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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737331
Species: Homo sapiens
RGD Object: Gene
Symbol: TTR
Name: transthyretin
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TTRaffects bindingEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether analog binds to TTR proteinPMID:20804816
TTRmultiple interactionsEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether analog inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]PMID:16601080
TTRaffects bindingISOTtr (Rattus norvegicus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether binds to TTR protein; 2,2',4,4'-tetrabromodiphenyl ether metabolite binds to TTR proteinPMID:18161906
TTRdecreases expressionISOTtr (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TTR mRNAPMID:17964624
TTRmultiple interactionsISOTtr (Rattus norvegicus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine binds to TTR protein]; 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [Thyroxine binds to TTR protein]PMID:18161906
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