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In response to vascular injury, the hemostatic system triggers platelet aggregation and initiation of the coagulation cascade, primary and secondary hemostasis, respectively, to prevent bleeding. The coagulation cascade initiated via tissue factor - the extrinsic pathway, or contact - the intrinsic pathway, converges into a common pathway leading to formation of insoluble fibrin clots. A fibrinolytic cascade follows coagulation to lyse fibrin and protect against blood clotting. Several anticoagu

Pathway Diagram:

Elsevier Inc. Proc_act_diss ---| coagulation cascade pathway coagulation cascade pathway Gla domain Thbd Procr F2 Proc Proc_act Proc_act_diss Pros1 protease mediated signaling pathway vitamin K-dependent proteins, anticoagulation vitamin K cycle pathway Proc_act_diss ---- Pros1 F2 ---- Thbd Proc ---- Procr F2 --+> Proc_act F2 ---> Proc Proc_act ---- Procr Proc_act --+> protease mediated signaling pathway

Genes in Pathway:

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protein C anticoagulant pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:1578508
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:1580373
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link 18 24,918,402 24,928,822 RGD:1578389
G Procr protein C receptor JBrowse link 3 151,285,321 151,289,581 RGD:1578508
G Pros1 protein S JBrowse link 7 1,206,648 1,288,140 RGD:1578508
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:11352294

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the protein C anticoagulant pathway

References Associated with the protein C anticoagulant pathway:

Ontology Path Diagram:

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