Proc (protein C, inactivator of coagulation factors Va and VIIIa) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Proc (protein C, inactivator of coagulation factors Va and VIIIa) Rattus norvegicus
Symbol: Proc
Name: protein C, inactivator of coagulation factors Va and VIIIa
RGD ID: 3411
Description: Enables oligopeptidase activity and protein self-association. Involved in liver development; negative regulation of blood coagulation; and protein catabolic process. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; central retinal vein occlusion; placental abruption; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa); PARTICIPATES IN coagulation cascade pathway; protease mediated signaling via protease-activated receptor 1; protein C anticoagulant pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
Previously known as: anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; protein C; vitamin K-dependent protein C
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Procm1Mcwi  
Genetic Models: FHH-Procm1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21823,764,367 - 23,774,816 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,764,368 - 23,775,133 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,892,461 - 23,902,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,648,935 - 24,660,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01823,987,447 - 23,997,792 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01824,918,402 - 24,928,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,918,398 - 24,929,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,633,206 - 24,643,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,563,368 - 24,573,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11824,590,014 - 24,600,361 (-)NCBI
Celera1823,516,361 - 23,526,709 (-)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
desogestrel  (ISO)
dextran sulfate  (ISO)
dienogest  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
flutamide  (EXP)
fonofos  (ISO)
furan  (EXP)
genistein  (ISO)
gestodene  (ISO)
glyphosate  (EXP)
heparin  (ISO)
L-ethionine  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP)
methylmercury(1+)  (EXP)
N-nitrosodiethylamine  (EXP)
nitrofen  (EXP)
norethisterone  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinorelbine  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endoplasmic reticulum  (IEA,ISO,ISS)
extracellular space  (IBA,IDA,IEA)
Golgi apparatus  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Anti-protein C antibodies are associated with resistance to endogenous protein C activation and a severe thrombotic phenotype in antiphospholipid syndrome. Arachchillage DR, etal., J Thromb Haemost. 2014 Nov;12(11):1801-9. doi: 10.1111/jth.12722. Epub 2014 Oct 3.
2. FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis. Berg DT, etal., Clin Vaccine Immunol. 2006 Mar;13(3):426-32.
3. Disruption of a binding site for hepatocyte nuclear factor 1 in the protein C gene promoter is associated with hereditary thrombophilia. Berg LP, etal., Hum Mol Genet. 1994 Dec;3(12):2147-52.
4. Comparative effects of recombinant human activated protein C and dexamethasone in experimental septic shock. Bouazza Y, etal., Intensive Care Med. 2011 Nov;37(11):1857-64. doi: 10.1007/s00134-011-2327-9. Epub 2011 Aug 18.
5. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
6. Activated protein C therapy in a rat heat stroke model. Chen CM, etal., Crit Care Med. 2006 Jul;34(7):1960-6.
7. Increase in activated protein C mediates acute traumatic coagulopathy in mice. Chesebro BB, etal., Shock. 2009 Dec;32(6):659-65. doi: 10.1097/SHK.0b013e3181a5a632.
8. The anticoagulant protein C pathway. Dahlback B and Villoutreix BO, FEBS Lett. 2005 Jun 13;579(15):3310-6. Epub 2005 Mar 13.
9. Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial. de Boer JD, etal., Eur Respir J. 2015 Dec;46(6):1636-44. doi: 10.1183/13993003.00459-2015. Epub 2015 Sep 17.
10. Activated protein C rescues the retina from ischemia-induced cell death. Du ZJ, etal., Invest Ophthalmol Vis Sci. 2011 Feb 23;52(2):987-93. doi: 10.1167/iovs.10-5557.
11. The effects of activated protein C and prostacyclin on arterial oxygenation and protein leakage in the lung and the gut under endotoxaemia in the rat. Dubniks M and Grande PO, Acta Anaesthesiol Scand. 2008 Mar;52(3):381-7. doi: 10.1111/j.1399-6576.2007.01532.x. Epub 2008 Jan 16.
12. Protein C, antithrombin, and venous thromboembolism incidence: a prospective population-based study. Folsom AR, etal., Arterioscler Thromb Vasc Biol. 2002 Jun 1;22(6):1018-22.
13. Compound heterozygosity in a family with protein C deficiency illustrating the complexity of the underlying molecular mechanism. Gandrille S, etal., Thromb Haemost. 1993 Nov 15;70(5):747-52.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Distinct functions of activated protein C differentially attenuate acute kidney injury. Gupta A, etal., J Am Soc Nephrol. 2009 Feb;20(2):267-77. doi: 10.1681/ASN.2008030294. Epub 2008 Dec 17.
17. Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis. Heuer JG, etal., Crit Care Med. 2004 Jul;32(7):1570-8.
18. Activated protein C in ischemia-reperfusion injury after experimental lung transplantation. Hirayama S, etal., J Heart Lung Transplant. 2009 Nov;28(11):1180-4. doi: 10.1016/j.healun.2009.06.026. Epub 2009 Sep 26.
19. Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation. Hirose K, etal., Ann Surg. 2000 Aug;232(2):272-80.
20. Activation of protein C during reperfusion in clinical liver transplantation. Ilmakunnas M, etal., Transplantation. 2003 Feb 27;75(4):467-72.
21. Activated protein C reduces stress-induced gastric mucosal injury in rats by inhibiting the endothelial cell injury. Isobe H, etal., J Thromb Haemost. 2004 Feb;2(2):313-20.
22. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. Jalbert LR, etal., J Clin Invest. 1998 Oct 15;102(8):1481-8.
23. Developmental expression of protein C and protein S in the rat. Jamison CS, etal., Thromb Res 1995 Jun 1;78(5):407-19.
24. Activated protein C ameliorates Bacillus anthracis lethal toxin-induced lethal pathogenesis in rats. Kau JH, etal., J Biomed Sci. 2012 Nov 21;19:98. doi: 10.1186/1423-0127-19-98.
25. Distinct frequencies and mutation spectrums of genetic thrombophilia in Korea in comparison with other Asian countries both in patients with thromboembolism and in the general population. Kim HJ, etal., Haematologica. 2014 Mar;99(3):561-9. doi: 10.3324/haematol.2013.092023. Epub 2013 Oct 25.
26. Purification of rabbit, rat and mouse protein C with the use of monoclonal antibody to human protein C, PC01. Kimura M, etal., Thromb Res. 1992 Sep 15;67(6):687-96.
27. Combined occurrence of a heterozygous missense mutation in the protein C gene and allelic exclusion of one protein S allele leading to severe venous thrombosis. Knoll B, etal., Thromb Res. 2001 Jul 1;103(1):3-8.
28. Activated protein C rescues the cochlea from noise-induced hearing loss. Kurioka T, etal., Brain Res. 2014 Oct 2;1583:201-10. doi: 10.1016/j.brainres.2014.07.052. Epub 2014 Aug 7.
29. Activated protein C prevents hepatic ischaemia-reperfusion injury in rats. Kuriyama N, etal., Liver Int. 2009 Feb;29(2):299-307. doi: 10.1111/j.1478-3231.2008.01796.x. Epub 2008 May 26.
30. Splice site mutation in the human protein C gene associated with venous thrombosis: demonstration of exon skipping by ectopic transcript analysis. Lind B, etal., Blood. 1993 Oct 15;82(8):2423-32.
31. Preeclampsia is associated with a reduced response to activated protein C. Lindoff C, etal., Am J Obstet Gynecol. 1997 Feb;176(2):457-60.
32. Compound heterozygous protein C deficiency in a family with venous thrombosis: Identification and in vitro study of p.Asp297His and p.Val420Leu mutations. Liu H, etal., Gene. 2015 May 25;563(1):35-40. doi: 10.1016/j.gene.2015.03.002. Epub 2015 Mar 4.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. MicroRNA expression following activated protein C treatment during septic shock. Moore CC, etal., J Surg Res. 2013 Jun 1;182(1):116-26. doi: 10.1016/j.jss.2012.07.063. Epub 2012 Aug 17.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
37. The cDNA cloning and mRNA expression of rat protein C. Okafuji T, etal., Biochim Biophys Acta 1992 Jul 15;1131(3):329-32.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. Activated protein C improves the severity of severe acute pancreatitis via up-regulating the expressions of endothelial cell protein C receptor and thrombomodulin. Ping C, etal., Dig Dis Sci. 2010 Jun;55(6):1599-609. doi: 10.1007/s10620-009-0909-y. Epub 2009 Aug 13.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. GOA pipeline RGD automated data pipeline
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Intravenous administration of activated protein C in Pseudomonas-induced lung injury: impact on lung fluid balance and the inflammatory response. Robriquet L, etal., Respir Res. 2006 Mar 22;7:41.
45. Hereditary thrombophilia: identification of nonsense and missense mutations in the protein C gene. Romeo G, etal., Proc Natl Acad Sci U S A. 1987 May;84(9):2829-32.
46. Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production. Safdar H, etal., Blood. 2013 May 23;121(21):4413-6. doi: 10.1182/blood-2012-11-465674. Epub 2013 Apr 2.
