Proc (protein C) - Rat Genome Database

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Gene: Proc (protein C) Mus musculus
Analyze
Symbol: Proc
Name: protein C
RGD ID: 11161
MGI Page MGI
Description: Enables peptidase activity. Acts upstream of or within liver development; negative regulation of blood coagulation; and regulation of circulating fibrinogen levels. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be part of serine-type endopeptidase complex. Predicted to be active in extracellular space. Is expressed in embryo; liver; and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; artery disease (multiple); placental abruption; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; inactivator of coagulation factors Va, VIII; P; PC; vitamin K-dependent protein C
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,256,179 - 32,272,623 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,256,179 - 32,272,623 (-)EnsemblGRCm39 Ensembl
GRCm381832,123,126 - 32,139,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,123,126 - 32,139,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371832,282,780 - 32,299,224 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,266,137 - 32,278,949 (-)NCBIMGSCv36mm8
Celera1832,604,740 - 32,621,169 (-)NCBICelera
Cytogenetic Map18B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1-dichloroethene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP)
desogestrel  (ISO)
dextran sulfate  (EXP)
dienogest  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP)
flutamide  (ISO)
fonofos  (ISO)
furan  (ISO)
genistein  (EXP)
gestodene  (ISO)
heparin  (ISO)
L-ethionine  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
methylmercury(1+)  (ISO)
N-nitrosodiethylamine  (ISO)
nitrofen  (ISO)
norethisterone  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
omeprazole  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinorelbine  (ISO)
warfarin  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood coagulation  (IAGP)
abnormal brain thrombosis  (IAGP)
abnormal cardiac thrombosis  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal innate immunity  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung thrombosis  (IAGP)
abnormal lymph circulation  (IAGP)
abnormal lymph node cortex morphology  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal respiratory system morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal thrombosis  (IAGP)
abnormal trachea morphology  (IAGP)
anisocytosis  (IAGP)
bruising  (IAGP)
cardiac fibrosis  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased locomotor activity  (IAGP)
decreased neutrophil cell number  (IAGP)
enlarged heart  (IAGP)
enlarged lymph nodes  (IAGP)
focal hepatic necrosis  (IAGP)
gangrene  (IAGP)
hemorrhage  (IAGP)
hepatic necrosis  (IAGP)
hydrops fetalis  (IAGP)
increased number of Howell-Jolly bodies  (IAGP)
increased vascular endothelial cell number  (IAGP)
internal hemorrhage  (IAGP)
intracranial hemorrhage  (IAGP)
liver degeneration  (IAGP)
liver fibrosis  (IAGP)
liver hemorrhage  (IAGP)
liver inflammation  (IAGP)
lung hemorrhage  (IAGP)
lung inflammation  (IAGP)
lymph node hemorrhage  (IAGP)
myocardial fiber degeneration  (IAGP)
myocardium necrosis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
respiratory distress  (IAGP)
reticulocytosis  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Anti-protein C antibodies are associated with resistance to endogenous protein C activation and a severe thrombotic phenotype in antiphospholipid syndrome. Arachchillage DR, etal., J Thromb Haemost. 2014 Nov;12(11):1801-9. doi: 10.1111/jth.12722. Epub 2014 Oct 3.
2. Disruption of a binding site for hepatocyte nuclear factor 1 in the protein C gene promoter is associated with hereditary thrombophilia. Berg LP, etal., Hum Mol Genet. 1994 Dec;3(12):2147-52.
3. Comparative effects of recombinant human activated protein C and dexamethasone in experimental septic shock. Bouazza Y, etal., Intensive Care Med. 2011 Nov;37(11):1857-64. doi: 10.1007/s00134-011-2327-9. Epub 2011 Aug 18.
4. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
5. Activated protein C therapy in a rat heat stroke model. Chen CM, etal., Crit Care Med. 2006 Jul;34(7):1960-6.
6. Increase in activated protein C mediates acute traumatic coagulopathy in mice. Chesebro BB, etal., Shock. 2009 Dec;32(6):659-65. doi: 10.1097/SHK.0b013e3181a5a632.
7. Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial. de Boer JD, etal., Eur Respir J. 2015 Dec;46(6):1636-44. doi: 10.1183/13993003.00459-2015. Epub 2015 Sep 17.
8. Activated protein C rescues the retina from ischemia-induced cell death. Du ZJ, etal., Invest Ophthalmol Vis Sci. 2011 Feb 23;52(2):987-93. doi: 10.1167/iovs.10-5557.
9. The effects of activated protein C and prostacyclin on arterial oxygenation and protein leakage in the lung and the gut under endotoxaemia in the rat. Dubniks M and Grande PO, Acta Anaesthesiol Scand. 2008 Mar;52(3):381-7. doi: 10.1111/j.1399-6576.2007.01532.x. Epub 2008 Jan 16.
10. Protein C, antithrombin, and venous thromboembolism incidence: a prospective population-based study. Folsom AR, etal., Arterioscler Thromb Vasc Biol. 2002 Jun 1;22(6):1018-22.
11. Compound heterozygosity in a family with protein C deficiency illustrating the complexity of the underlying molecular mechanism. Gandrille S, etal., Thromb Haemost. 1993 Nov 15;70(5):747-52.
12. Distinct functions of activated protein C differentially attenuate acute kidney injury. Gupta A, etal., J Am Soc Nephrol. 2009 Feb;20(2):267-77. doi: 10.1681/ASN.2008030294. Epub 2008 Dec 17.
13. Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis. Heuer JG, etal., Crit Care Med. 2004 Jul;32(7):1570-8.
14. Activated protein C in ischemia-reperfusion injury after experimental lung transplantation. Hirayama S, etal., J Heart Lung Transplant. 2009 Nov;28(11):1180-4. doi: 10.1016/j.healun.2009.06.026. Epub 2009 Sep 26.
15. Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation. Hirose K, etal., Ann Surg. 2000 Aug;232(2):272-80.
16. Activation of protein C during reperfusion in clinical liver transplantation. Ilmakunnas M, etal., Transplantation. 2003 Feb 27;75(4):467-72.
17. Activated protein C reduces stress-induced gastric mucosal injury in rats by inhibiting the endothelial cell injury. Isobe H, etal., J Thromb Haemost. 2004 Feb;2(2):313-20.
18. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. Jalbert LR, etal., J Clin Invest. 1998 Oct 15;102(8):1481-8.
19. Activated protein C ameliorates Bacillus anthracis lethal toxin-induced lethal pathogenesis in rats. Kau JH, etal., J Biomed Sci. 2012 Nov 21;19:98. doi: 10.1186/1423-0127-19-98.
20. Distinct frequencies and mutation spectrums of genetic thrombophilia in Korea in comparison with other Asian countries both in patients with thromboembolism and in the general population. Kim HJ, etal., Haematologica. 2014 Mar;99(3):561-9. doi: 10.3324/haematol.2013.092023. Epub 2013 Oct 25.
21. Combined occurrence of a heterozygous missense mutation in the protein C gene and allelic exclusion of one protein S allele leading to severe venous thrombosis. Knoll B, etal., Thromb Res. 2001 Jul 1;103(1):3-8.
22. Activated protein C rescues the cochlea from noise-induced hearing loss. Kurioka T, etal., Brain Res. 2014 Oct 2;1583:201-10. doi: 10.1016/j.brainres.2014.07.052. Epub 2014 Aug 7.
23. Activated protein C prevents hepatic ischaemia-reperfusion injury in rats. Kuriyama N, etal., Liver Int. 2009 Feb;29(2):299-307. doi: 10.1111/j.1478-3231.2008.01796.x. Epub 2008 May 26.
24. Splice site mutation in the human protein C gene associated with venous thrombosis: demonstration of exon skipping by ectopic transcript analysis. Lind B, etal., Blood. 1993 Oct 15;82(8):2423-32.
25. Preeclampsia is associated with a reduced response to activated protein C. Lindoff C, etal., Am J Obstet Gynecol. 1997 Feb;176(2):457-60.
26. Compound heterozygous protein C deficiency in a family with venous thrombosis: Identification and in vitro study of p.Asp297His and p.Val420Leu mutations. Liu H, etal., Gene. 2015 May 25;563(1):35-40. doi: 10.1016/j.gene.2015.03.002. Epub 2015 Mar 4.
27. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
28. MGDs mouse GO annotations MGD data from the GO Consortium
29. MGD IEA MGD IEA
30. MicroRNA expression following activated protein C treatment during septic shock. Moore CC, etal., J Surg Res. 2013 Jun 1;182(1):116-26. doi: 10.1016/j.jss.2012.07.063. Epub 2012 Aug 17.
31. A comparative study of partial primary structures of the catalytic region of mammalian protein C. Murakawa M, etal., Br J Haematol 1994 Mar;86(3):590-600.
32. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
33. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. Early embryonic expression of murine coagulation system components. Ong K, etal., Thromb Haemost 2000 Dec;84(6):1023-30.
36. Activated protein C improves the severity of severe acute pancreatitis via up-regulating the expressions of endothelial cell protein C receptor and thrombomodulin. Ping C, etal., Dig Dis Sci. 2010 Jun;55(6):1599-609. doi: 10.1007/s10620-009-0909-y. Epub 2009 Aug 13.
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. Mouse MP Annotation Import Pipeline RGD automated import pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Intravenous administration of activated protein C in Pseudomonas-induced lung injury: impact on lung fluid balance and the inflammatory response. Robriquet L, etal., Respir Res. 2006 Mar 22;7:41.
42. Hereditary thrombophilia: identification of nonsense and missense mutations in the protein C gene. Romeo G, etal., Proc Natl Acad Sci U S A. 1987 May;84(9):2829-32.
43. Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production. Safdar H, etal., Blood. 2013 May 23;121(21):4413-6. doi: 10.1182/blood-2012-11-465674. Epub 2013 Apr 2.
44. Inhibition of coagulation and inflammation by activated protein C or antithrombin reduces intestinal ischemia/reperfusion injury in rats. Schoots IG, etal., Crit Care Med. 2004 Jun;32(6):1375-83.
45. Homozygosity for R87H missense mutation and for a rare intron 7 DNA variant (7054G --> A) in the PROC genes of three siblings initially classified as heterozygotes for protein C deficiency. Soria JM, etal., Blood Coagul Fibrinolysis. 1996 Jan;7(1):15-23.
46. Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population. Sun W, etal., Int Orthop. 2006 Jun;30(3):143-6. doi: 10.1007/s00264-005-0067-6. Epub 2006 Mar 18.
47. [Hematological changes and related gene mutation of post-severe acute respiratory syndrome patients with osteonecrosis]. Sun W, etal., Zhonghua Yi Xue Za Zhi. 2006 Feb 21;86(7):442-5.
48. Genetic background analysis of protein C deficiency demonstrates a recurrent mutation associated with venous thrombosis in Chinese population. Tang L, etal., PLoS One. 2012;7(4):e35773. doi: 10.1371/journal.pone.0035773. Epub 2012 Apr 24.
49. Activated protein C attenuates intestinal reperfusion-induced acute lung injury: an experimental study in a rat model. Teke Z, etal., Am J Surg. 2008 Jun;195(6):861-73. doi: 10.1016/j.amjsurg.2007.06.025.
50. R147W mutation of PROC gene is common in venous thrombotic patients in Taiwanese Chinese. Tsay W and Shen MC, Am J Hematol. 2004 May;76(1):8-13.
51. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Wang Y, etal., Stroke. 2013 Dec;44(12):3529-36. doi: 10.1161/STROKEAHA.113.003350. Epub 2013 Oct 24.
52. Plasma levels of activated protein C-protein C inhibitor complex in patients with hypercoagulable states. Watanabe R, etal., Am J Hematol. 2000 Sep;65(1):35-40.
53. Resistance to activated protein C and the leiden mutation: high prevalence in patients with abruptio placentae. Wiener-Megnagi Z, etal., Am J Obstet Gynecol. 1998 Dec;179(6 Pt 1):1565-7.
54. Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock. Xu J, etal., J Thromb Haemost. 2009 May;7(5):851-6. doi: 10.1111/j.1538-7836.2009.03333.x. Epub 2009 Mar 5.
55. The antithrombotic effect of human activated protein C on He-Ne laser-induced thrombosis in rat mesenteric microvessels. Yamashita T, etal., Thromb Res. 1994 Jul 1;75(1):33-40.
56. Reduced protein C Global assay level in infertile women prior to IVF-ET treatment. Younis JS, etal., J Assist Reprod Genet. 2014 Jan;31(1):101-7. doi: 10.1007/s10815-013-0131-x. Epub 2013 Nov 6.
Additional References at PubMed
PMID:1618739   PMID:8707309   PMID:8798383   PMID:9493582   PMID:9611252   PMID:9616155   PMID:10691853   PMID:10749569   PMID:10922068   PMID:11159184   PMID:12477932   PMID:12558604  
PMID:12579195   PMID:12609841   PMID:12819125   PMID:14645112   PMID:14980205   PMID:15466407   PMID:15489334   PMID:15902301   PMID:16014564   PMID:16141072   PMID:16602821   PMID:16944957  
PMID:17015433   PMID:17047151   PMID:17540840   PMID:17872949   PMID:18647222   PMID:18799693   PMID:19036061   PMID:19188668   PMID:19350118   PMID:19363121   PMID:20348393   PMID:20442369  
PMID:20858853   PMID:21251201   PMID:21267068   PMID:21330465   PMID:21420234   PMID:21873635   PMID:22109555   PMID:22167755   PMID:22372856   PMID:22447930   PMID:23216621   PMID:23267072  
PMID:23348224   PMID:24177324   PMID:24753100   PMID:25069533   PMID:26045607   PMID:26069236   PMID:26341257   PMID:26457757   PMID:27295971   PMID:28302625   PMID:28468828   PMID:28687614  
PMID:28827518   PMID:29343482   PMID:30305662   PMID:30865333   PMID:32325033   PMID:34930019   PMID:35008942  


Genomics

Comparative Map Data
Proc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,256,179 - 32,272,623 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,256,179 - 32,272,623 (-)EnsemblGRCm39 Ensembl
GRCm381832,123,126 - 32,139,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,123,126 - 32,139,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371832,282,780 - 32,299,224 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,266,137 - 32,278,949 (-)NCBIMGSCv36mm8
Celera1832,604,740 - 32,621,169 (-)NCBICelera
Cytogenetic Map18B1NCBI
PROC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382127,418,427 - 127,429,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2127,418,427 - 127,429,242 (+)EnsemblGRCh38hg38GRCh38
GRCh372128,176,003 - 128,186,818 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,892,487 - 127,903,288 (+)NCBINCBI36Build 36hg18NCBI36
Build 342127,892,245 - 127,903,048NCBI
Celera2121,487,217 - 121,498,043 (+)NCBICelera
Cytogenetic Map2q14.3NCBI
HuRef2120,483,060 - 120,493,885 (+)NCBIHuRef
CHM1_12128,180,576 - 128,191,401 (+)NCBICHM1_1
T2T-CHM13v2.02127,853,697 - 127,864,511 (+)NCBIT2T-CHM13v2.0
Proc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21823,764,367 - 23,774,816 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,764,368 - 23,775,133 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,892,461 - 23,902,808 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01824,648,935 - 24,660,144 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01823,987,447 - 23,997,792 (-)NCBIRnor_WKY
Rnor_6.01824,918,402 - 24,928,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,918,398 - 24,929,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,633,206 - 24,643,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,563,368 - 24,573,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11824,590,014 - 24,600,361 (-)NCBI
Celera1823,516,361 - 23,526,709 (-)NCBICelera
Cytogenetic Map18p12NCBI
Proc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554593,094,120 - 3,104,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554593,097,229 - 3,105,566 (-)NCBIChiLan1.0ChiLan1.0
PROC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B128,083,794 - 128,094,625 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B128,083,794 - 128,094,625 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B32,846,899 - 32,859,060 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PROC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11923,173,626 - 23,183,634 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1923,173,635 - 23,183,563 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1923,421,177 - 23,431,114 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01924,500,225 - 24,510,240 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1924,500,234 - 24,510,166 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11923,203,858 - 23,213,794 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01923,398,248 - 23,408,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01924,530,694 - 24,540,633 (-)NCBIUU_Cfam_GSD_1.0
Dog Cytomap19q21-q22NCBI
Proc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,765,920 - 97,775,831 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493646943,841,989 - 43,850,322 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1525,043,545 - 25,056,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11525,043,543 - 25,054,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,724,914 - 28,735,638 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1102,789,227 - 2,799,783 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl102,789,277 - 2,799,531 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606119,959,230 - 19,968,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Proc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473213,915,402 - 13,923,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473213,915,361 - 13,922,182 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
Proc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS
cM Map18 UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133547739Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133547739Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
1301950Otx2m1_morthodenticle homolog 2 (Drosophila) modifier 1 (mouse)Not determined182156868236187740Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:126
Interacting mature miRNAs:133
Transcripts:ENSMUST00000171765
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001042767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001042768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF034569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF318182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI118438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI286922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX639472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY082597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY086829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY788141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA456834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA468822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB599669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF550816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ237265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D43755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV662175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM997836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000171765   ⟹   ENSMUSP00000132226
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,256,182 - 32,272,623 (-)Ensembl
GRCm38.p6 Ensembl1832,123,129 - 32,139,570 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234198
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,266,194 - 32,268,799 (-)Ensembl
GRCm38.p6 Ensembl1832,133,141 - 32,135,746 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234375   ⟹   ENSMUSP00000157207
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,266,200 - 32,272,623 (-)Ensembl
GRCm38.p6 Ensembl1832,133,147 - 32,139,570 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234386   ⟹   ENSMUSP00000157122
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,260,482 - 32,271,235 (-)Ensembl
GRCm38.p6 Ensembl1832,127,429 - 32,138,182 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234649
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,268,396 - 32,271,235 (-)Ensembl
GRCm38.p6 Ensembl1832,135,343 - 32,138,182 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234651   ⟹   ENSMUSP00000157269
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,256,179 - 32,271,252 (-)Ensembl
GRCm38.p6 Ensembl1832,123,126 - 32,138,199 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234657   ⟹   ENSMUSP00000156986
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,266,686 - 32,271,224 (-)Ensembl
GRCm38.p6 Ensembl1832,133,633 - 32,138,171 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234746   ⟹   ENSMUSP00000157002
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,260,466 - 32,271,079 (-)Ensembl
GRCm38.p6 Ensembl1832,127,413 - 32,138,026 (-)Ensembl
RefSeq Acc Id: NM_001042767   ⟹   NP_001036232
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,272,623 (-)NCBI
GRCm381832,123,126 - 32,139,570 (-)ENTREZGENE
MGSCv371832,282,780 - 32,299,224 (-)RGD
Celera1832,604,740 - 32,621,169 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001042768   ⟹   NP_001036233
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,258 (-)NCBI
GRCm381832,123,126 - 32,138,205 (-)NCBI
MGSCv371832,282,780 - 32,299,224 (-)RGD
Celera1832,604,740 - 32,621,169 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001313938   ⟹   NP_001300867
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,258 (-)NCBI
GRCm381832,123,126 - 32,138,205 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008934   ⟹   NP_032960
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,258 (-)NCBI
GRCm381832,123,126 - 32,138,205 (-)NCBI
MGSCv371832,282,780 - 32,299,224 (-)RGD
Celera1832,604,740 - 32,621,169 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006525721   ⟹   XP_006525784
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,116 (-)NCBI
GRCm381832,123,126 - 32,138,063 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006525722   ⟹   XP_006525785
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,249 (-)NCBI
GRCm381832,123,126 - 32,138,196 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246857   ⟹   XP_011245159
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,273 (-)NCBI
GRCm381832,123,126 - 32,138,220 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030250362   ⟹   XP_030106222
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,744 (-)NCBI
GRCm381832,123,126 - 32,138,691 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001036232   ⟸   NM_001042767
- Peptide Label: isoform 2 preproprotein
- UniProtKB: Q99PC6 (UniProtKB/Swiss-Prot),   P33587 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_032960   ⟸   NM_008934
- Peptide Label: isoform 1
- Sequence:
RefSeq Acc Id: NP_001036233   ⟸   NM_001042768
- Peptide Label: isoform 3 precursor
- Sequence:
RefSeq Acc Id: XP_006525785   ⟸   XM_006525722
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006525784   ⟸   XM_006525721
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011245159   ⟸   XM_011246857
- Peptide Label: isoform X3
- UniProtKB: Q99PC6 (UniProtKB/Swiss-Prot),   P33587 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001300867   ⟸   NM_001313938
- Peptide Label: isoform 2 preproprotein
- UniProtKB: Q99PC6 (UniProtKB/Swiss-Prot),   P33587 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030106222   ⟸   XM_030250362
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000132226   ⟸   ENSMUST00000171765
RefSeq Acc Id: ENSMUSP00000157002   ⟸   ENSMUST00000234746
RefSeq Acc Id: ENSMUSP00000157207   ⟸   ENSMUST00000234375
RefSeq Acc Id: ENSMUSP00000157122   ⟸   ENSMUST00000234386
RefSeq Acc Id: ENSMUSP00000157269   ⟸   ENSMUST00000234651
RefSeq Acc Id: ENSMUSP00000156986   ⟸   ENSMUST00000234657
Protein Domains
EGF-like   Gla   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33587-F1-model_v2 AlphaFold P33587 1-460 view protein structure

Promoters
RGD ID:13677314
Promoter ID:EPDNEW_M22806
Type:multiple initiation site
Name:Proc_1
Description:Mus musculus protein C , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381832,138,189 - 32,138,249EPDNEW
RGD ID:6848711
Promoter ID:MM_TRO:4679
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:MTR018377.18.385.5
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361832,292,476 - 32,292,976 (-)MPROMDB
RGD ID:6829480
Promoter ID:MM_KWN:24848
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NM_001042768,   NM_008934
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361832,297,606 - 32,298,106 (-)MPROMDB
RGD ID:6829479
Promoter ID:MM_KWN:24849
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NM_001042767
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361832,299,031 - 32,299,531 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97771 AgrOrtholog
Ensembl Genes ENSMUSG00000024386 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000132226 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000156986.2 UniProtKB/TrEMBL
  ENSMUSP00000157002.2 UniProtKB/TrEMBL
  ENSMUSP00000157122.2 UniProtKB/TrEMBL
  ENSMUSP00000157207.2 UniProtKB/TrEMBL
  ENSMUSP00000157269 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000171765 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000234375.2 UniProtKB/TrEMBL
  ENSMUST00000234386.2 UniProtKB/TrEMBL
  ENSMUST00000234651 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000234657.2 UniProtKB/TrEMBL
  ENSMUST00000234746.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  4.10.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Pept_S1A_FX UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report mmu:19123 UniProtKB/Swiss-Prot
MGD MGI:97771 ENTREZGENE
NCBI Gene 19123 ENTREZGENE
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot
PharmGKB PROC RGD
PhenoGen Proc PhenoGen
PIRSF Factor_X UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
  GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3Q4EBY5_MOUSE UniProtKB/TrEMBL
  A0A3Q4EC18_MOUSE UniProtKB/TrEMBL
  A0A3Q4EGI8_MOUSE UniProtKB/TrEMBL
  A0A3Q4EGJ8_MOUSE UniProtKB/TrEMBL
  P33587 ENTREZGENE, UniProtKB/Swiss-Prot
  Q99PC6 ENTREZGENE
UniProt Secondary O35498 UniProtKB/Swiss-Prot
  Q91WN8 UniProtKB/Swiss-Prot
  Q99PC6 UniProtKB/Swiss-Prot