Pik3c3 (phosphatidylinositol 3-kinase, catalytic subunit type 3) - Rat Genome Database

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Gene: Pik3c3 (phosphatidylinositol 3-kinase, catalytic subunit type 3) Rattus norvegicus
Analyze
Symbol: Pik3c3
Name: phosphatidylinositol 3-kinase, catalytic subunit type 3
RGD ID: 620899
Description: Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including autophagosome assembly; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and response to leucine. Predicted to be located in several cellular components, including autolysosome; cytoplasmic vesicle; and midbody. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in several cellular components, including endosome; peroxisome; and phagophore assembly site. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3); PARTICIPATES IN phosphatidylinositol 3-kinase signaling pathway; autophagy pathway; inositol metabolic pathway; INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3-methyladenine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: catalytic phosphatidylinositol 3-kinase 3; phosphatidylinositol 3-kinase; phosphatidylinositol 3-kinase catalytic subunit type 3; phosphoinositide-3-kinase, class 3; PI-3K Vps34p; PI3-kinase type 3; PI3K type 3; ptdIns-3-kinase type 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21821,845,282 - 21,934,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1821,845,295 - 21,929,048 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1821,980,005 - 22,057,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01822,758,425 - 22,836,045 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01822,068,675 - 22,152,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01822,964,121 - 23,047,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1822,964,210 - 23,047,895 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01822,694,862 - 22,778,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41822,495,197 - 22,579,656 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11822,521,842 - 22,606,301 (+)NCBI
Celera1821,624,416 - 21,707,267 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
carmustine  (ISO)
CCCP  (ISO)
celecoxib  (ISO)
ceritinib  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cypermethrin  (ISO)
deoxycholic acid  (ISO)
Deoxyschizandrin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
diquat  (ISO)
emodin  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
flurbiprofen  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gossypetin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mirtazapine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nefazodone  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phlorizin  (ISO)
pioglitazone  (ISO)
procyanidin B2  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Two modes of secretion in pancreatic acinar cells: involvement of phosphatidylinositol 3-kinase and regulation by capacitative Ca(2+) entry. Campos-Toimil M, etal., Curr Biol 2002 Feb 5;12(3):211-5.
2. Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. Carbott DE, etal., Apoptosis 2002 Feb;7(1):69-76.
3. Inhibition of autophagy in mitotic animal cells. Eskelinen EL, etal., Traffic. 2002 Dec;3(12):878-93.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines. Haller D, etal., J Biol Chem 2002 Oct 11;277(41):38168-78.
6. Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor. Hunyady L, etal., J Cell Biol 2002 Jun 24;157(7):1211-22.
7. Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration. Irani C, etal., Am J Physiol Lung Cell Mol Physiol 2002 Apr;282(4):L854-62.
8. Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. Ito N, etal., J Biol Chem 2002 Nov 22;277(47):44898-904.
9. The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells. Kamei T, etal., Mol Endocrinol 2002 Jul;16(7):1469-81.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. mVps34 is activated following high-resistance contractions. MacKenzie MG, etal., J Physiol. 2009 Jan 15;587(Pt 1):253-60. Epub 2008 Nov 17.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation. Row PE, etal., Biochem J 2001 Feb 1;353(Pt 3):655-61.
21. Phosphatidylinositide 3-kinase regulates angiotensin II-induced cytosolic phospholipase A2 activity and growth in vascular smooth muscle cells. Silfani TN and Freeman EJ, Arch Biochem Biophys 2002 Jun 1;402(1):84-93.
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells. Sun GW, etal., Endocrinology 2003 Mar;144(3):793-801.
24. Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase. Tu VC, etal., J Pharmacol Exp Ther 2002 Mar;300(3):1101-10.
25. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
26. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. Yu C, etal., J Biol Chem 2002 Dec 27;277(52):50230-6.