47. Inhibition of coagulation and inflammation by activated protein C or antithrombin reduces intestinal ischemia/reperfusion injury in rats. Schoots IG, etal., Crit Care Med. 2004 Jun;32(6):1375-83.
48. Homozygosity for R87H missense mutation and for a rare intron 7 DNA variant (7054G --> A) in the PROC genes of three siblings initially classified as heterozygotes for protein C deficiency. Soria JM, etal., Blood Coagul Fibrinolysis. 1996 Jan;7(1):15-23.
49. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
50. Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population. Sun W, etal., Int Orthop. 2006 Jun;30(3):143-6. doi: 10.1007/s00264-005-0067-6. Epub 2006 Mar 18.
51. [Hematological changes and related gene mutation of post-severe acute respiratory syndrome patients with osteonecrosis]. Sun W, etal., Zhonghua Yi Xue Za Zhi. 2006 Feb 21;86(7):442-5.
52. Genetic background analysis of protein C deficiency demonstrates a recurrent mutation associated with venous thrombosis in Chinese population. Tang L, etal., PLoS One. 2012;7(4):e35773. doi: 10.1371/journal.pone.0035773. Epub 2012 Apr 24.
53. Activated protein C attenuates intestinal reperfusion-induced acute lung injury: an experimental study in a rat model. Teke Z, etal., Am J Surg. 2008 Jun;195(6):861-73. doi: 10.1016/j.amjsurg.2007.06.025.
54. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
55. R147W mutation of PROC gene is common in venous thrombotic patients in Taiwanese Chinese. Tsay W and Shen MC, Am J Hematol. 2004 May;76(1):8-13.
56. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Wang Y, etal., Stroke. 2013 Dec;44(12):3529-36. doi: 10.1161/STROKEAHA.113.003350. Epub 2013 Oct 24.
57. Plasma levels of activated protein C-protein C inhibitor complex in patients with hypercoagulable states. Watanabe R, etal., Am J Hematol. 2000 Sep;65(1):35-40.
58. Resistance to activated protein C and the leiden mutation: high prevalence in patients with abruptio placentae. Wiener-Megnagi Z, etal., Am J Obstet Gynecol. 1998 Dec;179(6 Pt 1):1565-7.
59. Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock. Xu J, etal., J Thromb Haemost. 2009 May;7(5):851-6. doi: 10.1111/j.1538-7836.2009.03333.x. Epub 2009 Mar 5.
60. The antithrombotic effect of human activated protein C on He-Ne laser-induced thrombosis in rat mesenteric microvessels. Yamashita T, etal., Thromb Res. 1994 Jul 1;75(1):33-40.
61. Reduced protein C Global assay level in infertile women prior to IVF-ET treatment. Younis JS, etal., J Assist Reprod Genet. 2014 Jan;31(1):101-7. doi: 10.1007/s10815-013-0131-x. Epub 2013 Nov 6.
Additional References at PubMed
PMID:9616155   PMID:12563316   PMID:18620539   PMID:18708911   PMID:19278590   PMID:19931359   PMID:21962741   PMID:22426124   PMID:25651845   PMID:25813362  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21823,764,367 - 23,774,816 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,764,368 - 23,775,133 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,892,461 - 23,902,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,648,935 - 24,660,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01823,987,447 - 23,997,792 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01824,918,402 - 24,928,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,918,398 - 24,929,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,633,206 - 24,643,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,563,368 - 24,573,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11824,590,014 - 24,600,361 (-)NCBI
Celera1823,516,361 - 23,526,709 (-)NCBICelera
Cytogenetic Map18p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382127,418,427 - 127,429,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2127,418,427 - 127,429,242 (+)EnsemblGRCh38hg38GRCh38
GRCh372128,176,003 - 128,186,818 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,892,487 - 127,903,288 (+)NCBINCBI36Build 36hg18NCBI36
Build 342127,892,245 - 127,903,048NCBI
Celera2121,487,217 - 121,498,043 (+)NCBICelera
Cytogenetic Map2q14.3NCBI
HuRef2120,483,060 - 120,493,885 (+)NCBIHuRef
CHM1_12128,180,576 - 128,191,401 (+)NCBICHM1_1
T2T-CHM13v2.02127,853,697 - 127,864,511 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391832,256,179 - 32,272,623 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,256,179 - 32,272,623 (-)EnsemblGRCm39 Ensembl
GRCm381832,123,126 - 32,139,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,123,126 - 32,139,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371832,282,780 - 32,299,224 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,266,137 - 32,278,949 (-)NCBIMGSCv36mm8
