Pik3c3 (phosphatidylinositol 3-kinase, catalytic subunit type 3) - Rat Genome Database

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Gene: Pik3c3 (phosphatidylinositol 3-kinase, catalytic subunit type 3) Rattus norvegicus
Analyze
Symbol: Pik3c3
Name: phosphatidylinositol 3-kinase, catalytic subunit type 3
RGD ID: 620899
Description: Exhibits 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including autophagosome assembly; phosphatidylinositol-mediated signaling; and response to leucine. Predicted to localize to several cellular components, including autolysosome; cytoplasmic vesicle; and phosphatidylinositol 3-kinase complex, class III. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3); PARTICIPATES IN autophagy pathway; inositol metabolic pathway; phosphoinositide metabolic pathway; INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: catalytic phosphatidylinositol 3-kinase 3; phosphatidylinositol 3-kinase; phosphatidylinositol 3-kinase catalytic subunit type 3; phosphoinositide-3-kinase, class 3; PI-3K Vps34p; PI3-kinase type 3; PI3K type 3; ptdIns-3-kinase type 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21821,845,282 - 21,934,387 (+)NCBI
Rnor_6.0 Ensembl1822,964,210 - 23,047,895 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01822,964,121 - 23,047,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01822,694,862 - 22,778,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41822,495,197 - 22,579,656 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11822,521,842 - 22,606,301 (+)NCBI
Celera1821,624,416 - 21,707,267 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
calciol  (ISO)
carmustine  (ISO)
CCCP  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cypermethrin  (ISO)
deoxycholic acid  (ISO)
Deoxyschizandrin  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
diquat  (ISO)
emodin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
flurbiprofen  (ISO)
furan  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gossypetin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nefazodone  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phlorizin  (ISO)
pioglitazone  (ISO)
procyanidin B2  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
topotecan  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
1. Campos-Toimil M, etal., Curr Biol 2002 Feb 5;12(3):211-5.
2. Carbott DE, etal., Apoptosis 2002 Feb;7(1):69-76.
3. Eskelinen EL, etal., Traffic. 2002 Dec;3(12):878-93.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Haller D, etal., J Biol Chem 2002 Oct 11;277(41):38168-78.
6. Hunyady L, etal., J Cell Biol 2002 Jun 24;157(7):1211-22.
7. Irani C, etal., Am J Physiol Lung Cell Mol Physiol 2002 Apr;282(4):L854-62.
8. Ito N, etal., J Biol Chem 2002 Nov 22;277(47):44898-904.
9. Kamei T, etal., Mol Endocrinol 2002 Jul;16(7):1469-81.
10. KEGG
11. MacKenzie MG, etal., J Physiol. 2009 Jan 15;587(Pt 1):253-60. Epub 2008 Nov 17.
12. MGD data from the GO Consortium
13. NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Pipeline to import KEGG annotations from KEGG into RGD
15. Pipeline to import SMPDB annotations from SMPDB into RGD
16. RGD automated data pipeline
17. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. RGD automated import pipeline for gene-chemical interactions
19. RGD comprehensive gene curation
20. Row PE, etal., Biochem J 2001 Feb 1;353(Pt 3):655-61.
21. Silfani TN and Freeman EJ, Arch Biochem Biophys 2002 Jun 1;402(1):84-93.
22. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Sun GW, etal., Endocrinology 2003 Mar;144(3):793-801.
24. Tu VC, etal., J Pharmacol Exp Ther 2002 Mar;300(3):1101-10.
25. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
26. Yu C, etal., J Biol Chem 2002 Dec 27;277(52):50230-6.
Additional References at PubMed
PMID:12198247   PMID:12242025   PMID:12373512   PMID:12444071   PMID:12540590   PMID:12581861   PMID:12610654   PMID:12624428   PMID:12683952   PMID:12730091   PMID:12754199   PMID:12761242  
PMID:12766174   PMID:12789537   PMID:12816756   PMID:12829832   PMID:12876381   PMID:12880866   PMID:14563664   PMID:14578357   PMID:14617358   PMID:14645111   PMID:14670845   PMID:14742297  
PMID:14993194   PMID:14993225   PMID:14999001   PMID:15006556   PMID:15010863   PMID:15385613   PMID:15489334   PMID:15613677   PMID:15701816   PMID:15880264   PMID:15964902   PMID:16046456  
PMID:16095815   PMID:16533525   PMID:16648180   PMID:16682826   PMID:17241518   PMID:17393104   PMID:17437535   PMID:18040895   PMID:18716370   PMID:18777595   PMID:19946888   PMID:20208530  
PMID:20643123   PMID:22098068   PMID:22493499   PMID:23332761   PMID:24098492   PMID:25046113   PMID:25327288   PMID:25578879   PMID:27021411  


