Piezo2 (piezo-type mechanosensitive ion channel component 2) - Rat Genome Database

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Gene: Piezo2 (piezo-type mechanosensitive ion channel component 2) Rattus norvegicus
Analyze
Symbol: Piezo2
Name: piezo-type mechanosensitive ion channel component 2
RGD ID: 1582973
Description: Predicted to enable mechanosensitive monoatomic ion channel activity and monoatomic cation channel activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; detection of mechanical stimulus involved in sensory perception; and monoatomic cation transport. Predicted to be located in cuticular plate; neuronal cell body membrane; and stereocilium. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 3 and distal arthrogryposis type 5. Orthologous to human PIEZO2 (piezo type mechanosensitive ion channel component 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam38b; family with sequence similarity 38, member B; LOC307380; LOC688934; RGD1306866; similar to Hypothetical protein KIAA0233; similar to protein fam38b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81858,738,734 - 59,115,252 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1858,738,740 - 59,115,215 (-)EnsemblGRCr8
mRatBN7.21856,468,449 - 56,844,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1856,469,680 - 56,844,216 (-)EnsemblmRatBN7.2
Rnor_6.01858,353,361 - 58,728,555 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1858,354,648 - 58,499,836 (-)Ensemblrn6Rnor6.0
Rnor_5.01857,576,278 - 57,949,635 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41859,147,791 - 59,531,873 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1854,616,241 - 54,988,723 (-)NCBICelera
RGSC_v3.11859,220,826 - 59,402,111 (-)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibenz[a,h]anthracene  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
indometacin  (ISO)
inulin  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
succimer  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20813920   PMID:24344923   PMID:24717433   PMID:24746027   PMID:24911969   PMID:26929410   PMID:27481627   PMID:32100938   PMID:33893246   PMID:36149769   PMID:36810623   PMID:37227654  


Genomics

Comparative Map Data
Piezo2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81858,738,734 - 59,115,252 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1858,738,740 - 59,115,215 (-)EnsemblGRCr8
mRatBN7.21856,468,449 - 56,844,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1856,469,680 - 56,844,216 (-)EnsemblmRatBN7.2
Rnor_6.01858,353,361 - 58,728,555 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1858,354,648 - 58,499,836 (-)Ensemblrn6Rnor6.0
Rnor_5.01857,576,278 - 57,949,635 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41859,147,791 - 59,531,873 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1854,616,241 - 54,988,723 (-)NCBICelera
RGSC_v3.11859,220,826 - 59,402,111 (-)NCBI
Cytogenetic Map18q12.1NCBI
PIEZO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381810,670,247 - 11,149,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1810,666,483 - 11,149,569 (-)Ensemblhg38GRCh38
GRCh371810,670,244 - 11,149,568 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361810,660,850 - 10,687,814 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341810,660,859 - 10,687,814NCBI
Celera1810,552,160 - 11,030,879 (-)NCBICelera
Cytogenetic Map18p11.22-p11.21NCBI
HuRef1810,624,312 - 11,102,956 (-)NCBIHuRef
CHM1_11810,669,431 - 11,148,579 (-)NCBICHM1_1
T2T-CHM13v2.01810,832,368 - 11,311,713 (-)NCBIT2T-CHM13v2.0
Piezo2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391863,143,284 - 63,520,787 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1863,143,284 - 63,520,254 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381863,010,213 - 63,387,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1863,010,213 - 63,387,183 (-)Ensemblmm10GRCm38
MGSCv371863,169,867 - 63,546,837 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361863,167,798 - 63,511,826 (-)NCBIMGSCv36mm8
Celera1864,286,871 - 64,658,106 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1835.95NCBI
Piezo2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554021,650,726 - 1,871,876 (+)Ensembl
ChiLan1.0NW_0049554021,534,619 - 1,873,143 (+)NCBIChiLan1.0ChiLan1.0
PIEZO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21727,304,996 - 27,783,714 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11812,997,591 - 13,476,294 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0183,141,285 - 3,619,885 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1185,407,467 - 5,884,207 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl185,407,467 - 5,882,928 (+)EnsemblpanPan2panpan1.1
