RGD Reference Report - Mammalian autophagy: core molecular machinery and signaling regulation. - Rat Genome Database

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Mammalian autophagy: core molecular machinery and signaling regulation.

Authors: Yang, Z  Klionsky, DJ 
Citation: Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
RGD ID: 4889529
Pubmed: PMID:20034776   (View Abstract at PubMed)
PMCID: PMC2854249   (View Article at PubMed Central)
DOI: DOI:10.1016/j.ceb.2009.11.014   (Journal Full-text)

Autophagy, a cellular catabolic pathway, is evolutionarily conserved from yeast to mammals. Central to this process is the formation of autophagosomes, double-membrane vesicles responsible for delivering long-lived proteins and excess or damaged organelle into the lysosome for degradation and reuse of the resulting macromolecules. In addition to the hallmark discovery of core molecular machinery components involved in autophagosome formation, complex signaling cascades controlling autophagy have also begun to emerge, with mTOR as a central but far from exclusive player. Malfunction of autophagy has been linked to a wide range of human pathologies, including cancer, neurodegeneration, and pathogen infection. Here we highlight the recent advances in identifying and understanding the core molecular machinery and signaling pathways that are involved in mammalian autophagy.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
autophagy pathway   TAS 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529; 4889529 RGD 
autophagy pathway   ISOATG10 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOATG12 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOATG13 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOATG14 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOATG16L1 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOATG16L2 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOATG3 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOATG5 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOATG7 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOATG9A (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOATG9B (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOXPNPEP1 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOPIK3C3 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOPIK3R4 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISO4889529; 4889529 RGD 
autophagy pathway   ISORUBCN (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOULK1 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOULK2 (Homo sapiens)4889529; 4889529 RGD 
autophagy pathway   ISOUVRAG (Homo sapiens)4889529; 4889529 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Atg10  (autophagy related 10)
Atg12  (autophagy related 12)
Atg13  (autophagy related 13)
Atg14  (autophagy related 14)
Atg16l1  (autophagy related 16-like 1)
Atg16l2  (autophagy related 16-like 2)
Atg3  (autophagy related 3)
Atg5  (autophagy related 5)
Atg7  (autophagy related 7)
Atg9a  (autophagy related 9A)
Atg9b  (autophagy related 9B)
Becn1  (beclin 1)
Pik3c3  (phosphatidylinositol 3-kinase, catalytic subunit type 3)
Pik3r4  (phosphoinositide-3-kinase, regulatory subunit 4)
Rb1cc1  (RB1-inducible coiled-coil 1)
Rubcn  (rubicon autophagy regulator)
Ulk1  (unc-51 like autophagy activating kinase 1)
Ulk2  (unc-51 like autophagy activating kinase 2)
Uvrag  (UV radiation resistance associated)

Genes (Mus musculus)
Atg10  (autophagy related 10)
Atg12  (autophagy related 12)
Atg13  (autophagy related 13)
Atg14  (autophagy related 14)
Atg16l1  (autophagy related 16 like 1)
Atg16l2  (autophagy related 16 like 2)
Atg3  (autophagy related 3)
Atg5  (autophagy related 5)
Atg7  (autophagy related 7)
Atg9a  (autophagy related 9A)
Atg9b  (autophagy related 9B)
Becn1  (beclin 1, autophagy related)
Pik3c3  (phosphatidylinositol 3-kinase catalytic subunit type 3)
Pik3r4  (phosphoinositide-3-kinase regulatory subunit 4)
Rb1cc1  (RB1-inducible coiled-coil 1)
Rubcn  (RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein)
Ulk1  (unc-51 like kinase 1)
Ulk2  (unc-51 like kinase 2)
Uvrag  (UV radiation resistance associated gene)

Genes (Homo sapiens)
ATG10  (autophagy related 10)
ATG12  (autophagy related 12)
ATG13  (autophagy related 13)
ATG14  (autophagy related 14)
ATG16L1  (autophagy related 16 like 1)
ATG16L2  (autophagy related 16 like 2)
ATG3  (autophagy related 3)
ATG5  (autophagy related 5)
ATG7  (autophagy related 7)
ATG9A  (autophagy related 9A)
ATG9B  (autophagy related 9B)
BECN1  (beclin 1)
PIK3C3  (phosphatidylinositol 3-kinase catalytic subunit type 3)
PIK3R4  (phosphoinositide-3-kinase regulatory subunit 4)
RB1CC1  (RB1 inducible coiled-coil 1)
RUBCN  (rubicon autophagy regulator)
ULK1  (unc-51 like autophagy activating kinase 1)
ULK2  (unc-51 like autophagy activating kinase 2)
UVRAG  (UV radiation resistance associated)


Additional Information