Tmco6 (transmembrane and coiled-coil domains 6)

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Gene: Tmco6 (transmembrane and coiled-coil domains 6) Rattus norvegicus

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Symbol:

Tmco6

Name:

transmembrane and coiled-coil domains 6

RGD ID:

1309263

Description:

Predicted to enable nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Orthologous to human TMCO6 (transmembrane and coiled-coil domains 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC291661; RGD1309263; similar to hypothetical protein PRO1580; transmembrane and coiled-coil domain-containing protein 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	28,623,269 - 28,629,864 (+)	NCBI		GRCr8
mRatBN7.2	18	28,349,248 - 28,355,843 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	28,349,248 - 28,355,843 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	28,476,398 - 28,482,993 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	29,238,478 - 29,245,067 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	28,573,700 - 28,580,295 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	29,579,145 - 29,585,740 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	29,579,145 - 29,585,740 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	29,282,952 - 29,289,547 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	29,435,248 - 29,441,843 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	29,462,029 - 29,466,164 (+)	NCBI
Celera	18	28,069,801 - 28,076,396 (+)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 31 (ISO)

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

Leigh disease (ISO)

mitochondrial complex I deficiency (ISO)

Neurodevelopmental Disorders (ISO)

nuclear type mitochondrial complex I deficiency 1 (ISO)

nuclear type mitochondrial complex I deficiency 13 (ISO)

RNASET2-deficient cystic leukoencephalopathy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

acrylamide (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

finasteride (EXP)

folic acid (ISO)

gamma-hexachlorocyclohexane (ISO)

ochratoxin A (ISO)

paracetamol (ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

testosterone (ISO)

thioacetamide (EXP)

thiram (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein import into nucleus (IEA)

Molecular Function

nuclear import signal receptor activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Tmco6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	28,623,269 - 28,629,864 (+)	NCBI		GRCr8
mRatBN7.2	18	28,349,248 - 28,355,843 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	28,349,248 - 28,355,843 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	28,476,398 - 28,482,993 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	29,238,478 - 29,245,067 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	28,573,700 - 28,580,295 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	29,579,145 - 29,585,740 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	29,579,145 - 29,585,740 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	29,282,952 - 29,289,547 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	29,435,248 - 29,441,843 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	29,462,029 - 29,466,164 (+)	NCBI
Celera	18	28,069,801 - 28,076,396 (+)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

TMCO6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	140,596,530 - 140,647,732 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	140,639,435 - 140,645,408 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	140,019,036 - 140,024,989 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	139,999,196 - 140,005,173 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	136,095,757 - 136,101,734 (+)	NCBI		Celera
Cytogenetic Map	5	q31.3	NCBI
HuRef	5	135,164,249 - 135,170,226 (+)	NCBI		HuRef
CHM1_1	5	139,452,252 - 139,458,225 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	141,121,974 - 141,172,663 (+)	NCBI		T2T-CHM13v2.0

Tmco6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	36,868,072 - 36,875,453 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	36,868,092 - 36,875,450 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	36,735,019 - 36,742,400 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	36,735,039 - 36,742,397 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	36,894,724 - 36,902,045 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	36,861,042 - 36,868,371 (+)	NCBI		MGSCv36	mm8
Celera	18	37,187,143 - 37,194,456 (+)	NCBI		Celera
Cytogenetic Map	18	B2	NCBI
cM Map	18	19.46	NCBI

Tmco6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	55,110 - 61,705 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	55,110 - 61,670 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMCO6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	135,897,098 - 135,903,122 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	134,036,691 - 134,042,673 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	136,003,993 - 136,009,960 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	142,120,756 - 142,126,727 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	142,120,756 - 142,126,727 (+)	Ensembl	panpan1.1		panPan2

TMCO6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	35,797,298 - 35,803,491 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	35,797,464 - 35,803,199 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	32,836,310 - 32,842,502 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	36,252,697 - 36,259,144 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	36,252,863 - 36,258,852 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	33,305,443 - 33,311,513 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	34,173,074 - 34,179,277 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	34,925,782 - 34,931,978 (+)	NCBI		UU_Cfam_GSD_1.0

Tmco6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	152,024,429 - 152,032,212 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	9,579,316 - 9,587,009 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	9,579,316 - 9,587,057 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMCO6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	142,352,030 - 142,359,036 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	142,352,006 - 142,359,040 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	148,295,948 - 148,302,984 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMCO6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	43,272,568 - 43,278,525 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	43,272,662 - 43,278,223 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	34,605,998 - 34,611,962 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmco6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	33,382,973 - 33,401,509 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	33,383,047 - 33,398,774 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tmco6
20 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	162
Count of miRNA genes:	129
Interacting mature miRNAs:	143
Transcripts:	ENSRNOT00000038066
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26548082	46969551	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26548082	46969551	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26548082	46969551	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26548082	46969551	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26548082	46969551	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26548082	46969551	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26548082	46969551	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat

Markers in Region

RH131171

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	28,355,558 - 28,355,743 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	29,585,456 - 29,585,640	NCBI	Rnor6.0
Rnor_5.0	18	29,289,263 - 29,289,447	UniSTS	Rnor5.0
RGSC_v3.4	18	29,441,559 - 29,441,743	UniSTS	RGSC3.4
Celera	18	28,076,112 - 28,076,296	UniSTS
RH 3.4 Map	18	385.9	UniSTS
Cytogenetic Map	18	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166835	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000038066 ⟹ ENSRNOP00000038714

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,349,248 - 28,355,843 (+)	Ensembl
Rnor_6.0 Ensembl	18	29,579,145 - 29,585,740 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095755 ⟹ ENSRNOP00000082036

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	28,349,248 - 28,355,843 (+)	Ensembl

RefSeq Acc Id:

NM_001106154 ⟹ NP_001099624

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	28,623,269 - 28,629,864 (+)	NCBI
mRatBN7.2	18	28,349,248 - 28,355,843 (+)	NCBI
Rnor_6.0	18	29,579,145 - 29,585,740 (+)	NCBI
Rnor_5.0	18	29,282,952 - 29,289,547 (+)	NCBI
RGSC_v3.4	18	29,435,248 - 29,441,843 (+)	RGD
Celera	18	28,069,801 - 28,076,396 (+)	RGD

Sequence:

show sequence

CCTCACGCACAGCCCCACCCCTCACCCCTGCGCCGGGAGTGACTTTTTCTTCTGGTTTTGTCCA
GCGCCTGCGCAGTTCCAACCTTCCCCGGGCCGCGCCGTAGCCGCCGATCTCTAGGATTTTTTTG
GCTGCAAGATGTGGGGTCGGCGGCAGGGCCGCCTCAGGACGCTGGCGTGTGGGGTGGAGGAACT
GCGGCGCCGGCGGCGGGAACGGGAGGCAGCCCTGCGGAAGGCGCGGAGGGAGCAGCAATTGGTC
AGCAAGAGGCTGCTGAGGGAAGACGCCCCGGAAGAAACCGGAGGCCAGAGTGCAGCTGTGCTCC
TTGGGGAAGCCGAGGTCCAGCAGTTTCTTCGGCTAGCCCAACGGGGAACAGATGAAAAGGAGAG
GGAGAAGGCTCTGGTCAGCCTTCGTCGAGGCTTGCAGCACCCTGACACACAGCAAACCTTCATC
AGGCTGGAGGGCAGCATGCGGACCCTTGTCGGGCTCTTGACCAGCAATCGGGCCCTGTTGCAGC
TTGAGGCGGCTCGGTGCCTACATGAGCTCTCTCATTCTGAGCAGTCTGCAGTGGCTGAGGCCTG
CCTGCCAGCTACTTCCTACCTCCTCACCTACCTCTCTGGTCACAGCTCAGACTTCATAGAGCTG
TGTCTGTACACACTGGGGAACCTTATCGTGGAGAGCGAGGCTGTGAGAAAGCAGCTCCTGCCAC
AGGGCATTGTTCCGGCTTTTGCTGCCTGCATCCAGTCCCCCCATGTGGCTGTGCTGGAGGCCCT
TGGATATGCCTTGTCCCAGCTTCTGCAGGCTAAGGAAGCTCCAGAGAAGATCATTCCCTCTATT
CTGGACTCCAGCCTTCCCCAGCAGATGCTGCGATTGATGGGACCAGGCCCGAAGCTGAATCTTG
GGGTTGCTATGGAGTTTGCCTGGTGCCTTCACTATATCATTTGCAGCCAGGTCAACAATGCTGT
GCTCCTCACCCACGGGGCTCTGCCCACGTTGGTACTGCTGCTGGTGGACTTGGCTGGGGCTGTG
CAGAGAACGGATGATGTGGGACTAGAGCTGCTTGCATGCCCTGTGGTTCGGTGTCTAAGCAACC
TGTTAACAGAAGTGCCAGCGGAGGCCATGGGACAGCAAATGGAGCTCAGAGACGAGCGACTTGT
GGCAGCCTTATTTATCTTTCTCCAGTTCTTCCTTCAGAAACAGCCCGCCTTGCTACCTGAGGGC
CTCTGGCTCCTCAACAACCTCACTGCAAATAGTCCTACTTTTTGTACCTCATTGCTCTCCCTGA
ATCTGATTGAGCCCCTCTTGCAGCTGTTGCCGCTGTCAAATGTGGTCTGCATGTTGGTGCTTAC
AGTTCTGTGCAACGTTGTAGAGAAGGGTCCCGCTTACTGCCAGCGGTTATGGCCAGGACCCTTG
CTCTCCTGCTTGCTTAACACACTGGCTCTCTCTGACACCGACGTGGTAGGCCAGAGTTTGGAGC
TGCTGCAACTGCTGTTCTTGTATCAGCCAGAGGCTGCCCATGCCTTTCTGCAGCAGTCAGGGCT
TCAGGCCCTAGAAAAGCATCAGGAGGAAACTCAGCTTCACGATAGGATACATGCTCTCCGACAG
ACAACTGCTATTCTTGGATGATCTGGCTGCTTAATGTCACCCCCTGTCCCCTACAGCATATTTA
TTCTAGGGGCTCCTATTTCATTTTAGAAGCTAGCAGCTTTTTGTATACCTGAGAGTGGCGTTGC
ACTTGAGATCATACTGTTTCATCCTCTTCAGCAAGTTGGGTAATGACATGCGACATCCCAGCGG
GTAGCTGGGGTTTATTGATGAGAAATAAAATAGTATTTTTATATAAAGCT

