCCGGCAACGATCAGGCGGCGGCCAGCGGTTCCAGC
TCGGGCAGCGGCGGCATCTTCCGGAGTCCCGCGGCGAAGATGCTCAAAGTCACGGTGCCCTCCT
GTCCCTCCTCGCCCTGCTCCTCGGTCACCTCCAGTACTGAGAACCTCGTCCCGGATTACTGGAT
CGACGGCTCTAAACGGGATCCTCTGAGCGATTTCTTCGAGGTGGAGTCAGAGCTGGGACGGGGT
GCTACATCCATTGTGTACAGATGCAAACAGAAGGGGACCCAGAAGCCCTATGCTCTCAAAGTGT
TAAAGAAAACAGTGGACAAGAAGATCGTGAGAACTGAAATAGGAGTTCTCCTGAGACTCTCACA
CCCGAACATCATAAAACTCAAGGAAATATTTGAAACCCCCACAGAAATCAGCCTGGTTCTTGAG
CTAGTCACAGGAGGAGAACTGTTTGACAGGATTGTGGAGAAAGGCTATTACAGTGAACGCGACG
CGGCCGATGCTGTGAAGCAGATCCTGGAGGCAGTTGCTTACCTGCACGAAAATGGAATCGTCCA
TCGCGACCTCAAACCAGAGAATCTTCTTTATGCAACGCCAGCCCCTGATGCACCACTCAAAATT
GCTGATTTTGGACTTTCTAAAATCGTGGAACATCAAGTGCTCATGAAGACGGTGTGTGGAACCC
CGGGGTACTGTGCACCTGAGATTCTCCGAGGCTGTGCCTATGGCCCCGAGGTGGACATGTGGTC
TGTAGGAATAATTACCTACATCCTACTTTGTGGATTTGAACCATTCTATGATGAGAGAGGTGAT
CAGTTCATGTTCAGGAGAATTCTGAATTGTGAATATTACTTTATCTCCCCCTGGTGGGATGAAG
TTTCTTTAAATGCCAAGGACTTGGTCAAGAAACTCATTGTTTTGGACCCTAAGAAGCGGCTGAC
TACATTCCAAGCCCTCCAACACCCGTGGGTCACAGGAAAAGCAGCCAACTTTGTCCACATGGAT
ACCGCTCAGAAAAAGCTTCAAGAATTCAATGCTAGGCGCAAGCTTAAGGCGGCAGTGAAGGCTG
TGGTGGCCTCTTCTCGGCTGGGAAGTGCCAGCAGCAGTCACACCAACATCCAAGAAAGCAACAA
AGCCAGCTCGGAGGCACAGCCCGCCCAAGACGGCAAGGACAAGACAGATCCTCTGGAAAACAAA
ATGCAAGCGGGGGACCACGAGGCAGCCAAGGCTGCAGCCGATGAGACGATGAAGCTACAGTCCG
AGGAGGTGGAGGAAGAGGAAGGTGTAAAAGAAGAGGAGGAAGAGGAAGAAGAGGAAGAGGAGAC
CTCCAGGATGGTACCTCAGGAGCCAGAGGACAGGCTGGAGACAGATGACCAGGAAATGAAGAGA
AATTCAGAGGAGACGTTGAAGAGTGTGGAGGAAGAAATGGACCCGAAAGCTGAGGAGGAAGCCG
CTGCCGTGGGACTTGGGGTCCCTCCACAGCAGGATGCTATTCTGCCAGAGTACTAACCCGGCTT
CCTTTAGGGCCCCAGGCCAACCCCAGCATTTTATGCACTTTGTCCTTCAGCAAGGTGGGGAAGC
ATGATAAGCACTATAGTGATTCTGTTTTGAGGTGCAAAAAAAAAATCCATATATACCAGTTGGT
AACCCTAACGTCAGTGCATGTGTTTGCTTTATGAAATAATGAAGTTTTCTACGGCATGTAATGG
ATTCCTAATACCCAGGAGTTAAATTTGAAATTTCTAGCAAACAACACAGCCCTTAAAAATCATT
CCCGGCCTCTGGTAGCACACACTGAAGTGAAATAGCACAGGGACTTTGGAGGCTTAGGCATCCT
ACACCCTCCACAAGTCTTCAAAGAGGGCAACTCCTTTGAACTCAGCTACAACCAGCTGGAGTTA
CCAGACACATTCCCATGACTTTCCAAATACTTTGAGGGGGACCAGCCTTGTAGGCCGTTATAAA