PIEZO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1776,477,628 - 76,918,660 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl776,478,928 - 76,919,723 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha775,880,977 - 76,321,043 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0776,533,250 - 76,973,897 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl776,533,865 - 76,974,780 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1776,231,312 - 76,673,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0776,259,881 - 76,700,879 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0776,564,098 - 77,004,969 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Piezo2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049441,573,205 - 1,912,950 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936626802,490 - 1,140,082 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936626802,415 - 1,141,260 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIEZO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl697,643,978 - 97,944,456 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1697,644,115 - 97,945,693 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PIEZO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11870,161,961 - 70,623,912 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1870,246,132 - 70,622,611 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605045,184,171 - 45,648,978 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Piezo2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477018,836,899 - 19,157,114 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477018,835,706 - 19,157,177 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Piezo2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11568,905,324 - 69,272,499 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Piezo2
3029 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:148
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000000129, ENSRNOT00000025556, ENSRNOT00000065693
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Rat41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21856,594,589 - 56,594,808 (+)MAPPERmRatBN7.2
Rnor_6.01858,476,128 - 58,476,346NCBIRnor6.0
Rnor_5.01857,699,045 - 57,699,263UniSTSRnor5.0
RGSC_v3.41859,279,066 - 59,279,285RGDRGSC3.4
RGSC_v3.41859,279,067 - 59,279,285UniSTSRGSC3.4
Celera1854,738,316 - 54,738,534UniSTS
RGSC_v3.11859,352,268 - 59,352,486RGD
RH 3.4 Map18558.8RGD
RH 3.4 Map18558.8UniSTS
RH 2.0 Map18343.2RGD
SHRSP x BN Map1825.0199RGD
FHH x ACI Map1839.06RGD
Cytogenetic Map18q12.1UniSTS
BE106644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21856,469,269 - 56,469,448 (+)MAPPERmRatBN7.2
Rnor_6.01858,354,182 - 58,354,360NCBIRnor6.0
Rnor_5.01857,577,099 - 57,577,277UniSTSRnor5.0
RGSC_v3.41859,147,796 - 59,147,974UniSTSRGSC3.4
Celera1854,617,062 - 54,617,240UniSTS
RH 3.4 Map18567.0UniSTS
Cytogenetic Map18q12.1UniSTS
RH141033  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21856,477,591 - 56,477,772 (+)MAPPERmRatBN7.2
Rnor_6.01858,362,503 - 58,362,683NCBIRnor6.0
Rnor_5.01857,585,420 - 57,585,600UniSTSRnor5.0
RGSC_v3.41859,156,117 - 59,156,297UniSTSRGSC3.4
Celera1854,625,383 - 54,625,563UniSTS
RH 3.4 Map18555.1UniSTS
Cytogenetic Map18q12.1UniSTS
AW533757  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81858,739,386 - 58,739,582 (+)Marker Load Pipeline
mRatBN7.21856,469,095 - 56,469,291 (+)MAPPERmRatBN7.2
Rnor_6.01858,354,008 - 58,354,203NCBIRnor6.0
Rnor_5.01857,576,925 - 57,577,120UniSTSRnor5.0
RGSC_v3.41859,147,622 - 59,147,817UniSTSRGSC3.4
Celera1854,616,888 - 54,617,083UniSTS
RH 3.4 Map18569.3UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 67 150 91 90 59 34 59 6 295 134 11 129 81 92 31 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001063568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017587882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_225880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000025556   ⟹   ENSRNOP00000025552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1858,738,740 - 59,115,215 (-)Ensembl
mRatBN7.2 Ensembl1856,469,680 - 56,844,216 (-)Ensembl
Rnor_6.0 Ensembl1858,411,533 - 58,423,196 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000065693   ⟹   ENSRNOP00000063723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1858,738,740 - 59,115,215 (-)Ensembl
mRatBN7.2 Ensembl1856,469,680 - 56,844,216 (-)Ensembl
Rnor_6.0 Ensembl1858,354,648 - 58,499,836 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102225   ⟹   ENSRNOP00000085065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1858,738,740 - 59,115,215 (-)Ensembl
mRatBN7.2 Ensembl1856,469,680 - 56,844,216 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107888   ⟹   ENSRNOP00000084685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1858,738,740 - 59,114,538 (-)Ensembl
mRatBN7.2 Ensembl1856,469,680 - 56,844,216 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120243   ⟹   ENSRNOP00000088580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1858,837,557 - 59,115,215 (-)Ensembl
mRatBN7.2 Ensembl1856,567,268 - 56,844,216 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123549   ⟹   ENSRNOP00000106062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1858,738,740 - 59,115,215 (-)Ensembl
RefSeq Acc Id: NM_001427318   ⟹   NP_001414247
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81858,738,740 - 59,115,215 (-)NCBI
RefSeq Acc Id: XM_039097388   ⟹   XP_038953316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81858,738,734 - 59,115,251 (-)NCBI
mRatBN7.21856,468,449 - 56,844,983 (-)NCBI
RefSeq Acc Id: XM_039097389   ⟹   XP_038953317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81858,738,734 - 59,115,251 (-)NCBI
mRatBN7.21856,468,449 - 56,844,983 (-)NCBI
RefSeq Acc Id: XM_039097390   ⟹   XP_038953318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81858,738,734 - 59,115,251 (-)NCBI
mRatBN7.21856,468,449 - 56,844,983 (-)NCBI
RefSeq Acc Id: XM_039097391   ⟹   XP_038953319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81858,738,734 - 59,115,251 (-)NCBI
mRatBN7.21856,468,449 - 56,844,983 (-)NCBI
RefSeq Acc Id: XM_039097392   ⟹   XP_038953320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81858,738,734 - 58,834,632 (-)NCBI
mRatBN7.21856,468,449 - 56,564,341 (-)NCBI
RefSeq Acc Id: XM_063277327   ⟹   XP_063133397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81858,738,734 - 59,115,252 (-)NCBI
RefSeq Acc Id: XM_225880   ⟹   XP_225880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81858,738,734 - 59,115,251 (-)NCBI
mRatBN7.21856,468,449 - 56,844,982 (-)NCBI
Rnor_6.01858,353,361 - 58,728,552 (-)NCBI
Rnor_5.01857,576,278 - 57,949,635 (-)NCBI
RGSC_v3.41859,147,791 - 59,531,873 (-)RGD
Sequence:
RefSeq Acc Id: XR_005496481
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81858,743,776 - 59,115,252 (-)NCBI
mRatBN7.21856,473,544 - 56,844,984 (-)NCBI
RefSeq Acc Id: XP_225880   ⟸   XM_225880
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZZN0 (UniProtKB/TrEMBL),   A0A8I6A0I2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063723   ⟸   ENSRNOT00000065693
Ensembl Acc Id: ENSRNOP00000025552   ⟸   ENSRNOT00000025556
RefSeq Acc Id: XP_038953318   ⟸   XM_039097390
- Peptide Label: isoform X3
- UniProtKB: F1M208 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953316   ⟸   XM_039097388
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953317   ⟸   XM_039097389
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953319   ⟸   XM_039097391
- Peptide Label: isoform X4
- UniProtKB: F1M208 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953320   ⟸   XM_039097392
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000088580   ⟸   ENSRNOT00000120243
Ensembl Acc Id: ENSRNOP00000084685   ⟸   ENSRNOT00000107888
Ensembl Acc Id: ENSRNOP00000085065   ⟸   ENSRNOT00000102225
RefSeq Acc Id: XP_063133397   ⟸   XM_063277327
- Peptide Label: isoform X7
- UniProtKB: F1M208 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414247   ⟸   NM_001427318
- UniProtKB: F1M208 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106062   ⟸   ENSRNOT00000123549
Protein Domains
Piezo non-specific cation channel cap   Piezo THU9 and anchor   Piezo TM1-24   Piezo TM25-28   Piezo transmembrane helical unit

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1582973 AgrOrtholog
BioCyc Gene G2FUF-7274 BioCyc
Ensembl Genes ENSRNOG00000038784 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025556 ENTREZGENE
  ENSRNOT00000025556.7 UniProtKB/TrEMBL
  ENSRNOT00000065693 ENTREZGENE
  ENSRNOT00000065693.6 UniProtKB/TrEMBL
  ENSRNOT00000102225 ENTREZGENE
  ENSRNOT00000102225.2 UniProtKB/TrEMBL
  ENSRNOT00000107888 ENTREZGENE
  ENSRNOT00000107888.2 UniProtKB/TrEMBL
  ENSRNOT00000120243.2 UniProtKB/TrEMBL
  ENSRNOT00000123549.1 UniProtKB/TrEMBL
InterPro Piezo UniProtKB/TrEMBL
  Piezo_dom UniProtKB/TrEMBL
  Piezo_RRas-bd_dom UniProtKB/TrEMBL
  Piezo_THU9_anchor UniProtKB/TrEMBL
  Piezo_TM1-24 UniProtKB/TrEMBL
  THU_Piezo UniProtKB/TrEMBL
NCBI Gene Piezo2 ENTREZGENE
PANTHER PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT UniProtKB/TrEMBL
  PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG UniProtKB/TrEMBL
Pfam DUF3595 UniProtKB/TrEMBL
  PIEZO UniProtKB/TrEMBL
  Piezo_THU9_anchor UniProtKB/TrEMBL
  Piezo_TM1-24 UniProtKB/TrEMBL
  THU_Piezo1 UniProtKB/TrEMBL
PhenoGen Piezo2 PhenoGen
RatGTEx ENSRNOG00000038784 RatGTEx
UniProt A0A8I5ZZN0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0I2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9Q3_RAT UniProtKB/TrEMBL
  A0ABK0LKA2_RAT UniProtKB/TrEMBL
  D3ZXL7_RAT UniProtKB/TrEMBL
  F1M208 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-29 Piezo2  piezo-type mechanosensitive ion channel component 2  Fam38b  family with sequence similarity 38, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-12-10 Fam38b  family with sequence similarity 38, member B  RGD1306866  similar to Hypothetical protein KIAA0233  Data merged from RGD:1306866 737654 APPROVED
2008-07-08 Fam38b  family with sequence similarity 38, member B  LOC682475  similar to Protein FAM38B  Data merged from RGD:1583417 1643240 APPROVED
2008-04-30 RGD1306866  similar to Hypothetical protein KIAA0233   RGD1306866_predicted  similar to Hypothetical protein KIAA0233 (predicted)  'predicted' is removed 2292626 APPROVED
2008-03-06 Fam38b  family with sequence similarity 38, member B  LOC688934  similar to Protein FAM38B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC688934  similar to Protein FAM38B      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682475  similar to Protein FAM38B      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1306866_predicted  similar to Hypothetical protein KIAA0233 (predicted)  LOC307380_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC307380_predicted  similar to Hypothetical protein KIAA0233 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL