Gene: Proc (protein C, inactivator of coagulation factors Va and VIIIa) Rattus norvegicus
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Symbol: Proc
Name: protein C, inactivator of coagulation factors Va and VIIIa
Description: Exhibits oligopeptidase activity and protein self-association. Involved in liver development; negative regulation of blood coagulation; and proteolysis. Localizes to the extracellular space. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; artery disease (multiple); placental abruption; protein C deficiency; and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa); PARTICIPATES IN coagulation cascade pathway; protease mediated signaling via protease-activated receptor 1; protein C anticoagulant pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; protein C; vitamin K-dependent protein C
Orthologs:
Homo sapiens (human) : PROC (protein C, inactivator of coagulation factors Va and VIIIa)  HGNC  Alliance
Mus musculus (house mouse) : Proc (protein C)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Proc (protein C, inactivator of coagulation factors Va and VIIIa)
Pan paniscus (bonobo/pygmy chimpanzee) : PROC (protein C, inactivator of coagulation factors Va and VIIIa)
Canis lupus familiaris (dog) : PROC (protein C, inactivator of coagulation factors Va and VIIIa)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Proc (protein C, inactivator of coagulation factors Va and VIIIa)
Sus scrofa (pig) : PROC (protein C, inactivator of coagulation factors Va and VIIIa)
more info ...
Allele / Splice: Procm1Mcwi  
Genetic Models: FHH-Procm1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01824,918,402 - 24,928,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01824,633,206 - 24,643,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,563,368 - 24,573,715 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11824,590,014 - 24,600,361 (-)NCBI
Celera1823,516,361 - 23,526,709 (-)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

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Genomics

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QTLs in Region (Rnor_6.0)
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Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
  
More on Proc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3411
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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