Gene: Cdo1 (cysteine dioxygenase type 1) Rattus norvegicus
Analyze
Symbol:
Cdo1
Name:
cysteine dioxygenase type 1
Description:
Exhibits cysteine dioxygenase activity and ferrous iron binding activity. Involved in several processes, including L-cysteine catabolic process; lactation; and response to glucagon. Predicted to localize to the cytosol. Biomarker of hypertension. Orthologous to human CDO1 (cysteine dioxygenase type 1); PARTICIPATES IN cysteine metabolic pathway; mercaptolactate-cysteine disulfiduria pathway; ocular nonnephropathic cystinosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
CDO; CDO-I; cysteine dioxygenase; cysteine dioxygenase 1, cytosolic; cysteine dioxygenase, type I; cytosolic cysteine dioxygenase 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CDO1 (cysteine dioxygenase type 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Cdo1 (cysteine dioxygenase 1, cytosolic) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cdo1 (cysteine dioxygenase type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CDO1 (cysteine dioxygenase type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CDO1 (cysteine dioxygenase type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cdo1 (cysteine dioxygenase type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CDO1 (cysteine dioxygenase type 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
CDO1 (cysteine dioxygenase type 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Cdo1 (cysteine dioxygenase 1, cytosolic)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cdo1 (cysteine dioxygenase, type I)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
CG5493
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
cdo-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 18 40,702,027 - 40,716,901 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 18 40,701,984 - 40,716,686 (-) Ensembl Rnor_5.0 18 40,348,054 - 40,362,746 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 18 40,914,028 - 40,928,671 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 18 40,951,568 - 40,966,212 (-) NCBI Celera 18 37,683,907 - 37,698,550 (-) NCBI Celera Cytogenetic Map 18 q11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
autistic disorder ISO RGD:737394 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 Hereditary Neoplastic Syndromes ISO RGD:737394 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:28492532 Neurodevelopmental Disorders ISO RGD:737394 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868
Imported Annotations - CTD
Experimental Liver Cirrhosis ISO RGD:737394 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17072980 type 2 diabetes mellitus ISO RGD:737394 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23665415
1,1-dichloroethene decreases expression ISO RGD:737395 6480464 vinylidene chloride results in decreased expression of CDO1 mRNA CTD PMID:26682919 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of CDO1 mRNA CTD PMID:17108234 17beta-estradiol decreases expression ISO RGD:737394 6480464 Estradiol results in decreased expression of CDO1 mRNA CTD PMID:20106945 17beta-estradiol decreases expression ISO RGD:737395 6480464 Estradiol results in decreased expression of CDO1 mRNA CTD PMID:19484750 17beta-estradiol affects expression ISO RGD:737395 6480464 Estradiol affects the expression of CDO1 mRNA CTD PMID:16684588 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:737395 6480464 [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA] more ... CTD PMID:16054899 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CDO1 mRNA CTD PMID:16054898 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CDO1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:737395 6480464 Tetrachlorodibenzodioxin results in decreased expression of CDO1 mRNA CTD PMID:15667827 more ... 2,3,7,8-Tetrachlorodibenzofuran decreases expression ISO RGD:737395 6480464 2 more ... CTD PMID:25768209 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin analog results in decreased expression of CDO1 protein, alpha-Chlorohydrin results in decreased expression of CDO1 protein CTD PMID:26597043 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:737395 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA more ... CTD PMID:16054899 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:737394 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CDO1 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol increases expression ISO RGD:737395 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of CDO1 mRNA CTD PMID:30951980 4-octylphenol decreases expression ISO RGD:737394 6480464 4-octylphenol results in decreased expression of CDO1 mRNA CTD PMID:16223563 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of CDO1 mRNA CTD PMID:19483382 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of CDO1 mRNA CTD PMID:19483382 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of CDO1 mRNA CTD PMID:24780913 aflatoxin B1 affects expression ISO RGD:737394 6480464 Aflatoxin B1 affects the expression of CDO1 protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:737394 6480464 Aflatoxin B1 results in decreased expression of CDO1 mRNA CTD PMID:27153756 aflatoxin B1 decreases methylation ISO RGD:737394 6480464 Aflatoxin B1 results in decreased methylation of CDO1 gene CTD PMID:27153756 amiodarone affects expression EXP 6480464 Amiodarone affects the expression of CDO1 mRNA CTD PMID:19483382 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CDO1 mRNA CTD PMID:16483693 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CDO1 mRNA CTD PMID:18178546 arsenite(3-) decreases expression ISO RGD:737395 6480464 arsenite results in decreased expression of CDO1 mRNA CTD PMID:18191166 arsenite(3-) increases methylation ISO RGD:737394 6480464 arsenite results in increased methylation of CDO1 promoter CTD PMID:23974009 benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of CDO1 mRNA CTD PMID:19483382 benzo[a]pyrene decreases expression ISO RGD:737395 6480464 Benzo(a)pyrene results in decreased expression of CDO1 mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression ISO RGD:737394 6480464 Benzo(a)pyrene results in decreased expression of CDO1 mRNA CTD PMID:21632981 , PMID:26238291 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CDO1 mRNA CTD PMID:21839799 bexarotene decreases expression EXP 6480464 bexarotene results in decreased expression of CDO1 mRNA CTD PMID:16648578 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:737394 6480464 Diethylhexyl Phthalate results in decreased expression of CDO1 mRNA CTD PMID:16223563 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CDO1 mRNA CTD PMID:25181051 , PMID:30903817 bisphenol F increases expression ISO RGD:737395 6480464 bisphenol F results in increased expression of CDO1 mRNA CTD PMID:30951980 bromobenzene decreases expression EXP 6480464 bromobenzene results in decreased expression of CDO1 mRNA CTD PMID:12628495 bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of CDO1 mRNA CTD PMID:15056800 carbon nanotube decreases expression ISO RGD:737395 6480464 Nanotubes, Carbon results in decreased expression of CDO1 mRNA CTD PMID:25554681 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of CDO1 mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:737395 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDO1 gene CTD PMID:20938992 ciguatoxin CTX1B affects expression ISO RGD:737395 6480464 Ciguatoxins affects the expression of CDO1 mRNA CTD PMID:18353800 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of CDO1 mRNA CTD PMID:18246545 clofibrate affects expression EXP 6480464 Clofibrate affects the expression of CDO1 mRNA CTD PMID:19483382 clofibric acid affects expression EXP 6480464 Clofibric Acid affects the expression of CDO1 mRNA CTD PMID:17602206 copper atom decreases expression EXP 6480464 Copper results in decreased expression of CDO1 mRNA CTD PMID:22465980 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of CDO1 mRNA CTD PMID:22465980 corticosterone increases expression EXP 6480464 Corticosterone results in increased expression of CDO1 mRNA CTD PMID:15755911 coumarin affects expression EXP 6480464 coumarin affects the expression of CDO1 mRNA CTD PMID:16963487 cyclosporin A decreases expression ISO RGD:737395 6480464 Cyclosporine results in decreased expression of CDO1 mRNA CTD PMID:23830897 cyclosporin A decreases expression ISO RGD:737394 6480464 Cyclosporine results in decreased expression of CDO1 mRNA CTD PMID:20106945 more ... dexamethasone multiple interactions ISO RGD:737395 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CDO1 mRNA more ... CTD PMID:16054899 dexamethasone multiple interactions ISO RGD:737394 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CDO1 mRNA CTD PMID:28628672 dexamethasone increases expression ISO RGD:737394 6480464 Dexamethasone results in increased expression of CDO1 mRNA CTD PMID:25047013 dicrotophos decreases expression ISO RGD:737394 6480464 dicrotophos results in decreased expression of CDO1 mRNA CTD PMID:28302478 Diisodecyl phthalate decreases expression ISO RGD:737394 6480464 diisodecyl phthalate results in decreased expression of CDO1 mRNA CTD PMID:16223563 diuron decreases expression EXP 6480464 Diuron results in decreased expression of CDO1 mRNA CTD PMID:25152437 endosulfan affects expression EXP 6480464 Endosulfan affects the expression of CDO1 mRNA CTD PMID:29391264 ethanol affects expression ISO RGD:737395 6480464 Ethanol affects the expression of CDO1 mRNA CTD PMID:30319688 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of CDO1 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:737395 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDO1 gene CTD PMID:20938992 furan decreases expression EXP 6480464 furan results in decreased expression of CDO1 mRNA CTD PMID:25539665 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of CDO1 mRNA CTD PMID:24136188 glutathione increases abundance EXP 6480464 CDO1 protein results in increased abundance of Glutathione CTD PMID:23665415 hypotaurine increases abundance EXP 6480464 CDO1 protein results in increased abundance of hypotaurine CTD PMID:23665415 indometacin multiple interactions ISO RGD:737394 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CDO1 mRNA CTD PMID:28628672 iron atom multiple interactions EXP 6480464 Iron binds to and results in increased activity of CDO1 protein CTD PMID:16611640 iron(0) multiple interactions EXP 6480464 Iron binds to and results in increased activity of CDO1 protein CTD PMID:16611640 isoprenaline increases expression ISO RGD:737395 6480464 Isoproterenol results in increased expression of CDO1 mRNA CTD PMID:20003209 L-ethionine affects expression EXP 6480464 Ethionine affects the expression of CDO1 mRNA CTD PMID:19483382 L-methionine multiple interactions ISO RGD:737395 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDO1 gene CTD PMID:20938992 m-xylene decreases expression EXP 6480464 3-xylene results in decreased expression of CDO1 mRNA CTD PMID:12815608 