Atg5 (autophagy related 5) - Rat Genome Database

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Gene: Atg5 (autophagy related 5) Rattus norvegicus
Analyze
Symbol: Atg5
Name: autophagy related 5
RGD ID: 1359580
Description: Predicted to contribute to Atg8-family ligase activity. Involved in several processes, including chaperone-mediated autophagy; positive regulation of stress granule assembly; and response to iron(II) ion. Located in axon. Part of protein-containing complex. Is active in glutamatergic synapse. Biomarker of ischemia and metabolic dysfunction-associated steatohepatitis. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Orthologous to human ATG5 (autophagy related 5); PARTICIPATES IN autophagy pathway; Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 3-methyladenine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: APG5 autophagy 5-like; ATG5 autophagy related 5 homolog; ATG5 autophagy related 5 homolog (S. cerevisiae); autophagy protein 5; LOC365601; similar to autophagy 5-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82049,380,835 - 49,471,826 (+)NCBIGRCr8
mRatBN7.22047,798,217 - 47,889,216 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2047,798,290 - 47,889,209 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2049,539,098 - 49,629,485 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02049,188,983 - 49,279,371 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02049,872,609 - 49,962,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02049,301,783 - 49,393,147 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2049,318,308 - 49,393,140 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02050,934,688 - 51,026,125 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42048,273,977 - 48,366,743 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12048,302,673 - 48,395,435 (+)NCBI
Celera2052,117,260 - 52,207,732 (-)NCBICelera
Cytogenetic Map20q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Atg5Ratamyotrophic lateral sclerosis  ISOAtg5 (Mus musculus)11561951mRNA:increased expression:spinal cordRGD 
Atg5RatCardiomegaly treatmentIEP 11561938 RGD 
Atg5Ratischemia  IEP 11561945 RGD 
Atg5Ratmetabolic dysfunction-associated steatohepatitis treatmentIEP 407532640 RGD 
Atg5RatSpinal Cord Injuries  IEP 11553820protein:increased expression:axonRGD 
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Atg5Ratautosomal recessive spinocerebellar ataxia 25  ISOATG5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15981765 more ...
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Atg5Ratanemia  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26568842
Atg5RatChemical and Drug Induced Liver Injury  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22491424
Atg5RatHepatomegaly  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22491424
Atg5RatLethargy  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26568842
Atg5Ratliver cirrhosis  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:33549628
Atg5Ratlymphopenia  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26568842
Atg5RatNecrosis  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20578144
Atg5RatOvarian Neoplasms  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28408137
Atg5RatSpinal Cord Injuries  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29793971
Atg5RatTeratozoospermia  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:37506864
Atg5RatWeight Loss  ISOATG5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26568842
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Atg5Ratsystemic lupus erythematosus  ISSAtg5 (Mus musculus)13592920OMIM:152700 more ...MouseDO 
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Atg5Ratautosomal recessive spinocerebellar ataxia 25  ISOATG5 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Atg5Rat(+)-Tetrandrine increases expressionISOATG5 (Homo sapiens)6480464tetrandrine results in increased expression of ATG5 proteinCTDPMID:26822499
Atg5Rat(+)-Tetrandrine decreases expressionISOATG5 (Homo sapiens)6480464tetrandrine results in decreased expression of ATG5 proteinCTDPMID:25266202
Atg5Rat(-)-citrinin increases expressionISOAtg5 (Mus musculus)6480464Citrinin results in increased expression of ATG5 mRNACTDPMID:22771370
Atg5Rat(-)-epigallocatechin 3-gallate multiple interactionsISOATG5 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATG5 mRNA and TFEB protein affects the reaction [epigallocatechin gallate results in increased expression of ATG5 protein]CTDPMID:22079256 and PMID:39313106
Atg5Rat(-)-epigallocatechin 3-gallate increases expressionISOATG5 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of ATG5 proteinCTDPMID:39313106
Atg5Rat1,2-dimethylhydrazine multiple interactionsISOAtg5 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ATG5 mRNACTDPMID:22206623
Atg5Rat1,2-dimethylhydrazine decreases expressionISOAtg5 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of ATG5 mRNACTDPMID:22206623
Atg5Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOAtg5 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ATG5 mRNACTDPMID:21570461
Atg5Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ATG5 mRNACTDPMID:33387578
Atg5Rat2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one increases expressionISOATG5 (Homo sapiens)6480464buprofezin results in increased expression of ATG5 mRNACTDPMID:36287832
Atg5Rat2-hydroxyethyl methacrylate multiple interactionsISOATG5 (Homo sapiens)64804643-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein] more ...CTDPMID:28184909
Atg5Rat2-hydroxyethyl methacrylate increases expressionISOATG5 (Homo sapiens)6480464hydroxyethyl methacrylate results in increased expression of ATG5 proteinCTDPMID:28184909
Atg5Rat2-hydroxypropanoic acid decreases expressionISOATG5 (Homo sapiens)6480464Lactic Acid results in decreased expression of ATG5 mRNACTDPMID:30851411
Atg5Rat3,3',5-triiodo-L-thyronine increases expressionISOAtg5 (Mus musculus)6480464Triiodothyronine results in increased expression of ATG5 mRNA and Triiodothyronine results in increased expression of ATG5 proteinCTDPMID:30209975
Atg5Rat3,3',5-triiodo-L-thyronine affects response to substanceISOAtg5 (Mus musculus)6480464ATG5 protein affects the susceptibility to TriiodothyronineCTDPMID:30209975
Atg5Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of ATG5 proteinCTDPMID:34915118
Atg5Rat3-hydroxybutyric acid increases abundanceISOATG5 (Homo sapiens)6480464ATG5 protein results in increased abundance of 3-Hydroxybutyric AcidCTDPMID:25943029
Atg5Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOATG5 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ATG5 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of ATG5 mRNACTDPMID:28628672
Atg5Rat3-methyladenine multiple interactionsISOATG5 (Homo sapiens)64804643-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of ATG5 protein] more ...CTDPMID:18818525 more ...
Atg5Rat3-methyladenine increases expressionISOATG5 (Homo sapiens)64804643-methyladenine results in increased expression of ATG5 proteinCTDPMID:32587277

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Biological Process
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Original Reference(s)
Atg5Rataggrephagy involved_inISOAtg5 (Mus musculus)1624291 PMID:22982048RGDPMID:22982048
Atg5Rataggrephagy involved_inIBAMGI:1277186 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Atg5Rataggrephagy involved_inISOATG5 (Homo sapiens)1624291 PMID:22982048RGDPMID:22982048
Atg5Rataggrephagy involved_inIEAUniProtKB:Q99J83 and ensembl:ENSMUSP000000447691600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Rataggrephagy involved_inIEAUniProtKB:Q9H1Y0 and ensembl:ENSP000003580721600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Ratantigen processing and presentation of endogenous antigen acts_upstream_of_or_withinIEAUniProtKB:Q99J83 and ensembl:ENSMUSP000000447691600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Ratantigen processing and presentation of endogenous antigen acts_upstream_of_or_withinISOAtg5 (Mus musculus)1624291MGI:1338803 more ...RGDPMID:23382543
Atg5Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Atg5Ratapoptotic process acts_upstream_ofIEAUniProtKB:Q99J83 and ensembl:ENSMUSP000000447691600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Ratapoptotic process acts_upstream_ofISOAtg5 (Mus musculus)1624291MGI:3050453 more ...RGDPMID:17450150
Atg5Ratautophagosome assembly  IMP 1643189 RGD 
Atg5Ratautophagosome assembly acts_upstream_of_or_withinISOAtg5 (Mus musculus)1624291 PMID:23704209RGDPMID:23704209
Atg5Ratautophagosome assembly involved_inIEAUniProtKB:Q9H1Y0 and ensembl:ENSP000003580721600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Ratautophagosome assembly involved_inISOAtg5 (Mus musculus)1624291 PMID:11266458RGDPMID:11266458
Atg5Ratautophagosome assembly involved_inIEAUniProtKB:Q99J83 and ensembl:ENSMUSP000000447691600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Ratautophagosome assembly involved_inIBAMGI:1277186 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Atg5Ratautophagosome assembly involved_inISOATG5 (Homo sapiens)1624291 PMID:23202584RGDPMID:23202584
Atg5Ratautophagy  IMP 2301217 RGD 
Atg5Ratautophagy involved_inIEAUniProtKB:Q99J83 and ensembl:ENSMUSP000000447691600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Ratautophagy involved_inIEAUniProtKB:Q9H1Y0 and ensembl:ENSP000003580721600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Atg5RatAtg12-Atg5-Atg16 complex part_ofISOATG5 (Homo sapiens)1624291 PMID:23202584RGDPMID:23202584
Atg5RatAtg12-Atg5-Atg16 complex part_ofIBAMGI:1277186 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Atg5RatAtg12-Atg5-Atg16 complex part_ofISOAtg5 (Mus musculus)1624291 PMID:12665549RGDPMID:12665549
Atg5RatAtg12-Atg5-Atg16 complex part_ofIEAUniProtKB:Q9H1Y0 and ensembl:ENSP000003580721600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5RatAtg12-Atg5-Atg16 complex part_ofIEAUniProtKB:Q99J83 and ensembl:ENSMUSP000000447691600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Ratautophagosome located_inISOATG5 (Homo sapiens)1624291 PMID:15292400RGDPMID:15292400
Atg5Ratautophagosome located_inISOAtg5 (Mus musculus)1624291 PMID:11266458RGDPMID:11266458
Atg5Ratautophagosome is_active_inIBAFB:FBgn0029943 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Atg5Ratautophagosome located_inIEAUniProtKB:Q9H1Y0 and ensembl:ENSP000003580721600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Ratautophagosome located_inIEAUniProtKB:Q99J83 and ensembl:ENSMUSP000000447691600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Rataxon  IDA 11553820 RGD 
Atg5Rataxon located_inIEAGO:00989301600115GO_REF:0000108GOCGO_REF:0000108
Atg5Rataxoneme located_inISSUniProtKB:Q99J831600115GO_REF:0000024UniProtGO_REF:0000024
Atg5Rataxoneme located_inISOAtg5 (Mus musculus)1624291 PMID:24089209RGDPMID:24089209
Atg5Rataxoneme located_inIEAUniProtKB:Q99J83 and ensembl:ENSMUSP000000447691600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Ratcytoplasm located_inIEAInterPro:IPR0072391600115GO_REF:0000002InterProGO_REF:0000002
Atg5Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Atg5Ratcytoplasm located_inIEAUniProtKB:Q99J83 and ensembl:ENSMUSP000000447691600115GO_REF:0000107EnsemblGO_REF:0000107
Atg5Ratcytoplasm located_inISOAtg5 (Mus musculus)1624291 PMID:11266458RGDPMID:11266458
Atg5Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function

  

RGD Manual Annotations


  
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Original Reference(s)
Atg5Ratautophagy pathway   IMP 2301217 RGD 
Atg5Ratautophagy pathway   ISOATG5 (Homo sapiens)4889529 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Atg5Ratautophagy pathway   IEA 6907045 KEGGrno:04140
Atg5RatRetinoic acid-inducible gene (RIG) I-like receptor signaling pathway  IEA 6907045 KEGGrno:04622

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#
Reference Title
Reference Citation
1. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Castillo K, etal., Autophagy. 2013 Sep;9(9):1308-20. doi: 10.4161/auto.25188. Epub 2013 Jun 6.
2. Induction of autophagic cell death in the rat brain caused by iron. Chen G, etal., Am J Med Sci. 2013 May;345(5):369-74. doi: 10.1097/MAJ.0b013e318271c031.
3. Cold ischemia-induced autophagy in rat lung tissue. Chen X, etal., Mol Med Rep. 2015 Apr;11(4):2513-9. doi: 10.3892/mmr.2014.2999. Epub 2014 Nov 26.
4. Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition. El-Derany MO and AbdelHamid SG, Biochem Pharmacol. 2021 Aug;190:114624. doi: 10.1016/j.bcp.2021.114624. Epub 2021 May 27.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Jiang M, etal., Am J Pathol. 2010 Mar;176(3):1181-92. doi: 10.2353/ajpath.2010.090594. Epub 2010 Jan 14.
8. Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Kochl R, etal., Traffic. 2006 Feb;7(2):129-45.
9. Changes in autophagy after traumatic brain injury. Liu CL, etal., J Cereb Blood Flow Metab. 2008 Apr;28(4):674-83. Epub 2007 Dec 5.
10. RNA interference may suppress stress granule formation by preventing argonaute 2 recruitment. Lou Q, etal., Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C81-C91. doi: 10.1152/ajpcell.00251.2018. Epub 2018 Nov 7.
11. Glial Cell Line-Derived Neurotrophic Factor Enhances Autophagic Flux in Mouse and Rat Hepatocytes and Protects Against Palmitate Lipotoxicity. Mwangi SM, etal., Hepatology. 2019 Jun;69(6):2455-2470. doi: 10.1002/hep.30541. Epub 2019 Mar 22.
12. Bassoon Controls Presynaptic Autophagy through Atg5. Okerlund ND, etal., Neuron. 2017 Feb 22;93(4):897-913.e7. doi: 10.1016/j.neuron.2017.01.026.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Early and sustained activation of autophagy in degenerating axons after spinal cord injury. Ribas VT, etal., Brain Pathol. 2015 Mar;25(2):157-70. doi: 10.1111/bpa.12170. Epub 2014 Sep 12.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Sirtuin1 and autophagy protect cells from fluoride-induced cell stress. Suzuki M and Bartlett JD, Biochim Biophys Acta. 2014 Feb;1842(2):245-55. doi: 10.1016/j.bbadis.2013.11.023. Epub 2013 Dec 1.
20. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Ulbricht A, etal., Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21.
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PMID:11266458   PMID:15292400   PMID:17450150   PMID:19273585   PMID:19783847   PMID:20190558   PMID:20453062   PMID:20577052   PMID:22496425   PMID:22710871   PMID:22982048   PMID:23093945  
PMID:23382543   PMID:23446737   PMID:23455425   PMID:23704209   PMID:23863932   PMID:23878245   PMID:23918802   PMID:24035364   PMID:24089205   PMID:24089209   PMID:24185898   PMID:24550300  
PMID:24582693   PMID:26251076   PMID:26812546   PMID:28389568   PMID:29241069   PMID:29799519   PMID:30864677   PMID:33831322   PMID:34734681   PMID:34958937   PMID:35927903  



Atg5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82049,380,835 - 49,471,826 (+)NCBIGRCr8
mRatBN7.22047,798,217 - 47,889,216 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2047,798,290 - 47,889,209 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2049,539,098 - 49,629,485 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02049,188,983 - 49,279,371 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02049,872,609 - 49,962,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02049,301,783 - 49,393,147 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2049,318,308 - 49,393,140 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02050,934,688 - 51,026,125 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42048,273,977 - 48,366,743 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12048,302,673 - 48,395,435 (+)NCBI
Celera2052,117,260 - 52,207,732 (-)NCBICelera
Cytogenetic Map20q13NCBI
ATG5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386106,184,476 - 106,325,760 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6106,045,423 - 106,325,791 (-)EnsemblGRCh38hg38GRCh38
GRCh376106,632,351 - 106,773,635 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366106,739,045 - 106,880,388 (-)NCBINCBI36Build 36hg18NCBI36
Build 346106,739,044 - 106,880,359NCBI
Celera6107,253,905 - 107,395,251 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6104,079,375 - 104,220,613 (-)NCBIHuRef
CHM1_16106,894,763 - 107,036,172 (-)NCBICHM1_1
T2T-CHM13v2.06107,360,315 - 107,501,922 (-)NCBIT2T-CHM13v2.0
Atg5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391044,144,325 - 44,240,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1044,144,354 - 44,240,287 (+)EnsemblGRCm39 Ensembl
GRCm381044,268,322 - 44,364,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1044,268,358 - 44,364,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv371043,988,164 - 44,084,097 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361043,956,773 - 44,052,706 (+)NCBIMGSCv36mm8
Celera1045,141,131 - 45,237,099 (+)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1023.24NCBI
Atg5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541131,522,420 - 31,646,827 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541131,501,191 - 31,646,407 (-)NCBIChiLan1.0ChiLan1.0
ATG5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25126,183,703 - 126,346,578 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16124,071,501 - 124,233,849 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06103,997,824 - 104,140,931 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16107,871,201 - 108,027,064 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6107,871,208 - 108,013,807 (-)Ensemblpanpan1.1panPan2