AGTAGGTAATGGAGGGTTATAAAAGATACCTGGAGAAGGTGCAAAAACATCTGTTTATAGTGTA
GAGAAGCTGAAGCATTCTTACAGGGTACTGAGTCCACAGTCCCCTTAAGTGTATGCAGAGAATG
TCTAATTTTTTAGTACACCATATAATACCCAAAGTGCTCATCATAGAGTTCTGCCAGTTTACAG
TTCTTGGGAAATTATTTTTTAAACTGTGCCGCTCCCTTCCTTTACCTGCCTTTCAAATAAAATG
CCTCTTCAGAGTCTAAAACCTAGGAAAGAAGGAAGACACCTAAGTAAAATGAGATAGAATTAGG
CTTTAGACACACCGAGGTTAGCTCCTTTTCCTTTCTCACAAAAATTCACATCTATAAGCTTATG
TGACAGCTTACATATAAGAACATTTTTATGAAGATACTCTGCAAGTAACAAGTTTCGAGTTTTG
GAGAAGTCCATTGCACGAGTCAATGCCAAAGTATCTGAGTCGAGTAACAATACACTCACTAGTT
CGATCACTTAGAACTGATATTGTTTGAGTAAGGAAATGCTAACAGGAGACTCTCCTCCAACTAT
GTAGAAACACTGTTCACAGGGTTAAAATTCACTATGAAAGTCAGTACCATTTCCCAATGGAAGG
GTCCACACATTTTTTTTTTGGTTCTTTTTTTTCGGAGCTGGGGACTGAACCCAGGGCCTTGCAC
TTCCTAGGCAAGCACTCTACCACTGAGCTAAATCCCCAACCCCGGGTCCACACATTTTATAATG
TTGAACTATATTGAATATATGCCAAGGGATTTAGCATAGCGTGAACTTTTATTTGCCTTAAAAA
TAAGCAAAACCAAAAATGAAATGAAAAAGCATCCAGAACCAGACCTCGGGGAGGGCGAAGCATT
AGACCTTAGTCAGCATGATTTTTTTTTTTCTCGGAATAATTTTGGGGGTGGGATGGGTTCACAG
AAATCAAACTAAATCCAATACCTCAAATTTCGTGTTTGAGTAAAAATGAGCACTTTATCAAAAC
GACTTTAATATTTTGGGTGAGTTTTCTTGATATAAAAAAAAAGTATTATTTTTAAATTCCACAA
CAAGGGCAAGAAGAATGACTAGCACAGAATTAAACTAATAATGTGGTCAGATGCACTCAAACAG
TTATACTAGGAACTGAAATCAGATCTGGGGTTGCTCCAGGCTTTTAGGGTATCAGCACCTCAGC
TTATCAAGCCTCTAACAGCTTTTGGGGAGGGAGACAACGTGGTGCTTTGAGCATTTTGTGATTC
GGGTCCTTGACAGGCAGCTGACTCGGAGGGCATCATCTGACCGGGGCGATCCCTGCTCAGTTGA
TTTTAATTGACAGTGTTTATGACAGTGTTTACCTTCCTTCCTTCCACTTTAATTTTCCCTCTTG
GAACACTCATCCTGAGAATCATTAAGGGCTCCCTAGTTTCAACCATTAAGAATGCTTGTTACAA
TTTCCATTGAAGAAGAAGAATTCCCAGGTGTAATTTTCCTCATCAAACTTACCATATGTACAGT
GAGTGTCCCATATATGGGAAGAATGAAGAAGACTAGGTGGTCTTGTTAGAAGGTGGCAGTTAAA
TATCAGAACATATCCTCATTCAAACCCAGCTCAGGTCTTCTTTATTCCAACATAGGCTGGTTGC
CTTGAATGACCCCGTAGACTATAGGAAGAGCATACATGCCAAGGCCTCATGGATTTGAGAATCA
GTCGCATAAATGATTATACCTCATCCCTTCTTGGTGGTACTCAAGAGTTTTAGCACAATTCCCT
CCCTCTCTTTTATAACCTTTGCACTTCACTAGCTGAACATCATGAGCAGTTTTCAATTGTAACT
GGTATGCTAAAGATTAAGTCTTGCTAATGCTTACAAAGTCCTTTCACTGGGAGATAAGCCAAAC