Genomics

Comparative Map Data
Pik3c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21821,845,282 - 21,934,387 (+)NCBI
Rnor_6.0 Ensembl1822,964,210 - 23,047,895 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01822,964,121 - 23,047,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01822,694,862 - 22,778,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41822,495,197 - 22,579,656 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11822,521,842 - 22,606,301 (+)NCBI
Celera1821,624,416 - 21,707,267 (+)NCBICelera
Cytogenetic Map18p12NCBI
PIK3C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1841,955,234 - 42,087,830 (+)EnsemblGRCh38hg38GRCh38
GRCh381841,955,226 - 42,087,830 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371839,535,199 - 39,667,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361837,789,197 - 37,915,446 (+)NCBINCBI36hg18NCBI36
Build 341837,789,196 - 37,915,442NCBI
Celera1836,343,751 - 36,469,999 (+)NCBI
Cytogenetic Map18q12.3NCBI
HuRef1836,394,067 - 36,520,574 (+)NCBIHuRef
CHM1_11839,462,179 - 39,588,448 (+)NCBICHM1_1
Pik3c3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391830,390,441 - 30,481,179 (+)NCBIGRCm39mm39
GRCm39 Ensembl1830,405,800 - 30,481,179 (+)Ensembl
GRCm381830,265,615 - 30,348,126 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1830,272,747 - 30,348,126 (+)EnsemblGRCm38mm10GRCm38
MGSCv371830,432,550 - 30,507,774 (+)NCBIGRCm37mm9NCBIm37
MGSCv361830,415,906 - 30,491,130 (+)NCBImm8
Celera1830,744,294 - 30,819,480 (+)NCBICelera
Cytogenetic Map18B1NCBI
Pik3c3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540228,081,098 - 28,196,252 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540228,081,150 - 28,195,305 (+)NCBIChiLan1.0ChiLan1.0
PIK3C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11838,754,789 - 38,882,042 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1838,754,789 - 38,882,037 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01835,203,896 - 35,336,512 (+)NCBIMhudiblu_PPA_v0panPan3
PIK3C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1748,663,381 - 48,800,350 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl748,663,381 - 48,800,437 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha748,073,292 - 48,210,175 (-)NCBI
ROS_Cfam_1.0748,617,615 - 48,754,695 (-)NCBI
UMICH_Zoey_3.1748,315,599 - 48,452,309 (-)NCBI
UNSW_CanFamBas_1.0748,357,572 - 48,494,156 (-)NCBI
UU_Cfam_GSD_1.0748,638,915 - 48,775,800 (-)NCBI
Pik3c3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494444,700,595 - 44,818,119 (-)NCBI
SpeTri2.0NW_0049365174,009,938 - 4,145,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6125,890,708 - 126,043,161 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16125,890,598 - 126,038,753 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26117,947,967 - 118,097,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3C3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11838,785,476 - 38,914,279 (-)NCBI
ChlSab1.1 Ensembl1838,787,717 - 38,914,185 (-)Ensembl
Vero_WHO_p1.0NW_02366605013,268,474 - 13,404,235 (-)NCBI
Pik3c3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477916,307,875 - 16,435,567 (+)NCBI

Position Markers
RH140704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21821,928,725 - 21,928,934 (+)MAPPER
Rnor_6.01823,047,568 - 23,047,776NCBIRnor6.0
Rnor_5.01822,778,300 - 22,778,508UniSTSRnor5.0
RGSC_v3.41822,579,328 - 22,579,536UniSTSRGSC3.4
Celera1821,706,939 - 21,707,147UniSTS
RH 3.4 Map18265.3UniSTS
Cytogenetic Map18p12UniSTS
BF388154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21821,908,980 - 21,909,136 (+)MAPPER
Rnor_6.01823,027,823 - 23,027,978NCBIRnor6.0
Rnor_5.01822,758,555 - 22,758,710UniSTSRnor5.0
RGSC_v3.41822,559,583 - 22,559,738UniSTSRGSC3.4
Celera1821,687,187 - 21,687,342UniSTS
RH 3.4 Map18264.2UniSTS
Cytogenetic Map18p12UniSTS
AU048898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21821,846,977 - 21,847,232 (+)MAPPER
Rnor_6.01822,965,826 - 22,966,080NCBIRnor6.0
Rnor_5.01822,696,558 - 22,696,812UniSTSRnor5.0
RGSC_v3.41822,496,813 - 22,497,067UniSTSRGSC3.4
Celera1821,626,032 - 21,626,286UniSTS
Cytogenetic Map18p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125999214Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125999214Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135097280Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18138195967Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18138195967Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18138753381Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18247709623184414Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18247709623184414Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18371954732487870Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18440751362570466Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18543013441781619Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181467885259678852Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181553296332704022Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181553296332704022Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181553942725961165Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181553942732670473Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181553942753861431Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181553942761499684Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181553955127743236Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181553955127743236Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181553955127743236Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181553955127743236Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181553955127743236Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181553955127743236Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181553955127743236Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181553967129530300Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181553967161985648Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181569587268524999Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181569587287080053Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181569587287080053Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181903103068436105Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181925171732670473Rat
1331735Rf44Renal function QTL 442.981total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181925171732670473Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)182028575887080053Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142163949166639491Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182260373687074531Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182260476461985648Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:131
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000066816
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 10 37 21 19 21 2 3 74 35 36 11 2
Low 33 20 20 20 6 8 5 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066816   ⟹   ENSRNOP00000060791
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1822,964,210 - 23,047,895 (+)Ensembl
RefSeq Acc Id: NM_022958   ⟹   NP_075247
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21821,845,362 - 21,929,054 (+)NCBI
Rnor_6.01822,964,210 - 23,047,896 (+)NCBI
Rnor_5.01822,694,862 - 22,778,628 (+)NCBI
RGSC_v3.41822,495,197 - 22,579,656 (+)RGD
Celera1821,624,416 - 21,707,267 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254488   ⟹   XP_006254550
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21821,845,299 - 21,934,387 (+)NCBI
Rnor_6.01822,964,121 - 23,047,891 (+)NCBI
Rnor_5.01822,694,862 - 22,778,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097083   ⟹   XP_038953011
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21821,845,282 - 21,911,713 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_075247   ⟸   NM_022958
- UniProtKB: O88763 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006254550   ⟸   XM_006254488
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000060791   ⟸   ENSRNOT00000066816
RefSeq Acc Id: XP_038953011   ⟸   XM_039097083
- Peptide Label: isoform X2
Protein Domains
C2 PI3K-type   PI3K/PI4K   PIK helical

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700670
Promoter ID:EPDNEW_R11194
Type:initiation region
Name:Pik3c3_1
Description:phosphatidylinositol 3-kinase, catalytic subunit type 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01822,964,176 - 22,964,236EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620899 AgrOrtholog
Ensembl Genes ENSRNOG00000017840 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000060791 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000066816 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot
  1.25.40.70 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5597998 IMAGE-MGC_LOAD
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_CS UniProtKB/Swiss-Prot
  PI3K_accessory_sf UniProtKB/Swiss-Prot
  PI3K_C2_dom UniProtKB/Swiss-Prot
  PI3K_Vps34 UniProtKB/Swiss-Prot
  PI_Kinase UniProtKB/Swiss-Prot
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
KEGG Report rno:65052 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72433 IMAGE-MGC_LOAD
NCBI Gene 65052 ENTREZGENE
PANTHER PTHR10048 UniProtKB/Swiss-Prot
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
PhenoGen Pik3c3 PhenoGen
PIRSF PI3K_Vps34 UniProtKB/Swiss-Prot
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PIK_HELICAL UniProtKB/Swiss-Prot
SMART PI3K_C2 UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
  PI3Kc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt O88763 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Pik3c3  phosphatidylinositol 3-kinase, catalytic subunit type 3  Pik3c3  phosphoinositide-3-kinase, class 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pik3c3  phosphoinositide-3-kinase, class 3    phosphatidylinositol 3-kinase  Name updated 1299863 APPROVED
2002-08-07 Pik3c3  phosphatidylinositol 3-kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs inhibitors act on one transport step 628447
gene_process helps in the delivery of newly synthesized lysosomal hydrolases to lysosomes 628447