hide sequence

RefSeq Acc Id:

XM_063277214 ⟹ XP_063133284

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	28,625,523 - 28,629,861 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099624	(Get FASTA)	NCBI Sequence Viewer
	XP_063133284	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66835	(Get FASTA)	NCBI Sequence Viewer
	EDL76310	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000038714.4
	ENSRNOP00000082036.1

RefSeq Acc Id:

NP_001099624 ⟸ NM_001106154

- UniProtKB:

G3V979 (UniProtKB/TrEMBL), A6J328 (UniProtKB/TrEMBL), B2RYM7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWGRRQGRLRTLACGVEELRRRRREREAALRKARREQQLVSKRLLREDAPEETGGQSAAVLLGE
AEVQQFLRLAQRGTDEKEREKALVSLRRGLQHPDTQQTFIRLEGSMRTLVGLLTSNRALLQLEA
ARCLHELSHSEQSAVAEACLPATSYLLTYLSGHSSDFIELCLYTLGNLIVESEAVRKQLLPQGI
VPAFAACIQSPHVAVLEALGYALSQLLQAKEAPEKIIPSILDSSLPQQMLRLMGPGPKLNLGVA
MEFAWCLHYIICSQVNNAVLLTHGALPTLVLLLVDLAGAVQRTDDVGLELLACPVVRCLSNLLT
EVPAEAMGQQMELRDERLVAALFIFLQFFLQKQPALLPEGLWLLNNLTANSPTFCTSLLSLNLI
EPLLQLLPLSNVVCMLVLTVLCNVVEKGPAYCQRLWPGPLLSCLLNTLALSDTDVVGQSLELLQ
LLFLYQPEAAHAFLQQSGLQALEKHQEETQLHDRIHALRQTTAILG

hide sequence

Ensembl Acc Id:

ENSRNOP00000038714 ⟸ ENSRNOT00000038066

Ensembl Acc Id:

ENSRNOP00000082036 ⟸ ENSRNOT00000095755

RefSeq Acc Id:	XP_063133284 ⟸ XM_063277214
- Peptide Label:	isoform X1

Protein Domains

IBB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V979-F1-model_v2	AlphaFold	G3V979	1-494	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700727

Promoter ID:

EPDNEW_R11251

Type:

multiple initiation site

Name:

Tmco6_1

Description:

transmembrane and coiled-coil domains 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	29,579,219 - 29,579,279	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309263	AgrOrtholog
BioCyc Gene	G2FUF-7863	BioCyc
Ensembl Genes	ENSRNOG00000017718	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000038066.5	UniProtKB/TrEMBL
	ENSRNOT00000095755.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9023939	IMAGE-MGC_LOAD
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	Armadillo	UniProtKB/TrEMBL
	Importin-a_IBB	UniProtKB/TrEMBL
KEGG Report	rno:291661	UniProtKB/TrEMBL
MGC_CLONE	MGC:188725	IMAGE-MGC_LOAD
NCBI Gene	291661	ENTREZGENE
PANTHER	TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6	UniProtKB/TrEMBL
	TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 TMCO6	UniProtKB/TrEMBL
PhenoGen	Tmco6	PhenoGen
PROSITE	IBB	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017718	RatGTEx
SMART	ARM	UniProtKB/TrEMBL
Superfamily-SCOP	ARM-type_fold	UniProtKB/TrEMBL
UniProt	A0A8I6G8W3_RAT	UniProtKB/TrEMBL
	A6J328	ENTREZGENE, UniProtKB/TrEMBL
	B2RYM7	ENTREZGENE, UniProtKB/TrEMBL
	G3V979	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-26	Tmco6	transmembrane and coiled-coil domains 6	RGD1309263_predicted	similar to hypothetical protein PRO1580 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1309263_predicted	similar to hypothetical protein PRO1580 (predicted)	LOC291661_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC291661_predicted	similar to hypothetical protein PRO1580 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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