Celera1832,604,740 - 32,621,169 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.94NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554593,094,120 - 3,104,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554593,097,229 - 3,105,566 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12B48,225,133 - 48,240,711 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B32,846,899 - 32,859,060 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B128,083,794 - 128,094,625 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B128,083,794 - 128,094,625 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11923,173,626 - 23,183,634 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1923,173,635 - 23,183,563 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1923,421,177 - 23,431,114 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01924,500,225 - 24,510,240 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1924,500,234 - 24,510,166 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11923,203,858 - 23,213,794 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01923,398,248 - 23,408,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01924,530,694 - 24,540,633 (-)NCBIUU_Cfam_GSD_1.0
Dog Cytomap19q21-q22NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530397,765,920 - 97,775,831 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646943,841,989 - 43,850,304 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646943,841,989 - 43,850,322 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1525,043,545 - 25,056,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11525,043,543 - 25,054,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,724,914 - 28,735,638 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1102,789,227 - 2,799,783 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl102,789,277 - 2,799,531 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606119,959,230 - 19,968,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473213,915,402 - 13,923,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473213,915,361 - 13,922,182 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Proc
56 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:53
Interacting mature miRNAs:59
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21823,764,483 - 23,764,688 (+)MAPPERmRatBN7.2
Rnor_6.01824,918,519 - 24,918,723NCBIRnor6.0
Rnor_5.01824,633,323 - 24,633,527UniSTSRnor5.0
RGSC_v3.41824,563,485 - 24,563,689UniSTSRGSC3.4
Celera1823,516,478 - 23,516,682UniSTS
RH 3.4 Map18314.4UniSTS
Cytogenetic Map18p12UniSTS

Genetic Models
This gene Proc is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 41 41 41 9
Low 3 1 3 6 2 2 20 17 10 2
Below cutoff 12 12 13 5 5 35 6 22 1 5


RefSeq Acc Id: ENSRNOT00000019596   ⟹   ENSRNOP00000019596
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1823,764,368 - 23,775,133 (-)Ensembl
Rnor_6.0 Ensembl1824,918,398 - 24,929,091 (-)Ensembl
RefSeq Acc Id: NM_012803   ⟹   NP_036935
Rat AssemblyChrPosition (strand)Source
mRatBN7.21823,764,367 - 23,774,714 (-)NCBI
Rnor_6.01824,918,402 - 24,928,747 (-)NCBI
Rnor_5.01824,633,206 - 24,643,623 (-)NCBI
RGSC_v3.41824,563,368 - 24,573,715 (-)RGD
Celera1823,516,361 - 23,526,709 (-)RGD
RefSeq Acc Id: XM_006254527   ⟹   XP_006254589
Rat AssemblyChrPosition (strand)Source
mRatBN7.21823,764,367 - 23,774,816 (-)NCBI
Rnor_6.01824,918,402 - 24,928,822 (-)NCBI
Rnor_5.01824,633,206 - 24,643,623 (-)NCBI
RefSeq Acc Id: XM_008772018   ⟹   XP_008770240
Rat AssemblyChrPosition (strand)Source
mRatBN7.21823,764,367 - 23,774,616 (-)NCBI
Rnor_6.01824,918,402 - 24,928,383 (-)NCBI
RefSeq Acc Id: NP_036935   ⟸   NM_012803
- Peptide Label: precursor
- UniProtKB: P31394 (UniProtKB/Swiss-Prot),   A6J2Q1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254589   ⟸   XM_006254527
- Peptide Label: isoform X2
- UniProtKB: Q68FY8 (UniProtKB/TrEMBL),   A6J2Q1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770240   ⟸   XM_008772018
- Peptide Label: isoform X1
- UniProtKB: F7FMY6 (UniProtKB/TrEMBL),   A6J2Q1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019596   ⟸   ENSRNOT00000019596
Protein Domains
EGF-like   Gla   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31394-F1-model_v2 AlphaFold P31394 1-461 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700682
Promoter ID:EPDNEW_R11206
Type:multiple initiation site
Description:protein C, inactivator of coagulation factors Va and VIIIa
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01824,928,777 - 24,928,837EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3411 AgrOrtholog
BioCyc Gene G2FUF-8043 BioCyc
Ensembl Genes ENSRNOG00000014376 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019596 ENTREZGENE
  ENSRNOT00000019596.5 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Pept_S1A_FX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25268 UniProtKB/Swiss-Prot
Pfam FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Proc PhenoGen
PIRSF Factor_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014376 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC227906
  P31394 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-27 Proc  protein C, inactivator of coagulation factors Va and VIIIa  Proc  protein C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Proc  Protein C      Symbol and Name status set to approved 70586 APPROVED