ATTTCACTCAAGTCATTCAAAGATTCCATCTAAGAATAATTATTTTACCATTTTAAAAGAACAG
CCAACATTTATATTGCCTGTTAAAATTCTATTATCTATTTCAAAGATTACTTAAACTAAAGGAA
AACAGTCTTAATTTGAAAGAACACATTCTACTATTACTCTTAATTGGTAATTGTCTTTGTTAGG
GTTTTATTCCTGTGAACAGACACCATGACCAAAGCAACTCTTATAAAGGAAAACATTTAATTGG
GGGCTGGCTTACAGTTTCAGAGGTTCAGTCCACCATCATCCTGATAGGAAGCGTGGCAGCATCC
AGGCTGATATGGTGCTGGAGGTTGAGAGTTCTAGATTTTAATTCAAAGGTAGCAGCAGGAGACT
TGGATCACATTGGCCAGATTTAAGCATATATATGAGACATCAAAGCCCCCCTCCTCTACACTGA
CTAACTTCTCCTAATAAGGCCACACCTCCTCCAATAAGGCCACACCCCCTACGAGTGCCGCTTC
CCATGGGGCAAGCATATACAAAGCACCACAGTAATGTAGTCACAAAACAATATTTTAAATTTCA
GCAAATAATATAATTTGCATTTAAGAGATGACAGTTGCAAAGTGGTGTGAGGCAAAGGCAGATG
GATTTCTGAGTGCCAAGGCCAGCCTGTTCTACAACGTGAGTTCCAAGACATCCAGGGCTACAAA
GAGAAACCCTGTACTGCCAAAAAGCCAAAGCCAAAAAAAAAAAAAAAGAGTGAGGGAGGACAAT
TATAGTCATCATTGGTTTTTCTTTCAAGACCAGGCACATAGCATAACGAGGGTCTTTTACCACA
CAGGACAATCTGCCATTATTTCCCTTATTTAAAAAGTCCACCTGTGCTTCTCAAACTGTTGGCC
CTGTGGCCACAGCAGTGCAGAAATGAGGAGAGACTAGAATAGAATGGTTGCAAAGTTATCCTCT
GAGGTAAGTGCTTATATTAAGAACTTTAATAAGCTATACATATAAAAAAAATTCTGAGACAAGG
TTTTATATTTCCCAGGCTGGCCTTGAATTCACTTTGTAGCCCAGACTCAAACTCACACAGTGAT
GATCTCTCAGCTGTTTCTGATCTAGGGTTACAAACATAGGCCACCACTCCCATAACCATGCTTG
TGTCTTTAAATTCTCTATTAGCTACATTCCAAAAAGACAATATGAAATTAATGATAACATATTT
TAATCCAGTATACATGTATTATTACATCAAAACTTGAATTAATGTCATAATTTGAATCTATTTT
GTACTGTTTCTAAATTAGCAGTCTAGGCACTTTACATCGGGTGGTCACGAGCCGCATTAAGCCA
GGGGTTCCTATGGTAGGCACACTGGTCTAGCCTAGAGCACTTTTCTTCTGAGCAAAGTGGGACT
TGAGTTTCTACGGTCAGATCTGGGCTGATTTAGTTTTCTGCATTGGTAAGTTGGTGAGCAGCTA
AGATACAAATGTGTAGAAATAAAAATCCTGGCTACTCCTAGACATGACATGGGTTGTCTTAGAG
AAGTGATCTGCATTATTCCTTGAAAGTAACACTTCCTTAGGCATTACCAAATTGTGTGTGTACT
GGTCAGAGTCCAGCTTATCCACATTTGGCTCTGAAAACCTGACTGCACCCCAGTTTCCTGAGTA
CTGCCAGAGAGCAAACAGAATTTCCACTTAGCAGAAATTACTGTGGGCCCACCGTGCATCACCA
CTGAGCAGCCTATATACAGAATCCAGTCTCTAAAAACTGGACTAAGCTGGACATCATCCTCACA
TTGCAAGCAAACTTTCTAGAAGCCTCCTGGAAAGTACAGTTGTATGATGGGTATGTTATGATGG
CGGTGATGGAAATAAACTCACGCCTGGCATTTGTGAAGATTCATAGAAGGAACTGGTCCACACT