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of CDO1 mRNA CTD PMID:30467583 mono(2-ethylhexyl) phthalate increases expression EXP 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of CDO1 mRNA CTD PMID:16809437 N-methyl-4-phenylpyridinium decreases expression ISO RGD:737395 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of CDO1 mRNA CTD PMID:17475336 , PMID:18069091 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CDO1 mRNA CTD PMID:28943392 N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of CDO1 mRNA CTD PMID:17072980 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of CDO1 mRNA CTD PMID:24136188 nickel sulfate decreases expression ISO RGD:737394 6480464 nickel sulfate results in decreased expression of CDO1 mRNA CTD PMID:22714537 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of CDO1 mRNA CTD PMID:24136188 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of CDO1 mRNA CTD PMID:18417182 omeprazole affects expression EXP 6480464 Omeprazole affects the expression of CDO1 mRNA CTD PMID:19483382 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CDO1 mRNA CTD PMID:25729387 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of CDO1 mRNA CTD PMID:19103213 paracetamol increases expression ISO RGD:737394 6480464 Acetaminophen results in increased expression of CDO1 mRNA CTD PMID:21420995 paracetamol affects expression ISO RGD:737395 6480464 Acetaminophen affects the expression of CDO1 mRNA CTD PMID:17562736 paraquat affects expression EXP 6480464 Paraquat affects the expression of CDO1 mRNA CTD PMID:16854511 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of CDO1 mRNA CTD PMID:18692542 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of CDO1 mRNA CTD PMID:19162173 perfluorooctanoic acid affects expression ISO RGD:737395 6480464 perfluorooctanoic acid affects the expression of CDO1 mRNA CTD PMID:18281256 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of CDO1 mRNA CTD PMID:19162173 piperonyl butoxide decreases expression EXP 6480464 Piperonyl Butoxide results in decreased expression of CDO1 mRNA CTD PMID:22484513 pirinixic acid multiple interactions ISO RGD:737394 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDO1 mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:737395 6480464 pirinixic acid results in decreased expression of CDO1 mRNA CTD PMID:20813756 , PMID:23811191 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of CDO1 mRNA CTD PMID:19483382 pirinixic acid multiple interactions ISO RGD:737395 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDO1 mRNA, [pirinixic acid co-treated with PPARA] results in decreased expression of CDO1 mRNA CTD PMID:19710929 , PMID:20813756 potassium dichromate increases expression ISO RGD:737395 6480464 Potassium Dichromate results in increased expression of CDO1 mRNA CTD PMID:23608068 pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of CDO1 mRNA CTD PMID:19162173 progesterone affects expression ISO RGD:737395 6480464 Progesterone affects the expression of CDO1 mRNA CTD PMID:17251523 progesterone increases expression EXP 6480464 Progesterone results in increased expression of CDO1 mRNA CTD PMID:20726854 quercetin decreases expression ISO RGD:737394 6480464 Quercetin results in decreased expression of CDO1 mRNA CTD PMID:21632981 quinolin-8-ol decreases expression ISO RGD:737394 6480464 Oxyquinoline results in decreased expression of CDO1 mRNA CTD PMID:21632981 raloxifene multiple interactions ISO RGD:737394 6480464 [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDO1 mRNA CTD PMID:19059307 serpentine asbestos decreases expression ISO RGD:737395 6480464 Asbestos, Serpentine results in decreased expression of CDO1 mRNA CTD PMID:16251409 sodium arsenite decreases expression ISO RGD:737394 6480464 sodium arsenite results in decreased expression of CDO1 mRNA CTD PMID:29301061 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of CDO1 mRNA CTD PMID:27257137 succimer multiple interactions ISO RGD:737394 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CDO1 mRNA CTD PMID:26378955 tamoxifen multiple interactions ISO RGD:737394 6480464 [Tamoxifen co-treated with ESR2 protein] results in increased expression of CDO1 mRNA CTD PMID:19059307 tetrachloromethane increases expression ISO RGD:737395 6480464 Carbon Tetrachloride results in increased expression of CDO1 mRNA CTD PMID:17484886 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of CDO1 mRNA CTD PMID:19483382 thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CDO1 mRNA CTD PMID:28943392 titanium dioxide increases expression ISO RGD:737395 6480464 titanium dioxide results in increased expression of CDO1 mRNA CTD PMID:23557971 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CDO1 mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of CDO1 mRNA CTD PMID:25729387 tunicamycin increases expression ISO RGD:737394 6480464 Tunicamycin results in increased expression of CDO1 mRNA CTD PMID:22378314 valdecoxib decreases expression EXP 6480464 valdecoxib results in decreased expression of CDO1 mRNA CTD PMID:24136188 valproic acid decreases expression ISO RGD:737394 6480464 Valproic Acid results in decreased expression of CDO1 mRNA CTD PMID:23179753 valproic acid increases expression ISO RGD:737394 6480464 Valproic Acid results in increased expression of CDO1 mRNA CTD PMID:23179753 more ... vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of CDO1 mRNA CTD PMID:20566332 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of CDO1 mRNA CTD PMID:23034163
Gene-Chemical Interaction Annotations
