Ttr (transthyretin) - Rat Genome Database

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Gene: Ttr (transthyretin) Rattus norvegicus
Analyze
Symbol: Ttr
Name: transthyretin
RGD ID: 3916
Description: Enables hormone binding activity. Predicted to be involved in purine nucleobase metabolic process. Located in extracellular space. Part of protein-containing complex. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome 1; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin); PARTICIPATES IN forkhead class A signaling pathway; retinoic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LR1; prealbumin; prealbumin, amyloidosis type I; Tbpa; Transthyretin (prealbumin amyloidosis type I); Transthyretin (prealbumin, amyloidosis type I); TT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bp46   Scl22  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,216,684 - 12,225,972 (+)NCBIGRCr8
mRatBN7.21811,941,791 - 11,951,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,943,789 - 11,951,008 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1812,139,290 - 12,146,732 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01812,926,943 - 12,934,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01812,198,580 - 12,206,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01815,532,963 - 15,542,180 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,532,963 - 15,540,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01815,307,563 - 15,316,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,406,571 - 12,413,680 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11812,433,216 - 12,440,326 (+)NCBI
Celera1811,951,406 - 11,958,617 (+)NCBICelera
RH 3.4 Map1891.82RGD
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4',5,6'-Hexabromodiphenyl ether  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,5'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetamidofluorene  (ISO)
2-aminoacetyl fluoride  (EXP)
2-bromohexadecanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dibromo-4-hydroxybenzonitrile  (EXP)
3,5-dichlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-chlorobiphenyl  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
8-anilinonaphthalene-1-sulfonic acid  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinol  (ISO)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chloroform  (EXP)
chlorohydrocarbon  (EXP)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (EXP)
DDT  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
diclofenac  (ISO)
dicofol  (EXP)
diethylstilbestrol  (ISO)
diflunisal  (ISO)
diiodine  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
erythromycin estolate  (EXP)
fentin chloride  (EXP)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (EXP)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
glycidol  (EXP)
glyphosate  (EXP)
hexachlorobenzene  (EXP)
hydrazine  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
Mesaconitine  (EXP)
methotrexate  (EXP)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
morphine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
Nonylphenol  (ISO)
olanzapine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phencyclidine  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
T-2 toxin  (ISO)
tafamidis  (ISO)
tamibarotene  (ISO)
terbufos  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachlorohydroquinone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (EXP)
thyroxine  (EXP,ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
urea  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
XAV939  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of tetranectin as a potential biomarker for metastatic oral cancer. Arellano-Garcia ME, etal., Int J Mol Sci. 2010 Sep 2;11(9):3106-21. doi: 10.3390/ijms11093106.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Berry DC and Noy N, Biochim Biophys Acta. 2012 Jan;1821(1):168-76. Epub 2011 Jul 12.
4. Differential post-translational modifications of transthyretin in Alzheimer's disease: a study of the cerebral spinal fluid. Biroccio A, etal., Proteomics. 2006 Apr;6(7):2305-13.
5. Biomarkers for the early detection of relapses in metastatic colorectal cancers. Chereches G, etal., J BUON. 2017 May-Jun;22(3):658-666.
6. Cloning and nucleotide sequencing of transthyretin (prealbumin) cDNA from rat choroid plexus and liver. Duan W, etal., Nucleic Acids Res 1989 May 25;17(10):3979.
7. Heat-shock protein 27: a potential biomarker for hepatocellular carcinoma identified by serum proteome analysis. Feng JT, etal., Proteomics. 2005 Nov;5(17):4581-8. doi: 10.1002/pmic.200401309.
8. Detection of colorectal adenoma and cancer based on transthyretin and C3a-desArg serum levels. Fentz AK, etal., Proteomics Clin Appl. 2007 Jun;1(6):536-44. doi: 10.1002/prca.200600664. Epub 2007 May 14.
