RGD Reference Report - Resistance to activated protein C and the leiden mutation: high prevalence in patients with abruptio placentae. - Rat Genome Database

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Resistance to activated protein C and the leiden mutation: high prevalence in patients with abruptio placentae.

Authors: Wiener-Megnagi, Z  Ben-Shlomo, I  Goldberg, Y  Shalev, E 
Citation: Wiener-Megnagi Z, etal., Am J Obstet Gynecol. 1998 Dec;179(6 Pt 1):1565-7.
RGD ID: 11564329
Pubmed: PMID:9855597   (View Abstract at PubMed)

OBJECTIVE: The Leiden mutation, a point mutation in the gene encoding coagulation factor V, is associated with a high frequency of thromboembolic phenomena. It has recently been connected with adverse outcomes of pregnancy. We carried out this study to define its connection with abruptio placentae. STUDY DESIGN: Twenty-seven women who had abruptio placentae and 29 control subjects matched for age, parity, and ethnic origin were studied. We studied all women for possible hypercoagulation defects. All women demonstrating resistance to activated protein C were studied for the presence of the factor V Leiden mutation. RESULTS: Seventeen of 27 case patients had an activated protein C ratio



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PROCHumanplacental abruption susceptibilityIDA  RGD 
ProcRatplacental abruption susceptibilityISOPROC (Homo sapiens) RGD 
ProcMouseplacental abruption susceptibilityISOPROC (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Proc  (protein C, inactivator of coagulation factors Va and VIIIa)

Genes (Mus musculus)
Proc  (protein C)

Genes (Homo sapiens)
PROC  (protein C, inactivator of coagulation factors Va and VIIIa)


Additional Information