PROTEIN C ANTICOAGULANT PATHWAY (PW:0000480)

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Description

In response to vascular injury, the hemostatic system triggers platelet aggregation and initiation of the coagulation cascade, primary and secondary hemostasis, respectively, to prevent bleeding. The coagulation cascade initiated via tissue factor - the extrinsic pathway, or contact - the intrinsic pathway, converges into a common pathway leading to formation of insoluble fibrin clots. A fibrinolytic cascade follows coagulation to lyse fibrin and protect against blood clotting. Several anticoagu

Pathway Diagram:

Elsevier Inc. Proc_act_diss ---| coagulation cascade pathway coagulation cascade pathway Gla domain Thbd Procr F2 Proc Proc_act Proc_act_diss Pros1 protease mediated signaling pathway vitamin K-dependent proteins, anticoagulation vitamin K cycle pathway Proc_act_diss ---- Pros1 F2 ---- Thbd Proc ---- Procr F2 --+> Proc_act F2 ---> Proc Proc_act ---- Procr Proc_act --+> protease mediated signaling pathway
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Genes in Pathway:

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protein C anticoagulant pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:1578508
RGD:11352294
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:1580373
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link 18 24,918,402 24,928,822 RGD:1578389
RGD:11352294
G Procr protein C receptor JBrowse link 3 151,285,321 151,289,581 RGD:1578508
RGD:11352294
G Pros1 protein S JBrowse link 7 1,206,648 1,288,140 RGD:1578508
RGD:11352294
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:11352294

Pathway Gene Annotations

Disease Annotations Associated with Genes in the protein C anticoagulant pathway
Disease TermsGene Symbols
Abortion, HabitualF5 , Thbd
Acquired AngioedemaF2
Activated Protein C ResistanceF5 , Proc , Pros1
Acute Coronary SyndromeF2
acute kidney failureProc , Procr , Thbd
Acute Liver FailureThbd
Acute Lung InjuryF2 , Proc , Procr , Thbd
acute promyelocytic leukemiaThbd
adult respiratory distress syndromePros1 , Thbd
allergic rhinitisF2
Alzheimer's diseaseF2 , Thbd
ankylosing spondylitisThbd
anterior ischemic optic neuropathyF5
antiphospholipid syndromeProc
appendicitisF2
ArteritisProc
asthmaF2 , Proc , Thbd
atherosclerosisF2
atopic dermatitisF2
atypical hemolytic-uremic syndromeThbd
autoimmune hepatitisF2
bacterial pneumoniaF2
Behcet's diseaseF5
blood coagulation diseaseF2 , F5 , Proc , Pros1
brain edemaF2
Brain InjuriesF2 , Thbd
brain ischemiaF2 , F5
Breast NeoplasmsF5
Budd-Chiari syndromeF5
bullous pemphigoidF2
carotid artery thrombosisThbd
carotid stenosisF2 , Procr
celiac diseaseF2
central retinal vein occlusionProc
Cerebral HemorrhageF2
cerebral infarctionF2 , F5 , Pros1
Cerebral Small Vessel DiseasesThbd
cerebrovascular diseaseF2 , F5
Chagas diseaseF2
Chronic Lymphocytic Leukemia, B-CellThbd
chronic obstructive pulmonary diseaseF2
clear cell renal cell carcinomaF2
Colonic NeoplasmsF5
Colorectal NeoplasmsF5
Congenital Thrombotic Disease, due to Protein C DeficiencyProc
ContusionsF2
coronary artery diseaseF2 , Procr , Thbd
Coronary DiseaseThbd
Crohn's diseaseF2 , Thbd
dermatomyositisThbd
Diabetic NephropathiesF2 , Pros1
disseminated intravascular coagulationF2 , Proc , Thbd
Drug-Related Side Effects and Adverse ReactionsThbd
DysarthriaF5
DyspneaF5
DysprothrombinemiaF2
end stage renal failureF2 , F5 , Thbd
EndotoxemiaF2 , F5 , Proc , Thbd
Endotoxin-Induced UveitisThbd
Experimental ArthritisF2 , Thbd
Experimental Diabetes MellitusF2
Experimental Liver CirrhosisF5 , Procr , Pros1 , Thbd
eye diseaseF2
factor V deficiencyF5
factor VIII deficiencyF2
familial adenomatous polyposisF5
familial combined hyperlipidemiaThbd
familial Mediterranean feverThbd
fatty liver diseaseF2
Female InfertilityProc
Femur Head NecrosisF2 , F5
Fetal DeathF5
genetic diseasePros1
glomerulonephritisF2
Hearing Loss, Noise-InducedProc
Heat StrokeProc , Thbd
hemolytic-uremic syndromeThbd
hemophilia BF2
HemorrhageF2
hepatocellular carcinomaF2
hereditary angioedemaF2
Hereditary ThrombophiliaF5
Hereditary Thrombophilia, due To Protein C Deficiency, Autosomal DominantProc
Hereditary Thrombophilia, due to Protein C Deficiency, Autosomal RecessiveProc
Huntington's diseaseF2
HyperalgesiaF2 , Thbd
hypereosinophilic syndromeF5
hyperglycemiaF2
hyperhomocysteinemiaF2
hypertensionProc , Thbd
HypertrophyF2
hypothyroidismThbd
idiopathic pulmonary fibrosisThbd
impotenceThbd
InflammationProcr , Thbd
Insulin ResistanceThbd
Intestinal Reperfusion InjuryProc
intracranial sinus thrombosisF2
ischemiaThbd
juvenile rheumatoid arthritisPros1 , Thbd
Kidney CalculiF2
lattice corneal dystrophyF2
liver cirrhosisF2 , F5
liver diseaseThbd
Liver FailureF2
Liver Reperfusion InjuryProc
Lung Reperfusion InjuryProc
malignant gliomaF2
membranoproliferative glomerulonephritisF5
Mesenteric IschemiaF2 , F5
Metabolic SyndromeThbd
middle cerebral artery infarctionProc
Multiple Organ FailureThbd
myocardial infarctionF2 , F5 , Proc , Thbd
Myocardial IschemiaF5
Myocardial Reperfusion InjuryProcr
Neoplasm MetastasisF2
Nephrolithiasis, Calcium OxalateF2
nephrosisF2
Nerve DegenerationF2
Neuropathy, PainfulThbd
non-small cell lung carcinomaThbd
nonalcoholic fatty liver diseaseF2
obesityF2 , Thbd
Osteoarthritis, KneeF2
Ovarian NeoplasmsF2
Pancreatitis, Experimental, Acute Proc , Procr
ParatuberculosisF2
Pediatric Crohn's DiseaseF2
Peripheral Nerve InjuriesProcr
Peritoneal FibrosisF5
placental abruptionProc
pre-eclampsiaF2 , F5 , Proc
PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 1F5
PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 2F2
prostate cancerF2 , F5
protein C deficiencyProc
protein S deficiencyPros1
prothrombin deficiencyF2
Prothrombin Deficiency, CongenitalF2
pulmonary embolismF2 , F5 , Proc , Pros1 , Thbd
pulmonary fibrosisF2 , F5
pulmonary hypertensionF5 , Thbd
purpura fulminansProc
Reperfusion InjuryF2 , Thbd
retinal artery occlusionF5
retinal vein occlusionF2 , F5
rheumatoid arthritisF2 , Thbd
sagittal sinus thrombosisF5 , Pros1
schizophreniaF2
sensorineural hearing lossF2 , F5
SepsisF2 , F5 , Proc , Thbd
Septic PeritonitisF5
Shock, HemorrhagicF2
sickle cell anemiaF2
Spinal Cord InjuriesF2 , Thbd
Spinal Cord Reperfusion InjuryProc
Stomach NeoplasmsThbd
StrokeF2 , F5 , Thbd
Systemic Inflammatory Response SyndromeThbd
systemic lupus erythematosusF2 , Thbd
systemic sclerodermaF2
ThromboembolismF2 , F5 , Proc , Pros1 , Thbd
thrombophiliaF2 , F5 , Proc , Thbd
Thrombophilia due to Thrombomodulin DefectThbd
Thrombophilia, Hereditary, Due To Protein S Deficiency, Autosomal DominantPros1
Thrombophilia, Hereditary, Due To Protein S Deficiency, Autosomal RecessivePros1
thrombophlebitisPros1
thrombosisF2 , F5 , Proc , Pros1 , Thbd
thrombotic thrombocytopenic purpuraProc , Thbd
toxic shock syndromeProc
type 1 diabetes mellitusThbd
type 2 diabetes mellitusF2 , Thbd
ulcerative colitisF2 , Thbd
urinary bladder cancerF2
Urinary CalculiF2
urticariaF2
vascular diseasePros1
vascular skin diseaseF2
Venous ThromboembolismF2 , F5 , Proc , Pros1
Venous ThrombosisF2 , F5 , Proc , Pros1
Ventricular Dysfunction, LeftF2
Ventricular FibrillationF2
Viral Hepatitis, HumanF2
Wegener's granulomatosisThbd
Pathway Annotations Associated with Genes in the protein C anticoagulant pathway

References Associated with the protein C anticoagulant pathway:

Ontology Path Diagram:

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