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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737331
Species: Homo sapiens
RGD Object: Gene
Symbol: TTR
Name: transthyretin
Acc ID: CHEBI:78538
Term: tafamidis
Definition: A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.
Chemical ID: MESH:C547076
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TTRmultiple interactionsEXP 6480464CTDtafamidis promotes the reaction [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]; tafamidis results in increased stability of [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]PMID:25595224 PMID:27093678
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