Gene: Proc (protein C, inactivator of coagulation factors Va and VIIIa) Rattus norvegicus
Analyze
Symbol:
Proc
Name:
protein C, inactivator of coagulation factors Va and VIIIa
Description:
Exhibits oligopeptidase activity and protein self-association. Involved in liver development; negative regulation of blood coagulation; and proteolysis. Localizes to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; artery disease (multiple); placental abruption; protein C deficiency; and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa); PARTICIPATES IN coagulation cascade pathway; protease mediated signaling via protease-activated receptor 1; protein C anticoagulant pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; protein C; vitamin K-dependent protein C
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PROC (protein C, inactivator of coagulation factors Va and VIIIa) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, Treefam
Mus musculus (house mouse):
Proc (protein C) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Proc (protein C, inactivator of coagulation factors Va and VIIIa) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PROC (protein C, inactivator of coagulation factors Va and VIIIa) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PROC (protein C, inactivator of coagulation factors Va and VIIIa) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Proc (protein C, inactivator of coagulation factors Va and VIIIa) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PROC (protein C, inactivator of coagulation factors Va and VIIIa) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PROC (protein C, inactivator of coagulation factors Va and VIIIa) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Proc (protein C, inactivator of coagulation factors Va and VIIIa) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Proc (protein C)
Alliance
DIOPT (PANTHER|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Homo sapiens (human):
PROC (protein C, inactivator of coagulation factors Va and VIIIa)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
proca (protein C (inactivator of coagulation factors Va and VIIIa), a)
Alliance
DIOPT (TreeFam|PhylomeDB)
Allele / Splice:
Procm1Mcwi
Genetic Models:
FHH-Procm1Mcwi
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 18 24,918,402 - 24,928,822 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 18 24,918,398 - 24,929,091 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 18 24,633,206 - 24,643,623 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 18 24,563,368 - 24,573,715 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 18 24,590,014 - 24,600,361 (-) NCBI Celera 18 23,516,361 - 23,526,709 (-) NCBI Celera Cytogenetic Map 18 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
acute kidney failure treatment ISO RGD:737321 11250410 RGD Acute Lung Injury treatment ISO RGD:737321 11100043 associated with Pseudomonas Infections RGD Acute Lung Injury treatment ISO RGD:737321 11250405 associated with Intestinal Reperfusion Injury RGD antiphospholipid syndrome ISO RGD:737321 11099994 RGD asthma treatment ISO RGD:737321 11099992 RGD blood coagulation disease ISO RGD:11161 11100017 RGD central retinal vein occlusion treatment ISO RGD:737321 11100028 RGD disseminated intravascular coagulation ISO RGD:11161 11099993 RGD disseminated intravascular coagulation treatment ISO RGD:737321 11100014 RGD Endotoxemia treatment ISO RGD:737321 11100030 ; 11100034 RGD Experimental Pancreatitis, Acute treatment ISO RGD:737321 11100040 RGD Female Infertility ISO RGD:737321 11099991 RGD Hearing Loss, Noise-Induced treatment ISO RGD:737321 11100045 RGD Heat Stroke treatment ISO RGD:737321 11250411 RGD Intestinal Reperfusion Injury treatment ISO RGD:737321 11250409 RGD Liver Reperfusion Injury ISO RGD:737321 11100021 RGD Liver Reperfusion Injury treatment ISO RGD:737321 11100046 RGD Lung Reperfusion Injury treatment ISO RGD:737321 11100035 RGD middle cerebral artery infarction treatment ISO RGD:11161 11100027 RGD myocardial infarction ISO RGD:737321 11100014 RGD osteonecrosis ISO RGD:737321 30309948 ; 30309951 associated with severe acute respiratory syndrome, protein:decreased expression:plasma (human) RGD placental abruption susceptibility ISO RGD:737321 11564329 RGD pre-eclampsia ISO RGD:737321 11564336 RGD protein C deficiency ISO RGD:737321 11099985 DNA:missense mutation:exon:p.R87H (3203G>A) (human) RGD protein C deficiency ISO RGD:737321 1578392 DNA:missense mutations:cds:p.L223F, p.I403M (human) RGD protein C deficiency ISO RGD:737321 11099984 DNA:missense mutation:exon:p.A259T (8490G>A) (human) RGD pulmonary embolism ISO RGD:737321 11100014 RGD Sepsis disease_progression IEP 11250412 mRNA, protein:decreased expression:liver, plasma RGD Sepsis treatment ISO RGD:737321 11100029 RGD Spinal Cord Reperfusion Injury treatment ISO RGD:737321 11100044 RGD Thromboembolism ISO RGD:737321 1578517 RGD thrombophilia ISO RGD:737321 11099991 associated with Infertility, Female RGD thrombophilia ISO RGD:737321 1578514 DNA:nonsense mutation, missense mutation:cds:p.R306X, p.W402C (human) RGD thrombophilia ISO RGD:737321 1581278 RGD thrombophilia due to activated protein C resistance ISO RGD:737321 11099994 RGD thrombosis treatment ISO RGD:737321 11250413 RGD thrombotic thrombocytopenic purpura ISO RGD:737321 11100014 RGD toxic shock syndrome ISO RGD:11161 11100015 RGD toxic shock syndrome treatment ISO RGD:737321 11100041 RGD Venous Thromboembolism ISO RGD:737321 11099988 ; 11099984 RGD Venous Thrombosis ISO RGD:11161 11035247 RGD Venous Thrombosis ISO RGD:737321 11100014 RGD Venous Thrombosis ISO RGD:737321 1578515 DNA:missense mutation:cds:p.Q184H (human) RGD Venous Thrombosis ISO RGD:737321 1578391 DNA:silent mutation, missense mutation:cds:g.66C>T, p.R147W (human) RGD Venous Thrombosis ISO RGD:737321 11099989 DNA:missense mutations: :p.D297H, p.V420L (human) RGD Venous Thrombosis ISO RGD:737321 11099990 DNA:missense mutation: :c.565C>T (rs146922325) (human) RGD
Imported Annotations - ClinVar
autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:17152060 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:22425321 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:2991887 , PMID:7670104 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:10669160 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:22627591 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:17152060 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:14642106 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:18573519 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:25741868 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:1347608 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:17152060 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:25741868 , PMID:31064749 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:10942114 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:1868249 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:1301954 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:10942114 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:22545135 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:1593215 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:1347608 , PMID:28492532 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:27517348 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:17152060 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:17152060 , PMID:28492532 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:18954896 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:22627591 , PMID:28492532 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:25741868 , PMID:28492532 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:24028705 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:25039884 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:7881411 , PMID:9553065 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:8400292 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:2602169 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:1301954 , PMID:6589623 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:2437584 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:8218861 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:1511989 , PMID:2437584 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:1469096 , PMID:8639775 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:25741868 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:16867987 more ... autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:9683579 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:1301954 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:25637381 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:28492532 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:18954896 , PMID:25741868 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:11380450 , PMID:28492532 autosomal dominant thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal dominant ClinVar PMID:25741868 more ... autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal recessive ClinVar PMID:1347608 more ... autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal recessive ClinVar PMID:25741868 , PMID:31064749 autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal recessive ClinVar PMID:10942114 more ... autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal recessive ClinVar PMID:1347706 more ... autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal recessive ClinVar PMID:25741868 more ... autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal recessive ClinVar PMID:25741868 autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal recessive ClinVar PMID:1593215 more ... autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thrombophilia, hereditary, due to protein C deficiency, autosomal recessive ClinVar PMID:1347608 , PMID:28492532 autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by OMIM:612304 ClinVar PMID:1348046 autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by OMIM:612304 ClinVar PMID:1678832 autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by OMIM:612304 ClinVar PMID:1347608 autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by OMIM:612304 ClinVar PMID:8128429 autosomal recessive thrombophilia due to protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by OMIM:612304 ClinVar PMID:1347706 protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Protein C deficiency ClinVar PMID:25741868 more ... protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Protein C deficiency ClinVar PMID:10942114 more ... protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Protein C deficiency ClinVar PMID:22545135 more ... protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Protein C deficiency ClinVar PMID:1301954 more ... protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Protein C deficiency ClinVar PMID:25741868 , PMID:31064749 protein C deficiency ISO RGD:737321 8554872 ClinVar Annotator: match by term: Protein C deficiency ClinVar PMID:25741868 more ... Thromboembolism ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thromboembolism ClinVar PMID:1868249 more ... Thromboembolism ISO RGD:737321 8554872 ClinVar Annotator: match by term: Thromboembolism ClinVar PMID:25741868 , PMID:31064749 Venous Thrombosis ISO RGD:737321 8554872 ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:17152060 more ... Venous Thrombosis ISO RGD:737321 8554872 ClinVar Annotator: match by term: Deep vein thrombosis ClinVar PMID:25741868 more ... Venous Thrombosis ISO RGD:737321 8554872 ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:17152060 more ... Venous Thrombosis ISO RGD:737321 8554872 ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 , PMID:31064749
Gene-Chemical Interaction Annotations