ATG5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11263,565,859 - 63,692,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1263,567,568 - 63,683,485 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1263,353,188 - 63,480,151 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01264,411,072 - 64,538,081 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1264,410,753 - 64,538,102 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11263,770,621 - 63,897,766 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01263,612,694 - 63,739,640 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01263,886,649 - 64,013,653 (-)NCBIUU_Cfam_GSD_1.0
Atg5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494698,484,245 - 98,610,566 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365642,758,598 - 2,885,420 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365642,759,085 - 2,885,394 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATG5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl172,270,799 - 72,520,396 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1172,343,950 - 72,520,402 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ATG5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11367,482,538 - 67,619,201 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1367,482,595 - 67,617,902 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604039,817,584 - 39,954,576 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atg5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478015,987,397 - 16,124,151 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478015,987,483 - 16,124,158 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Atg5
896 total Variants

Predicted Target Of
Summary Value
Count of predictions:467
Count of miRNA genes:245
Interacting mature miRNAs:284
Transcripts:ENSRNOT00000057078
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 9 of 9 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

1 to 9 of 9 rows
C88337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,888,971 - 47,889,178 (+)MAPPERmRatBN7.2
Rnor_6.02049,392,903 - 49,393,109NCBIRnor6.0
Rnor_5.02051,025,881 - 51,026,087UniSTSRnor5.0
RGSC_v3.42048,366,499 - 48,366,705UniSTSRGSC3.4
Celera2052,117,298 - 52,117,504UniSTS
Cytogenetic Map20q13UniSTS
AA859872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,888,177 - 47,888,370 (+)MAPPERmRatBN7.2
Rnor_6.02049,392,109 - 49,392,301NCBIRnor6.0
Rnor_5.02051,025,087 - 51,025,279UniSTSRnor5.0
RGSC_v3.42048,365,705 - 48,365,897UniSTSRGSC3.4
Celera2052,118,106 - 52,118,298UniSTS
RH 3.4 Map20497.9UniSTS
Cytogenetic Map20q13UniSTS
RH127825  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,888,177 - 47,888,368 (+)MAPPERmRatBN7.2
Rnor_6.02049,392,109 - 49,392,299NCBIRnor6.0
Rnor_5.02051,025,087 - 51,025,277UniSTSRnor5.0
RGSC_v3.42048,365,705 - 48,365,895UniSTSRGSC3.4
Celera2052,118,108 - 52,118,298UniSTS
RH 3.4 Map20497.91UniSTS
Cytogenetic Map20q13UniSTS
AW528235  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,816,613 - 47,816,767 (+)MAPPERmRatBN7.2
Rnor_6.02049,319,491 - 49,319,644NCBIRnor6.0
Rnor_5.02050,952,750 - 50,952,903UniSTSRnor5.0
RGSC_v3.42048,292,595 - 48,292,748UniSTSRGSC3.4
Celera2052,189,058 - 52,189,211UniSTS
RH 3.4 Map20497.3UniSTS
Cytogenetic Map20q13UniSTS
AI178683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,889,032 - 47,889,150 (+)MAPPERmRatBN7.2
Rnor_6.02049,392,964 - 49,393,081NCBIRnor6.0
Rnor_5.02051,025,942 - 51,026,059UniSTSRnor5.0
RGSC_v3.42048,366,560 - 48,366,677UniSTSRGSC3.4
Celera2052,117,326 - 52,117,443UniSTS
RH 3.4 Map20498.4UniSTS
Cytogenetic Map20q13UniSTS
AU049869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22047,878,216 - 47,878,400 (+)MAPPERmRatBN7.2
Rnor_6.02049,382,150 - 49,382,329NCBIRnor6.0
Celera2052,127,977 - 52,128,202UniSTS
Cytogenetic Map20q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000057078   ⟹   ENSRNOP00000053910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,815,494 - 47,889,209 (+)Ensembl
