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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737331
Species: Homo sapiens
RGD Object: Gene
Symbol: TTR
Name: transthyretin
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TTRaffects expressionISOTtr (Rattus norvegicus)6480464CTDpirinixic acid affects the expression of TTR proteinPMID:16099942
TTRdecreases expressionISOTtr (Mus musculus)6480464CTDpirinixic acid results in decreased expression of TTR mRNAPMID:15302862 PMID:16221962 PMID:16985257 PMID:20059764 PMID:20813756
TTRmultiple interactionsISOTtr (Mus musculus)6480464CTD[pirinixic acid co-treated with PPARA] results in decreased expression of TTR mRNA; PPARA protein promotes the reaction [pirinixic acid results in decreased expression of TTR mRNA]PMID:20059764 PMID:20813756
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