9. Structure and expression of the rat transthyretin (prealbumin) gene. Fung WP, etal., J Biol Chem 1988 Jan 5;263(1):480-8.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Hu Z, etal., Exp Ther Med. 2016 Jan;11(1):89-97. doi: 10.3892/etm.2015.2868. Epub 2015 Nov 13.
13. Aberrant proteins in the saliva of patients with oral squamous cell carcinoma. Jessie K, etal., Electrophoresis. 2013 Sep;34(17):2495-502. doi: 10.1002/elps.201300107. Epub 2013 Aug 2.
14. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. A combined biomarker pattern improves the discrimination of lung cancer. Liu L, etal., Biomarkers. 2011 Feb;16(1):20-30. doi: 10.3109/1354750X.2010.521257. Epub 2010 Oct 22.
17. Reduced transthyretin expression in sera of lung cancer. Liu L, etal., Cancer Sci. 2007 Oct;98(10):1617-24. doi: 10.1111/j.1349-7006.2007.00576.x. Epub 2007 Aug 7.
18. Serum levels of variants of transthyretin down-regulation in cholangiocarcinoma. Liu L, etal., J Cell Biochem. 2008 Jun 1;104(3):745-55. doi: 10.1002/jcb.21661.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution. Muziol T, etal., Acta Biochim Pol 2001;48(4):877-84.
21. Comparison of binding interactions of dibromoflavonoids with transthyretin. Muziol T, etal., Acta Biochim Pol. 2001;48(4):885-92.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Novel mutations in transthyretin gene associated with hepatocellular carcinoma. P Katare D, etal., Mol Carcinog. 2018 Jan;57(1):70-77. doi: 10.1002/mc.22732. Epub 2017 Sep 21.
25. A novel transthyretin mutation V32A in a Chinese man with late-onset amyloid polyneuropathy. Pica EC, etal., Muscle Nerve. 2005 Aug;32(2):223-5.
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Early onset aggressive hereditary amyloidosis: report of an Italian family with TTR Arg47 mutation. Salvi F, etal., Neurol Sci. 2005 Jun;26(2):140-2.
31. Clinical significance of serum transthyretin level in patients with hepatocellular carcinoma. Shimura T, etal., ANZ J Surg. 2018 Dec;88(12):1328-1332. doi: 10.1111/ans.14458. Epub 2018 Mar 13.
32. Serum transthyretin level is associated with prognosis of patients with gastric cancer. Shimura T, etal., J Surg Res. 2018 Jul;227:145-150. doi: 10.1016/j.jss.2018.02.035. Epub 2018 Mar 15.
33. Prognostic impact of serum transthyretin in patients with non-small cell lung cancer. Shimura T, etal., Mol Clin Oncol. 2019 Jun;10(6):597-604. doi: 10.3892/mco.2019.1837. Epub 2019 Apr 3.
34. Combined proteomic approach with SELDI-TOF-MS and peptide mass fingerprinting identified the rapid increase of monomeric transthyretin in rat cerebrospinal fluid after transient focal cerebral ischemia. Suzuyama K, etal., Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):44-53.
35. Amyloid formation in rat transthyretin: effect of oxidative stress. Tajiri T, etal., Clin Chim Acta 2002 Sep;323(1-2):129-37.
36. Expression of material mRNA in the hypothalamus and frontal cortex in a rat model of fatal hypothermia. Umehara T, etal., Leg Med (Tokyo). 2011 Jul;13(4):165-70. doi: 10.1016/j.legalmed.2011.01.005. Epub 2011 Mar 5.
37. Immunohistochemical Assessment of Transthyretin Association with Colorectal Adenocarcinoma. Wang B, etal., Clin Lab. 2021 Mar 1;67(3). doi: 10.7754/Clin.Lab.2020.200641.
38. Cloning and analysing the up-regulated expression of transthyretin-related gene (LR1) in rat liver regeneration following short interval successive partial hepatectomy. Xu CS, etal., World J Gastroenterol 2003 Jan;9(1):148-51.