Additional References at PubMed
PMID:12198247   PMID:12242025   PMID:12373512   PMID:12444071   PMID:12540590   PMID:12581861   PMID:12610654   PMID:12624428   PMID:12683952   PMID:12730091   PMID:12754199   PMID:12761242  
PMID:12766174   PMID:12789537   PMID:12816756   PMID:12829832   PMID:12876381   PMID:12880866   PMID:14563664   PMID:14578357   PMID:14617358   PMID:14645111   PMID:14670845   PMID:14742297  
PMID:14993194   PMID:14993225   PMID:14999001   PMID:15006556   PMID:15010863   PMID:15385613   PMID:15489334   PMID:15613677   PMID:15701816   PMID:15880264   PMID:15964902   PMID:16046456  
PMID:16095815   PMID:16533525   PMID:16648180   PMID:16682826   PMID:17241518   PMID:17393104   PMID:17437535   PMID:18040895   PMID:18716370   PMID:18777595   PMID:19946888   PMID:20208530  
PMID:20643123   PMID:22098068   PMID:22493499   PMID:23332761   PMID:24098492   PMID:25046113   PMID:25327288   PMID:25578879   PMID:27021411  


Genomics

Comparative Map Data
Pik3c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21821,845,282 - 21,934,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1821,845,295 - 21,929,048 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1821,980,005 - 22,057,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01822,758,425 - 22,836,045 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01822,068,675 - 22,152,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01822,964,121 - 23,047,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1822,964,210 - 23,047,895 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01822,694,862 - 22,778,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41822,495,197 - 22,579,656 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11822,521,842 - 22,606,301 (+)NCBI
Celera1821,624,416 - 21,707,267 (+)NCBICelera
Cytogenetic Map18p12NCBI
PIK3C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381841,955,234 - 42,087,830 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1841,955,234 - 42,087,830 (+)EnsemblGRCh38hg38GRCh38
GRCh371839,535,199 - 39,667,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361837,789,197 - 37,915,446 (+)NCBINCBI36Build 36hg18NCBI36
Build 341837,789,196 - 37,915,442NCBI
Celera1836,343,751 - 36,469,999 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
HuRef1836,394,067 - 36,520,574 (+)NCBIHuRef
CHM1_11839,462,215 - 39,588,448 (+)NCBICHM1_1
T2T-CHM13v2.01842,146,975 - 42,279,510 (+)NCBIT2T-CHM13v2.0
Pik3c3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391830,390,441 - 30,481,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1830,405,800 - 30,481,179 (+)EnsemblGRCm39 Ensembl
GRCm381830,265,615 - 30,348,126 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1830,272,747 - 30,348,126 (+)EnsemblGRCm38mm10GRCm38
MGSCv371830,432,550 - 30,507,774 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361830,415,906 - 30,491,130 (+)NCBIMGSCv36mm8
Celera1830,744,294 - 30,819,480 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.41NCBI
Pik3c3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540228,081,098 - 28,196,252 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540228,081,150 - 28,195,305 (+)NCBIChiLan1.0ChiLan1.0
PIK3C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11845,039,112 - 45,168,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01835,203,896 - 35,336,512 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11838,754,789 - 38,882,042 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1838,754,789 - 38,882,037 (+)Ensemblpanpan1.1panPan2
PIK3C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1748,663,381 - 48,800,350 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl748,663,381 - 48,800,437 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha748,073,292 - 48,210,175 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0748,617,615 - 48,754,695 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl748,614,671 - 48,754,703 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1748,315,599 - 48,452,309 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0748,357,572 - 48,494,156 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0748,638,915 - 48,775,800 (-)NCBIUU_Cfam_GSD_1.0
Pik3c3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494444,700,595 - 44,818,119 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365174,033,247 - 4,145,422 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365174,009,938 - 4,145,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6125,890,712 - 126,043,157 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16125,890,598 - 126,038,753 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26117,947,967 - 118,097,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3C3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11838,785,476 - 38,914,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1838,787,717 - 38,914,185 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605013,268,474 - 13,404,235 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3c3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477916,307,800 - 16,434,169 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477916,307,875 - 16,435,567 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3c3
714 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:131
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000066816
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat

Markers in Region
RH140704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21821,928,725 - 21,928,934 (+)MAPPERmRatBN7.2
Rnor_6.01823,047,568 - 23,047,776NCBIRnor6.0
Rnor_5.01822,778,300 - 22,778,508UniSTSRnor5.0
RGSC_v3.41822,579,328 - 22,579,536UniSTSRGSC3.4
Celera1821,706,939 - 21,707,147UniSTS
RH 3.4 Map18265.3UniSTS
Cytogenetic Map18p12UniSTS
BF388154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21821,908,980 - 21,909,136 (+)MAPPERmRatBN7.2
Rnor_6.01823,027,823 - 23,027,978NCBIRnor6.0
Rnor_5.01822,758,555 - 22,758,710UniSTSRnor5.0
RGSC_v3.41822,559,583 - 22,559,738UniSTSRGSC3.4
Celera1821,687,187 - 21,687,342UniSTS
RH 3.4 Map18264.2UniSTS
Cytogenetic Map18p12UniSTS
AU048898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21821,846,977 - 21,847,232 (+)MAPPERmRatBN7.2
Rnor_6.01822,965,826 - 22,966,080NCBIRnor6.0
Rnor_5.01822,696,558 - 22,696,812UniSTSRnor5.0
RGSC_v3.41822,496,813 - 22,497,067UniSTSRGSC3.4
Celera1821,626,032 - 21,626,286UniSTS
Cytogenetic Map18p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 10 37 21 19 21 2 3 74 35 36 11 2
Low 33 20 20 20 6 8 5 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066816   ⟹   ENSRNOP00000060791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1821,845,295 - 21,929,048 (+)Ensembl
Rnor_6.0 Ensembl1822,964,210 - 23,047,895 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106926   ⟹   ENSRNOP00000080772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1821,845,295 - 21,912,097 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109777   ⟹   ENSRNOP00000092703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1821,845,295 - 21,856,369 (+)Ensembl
RefSeq Acc Id: NM_022958   ⟹   NP_075247
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21821,845,362 - 21,929,054 (+)NCBI
Rnor_6.01822,964,210 - 23,047,896 (+)NCBI
Rnor_5.01822,694,862 - 22,778,628 (+)NCBI
RGSC_v3.41822,495,197 - 22,579,656 (+)RGD
Celera1821,624,416 - 21,707,267 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254488   ⟹   XP_006254550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21821,845,299 - 21,934,387 (+)NCBI
Rnor_6.01822,964,121 - 23,047,891 (+)NCBI
Rnor_5.01822,694,862 - 22,778,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097083   ⟹   XP_038953011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21821,845,282 - 21,911,713 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_075247   ⟸   NM_022958
- UniProtKB: O88763 (UniProtKB/Swiss-Prot),   A6J2N0 (UniProtKB/TrEMBL),   A0A8I5ZQC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254550   ⟸   XM_006254488
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QUD7 (UniProtKB/TrEMBL),   A0A8I5ZQC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060791   ⟸   ENSRNOT00000066816
RefSeq Acc Id: XP_038953011   ⟸   XM_039097083
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092703   ⟸   ENSRNOT00000109777
RefSeq Acc Id: ENSRNOP00000080772   ⟸   ENSRNOT00000106926
Protein Domains
C2 PI3K-type   PI3K/PI4K catalytic   PIK helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88763-F1-model_v2 AlphaFold O88763 1-887 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700670
Promoter ID:EPDNEW_R11194
Type:initiation region
Name:Pik3c3_1
Description:phosphatidylinositol 3-kinase, catalytic subunit type 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01822,964,176 - 22,964,236EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620899 AgrOrtholog
BioCyc Gene G2FUF-8083 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000017840 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066816 ENTREZGENE
  ENSRNOT00000066816.3 UniProtKB/TrEMBL
  ENSRNOT00000106926 ENTREZGENE
  ENSRNOT00000106926.1 UniProtKB/TrEMBL
  ENSRNOT00000109777.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5597998 IMAGE-MGC_LOAD
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K-type_C2_dom UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2_dom UniProtKB/Swiss-Prot
  PI3K_Vps34 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI_Kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
KEGG Report rno:65052 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72433 IMAGE-MGC_LOAD
NCBI Gene 65052 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10048 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pik3c3 PhenoGen
PIRSF PI3K_Vps34 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C2_PI3K UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot
  PIK_HELICAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017840 RatGTEx
SMART PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZQC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AH28_RAT UniProtKB/TrEMBL
  A0A8L2QUD7 ENTREZGENE, UniProtKB/TrEMBL
  A6J2N0 ENTREZGENE, UniProtKB/TrEMBL
  O88763 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Pik3c3  phosphatidylinositol 3-kinase, catalytic subunit type 3  Pik3c3  phosphoinositide-3-kinase, class 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pik3c3  phosphoinositide-3-kinase, class 3    phosphatidylinositol 3-kinase  Name updated 1299863 APPROVED
2002-08-07 Pik3c3  phosphatidylinositol 3-kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs inhibitors act on one transport step 628447
gene_process helps in the delivery of newly synthesized lysosomal hydrolases to lysosomes 628447