Proc (protein C, inactivator of coagulation factors Va and VIIIa) - Rat Genome Database

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Gene: Proc (protein C, inactivator of coagulation factors Va and VIIIa) Chinchilla lanigera
Analyze
Symbol: Proc
Name: protein C, inactivator of coagulation factors Va and VIIIa
RGD ID: 8873519
Description: ENCODES a protein that exhibits identical protein binding (ortholog); oligopeptidase activity (ortholog); peptidase activity (ortholog); INVOLVED IN liver development (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of blood coagulation (ortholog); PARTICIPATES IN coagulation cascade pathway; protease mediated signaling via protease-activated receptor 1; protein C anticoagulant pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN endoplasmic reticulum (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: vitamin K-dependent protein C
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554593,094,120 - 3,104,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554593,097,229 - 3,105,566 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Proc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554593,094,120 - 3,104,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554593,097,229 - 3,105,566 (-)NCBIChiLan1.0ChiLan1.0
PROC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382127,418,427 - 127,429,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2127,418,427 - 127,429,242 (+)EnsemblGRCh38hg38GRCh38
GRCh372128,176,003 - 128,186,818 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,892,487 - 127,903,288 (+)NCBINCBI36Build 36hg18NCBI36
Build 342127,892,245 - 127,903,048NCBI
Celera2121,487,217 - 121,498,043 (+)NCBICelera
Cytogenetic Map2q14.3NCBI
HuRef2120,483,060 - 120,493,885 (+)NCBIHuRef
CHM1_12128,180,576 - 128,191,401 (+)NCBICHM1_1
T2T-CHM13v2.02127,853,697 - 127,864,511 (+)NCBIT2T-CHM13v2.0
Proc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,256,179 - 32,272,623 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,256,179 - 32,272,623 (-)EnsemblGRCm39 Ensembl
GRCm381832,123,126 - 32,139,570 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,123,126 - 32,139,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv371832,282,780 - 32,299,224 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361832,266,137 - 32,278,949 (-)NCBIMGSCv36mm8
Celera1832,604,740 - 32,621,169 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.94NCBI
Proc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,038,596 - 24,049,061 (-)NCBIGRCr8
mRatBN7.21823,764,367 - 23,774,816 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1823,764,368 - 23,775,133 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1823,892,461 - 23,902,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01824,648,935 - 24,660,144 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01823,987,447 - 23,997,792 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01824,918,402 - 24,928,822 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1824,918,398 - 24,929,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01824,633,206 - 24,643,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41824,563,368 - 24,573,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11824,590,014 - 24,600,361 (-)NCBI
Celera1823,516,361 - 23,526,709 (-)NCBICelera
Cytogenetic Map18p12NCBI
PROC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21348,216,407 - 48,225,782 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B48,225,133 - 48,240,711 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B32,846,899 - 32,859,060 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B128,083,794 - 128,094,625 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B128,083,794 - 128,094,625 (+)Ensemblpanpan1.1panPan2
PROC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11923,173,626 - 23,183,634 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1923,173,635 - 23,183,563 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1923,421,177 - 23,431,114 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01924,500,225 - 24,510,240 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1924,500,234 - 24,510,166 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11923,203,858 - 23,213,794 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01923,398,248 - 23,408,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01924,530,694 - 24,540,633 (-)NCBIUU_Cfam_GSD_1.0
Dog Cytomap19q21-q22NCBI
Proc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530397,765,920 - 97,775,831 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646943,841,989 - 43,850,304 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646943,841,989 - 43,850,322 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1525,043,545 - 25,056,595 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11525,043,543 - 25,054,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,724,914 - 28,735,638 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1102,789,227 - 2,799,783 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl102,789,277 - 2,799,531 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606119,959,230 - 19,968,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Proc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473213,915,402 - 13,923,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473213,915,361 - 13,922,182 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000003856   ⟹   ENSCLAP00000003780
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554593,094,120 - 3,104,135 (-)Ensembl
RefSeq Acc Id: XM_005397611   ⟹   XP_005397668
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554593,097,229 - 3,105,465 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005397612   ⟹   XP_005397669
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554593,097,229 - 3,105,464 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005397613   ⟹   XP_005397670
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554593,097,229 - 3,105,552 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005397614   ⟹   XP_005397671
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554593,097,229 - 3,105,566 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521066   ⟹   XP_013376520
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554593,097,229 - 3,105,465 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013521067   ⟹   XP_013376521
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554593,097,229 - 3,105,566 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005397671   ⟸   XM_005397614
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UQN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005397670   ⟸   XM_005397613
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UQN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005397668   ⟸   XM_005397611
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UQN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005397669   ⟸   XM_005397612
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UQN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013376521   ⟸   XM_013521067
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UQN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013376520   ⟸   XM_013521066
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UQN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000003780   ⟸   ENSCLAT00000003856
Protein Domains
EGF-like   Gla   Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002690 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000003856 ENTREZGENE
  ENSCLAT00000003856.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  4.10.740.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  Pept_S1A_FX UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene Proc ENTREZGENE
PANTHER COAGULATION FACTOR UniProtKB/TrEMBL
  VITAMIN K-DEPENDENT PROTEIN C UniProtKB/TrEMBL
Pfam FXa_inhibition UniProtKB/TrEMBL
  Gla UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PIRSF Factor_X UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
  GLABLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF50494 UniProtKB/TrEMBL
  SSF57630 UniProtKB/TrEMBL
UniProt A0A8C2UQN7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Proc  protein C, inactivator of coagulation factors Va and VIIIa    protein C (inactivator of coagulation factors Va and VIIIa)  Symbol and/or name change 5135510 APPROVED