39. Interactions of transthyretin (TTR) and retinol-binding protein (RBP) in the uptake of retinol by primary rat hepatocytes. Yamamoto Y, etal., Exp Cell Res. 1997 Aug 1;234(2):373-8.
40. Muscular amyloid angiopathy with amyloidgenic transthyretin Ser50Ile and Tyr114Cys. Yamashita T, etal., Muscle Nerve. 2005 Jan;31(1):41-5.
41. Serum proteome analysis for profiling protein markers associated with lymph node metastasis in colorectal carcinoma. Zhao L, etal., J Comp Pathol. 2011 Feb-Apr;144(2-3):187-94. doi: 10.1016/j.jcpa.2010.09.001. Epub 2010 Nov 12.
Additional References at PubMed
PMID:873934   PMID:2256922   PMID:3839240   PMID:3922975   PMID:9208931   PMID:9511961   PMID:11995997   PMID:12477932   PMID:15489334   PMID:16502470   PMID:17512093   PMID:18406527  
PMID:18568387   PMID:19103603   PMID:19130215   PMID:19167467   PMID:19602727   PMID:19861125   PMID:20535645   PMID:21147258   PMID:21422279   PMID:21740906   PMID:21777382   PMID:22015466  
PMID:22371232   PMID:23376485   PMID:23533145   PMID:23792159   PMID:23850452   PMID:27068327   PMID:32852783   PMID:35352799   PMID:39039431  


Genomics

Comparative Map Data
Ttr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,216,684 - 12,225,972 (+)NCBIGRCr8
mRatBN7.21811,941,791 - 11,951,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1811,943,789 - 11,951,008 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1812,139,290 - 12,146,732 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01812,926,943 - 12,934,381 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01812,198,580 - 12,206,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01815,532,963 - 15,542,180 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,532,963 - 15,540,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01815,307,563 - 15,316,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,406,571 - 12,413,680 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11812,433,216 - 12,440,326 (+)NCBI
Celera1811,951,406 - 11,958,617 (+)NCBICelera
RH 3.4 Map1891.82RGD
Cytogenetic Map18p12NCBI
TTR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381831,591,877 - 31,598,821 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1831,557,009 - 31,598,833 (+)EnsemblGRCh38hg38GRCh38
GRCh371829,171,840 - 29,178,784 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361827,425,838 - 27,432,781 (+)NCBINCBI36Build 36hg18NCBI36
Build 341827,425,837 - 27,432,781NCBI
Celera1825,978,845 - 25,986,103 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1826,028,609 - 26,035,866 (+)NCBIHuRef
CHM1_11829,099,038 - 29,106,294 (+)NCBICHM1_1
T2T-CHM13v2.01831,782,391 - 31,789,335 (+)NCBIT2T-CHM13v2.0
Ttr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391820,797,266 - 20,807,383 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1820,798,337 - 20,807,378 (+)EnsemblGRCm39 Ensembl
GRCm381820,664,209 - 20,674,326 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1820,665,280 - 20,674,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv371820,823,751 - 20,832,827 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361820,808,423 - 20,817,329 (+)NCBIMGSCv36mm8
Celera1821,160,622 - 21,169,698 (+)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.47NCBI
Ttr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540218,921,274 - 18,928,108 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540218,921,235 - 18,927,976 (+)NCBIChiLan1.0ChiLan1.0
TTR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21748,984,354 - 48,991,368 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11834,676,950 - 34,683,964 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01824,809,707 - 24,816,713 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11828,407,893 - 28,414,960 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1828,407,893 - 28,414,960 (+)Ensemblpanpan1.1panPan2
TTR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1757,940,354 - 57,947,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl757,914,381 - 57,947,058 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha757,377,465 - 57,384,221 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0757,925,488 - 57,932,242 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl757,925,494 - 58,154,308 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1757,602,079 - 57,608,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0757,628,089 - 57,634,838 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0757,917,256 - 57,924,010 (-)NCBIUU_Cfam_GSD_1.0
Ttr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494453,626,908 - 53,633,974 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366821,628,341 - 1,635,566 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366821,628,489 - 1,635,495 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6115,496,326 - 115,503,977 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16115,496,338 - 115,503,974 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26108,123,921 - 108,131,547 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11849,124,302 - 49,131,495 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1849,124,121 - 49,131,399 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605023,774,027 - 23,781,168 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247701,251,716 - 1,262,213 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247701,255,401 - 1,262,019 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ttr
58 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:90
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000022113
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18679125112205285Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18679125112205285Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18679125112205285Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18679125112205285Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18679125112205285Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat

Markers in Region
D18Mit1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,944,299 - 11,944,544 (-)MAPPERmRatBN7.2
Rnor_6.01815,539,427 - 15,539,671NCBIRnor6.0
Rnor_5.01815,314,027 - 15,314,271UniSTSRnor5.0
RGSC_v3.41880,277,473 - 80,277,631RGDRGSC3.4
RGSC_v3.41812,406,975 - 12,407,219UniSTSRGSC3.4
RGSC_v3.11812,433,620 - 12,433,865RGD
Celera1811,951,912 - 11,952,156UniSTS
RH 3.4 Map18134.2UniSTS
RH 3.4 Map18134.2RGD
RH 2.0 Map18760.7RGD
SHRSP x BN Map183.6099RGD
FHH x ACI Map186.08RGD
Cytogenetic Map18pUniSTS
D18Wox7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,944,273 - 11,944,420 (-)MAPPERmRatBN7.2
Rnor_6.01815,539,551 - 15,539,697NCBIRnor6.0
Rnor_5.01815,314,151 - 15,314,297UniSTSRnor5.0
RGSC_v3.41812,406,948 - 12,407,095RGDRGSC3.4
RGSC_v3.41812,406,949 - 12,407,095UniSTSRGSC3.4
RGSC_v3.11812,433,594 - 12,433,741RGD
Celera1811,951,886 - 11,952,032UniSTS
RH 3.4 Map18133.3UniSTS
RH 3.4 Map18133.3RGD
RH 2.0 Map18759.5RGD
Cytogenetic Map18pUniSTS
D18Arb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,942,857 - 11,943,232 (-)MAPPERmRatBN7.2
Rnor_6.01815,540,739 - 15,541,113NCBIRnor6.0
Rnor_5.01815,315,339 - 15,315,713UniSTSRnor5.0
RGSC_v3.41812,405,533 - 12,405,907UniSTSRGSC3.4
Celera1811,950,470 - 11,950,844UniSTS
Cytogenetic Map18pUniSTS
D18Chm93  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,948,906 - 11,949,143 (-)MAPPERmRatBN7.2
Rnor_6.01815,534,828 - 15,535,064NCBIRnor6.0
Rnor_5.01815,309,428 - 15,309,664UniSTSRnor5.0
RGSC_v3.41812,411,582 - 12,411,818UniSTSRGSC3.4
Celera1811,956,523 - 11,956,760UniSTS
Cytogenetic Map18pUniSTS
RH94739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,950,883 - 11,950,985 (-)MAPPERmRatBN7.2
Rnor_6.01815,532,986 - 15,533,087NCBIRnor6.0
Rnor_5.01815,307,586 - 15,307,687UniSTSRnor5.0
RGSC_v3.41812,413,559 - 12,413,660UniSTSRGSC3.4
Celera1811,958,493 - 11,958,594UniSTS
RH 3.4 Map1891.82UniSTS
Cytogenetic Map18pUniSTS
RH124760  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21811,950,757 - 11,950,972 (-)MAPPERmRatBN7.2
Rnor_6.01815,532,999 - 15,533,213NCBIRnor6.0
Rnor_5.01815,307,599 - 15,307,813UniSTSRnor5.0
RGSC_v3.41812,413,433 - 12,413,647UniSTSRGSC3.4
Celera1811,958,367 - 11,958,581UniSTS
Cytogenetic Map18pUniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 10 49 112 89 86 59 19 59 6 207 89 92 45 57 27

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF479660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K03251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K03252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022113   ⟹   ENSRNOP00000022113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1811,943,789 - 11,951,008 (+)Ensembl
Rnor_6.0 Ensembl1815,532,963 - 15,540,177 (-)Ensembl
RefSeq Acc Id: NM_012681   ⟹   NP_036813
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81812,218,758 - 12,225,972 (+)NCBI
mRatBN7.21811,943,794 - 11,951,008 (+)NCBI
Rnor_6.01815,532,963 - 15,540,177 (-)NCBI
Rnor_5.01815,307,563 - 15,316,780 (-)NCBI
RGSC_v3.41812,406,571 - 12,413,680 (+)RGD
Celera1811,951,406 - 11,958,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254457   ⟹   XP_006254519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81812,216,684 - 12,225,972 (+)NCBI
mRatBN7.21811,941,791 - 11,951,008 (+)NCBI
Rnor_6.01815,532,963 - 15,542,180 (-)NCBI
Rnor_5.01815,307,563 - 15,316,780 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036813   ⟸   NM_012681
- Peptide Label: precursor
- UniProtKB: Q547K9 (UniProtKB/Swiss-Prot),   P02767 (UniProtKB/Swiss-Prot),   A6J2G2 (UniProtKB/TrEMBL),   A0A8L2QBL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254519   ⟸   XM_006254457
- Peptide Label: isoform X1
- UniProtKB: Q547K9 (UniProtKB/Swiss-Prot),   P02767 (UniProtKB/Swiss-Prot),   A6J2G2 (UniProtKB/TrEMBL),   A0A8L2QBL5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022113   ⟸   ENSRNOT00000022113
Protein Domains
Transthyretin/hydroxyisourate hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02767-F1-model_v2 AlphaFold P02767 1-147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700657
Promoter ID:EPDNEW_R11180
Type:multiple initiation site
Name:Ttr_1
Description:transthyretin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01815,540,092 - 15,540,152EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3916 AgrOrtholog
BioCyc Gene G2FUF-8222 BioCyc
Ensembl Genes ENSRNOG00000016275 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055018337 UniProtKB/Swiss-Prot
  ENSRNOG00060012581 UniProtKB/Swiss-Prot
  ENSRNOG00065015173 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022113.5 UniProtKB/TrEMBL
  ENSRNOT00055031120 UniProtKB/Swiss-Prot
  ENSRNOT00060021345 UniProtKB/Swiss-Prot
  ENSRNOT00065025132 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7322736 IMAGE-MGC_LOAD
InterPro Thyroxine_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transthyretin/HIU_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transthyretin/HIU_hydrolase_d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transthyretin/HIU_hydrolase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transthyretin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24856 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108737 IMAGE-MGC_LOAD
NCBI Gene 24856 ENTREZGENE
PANTHER PTHR10395 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10395:SF12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Transthyretin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ttr PhenoGen
PRINTS TRNSTHYRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRANSTHYRETIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSTHYRETIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016275 RatGTEx
  ENSRNOG00055018337 RatGTEx
  ENSRNOG00060012581 RatGTEx
  ENSRNOG00065015173 RatGTEx
SMART TR_THY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49472 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QBL5 ENTREZGENE, UniProtKB/TrEMBL
  A6J2G2 ENTREZGENE, UniProtKB/TrEMBL
  A6J2G3_RAT UniProtKB/TrEMBL
  P02767 ENTREZGENE
  Q547K9 ENTREZGENE
  TTHY_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q547K9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ttr  Transthyretin (prealbumin, amyloidosis type I)      Symbol and Name status set to approved 70586 APPROVED