Rnor_6.0 Ensembl2049,319,307 - 49,393,140 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080283   ⟹   ENSRNOP00000075339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,798,330 - 47,888,589 (+)Ensembl
Rnor_6.0 Ensembl2049,318,308 - 49,391,940 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101057   ⟹   ENSRNOP00000086278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2047,798,290 - 47,889,209 (+)Ensembl
RefSeq Acc Id: NM_001014250   ⟹   NP_001014272
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82049,380,835 - 49,471,826 (+)NCBI
mRatBN7.22047,798,217 - 47,889,216 (+)NCBI
Rnor_6.02049,301,783 - 49,393,147 (+)NCBI
Rnor_5.02050,934,688 - 51,026,125 (+)NCBI
RGSC_v3.42048,273,977 - 48,366,743 (+)RGD
Celera2052,117,260 - 52,207,732 (-)RGD
Sequence:
RefSeq Acc Id: NM_001399019   ⟹   NP_001385948
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82049,380,835 - 49,471,826 (+)NCBI
mRatBN7.22047,798,217 - 47,889,216 (+)NCBI
RefSeq Acc Id: NM_001399020   ⟹   NP_001385949
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82049,380,835 - 49,471,826 (+)NCBI
mRatBN7.22047,798,217 - 47,889,216 (+)NCBI
RefSeq Acc Id: NM_001399021   ⟹   NP_001385950
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82049,380,835 - 49,471,826 (+)NCBI
mRatBN7.22047,798,217 - 47,889,216 (+)NCBI
1 to 12 of 12 rows
Protein RefSeqs NP_001014272 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385948 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385949 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385950 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83602 (Get FASTA)   NCBI Sequence Viewer  
  CAJ31281 (Get FASTA)   NCBI Sequence Viewer  
  EDL99678 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075339
  ENSRNOP00000075339.2
  ENSRNOP00000086278
  ENSRNOP00000107876
GenBank Protein Q3MQ06 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
RefSeq Acc Id: NP_001014272   ⟸   NM_001014250
- Peptide Label: isoform 1
- UniProtKB: Q5XIS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075339   ⟸   ENSRNOT00000080283
Ensembl Acc Id: ENSRNOP00000053910   ⟸   ENSRNOT00000057078
Ensembl Acc Id: ENSRNOP00000086278   ⟸   ENSRNOT00000101057
RefSeq Acc Id: NP_001385950   ⟸   NM_001399021
- Peptide Label: isoform 3
- UniProtKB: Q3MQ06 (UniProtKB/Swiss-Prot),   A6K6V9 (UniProtKB/TrEMBL),   A0A0G2KAB9 (UniProtKB/TrEMBL)
Autophagy protein ATG5 alpha-helical bundle region   Autophagy protein ATG5 UblA   Autophagy protein ATG5 UblB

Name Modeler Protein Id AA Range Protein Structure
AF-Q3MQ06-F1-model_v2 AlphaFold Q3MQ06 1-275 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-3293 BioCyc
Ensembl Genes ENSRNOG00000000322 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080283 ENTREZGENE
  ENSRNOT00000080283.2 UniProtKB/Swiss-Prot
  ENSRNOT00000101057 ENTREZGENE
  ENSRNOT00000133750 ENTREZGENE
Gene3D-CATH 1.10.246.190 UniProtKB/Swiss-Prot
  3.10.20.620 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133143 IMAGE-MGC_LOAD
InterPro Atg5 UniProtKB/Swiss-Prot
  ATG5_HBR UniProtKB/Swiss-Prot
  Atg5_HR UniProtKB/Swiss-Prot
  ATG5_UblA UniProtKB/Swiss-Prot
  Atg5_UblA_dom UniProtKB/Swiss-Prot
  ATG5_UblB UniProtKB/Swiss-Prot
MGC_CLONE MGC:94348 IMAGE-MGC_LOAD
NCBI Gene 365601 ENTREZGENE
PANTHER AUTOPHAGY PROTEIN 5 UniProtKB/Swiss-Prot
  PTHR13040 UniProtKB/Swiss-Prot
Pfam APG5 UniProtKB/Swiss-Prot
  ATG5_HBR UniProtKB/Swiss-Prot
  ATG5_UblA UniProtKB/Swiss-Prot
PhenoGen Atg5 PhenoGen
RatGTEx ENSRNOG00000000322 RatGTEx
UniProt A0A0G2KAB9 ENTREZGENE, UniProtKB/TrEMBL
  A6K6V9 ENTREZGENE, UniProtKB/TrEMBL
  ATG5_RAT UniProtKB/Swiss-Prot
  D3ZJZ1_RAT UniProtKB/TrEMBL
  Q3MQ06 ENTREZGENE
  Q5XIS0 ENTREZGENE, UniProtKB/TrEMBL
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-07 Atg5  autophagy related 5  Atg5  ATG5 autophagy related 5 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Atg5  ATG5 autophagy related 5 homolog (S. cerevisiae)  Atg5  autophagy related 5 homolog (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-03 Atg5  autophagy related 5 homolog (S. cerevisiae)   LOC365601  similar to autophagy 5-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED