Proc (protein C) - Rat Genome Database

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Gene: Proc (protein C) Mus musculus
Analyze
Symbol: Proc
Name: protein C
RGD ID: 11161
MGI Page MGI
Description: Enables peptidase activity. Acts upstream of or within liver development; negative regulation of blood coagulation; and regulation of circulating fibrinogen levels. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be active in extracellular space. Is expressed in embryo; liver; and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; artery disease (multiple); placental abruption; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; inactivator of coagulation factors Va, VIII; P; PC; vitamin K-dependent protein C
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,256,179 - 32,272,623 (-)NCBIGRCm39mm39
GRCm39 Ensembl1832,256,179 - 32,272,623 (-)Ensembl
GRCm381832,123,126 - 32,139,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,123,126 - 32,139,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371832,282,780 - 32,299,224 (-)NCBIGRCm37mm9NCBIm37
MGSCv361832,266,137 - 32,278,949 (-)NCBImm8
Celera1832,604,740 - 32,621,169 (-)NCBICelera
Cytogenetic Map18B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1-dichloroethene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP)
desogestrel  (ISO)
dextran sulfate  (EXP)
dienogest  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
flutamide  (ISO)
fonofos  (ISO)
furan  (ISO)
genistein  (EXP)
gestodene  (ISO)
heparin  (ISO)
L-ethionine  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
methylmercury(1+)  (ISO)
N-nitrosodiethylamine  (ISO)
nitrofen  (ISO)
norethisterone  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
omeprazole  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinorelbine  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood coagulation  (IAGP)
abnormal brain thrombosis  (IAGP)
abnormal cardiac thrombosis  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal innate immunity  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung thrombosis  (IAGP)
abnormal lymph circulation  (IAGP)
abnormal lymph node cortex morphology  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal respiratory system morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal thrombosis  (IAGP)
abnormal trachea morphology  (IAGP)
anisocytosis  (IAGP)
bruising  (IAGP)
cardiac fibrosis  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
enlarged heart  (IAGP)
enlarged lymph nodes  (IAGP)
focal hepatic necrosis  (IAGP)
gangrene  (IAGP)
hemorrhage  (IAGP)
hepatic necrosis  (IAGP)
hydrops fetalis  (IAGP)
hypoactivity  (IAGP)
increased number of Howell-Jolly bodies  (IAGP)
increased vascular endothelial cell number  (IAGP)
internal hemorrhage  (IAGP)
intracranial hemorrhage  (IAGP)
liver degeneration  (IAGP)
liver fibrosis  (IAGP)
liver hemorrhage  (IAGP)
liver inflammation  (IAGP)
lung hemorrhage  (IAGP)
lung inflammation  (IAGP)
lymph node hemorrhage  (IAGP)
myocardial fiber degeneration  (IAGP)
myocardium necrosis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
respiratory distress  (IAGP)
reticulocytosis  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
References

References - curated
1. Arachchillage DR, etal., J Thromb Haemost. 2014 Nov;12(11):1801-9. doi: 10.1111/jth.12722. Epub 2014 Oct 3.
2. Berg LP, etal., Hum Mol Genet. 1994 Dec;3(12):2147-52.
3. Bouazza Y, etal., Intensive Care Med. 2011 Nov;37(11):1857-64. doi: 10.1007/s00134-011-2327-9. Epub 2011 Aug 18.
4. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
5. Chen CM, etal., Crit Care Med. 2006 Jul;34(7):1960-6.
6. Chesebro BB, etal., Shock. 2009 Dec;32(6):659-65. doi: 10.1097/SHK.0b013e3181a5a632.
7. de Boer JD, etal., Eur Respir J. 2015 Dec;46(6):1636-44. doi: 10.1183/13993003.00459-2015. Epub 2015 Sep 17.
8. Du ZJ, etal., Invest Ophthalmol Vis Sci. 2011 Feb 23;52(2):987-93. doi: 10.1167/iovs.10-5557.
9. Dubniks M and Grande PO, Acta Anaesthesiol Scand. 2008 Mar;52(3):381-7. doi: 10.1111/j.1399-6576.2007.01532.x. Epub 2008 Jan 16.
10. Folsom AR, etal., Arterioscler Thromb Vasc Biol. 2002 Jun 1;22(6):1018-22.
11. Gandrille S, etal., Thromb Haemost. 1993 Nov 15;70(5):747-52.
12. Gupta A, etal., J Am Soc Nephrol. 2009 Feb;20(2):267-77. doi: 10.1681/ASN.2008030294. Epub 2008 Dec 17.
13. Heuer JG, etal., Crit Care Med. 2004 Jul;32(7):1570-8.
14. Hirayama S, etal., J Heart Lung Transplant. 2009 Nov;28(11):1180-4. doi: 10.1016/j.healun.2009.06.026. Epub 2009 Sep 26.
15. Hirose K, etal., Ann Surg. 2000 Aug;232(2):272-80.
16. Ilmakunnas M, etal., Transplantation. 2003 Feb 27;75(4):467-72.
17. Isobe H, etal., J Thromb Haemost. 2004 Feb;2(2):313-20.
18. Jalbert LR, etal., J Clin Invest. 1998 Oct 15;102(8):1481-8.
19. Kau JH, etal., J Biomed Sci. 2012 Nov 21;19:98. doi: 10.1186/1423-0127-19-98.
20. Kim HJ, etal., Haematologica. 2014 Mar;99(3):561-9. doi: 10.3324/haematol.2013.092023. Epub 2013 Oct 25.
21. Knoll B, etal., Thromb Res. 2001 Jul 1;103(1):3-8.
22. Kurioka T, etal., Brain Res. 2014 Oct 2;1583:201-10. doi: 10.1016/j.brainres.2014.07.052. Epub 2014 Aug 7.
23. Kuriyama N, etal., Liver Int. 2009 Feb;29(2):299-307. doi: 10.1111/j.1478-3231.2008.01796.x. Epub 2008 May 26.
24. Lind B, etal., Blood. 1993 Oct 15;82(8):2423-32.
25. Lindoff C, etal., Am J Obstet Gynecol. 1997 Feb;176(2):457-60.
26. Liu H, etal., Gene. 2015 May 25;563(1):35-40. doi: 10.1016/j.gene.2015.03.002. Epub 2015 Mar 4.
27. MGD and Homologene mouse data transfer
28. MGD data from the GO Consortium
29. MGD IEA
30. Moore CC, etal., J Surg Res. 2013 Jun 1;182(1):116-26. doi: 10.1016/j.jss.2012.07.063. Epub 2012 Aug 17.
31. Murakawa M, etal., Br J Haematol 1994 Mar;86(3):590-600.
32. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
33. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
34. OMIM Disease Annotation Pipeline
35. Ong K, etal., Thromb Haemost 2000 Dec;84(6):1023-30.
36. Ping C, etal., Dig Dis Sci. 2010 Jun;55(6):1599-609. doi: 10.1007/s10620-009-0909-y. Epub 2009 Aug 13.
37. Pipeline to import KEGG annotations from KEGG into RGD
38. RGD automated import pipeline
39. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. RGD automated import pipeline for gene-chemical interactions
41. Robriquet L, etal., Respir Res. 2006 Mar 22;7:41.
42. Romeo G, etal., Proc Natl Acad Sci U S A. 1987 May;84(9):2829-32.
43. Safdar H, etal., Blood. 2013 May 23;121(21):4413-6. doi: 10.1182/blood-2012-11-465674. Epub 2013 Apr 2.
44. Schoots IG, etal., Crit Care Med. 2004 Jun;32(6):1375-83.
45. Soria JM, etal., Blood Coagul Fibrinolysis. 1996 Jan;7(1):15-23.
46. Sun W, etal., Int Orthop. 2006 Jun;30(3):143-6. doi: 10.1007/s00264-005-0067-6. Epub 2006 Mar 18.
47. Sun W, etal., Zhonghua Yi Xue Za Zhi. 2006 Feb 21;86(7):442-5.
48. Tang L, etal., PLoS One. 2012;7(4):e35773. doi: 10.1371/journal.pone.0035773. Epub 2012 Apr 24.
49. Teke Z, etal., Am J Surg. 2008 Jun;195(6):861-73. doi: 10.1016/j.amjsurg.2007.06.025.
50. Tsay W and Shen MC, Am J Hematol. 2004 May;76(1):8-13.
51. Wang Y, etal., Stroke. 2013 Dec;44(12):3529-36. doi: 10.1161/STROKEAHA.113.003350. Epub 2013 Oct 24.
52. Watanabe R, etal., Am J Hematol. 2000 Sep;65(1):35-40.
53. Wiener-Megnagi Z, etal., Am J Obstet Gynecol. 1998 Dec;179(6 Pt 1):1565-7.
54. Xu J, etal., J Thromb Haemost. 2009 May;7(5):851-6. doi: 10.1111/j.1538-7836.2009.03333.x. Epub 2009 Mar 5.
55. Yamashita T, etal., Thromb Res. 1994 Jul 1;75(1):33-40.
56. Younis JS, etal., J Assist Reprod Genet. 2014 Jan;31(1):101-7. doi: 10.1007/s10815-013-0131-x. Epub 2013 Nov 6.
Additional References at PubMed
PMID:1618739   PMID:8707309   PMID:8798383   PMID:9493582   PMID:9611252   PMID:9616155   PMID:10691853   PMID:10749569   PMID:10922068   PMID:11159184   PMID:12477932   PMID:12558604  
PMID:12579195   PMID:12609841   PMID:12819125   PMID:14645112   PMID:14980205   PMID:15466407   PMID:15489334   PMID:15902301   PMID:16014564   PMID:16141072   PMID:16602821   PMID:16944957  
PMID:17015433   PMID:17047151   PMID:17540840   PMID:17872949   PMID:18647222   PMID:18799693   PMID:19036061   PMID:19188668   PMID:19350118   PMID:19363121   PMID:20348393   PMID:20442369  
PMID:20858853   PMID:21251201   PMID:21267068   PMID:21330465   PMID:21420234   PMID:21873635   PMID:22109555   PMID:22167755   PMID:22372856   PMID:22447930   PMID:23216621   PMID:23267072  
PMID:23348224   PMID:24177324   PMID:24753100   PMID:25069533   PMID:26045607   PMID:26069236   PMID:26341257   PMID:26457757   PMID:27295971   PMID:28302625   PMID:28468828   PMID:28687614  
PMID:28827518   PMID:29343482   PMID:30305662   PMID:30865333   PMID:32325033  


Genomics

Comparative Map Data
Proc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,256,179 - 32,272,623 (-)NCBIGRCm39mm39
GRCm39 Ensembl1832,256,179 - 32,272,623 (-)Ensembl
GRCm381832,123,126 - 32,139,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,123,126 - 32,139,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371832,282,780 - 32,299,224 (-)NCBIGRCm37mm9NCBIm37
MGSCv361832,266,137 - 32,278,949 (-)NCBImm8
Celera1832,604,740 - 32,621,169 (-)NCBICelera
Cytogenetic Map18B1NCBI
PROC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2127,418,427 - 127,429,242 (+)EnsemblGRCh38hg38GRCh38
GRCh382127,418,143 - 127,429,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372128,176,003 - 128,186,818 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,892,487 - 127,903,288 (+)NCBINCBI36hg18NCBI36
Build 342127,892,245 - 127,903,048NCBI
Celera2121,487,217 - 121,498,043 (+)NCBI
Cytogenetic Map2q14.3NCBI
HuRef2120,483,060 - 120,493,885 (+)NCBIHuRef
CHM1_12128,180,576 - 128,191,401 (+)NCBICHM1_1
Proc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21823,764,367 - 23,774,816 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1823,764,368 - 23,775,133 (-)Ensembl
Rnor_6.01824,918,402 - 24,928,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,918,398 - 24,929,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,633,206 - 24,643,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,563,368 - 24,573,715 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11824,590,014 - 24,600,361 (-)NCBI
Celera1823,516,361 - 23,526,709 (-)NCBICelera
Cytogenetic Map18p12NCBI
Proc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554593,094,120 - 3,104,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554593,097,229 - 3,105,566 (-)NCBIChiLan1.0ChiLan1.0
PROC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B128,083,794 - 128,094,625 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B128,083,794 - 128,094,625 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B32,846,899 - 32,859,060 (-)NCBIMhudiblu_PPA_v0panPan3
PROC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11923,173,626 - 23,183,634 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1923,173,635 - 23,183,563 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1923,421,177 - 23,431,114 (-)NCBI
ROS_Cfam_1.01924,500,225 - 24,510,240 (-)NCBI
UMICH_Zoey_3.11923,203,858 - 23,213,794 (-)NCBI
UNSW_CanFamBas_1.01923,398,248 - 23,408,180 (-)NCBI
UU_Cfam_GSD_1.01924,530,694 - 24,540,633 (-)NCBI
Dog Cytomap19q21-q22NCBI
Proc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,765,920 - 97,775,831 (+)NCBI
SpeTri2.0NW_00493646943,841,989 - 43,850,322 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1525,032,622 - 25,056,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11525,043,543 - 25,054,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,724,914 - 28,735,638 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1102,789,227 - 2,799,783 (-)NCBI
ChlSab1.1 Ensembl102,789,277 - 2,799,531 (-)Ensembl
Vero_WHO_p1.0NW_02366606119,959,230 - 19,968,598 (+)NCBI
Proc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473213,915,361 - 13,922,182 (+)NCBI

Position Markers
Proc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18B3UniSTS
cM Map18 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133414682Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133414682Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060800000Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961139571Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18795390741954049Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181350407347504073Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181389696666965891Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181606658750066723Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181800665152006806Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181888582152885939Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181888582152885939Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182082063757457636Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182108452755084674Mouse
1301950Otx2m1_morthodenticle homolog 2 (Drosophila) modifier 1 (mouse)Not determined182143562536054687Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182248686156487074Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182248686156487074Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182248686156487074Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182248686156487074Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182248686156487074Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182398250757982677Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182476282478296340Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182592381059923810Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182710806258694005Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182710806258694005Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182710806258694005Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182797631361976451Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2799753761997672Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182953484763534993Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183010000064100000Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183185541365855562Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:126
Interacting mature miRNAs:133
Transcripts:ENSMUST00000171765
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001042767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001042768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF034569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF318182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI118438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI286922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX639472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY082597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY086829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY788141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA456834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA468822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB599669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF550816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ237265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D43755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV662175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM997836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000171765   ⟹   ENSMUSP00000132226
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,256,182 - 32,272,623 (-)Ensembl
GRCm38.p6 Ensembl1832,123,129 - 32,139,570 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234198
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,266,194 - 32,268,799 (-)Ensembl
GRCm38.p6 Ensembl1832,133,141 - 32,135,746 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234375   ⟹   ENSMUSP00000157207
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,266,200 - 32,272,623 (-)Ensembl
GRCm38.p6 Ensembl1832,133,147 - 32,139,570 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234386   ⟹   ENSMUSP00000157122
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,260,482 - 32,271,235 (-)Ensembl
GRCm38.p6 Ensembl1832,127,429 - 32,138,182 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234649
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,268,396 - 32,271,235 (-)Ensembl
GRCm38.p6 Ensembl1832,135,343 - 32,138,182 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234651   ⟹   ENSMUSP00000157269
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,256,179 - 32,271,252 (-)Ensembl
GRCm38.p6 Ensembl1832,123,126 - 32,138,199 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234657   ⟹   ENSMUSP00000156986
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,266,686 - 32,271,224 (-)Ensembl
GRCm38.p6 Ensembl1832,133,633 - 32,138,171 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234746   ⟹   ENSMUSP00000157002
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1832,260,466 - 32,271,079 (-)Ensembl
GRCm38.p6 Ensembl1832,127,413 - 32,138,026 (-)Ensembl
RefSeq Acc Id: NM_001042767   ⟹   NP_001036232
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,272,623 (-)NCBI
GRCm381832,123,126 - 32,139,570 (-)ENTREZGENE
MGSCv371832,282,780 - 32,299,224 (-)RGD
Celera1832,604,740 - 32,621,169 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001042768   ⟹   NP_001036233
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,258 (-)NCBI
GRCm381832,123,126 - 32,138,205 (-)NCBI
MGSCv371832,282,780 - 32,299,224 (-)RGD
Celera1832,604,740 - 32,621,169 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001313938   ⟹   NP_001300867
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,258 (-)NCBI
GRCm381832,123,126 - 32,138,205 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008934   ⟹   NP_032960
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,258 (-)NCBI
GRCm381832,123,126 - 32,138,205 (-)NCBI
MGSCv371832,282,780 - 32,299,224 (-)RGD
Celera1832,604,740 - 32,621,169 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006525721   ⟹   XP_006525784
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,116 (-)NCBI
GRCm381832,123,126 - 32,138,063 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006525722   ⟹   XP_006525785
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,249 (-)NCBI
GRCm381832,123,126 - 32,138,196 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246857   ⟹   XP_011245159
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,273 (-)NCBI
GRCm381832,123,126 - 32,138,220 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030250362   ⟹   XP_030106222
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391832,256,179 - 32,271,744 (-)NCBI
GRCm381832,123,126 - 32,138,691 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001036232   ⟸   NM_001042767
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P33587 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_032960   ⟸   NM_008934
- Peptide Label: isoform 1
- Sequence:
RefSeq Acc Id: NP_001036233   ⟸   NM_001042768
- Peptide Label: isoform 3 precursor
- Sequence:
RefSeq Acc Id: XP_006525785   ⟸   XM_006525722
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006525784   ⟸   XM_006525721
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011245159   ⟸   XM_011246857
- Peptide Label: isoform X3
- UniProtKB: P33587 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001300867   ⟸   NM_001313938
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P33587 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030106222   ⟸   XM_030250362
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000132226   ⟸   ENSMUST00000171765
RefSeq Acc Id: ENSMUSP00000157002   ⟸   ENSMUST00000234746
RefSeq Acc Id: ENSMUSP00000157207   ⟸   ENSMUST00000234375
RefSeq Acc Id: ENSMUSP00000157122   ⟸   ENSMUST00000234386
RefSeq Acc Id: ENSMUSP00000157269   ⟸   ENSMUST00000234651
RefSeq Acc Id: ENSMUSP00000156986   ⟸   ENSMUST00000234657
Protein Domains
EGF-like   Gla   Peptidase S1

Promoters
RGD ID:13677314
Promoter ID:EPDNEW_M22806
Type:multiple initiation site
Name:Proc_1
Description:Mus musculus protein C , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381832,138,189 - 32,138,249EPDNEW
RGD ID:6848711
Promoter ID:MM_TRO:4679
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:MTR018377.18.385.5
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361832,292,476 - 32,292,976 (-)MPROMDB
RGD ID:6829480
Promoter ID:MM_KWN:24848
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NM_001042768,   NM_008934
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361832,297,606 - 32,298,106 (-)MPROMDB
RGD ID:6829479
Promoter ID:MM_KWN:24849
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NM_001042767
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361832,299,031 - 32,299,531 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97771 AgrOrtholog
Ensembl Genes ENSMUSG00000024386 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000132226 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000156986 UniProtKB/TrEMBL
  ENSMUSP00000157002 UniProtKB/TrEMBL
  ENSMUSP00000157122 UniProtKB/TrEMBL
  ENSMUSP00000157207 UniProtKB/TrEMBL
  ENSMUSP00000157269 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000171765 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000234375 UniProtKB/TrEMBL
  ENSMUST00000234386 UniProtKB/TrEMBL
  ENSMUST00000234651 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000234657 UniProtKB/TrEMBL
  ENSMUST00000234746 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  4.10.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Pept_S1A_FX UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report mmu:19123 UniProtKB/Swiss-Prot
MGD MGI:97771 ENTREZGENE
NCBI Gene 19123 ENTREZGENE
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot
PharmGKB PROC RGD
PhenoGen Proc PhenoGen
PIRSF Factor_X UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
  GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3Q4EBY5_MOUSE UniProtKB/TrEMBL
  A0A3Q4EC18_MOUSE UniProtKB/TrEMBL
  A0A3Q4EGI8_MOUSE UniProtKB/TrEMBL
  A0A3Q4EGJ8_MOUSE UniProtKB/TrEMBL
  P33587 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O35498 UniProtKB/Swiss-Prot
  Q91WN8 UniProtKB/Swiss-Prot
  Q99PC6 UniProtKB/Swiss-Prot