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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ttr
Name: transthyretin
Acc ID: CHEBI:33217
Term: 3,3',5,5'-tetrabromobisphenol A
Definition: A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID: MESH:C020806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ttrincreases expressionEXP 6480464CTDtetrabromobisphenol A results in increased expression of TTR mRNAPMID:26988606
Ttraffects bindingISOTTR (Homo sapiens)6480464CTDtetrabromobisphenol A analog binds to TTR protein; tetrabromobisphenol A binds to TTR proteinPMID:10869457 PMID:27093678 PMID:33095664
Ttrmultiple interactionsISOTTR (Homo sapiens)6480464CTDtetrabromobisphenol A inhibits the reaction [Thyroxine binds to TTR protein]; tetrabromobisphenol A results in increased stability of [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]PMID:16478101 PMID:16601080 PMID:27093678 PMID:31077750
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