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Gene: TTR (transthyretin) Homo sapiens
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Symbol: TTR
Name: transthyretin
Description: Exhibits identical protein binding activity. Predicted to be involved in purine nucleobase metabolic process. Localizes to the extracellular exosome. Implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATTR; carpal tunnel syndrome 1; CTS; CTS1; epididymis luminal protein 111; HEL111; HsT2651; PALB; prealbumin, amyloidosis type I; TBPA; thyroxine-binding prealbumin; transthyretin (prealbumin, amyloidosis type I)
Orthologs:
Mus musculus (house mouse) : Ttr (transthyretin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ttr (transthyretin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ttr (transthyretin)
Pan paniscus (bonobo/pygmy chimpanzee) : TTR (transthyretin)
Canis lupus familiaris (dog) : TTR (transthyretin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ttr (transthyretin)
Sus scrofa (pig) : TTR (transthyretin)
Chlorocebus sabaeus (African green monkey) : TTR (transthyretin)
Heterocephalus glaber (naked mole-rat) : Ttr (transthyretin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1831,557,010 - 31,599,021 (+)EnsemblGRCh38hg38GRCh38
GRCh381831,591,877 - 31,598,821 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371829,171,730 - 29,178,987 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361827,425,838 - 27,432,781 (+)NCBINCBI36hg18NCBI36
Build 341827,425,837 - 27,432,781NCBI
Celera1825,978,845 - 25,986,103 (+)NCBI
Cytogenetic Map18q12.1NCBI
HuRef1826,028,609 - 26,035,866 (+)NCBIHuRef
CHM1_11829,099,038 - 29,106,294 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TTR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737331
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.