GCCACTGACAGATTTTTTTAAAAAAAAAAGACTTTTGGAAATTTTTACATGCTGATTTTAGAAT
AATATCCTACAGTCATTCTACTGGCAGATTTATAGACAAGGAGAAGCTTGCCTTTTAAAGGGAC
CTCAATTGTATACCATTTGATATTTTGTAATGTAGAGAGTTCAGCATTTTTTTATTGGCTGTTT
CCAGCATCATACGCAAGGTTGCTAACTGTGAGCTCCCCACAAGTTAAAGCTTCCAAAGAGCCAC
TGTATTTCCTGGTTCAGTTTTTATTACATAGAAGCAGTTGGTTGCATTTCAAATTGGAAAAAGA
AAAGAAACGCCAGAAAAGGCAACACACTTCTACTTTAAGATTGCTCTTACAAAGCCAAATAAAA
AATGATTTTAAAAGAGGTCATCAATGTGAATTAGCACCAGGCTCATACACAGAACGGTCACTTG
CAGGAGTTTGATGCCATTGTGTGATTGCGAAGTCCTCCATCTGGCTGTCGAGGTTTATTTGAGA
CAGCACAAAGTTTCCAGACATTACTTATGTAATGAGATTTGTAATATCTTTGTAATTACTGTCC
ATTAGGTCATGCTCCAATTTCCTTAATGTTTCTCACTGATAAATTTTTGATCAGCATCATTTCT
GACATTTGAGCACTTTCCGGTGGATCACGGCTGAAGGTTGGATCTCGTGCCAGCAGTGTTTGTT
TTAATGTGCAAATATAGTTCTGTGTTAGTGTTTATAGCCACAGGATGAAATGTACAAAATTTTC
TACCTAAAAGCTGTAAGACATTGTACTTTCTTATAAAAAGATGGCTCTCTAGTTTCTTGAAAGT
GAAGGGAGGAAAGAGGAGGGAGACAGAAGCGGGTGGGGATACATAACACACCCAGTGCCTTCTT
TGCATTCAAAGACAAGCTTCTGTCATTCTTCTTTGGGAATACCACCTGAGATCAAATGATGTAG
ACCCAGTCCACATTACATAAGTTTTTCACTTACCTTGGGAAGCAGTAGCAGACAATTTATAATT
GTTAAAATCAATGCTCATAAGTGATCTGTGATGGATTCAGAAAGGCTCGAGTATCTGTTCCAAG
GCATCTGGTCCAGGAGTTTACTGAGGTCAGTAAATTTACTGAGGTCAAAACCTTGCCATGGAAC
CAGACTTCCTGACAATATGGCAGGAATGAGCTTCAAAGATCTCCAGCCTCTGACCCAGTTAGAC
TCTAAAATGTACAGCTCTCCCATGCTCTGCGGGACTGAATGATCTTTAAATTCTGTATTGTTCT
TGACCAATGGTAGGAAAAGGATATTCTGCCAATCACGTTTCTTTGTGTTGGCGTCCCCAACTTG
TCCCAAGTCAGGGTTTTGTTTTATCCATCCAGACAGCAGCCTGTCTCACTTTGGAATGTGGGAC
ATTCCATACTAGCGAGAACAGGTTCTTGTTGCCTCAGGTAGAAGCACTGATGAGCAATCCTAAG
AATGTAAAATCACACTGTTCCTAATTATTCTCATTGTATTTGAAGACTGACTTGAAAGACCCAC
AGATACAGATATTTATATCCAGGCTAATAATTGCTTTGATTCATTATGTTGAAAATGACAGATA
TTTAATCTCCAGTCAGATTGAATAATCTTATTTTCCACCTAAAAGGTTACTTCAGGATACTCAA
ATACAGTAAGCTTCACCACTTTGAAGCTGTTTACTGAAGCTCTCTCCAAATTCCGATAGTTATG
GATGATAAAAATCTTCTAGATGTGTGTTTCTCCTGTCTTTGAAACACGGAGAATATATTTTATA
TATGACACAAGTATGGCCATAATATGAAAATTATGATCACATGGTGCCTCCTTTTAACCTGACC
TGTTTTGTATGCCTGGTCAACTAACTGTATATTAGTGTAACTAATATACAATTGTATTGGTTAC
TAAATACCATACCCATGACTGATGTCTCTTCTGGCCATGACAGTTTTATGACCACTTATAAACC
CATTTTCTAAATGTTACGTTCTTTGGTTGAAATGGCATAGATGTAGTCTGTCATTCTACATTCA
ACAGATACTGCTTTTCCCCTTAAAGTCTGTAAACATGAGTTTTGTGAAGTGACTCGAGTACAGA
CAAATCCAGTGACTGAAAGTTACAAACAAACGGGCTATCAGAGTGATGTTTTAAGTTAATAATC
ATACCAGTTTGTATTCTAATTATTTTTTATGTATCTCTAGTCATTAAAATACATATAAGCTCTA
GGTTTCTTTGATATGATAAATACCATAACCAAAAACAATGTGGAAGAGGAAAAGGTCTATTTTA
TGTCAGTGGCTCCAATCTGTCCTGAGGAAAGGCCACAGCAAGAACAGAGGACAGGCACCTGGAG
GCAGAATGTGGTACAGAGCGCACAGGGAACACTTTCCTGGCTTGCTTCTCCAGTGTGCTCAGCT
CTCACAGTCCAGGCCCCCTGCCTATGGATGGTACTGCCCACAGTGGGCTGAACCCTCACACCAA
TTAGTAATCAAGGAAACGCCAAACAGCAAAACTCAAAGGTCAGTCTGATCAAGACCGTCTCTAA
TCGAGGCTCCCTCATACCATTTGGGGCTATGCCAAGCTGACATCTGACGCCAACTAGGACATAT
AAAACTACATACATGTAAAGAGCTAACTAGGACATATAAAACTACATACATGTGAAGACTTTTC
CCCACAGGGTTCTCCAAATAACTAAATTTAAATCTCAAAAAAGAAAAAGTTTTTAGGACTCAGG
CAAACTATAGCTAAAAGAGCAAATCTTAATTAAGGACTTAGATTACTATCATAATTAACTCACA
ATTTTTTATTGTAATGGTCAGACTCATTTTTTTTGGTTTGGTTTTTGTTTTTGTTTTTTGTTGT
TTGTCTATTTGCAAGCTACCAGAATAGCACTGAATATTTTCAATAGAGACAATATAATCTATAT
CACCTAAAATGTCTATCTGGCCCTTTATAGAGAAAACAAAACTCAGATTTTCATTGTACCTCAT
GCTTTGCAATGACCTTTAGGAATCCCTTTTCCACACTGTAGCCTTTTTTTCCCCTTTAGTTAGT
TTCTCTTATTTGCTTCTTGGAAGTTAGGTGAGCTTTGTTTCATGTTGCAAATGGTCTCCCAACA
ATTGTGTAGGAAGCAAAAACTAAAATTTCCATGTAGAACAGAAAATGCCAAGTTCCGTTATTTC
TGAAGAAGGAAATGAGTTAAAGATGGATGCTCTGACTCCTCATTGTCTGAACGTGCTTTACAAA
CATGAATTAAACAGAAAACCCCCACTGACTTTGACTCGTGTAAAAGTAGTGCCCTATGCTTAAC
AAGCTTCAGATGAGCACTGCCGCCTCAGGACCTCTAAATGCAAGGAAGCAACTTCCAGCAATTA
GATTTCACTCATGTTTAGGAAGTGCTGTGTTCTATGAAAATGACTTGCTTGCCAACATTCCAGG
GAACACAGCCACCTTTAATTTTAAAAGCTACTGTTCTTTTTCCGTGTTTCTCTGAGTGTTGTAG
CTCTCATGCGAAACGAGCCTTCAGTACATGGTTTTCTAGCAAATTTAGAAACCCAAGAAAAGCC
CTCTAATCTATTTCTACCTTAACAAATTACCCATTCCAAAATATCTGCCTTAAGGGAACCACGT
AGCCCAGTTACTGAGGGAACTTTAGACATTTGTGACTTTCGTTTCAGTTTGACTGTCAACTTTG
TAACCACAAAGGTCACAGATGAGTAGGAGACCTTTGCCAGCTATCATTAGGAATAGCTACAATG
ACTGGCATATTCTTTTCTTGAAACAGTTGCAGCAATCAGTGAGATGGTCTAGTCCCTGGGATGT
TACAGACTATGACAACAAATGACAGAAGTCATTCTTCATTGGAGGTAGTTATTGATAAACTTCA
AAACTTAAAATGAGATGAAAATTAATATCTACTTTTCCTTTTAGAAATTAAATGGCTTAGAGGA
TATTTGGCCTATGTGGAAAGCCACCTTTAAGGGCATGATTCATTAACAACGAAAGCTTCCCAGA
AACAGACCATTCCAGCAACTCTTTTCCCATAGTACATTTTTCCTGATGAGCCCTTACTCGCAAT
AGAGGAGCCAGGAATAAAGTAAACGCAGCTCTGCCCTACAGGAGGAGACATTTTGGTTGGAAAG
AAAAGGCAAGTAAGTACACCCAACCTGTGCTAGATACCTGCAGGCGGCAAGCTCTCCATGTAGG
AAAGGGGACAACGGTCTCCTGCCAAAAATGTGCAAGGGAAGCTTCATGGGAACACAGCAAATGC
TGAAGGATGCACCAATCTTTAAGGATAAGGCAGAGAGAACAGGCACGTTGACTAAGGAATGGCC
AGGCCAGGGTGGAGGTGCACACATCAAGGAGTTAACAATGAGAAGAACTGAGGTACCCAGGGAA
GTGTTATGGAGTGTGGAGCGGTCTCAGATCTCCTCTGAGTTCCTTGCTTTCTTATTCTGGACAG
ACGCAGGCGAAGCCTCTCTTCAGAGCACTAACCCCTGCTACTTAACCCAGCCTCCTGGTACATA
TCCGACAGGATAAATAGCGCCCAGTGTATCGAAGACATGTTTGCAAGTCTACAGCTAATCTTCA
GACCTCAAGTTGGTCCTGCCAGGTTTTTAATTCTTCATTGCCCAGTGTATATAATCTACAGGTT
TATAATTATGAATTATATAAAATCTAAAGAATTTGTTATATCTCTTCTCTGAGGCACTATTTTT
CCATTCATCTTCAAGACGCCTTTTTAAAATTGCCCATTAGAATTAGGTTACACTGTGACTACTC
TGGCTTGTACATCTCTGTTTATTTCTCCTGACATTTGTGGATAGTGGATGAGTTACATTACTCC
GGGATGAATGAAATGAGGAGAGCTAGAGACAAAGACTGGATCTCAGTTGAGAGGGGCAAAGATG
CTAAGAAATAAAAATGCTATCAGAACACAGAGCAGGTTAGTGGACACTAAGACAAAAAGACGGG
CTATGACGGGTTTTCTGGCTTAGATGGCATTATCTGAGACATTCTTGTTGAGACTGTATCAGAT
ATGAAATCTACATCGATGGGTGTTGAAAGCTTTTTGGATTAATGGGTCATAAGTAGCTTCAATA
ACAACATGGAGGAGTATAATACAAAAGAAACCCAGATTCCCAGTAGTCTGGATCACAAGGCATT
AGCCCAAAGCACGAGCTTGTGTGACTTGGAGGAGAAAGTCTTAAGTACCTTAATTTACACAGCT
AAGACTGTGGTTGGCTTTTTCACTGTCTAACACAAAATCCTAAGAGGGAGCTGTGAACATTTCA
TTTTCTAAATGTGTCAAAATGGTGCTATTGATTCCTTAATACAAAGACAGAATTATAATATTTT
TAGGTAAGTTGTTAAGCCCGGCTTGGCTATAAGTGTAAATACATAAAATGTTTGCAAAGCATCC
AACATGACCACGCCCATTTGTAAACAGTTGAGGTACTGTGTTCTTCAATGTTCTTCAGGCACTG
ACCTGAGCTCAAATTTTCTATTAAGAGAACAGGACAGCCATTGGCTCTCTATCAACTGCCAAAA
CCGCCCACCTTCGACAGCTCACTAAGTTCTCCTTGGATGCAGGTTGGACAATCCAATTCAAGAG
TTAAGTAGGCTCCTTTGGTGATAGTAGGGGTGTTGGCCAAGGACTTGAAGGATGTGTGCTGTGA
GCAAAGCCAATGCTGCCAGACTGACTTTAGTGAGGGCCAATGTAACTGAGTTCACCTAGACTGT
CAGAACATGCCAAACAAAGGTACTCGGTACCTTGCAATTGGTCAATCTGTAAAAGAATCTGCAT
GTACAGTGTGACAATAAATCGTCTAAGAGCCCA

hide sequence

RefSeq Acc Id:

XM_039096574 ⟹ XP_038952502

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	25,039,484 - 25,076,054 (+)	NCBI
mRatBN7.2	18	24,764,902 - 24,811,918 (+)	NCBI

RefSeq Acc Id:

XM_063277096 ⟹ XP_063133166

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	24,861,332 - 25,076,054 (+)	NCBI

RefSeq Acc Id:

XM_063277097 ⟹ XP_063133167

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	24,861,942 - 25,076,054 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_036859	(Get FASTA)	NCBI Sequence Viewer
	XP_006254585	(Get FASTA)	NCBI Sequence Viewer
	XP_038952502	(Get FASTA)	NCBI Sequence Viewer
	XP_063133166	(Get FASTA)	NCBI Sequence Viewer
	XP_063133167	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA17443	(Get FASTA)	NCBI Sequence Viewer
	AAA40845	(Get FASTA)	NCBI Sequence Viewer
	AAA40856	(Get FASTA)	NCBI Sequence Viewer
	AAA40865	(Get FASTA)	NCBI Sequence Viewer
	AAA40990	(Get FASTA)	NCBI Sequence Viewer
	AAA41867	(Get FASTA)	NCBI Sequence Viewer
	AAB28372	(Get FASTA)	NCBI Sequence Viewer
	AAI28707	(Get FASTA)	NCBI Sequence Viewer
	CAA63029	(Get FASTA)	NCBI Sequence Viewer
	EDL76194	(Get FASTA)	NCBI Sequence Viewer
	EDL76195	(Get FASTA)	NCBI Sequence Viewer
	EDL76196	(Get FASTA)	NCBI Sequence Viewer
	EDL76197	(Get FASTA)	NCBI Sequence Viewer
	EDL76198	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027771.4
	ENSRNOP00000072926.2
	ENSRNOP00055033117
	ENSRNOP00060041214
	ENSRNOP00065015582
GenBank Protein	P13234	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036859 ⟸ NM_012727

- UniProtKB:

A1A5L5 (UniProtKB/Swiss-Prot), Q63892 (UniProtKB/Swiss-Prot), P13234 (UniProtKB/Swiss-Prot), A6J2R5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLKVTVPSCPSSPCSSVTSSTENLVPDYWIDGSKRDPLSDFFEVESELGRGATSIVYRCKQKGT
QKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVE
KGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQV
LMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYY
FISPWWDEVSLNAKDLVKKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARR
KLKAAVKAVVASSRLGSASSSHTNIQESNKASSEAQPAQDGKDKTDPLENKMQAGDHEAAKAAA
DETMKLQSEEVEEEEGVKEEEEEEEEEEETSRMVPQEPEDRLETDDQEMKRNSEETLKSVEEEM
DPKAEEEAAAVGLGVPPQQDAILPEY

hide sequence

RefSeq Acc Id:	XP_006254585 ⟸ XM_006254523
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2UQP4 (UniProtKB/TrEMBL), A6J2R2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSCAGNDQAAASGSSSGSGGIFRSPAAKMLKVTVPSCPSSPCSSVTSSTENLVPDYWIDGSKRD PLSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKL KEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPE NLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITY ILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKLIVLDPKKRLTTFQALQ HPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHTNIQESNKASSEAQ PAQDGKDKTDPLENKMQAGDHEAAKAAADETMKLQSEEVEEEEGVKEEEEEEEEEEETSRMVPQ EPEDRLETDDQEMKRNSEETLKSVEEEMDPKAEEEAAAVGLGVPPQQDAILPEY hide sequence

RefSeq Acc Id:

ENSRNOP00000072926 ⟸ ENSRNOT00000078822

RefSeq Acc Id:

ENSRNOP00000027771 ⟸ ENSRNOT00000027771

RefSeq Acc Id:	XP_038952502 ⟸ XM_039096574
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063133166 ⟸ XM_063277096
- Peptide Label:	isoform X1
- UniProtKB:	A6J2R3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133167 ⟸ XM_063277097
- Peptide Label:	isoform X4

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P13234-F1-model_v2	AlphaFold	P13234	1-474	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700694

Promoter ID:

EPDNEW_R11212

Type:

multiple initiation site

Name:

Camk4_1

Description:

calcium/calmodulin-dependent protein kinase IV

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	25,962,844 - 25,962,904	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2264	AgrOrtholog
BioCyc Gene	G2FUF-8003	BioCyc
Ensembl Genes	ENSRNOG00000020478	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055023745	UniProtKB/Swiss-Prot
	ENSRNOG00060028383	UniProtKB/Swiss-Prot
	ENSRNOG00065012456	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000027771.5	UniProtKB/Swiss-Prot
	ENSRNOT00000078822.2	UniProtKB/TrEMBL
	ENSRNOT00055040773	UniProtKB/Swiss-Prot
	ENSRNOT00060049398	UniProtKB/Swiss-Prot
	ENSRNOT00065020284	UniProtKB/Swiss-Prot
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7455982	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25050	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:156504	IMAGE-MGC_LOAD
NCBI Gene	25050	ENTREZGENE
PANTHER	CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE IV	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Camk4	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020478	RatGTEx
	ENSRNOG00055023745	RatGTEx
	ENSRNOG00060028383	RatGTEx
	ENSRNOG00065012456	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC206301
UniProt	A0A8L2UQP4	ENTREZGENE, UniProtKB/TrEMBL
	A1A5L5	ENTREZGENE
	A6J2R2	ENTREZGENE, UniProtKB/TrEMBL
	A6J2R3	ENTREZGENE, UniProtKB/TrEMBL
	A6J2R5	ENTREZGENE, UniProtKB/TrEMBL
	A6J2R6_RAT	UniProtKB/TrEMBL
	KCC4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q63892	ENTREZGENE
UniProt Secondary	A1A5L5	UniProtKB/Swiss-Prot
	Q63892	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-11-06	Camk4	calcium/calmodulin-dependent protein kinase IV		Calmodulin-dependent protein kinase IV	Name updated	625702	APPROVED
2002-06-10	Camk4	Calmodulin-dependent protein kinase IV			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	is enriched in the granule cells of the cerebellum	634691
gene_expression	expressed in T-lymphocytes, granule cells of the cerebellum and meiotic male germ cells	634692
gene_function	monomeric multifunctional enzyme	634692
gene_function	phosphorylates synapsin I	634691
gene_process	involved in neuronal Ca2+ signaling	634691
gene_transcript	alternative splicing of the gene appears to produce calspermin protein transcript	634692
gene_transcript	alternative splicing of the gene appears to produce calspermin protein transcript	1299832

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)