RGD Reference Report - Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population. - Rat Genome Database

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Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population.

Authors: Sun, Wei  Li, Zi-rong  Shi, Zhen-cai  Zhang, Nian-fei  Zhang, Yuan-chun 
Citation: Sun W, etal., Int Orthop. 2006 Jun;30(3):143-6. doi: 10.1007/s00264-005-0067-6. Epub 2006 Mar 18.
RGD ID: 30309948
Pubmed: (View Article at PubMed) PMID:16547717
DOI: Full-text: DOI:10.1007/s00264-005-0067-6

The purpose of this study was to detect changes in coagulation and fibrinolysis of post-severe acute respiratory syndrome (SARS) Chinese patients with osteonecrosis, investigate the aetiology of post-SARS osteonecrosis (ON), and select the sensitive molecular markers for identifying the susceptible population. For this study, blood samples were collected from 88 patients with post-SARS ON and 52 healthy people. Activated partial thromboplastin time (APTT), protein C (PC), antithrombin III (AT-III), plasminogen activator inhibitor (PAI), activated protein C resistance (APC-R), plasminogen (PLG), von Willebrand's factor(vWF), D-dimer (D-D), fibrinogen (Fib), and homocysteine (HCY) were examined by enzyme-linked immunosorbent assay (ELISA). We noted that blood agents of patients with ON changed obviously. APTT, PC, AT-III, PAI, APC-R, and PLG were significantly different between the two groups. Hypercoagulation and hypofibrinolysis were found in patients with post-SARS ON. Therefore, these examinations can be used to screen a population susceptible to ON. Measurements of APTT, PC, AT-III, PAI, APC-R, and PLG are sensitive blood tests for screening purposes.

Annotation

Disease Annotations    
osteonecrosis  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Plg  (plasminogen)
Proc  (protein C, inactivator of coagulation factors Va and VIIIa)
Serpinc1  (serpin family C member 1)
Vwf  (von Willebrand factor)

Genes (Mus musculus)
Plg  (plasminogen)
Proc  (protein C)
Serpinc1  (serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1)
Vwf  (Von Willebrand factor)

Genes (Homo sapiens)
PLG  (plasminogen)
PROC  (protein C, inactivator of coagulation factors Va and VIIIa)
SERPINC1  (serpin family C member 1)
VWF  (von Willebrand factor)


Additional Information