Atg12 (autophagy related 12) - Rat Genome Database

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Gene: Atg12 (autophagy related 12) Rattus norvegicus
Analyze
Symbol: Atg12
Name: autophagy related 12
RGD ID: 1306306
Description: Predicted to enable protein tag activity. Predicted to contribute to Atg8-family ligase activity. Involved in autophagy. Part of protein-containing complex. Biomarker of metabolic dysfunction-associated steatohepatitis. Orthologous to human ATG12 (autophagy related 12); PARTICIPATES IN autophagy pathway; Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 4-nonylphenol; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: APG12-like; Apg12l; ATG12 autophagy related 12 homolog; ATG12 autophagy related 12 homolog (S. cerevisiae); autophagy 12-like; autophagy 12-like (S. cerevisiae); autophagy-related 12; autophagy-related 12 (yeast); autophagy-related protein 12; LOC361321; MGC125080; ubiquitin-like protein ATG12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,638,841 - 41,649,311 (-)NCBIGRCr8
mRatBN7.21839,452,247 - 39,462,424 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1839,452,191 - 39,462,418 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1841,485,451 - 41,495,628 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01842,187,696 - 42,197,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01839,980,798 - 39,990,975 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01840,721,799 - 40,732,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,721,800 - 40,732,126 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01840,367,826 - 40,378,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41840,933,793 - 40,943,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11840,971,333 - 40,981,496 (-)NCBI
Celera1837,703,672 - 37,713,849 (-)NCBICelera
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
astaxanthin  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
buprofezin  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloramphenicol  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colistin  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
Curcumol  (EXP)
cypermethrin  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
embelin  (ISO)
enniatin  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fingolimod hydrochloride  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
galangin  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (ISO)
gossypetin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ketamine  (EXP)
lanthanum trichloride  (EXP)
lipopolysaccharide  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
Nonidet P-40  (ISO)
oligopeptide  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
procyanidin B2  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (ISO)
thymoquinone  (ISO)
torcetrapib  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition. El-Derany MO and AbdelHamid SG, Biochem Pharmacol. 2021 Aug;190:114624. doi: 10.1016/j.bcp.2021.114624. Epub 2021 May 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Changes in autophagy after traumatic brain injury. Liu CL, etal., J Cereb Blood Flow Metab. 2008 Apr;28(4):674-83. Epub 2007 Dec 5.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. LC3 conjugation system in mammalian autophagy. Tanida I, etal., Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18.
10. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
Additional References at PubMed
PMID:11266458   PMID:12477932   PMID:15489334   PMID:18321988   PMID:20080761   PMID:24954904   PMID:27630106   PMID:33513383   PMID:33673233  


Genomics

Comparative Map Data
Atg12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,638,841 - 41,649,311 (-)NCBIGRCr8
mRatBN7.21839,452,247 - 39,462,424 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1839,452,191 - 39,462,418 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1841,485,451 - 41,495,628 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01842,187,696 - 42,197,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01839,980,798 - 39,990,975 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01840,721,799 - 40,732,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,721,800 - 40,732,126 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01840,367,826 - 40,378,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41840,933,793 - 40,943,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11840,971,333 - 40,981,496 (-)NCBI
Celera1837,703,672 - 37,713,849 (-)NCBICelera
Cytogenetic Map18q11NCBI
ATG12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385115,828,200 - 115,841,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5115,828,200 - 115,841,837 (-)EnsemblGRCh38hg38GRCh38
GRCh375115,163,897 - 115,177,262 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365115,193,714 - 115,205,398 (-)NCBINCBI36Build 36hg18NCBI36
Build 345115,193,713 - 115,205,398NCBI
Celera5111,112,297 - 111,125,961 (-)NCBICelera
Cytogenetic Map5q22.3NCBI
HuRef5110,344,587 - 110,358,250 (-)NCBIHuRef
CHM1_15114,596,527 - 114,610,191 (-)NCBICHM1_1
T2T-CHM13v2.05116,340,597 - 116,353,961 (-)NCBIT2T-CHM13v2.0
Atg12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391846,865,484 - 46,874,683 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1846,863,211 - 46,874,647 (-)EnsemblGRCm39 Ensembl
GRCm381846,732,417 - 46,741,724 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1846,730,144 - 46,741,580 (-)EnsemblGRCm38mm10GRCm38
MGSCv371846,892,071 - 46,901,233 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361846,857,758 - 46,866,888 (-)NCBIMGSCv36mm8
Celera1848,091,663 - 48,100,825 (-)NCBICelera
Cytogenetic Map18CNCBI
cM Map1824.76NCBI
Atg12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540835,607,541 - 35,620,878 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540835,607,541 - 35,620,878 (-)NCBIChiLan1.0ChiLan1.0
ATG12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24111,074,139 - 111,086,535 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15109,227,800 - 109,240,196 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05111,184,617 - 111,196,038 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15116,979,738 - 116,992,288 (-)NCBIpanpan1.1PanPan1.1panPan2
ATG12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1115,531,062 - 5,543,034 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl115,531,759 - 5,542,743 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha115,681,691 - 5,693,659 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0115,522,868 - 5,534,845 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl115,522,246 - 5,534,875 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1115,478,061 - 5,490,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0115,549,224 - 5,561,188 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0115,801,442 - 5,813,410 (-)NCBIUU_Cfam_GSD_1.0
Atg12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213128,299,258 - 128,306,932 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936742999,771 - 1,007,885 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367421,000,029 - 1,007,885 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATG12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2119,941,997 - 119,965,696 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12119,948,443 - 119,965,702 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22124,835,748 - 124,851,487 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATG12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12319,073,545 - 19,087,603 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2319,072,401 - 19,087,625 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603459,321,234 - 59,334,961 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atg12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247336,045,432 - 6,060,784 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247336,046,073 - 6,056,321 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atg12
43 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:421
Count of miRNA genes:236
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000000170
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat

Markers in Region
RH138037  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21839,461,446 - 39,461,595 (+)MAPPERmRatBN7.2
Rnor_6.01840,731,149 - 40,731,297NCBIRnor6.0
Rnor_5.01840,377,176 - 40,377,324UniSTSRnor5.0
RGSC_v3.41840,942,993 - 40,943,141UniSTSRGSC3.4
Celera1837,712,872 - 37,713,020UniSTS
Cytogenetic Map18q11UniSTS
RH129009  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21839,452,286 - 39,452,468 (+)MAPPERmRatBN7.2
Rnor_6.01840,721,839 - 40,722,020NCBIRnor6.0
Rnor_5.01840,367,866 - 40,368,047UniSTSRnor5.0
RGSC_v3.41840,933,833 - 40,934,014UniSTSRGSC3.4
Celera1837,703,712 - 37,703,893UniSTS
Cytogenetic Map18q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000000170   ⟹   ENSRNOP00000000170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1839,452,191 - 39,462,418 (-)Ensembl
Rnor_6.0 Ensembl1840,721,800 - 40,732,126 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116566   ⟹   ENSRNOP00000084125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1839,452,265 - 39,459,517 (-)Ensembl
RefSeq Acc Id: NM_001038495   ⟹   NP_001033584
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81841,638,841 - 41,649,018 (-)NCBI
mRatBN7.21839,452,247 - 39,462,424 (-)NCBI
Rnor_6.01840,721,799 - 40,732,126 (-)NCBI
Rnor_5.01840,367,826 - 40,378,153 (-)NCBI
RGSC_v3.41840,933,793 - 40,943,970 (-)RGD
Celera1837,703,672 - 37,713,849 (-)RGD
Sequence:
RefSeq Acc Id: XM_039096963   ⟹   XP_038952891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81841,638,841 - 41,648,977 (-)NCBI
mRatBN7.21839,452,247 - 39,462,376 (-)NCBI
RefSeq Acc Id: XM_039096964   ⟹   XP_038952892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81841,638,841 - 41,648,977 (-)NCBI
mRatBN7.21839,452,247 - 39,462,376 (-)NCBI
RefSeq Acc Id: XM_063277470   ⟹   XP_063133540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81841,641,733 - 41,649,311 (-)NCBI
RefSeq Acc Id: NP_001033584   ⟸   NM_001038495
- UniProtKB: Q5M9F9 (UniProtKB/Swiss-Prot),   Q2TBJ5 (UniProtKB/Swiss-Prot),   A6IWW9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000170   ⟸   ENSRNOT00000000170
RefSeq Acc Id: XP_038952892   ⟸   XM_039096964
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038952891   ⟸   XM_039096963
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYH3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084125   ⟸   ENSRNOT00000116566
RefSeq Acc Id: XP_063133540   ⟸   XM_063277470
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2TBJ5-F1-model_v2 AlphaFold Q2TBJ5 1-141 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700769
Promoter ID:EPDNEW_R11292
Type:multiple initiation site
Name:Atg12_1
Description:autophagy related 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01840,732,140 - 40,732,200EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306306 AgrOrtholog
BioCyc Gene G2FUF-7621 BioCyc
Ensembl Genes ENSRNOG00000000157 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000170 ENTREZGENE
  ENSRNOT00000000170.6 UniProtKB/Swiss-Prot
  ENSRNOT00000116566.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126298 IMAGE-MGC_LOAD
  IMAGE:7443799 IMAGE-MGC_LOAD
InterPro Atg12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361321 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:125080 IMAGE-MGC_LOAD
  MGC:95084 IMAGE-MGC_LOAD
NCBI Gene 361321 ENTREZGENE
PANTHER PTHR13385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN-LIKE PROTEIN ATG12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam APG12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atg12 PhenoGen
RatGTEx ENSRNOG00000000157 RatGTEx
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZYH3 ENTREZGENE, UniProtKB/TrEMBL
  A6IWW9 ENTREZGENE, UniProtKB/TrEMBL
  ATG12_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5M9F9 ENTREZGENE
UniProt Secondary Q5M9F9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-07 Atg12  autophagy related 12  Atg12  ATG12 autophagy related 12 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Atg12  ATG12 autophagy related 12 homolog (S. cerevisiae)  Atg12  autophagy-related 12 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Atg12  autophagy-related 12 (yeast)  Apg12l  autophagy 12-like (S. cerevisiae)  Symbol and Name updated 1299863 APPROVED
2005-12-06 Apg12l  autophagy 12-like (S. cerevisiae)  Apg12l_predicted  autophagy 12-like (S. cerevisiae) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Apg12l_predicted  autophagy 12-like (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED