PROC (protein C, inactivator of coagulation factors Va and VIIIa) - Rat Genome Database

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Gene: PROC (protein C, inactivator of coagulation factors Va and VIIIa) Sus scrofa
Analyze
Symbol: PROC
Name: protein C, inactivator of coagulation factors Va and VIIIa
RGD ID: 14170678
Description: ENCODES a protein that exhibits oligopeptidase activity (ortholog); peptidase activity (ortholog); protein self-association (ortholog); INVOLVED IN liver development (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of blood coagulation (ortholog); PARTICIPATES IN coagulation cascade pathway; protease mediated signaling via protease-activated receptor 1; protein C anticoagulant pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN endoplasmic reticulum (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; vitamin K-dependent protein C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1525,032,622 - 25,056,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11525,043,543 - 25,054,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,724,914 - 28,735,638 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:11229814  


Genomics

Comparative Map Data
PROC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1525,032,622 - 25,056,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11525,043,543 - 25,054,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,724,914 - 28,735,638 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2127,418,427 - 127,429,242 (+)EnsemblGRCh38hg38GRCh38
GRCh382127,418,143 - 127,429,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372128,176,003 - 128,186,818 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,892,487 - 127,903,288 (+)NCBINCBI36hg18NCBI36
Build 342127,892,245 - 127,903,048NCBI
Celera2121,487,217 - 121,498,043 (+)NCBI
Cytogenetic Map2q14.3NCBI
HuRef2120,483,060 - 120,493,885 (+)NCBIHuRef
CHM1_12128,180,576 - 128,191,401 (+)NCBICHM1_1
Proc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,256,179 - 32,272,623 (-)NCBIGRCm39mm39
GRCm39 Ensembl1832,256,179 - 32,272,623 (-)Ensembl
GRCm381832,123,126 - 32,139,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,123,126 - 32,139,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371832,282,780 - 32,299,224 (-)NCBIGRCm37mm9NCBIm37
MGSCv361832,266,137 - 32,278,949 (-)NCBImm8
Celera1832,604,740 - 32,621,169 (-)NCBICelera
Cytogenetic Map18B1NCBI
Proc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21823,764,367 - 23,774,816 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1824,918,398 - 24,929,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01824,918,402 - 24,928,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01824,633,206 - 24,643,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,563,368 - 24,573,715 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11824,590,014 - 24,600,361 (-)NCBI
Celera1823,516,361 - 23,526,709 (-)NCBICelera
Cytogenetic Map18p12NCBI
Proc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554593,094,120 - 3,104,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554593,097,229 - 3,105,566 (-)NCBIChiLan1.0ChiLan1.0
PROC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B128,083,794 - 128,094,625 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B128,083,794 - 128,094,625 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B32,846,899 - 32,859,060 (-)NCBIMhudiblu_PPA_v0panPan3
PROC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11923,173,626 - 23,183,634 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1923,173,635 - 23,183,563 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1923,421,177 - 23,431,114 (-)NCBI
ROS_Cfam_1.01924,500,225 - 24,510,240 (-)NCBI
UMICH_Zoey_3.11923,203,858 - 23,213,794 (-)NCBI
UNSW_CanFamBas_1.01923,398,248 - 23,408,180 (-)NCBI
UU_Cfam_GSD_1.01924,530,694 - 24,540,633 (-)NCBI
Dog Cytomap19q21-q22NCBI
Proc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,765,920 - 97,775,831 (+)NCBI
SpeTri2.0NW_00493646943,841,989 - 43,850,322 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1102,789,227 - 2,799,783 (-)NCBI
ChlSab1.1 Ensembl102,789,277 - 2,799,531 (-)Ensembl
Vero_WHO_p1.0NW_02366606119,959,230 - 19,968,598 (+)NCBI
Proc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473213,915,361 - 13,922,182 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system musculoskeletal system nervous system renal system respiratory system
High
Medium 2
Low 4 1
Below cutoff 2 1 2 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000026256   ⟹   ENSSSCP00000026729
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1525,043,551 - 25,054,225 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000067055   ⟹   ENSSSCP00000071272
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1525,043,549 - 25,055,107 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000074759   ⟹   ENSSSCP00000063547
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1525,043,545 - 25,054,205 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000079109   ⟹   ENSSSCP00000064932
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1525,043,545 - 25,054,205 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000088230   ⟹   ENSSSCP00000072099
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1525,032,622 - 25,052,965 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000088309   ⟹   ENSSSCP00000070853
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1525,043,549 - 25,056,595 (-)Ensembl
RefSeq Acc Id: NM_213918   ⟹   NP_999083
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11525,043,548 - 25,052,955 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005671629   ⟹   XP_005671686
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11525,043,543 - 25,054,286 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005671630   ⟹   XP_005671687
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11525,043,543 - 25,054,306 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013983970   ⟹   XP_013839424
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11525,043,543 - 25,054,310 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013983971   ⟹   XP_013839425
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11525,043,543 - 25,054,242 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021074671   ⟹   XP_020930330
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11525,043,543 - 25,054,260 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021074672   ⟹   XP_020930331
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11525,043,543 - 25,054,243 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021074673   ⟹   XP_020930332
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11525,043,543 - 25,054,260 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013839424   ⟸   XM_013983970
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005671687   ⟸   XM_005671630
- Peptide Label: isoform X5
- UniProtKB: I3LRJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005671686   ⟸   XM_005671629
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020930332   ⟸   XM_021074673
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_020930330   ⟸   XM_021074671
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020930331   ⟸   XM_021074672
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013839425   ⟸   XM_013983971
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: NP_999083   ⟸   NM_213918
- Peptide Label: precursor
- UniProtKB: Q9GLP2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000072099   ⟸   ENSSSCT00000088230
RefSeq Acc Id: ENSSSCP00000070853   ⟸   ENSSSCT00000088309
RefSeq Acc Id: ENSSSCP00000026729   ⟸   ENSSSCT00000026256
RefSeq Acc Id: ENSSSCP00000063547   ⟸   ENSSSCT00000074759
RefSeq Acc Id: ENSSSCP00000064932   ⟸   ENSSSCT00000079109
RefSeq Acc Id: ENSSSCP00000071272   ⟸   ENSSSCT00000067055
Protein Domains
EGF-like   Gla   Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000023693 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070002158 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000026729 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063547 UniProtKB/TrEMBL
  ENSSSCP00000064932 UniProtKB/TrEMBL
  ENSSSCP00000070853 UniProtKB/TrEMBL
  ENSSSCP00000071272 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000072099 UniProtKB/TrEMBL
  ENSSSCP00070003347 UniProtKB/TrEMBL
  ENSSSCP00070003355 UniProtKB/TrEMBL
  ENSSSCP00070003363 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000026256 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000067055 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000074759 UniProtKB/TrEMBL
  ENSSSCT00000079109 UniProtKB/TrEMBL
  ENSSSCT00000088230 UniProtKB/TrEMBL
  ENSSSCT00000088309 UniProtKB/TrEMBL
  ENSSSCT00070004044 UniProtKB/TrEMBL
  ENSSSCT00070004053 UniProtKB/TrEMBL
  ENSSSCT00070004066 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S1A_FX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396954 UniProtKB/Swiss-Prot
NCBI Gene PROC ENTREZGENE
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Factor_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1SLH7_PIG UniProtKB/TrEMBL
  A0A4X1SMT6_PIG UniProtKB/TrEMBL
  A0A4X1SMT7_PIG UniProtKB/TrEMBL
  A0A5G2QFN7_PIG UniProtKB/TrEMBL
  A0A5G2QSF4_PIG UniProtKB/TrEMBL
  A0A5G2R164_PIG UniProtKB/TrEMBL
  A0A5G2RIA8_PIG UniProtKB/TrEMBL
  A0A5G2RJM5_PIG UniProtKB/TrEMBL
  I3LRJ4 ENTREZGENE, UniProtKB/TrEMBL
  PROC_PIG UniProtKB/Swiss-Prot, ENTREZGENE