Csnk1a1 (casein kinase 1, alpha 1) - Rat Genome Database

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Gene: Csnk1a1 (casein kinase 1, alpha 1) Rattus norvegicus
Analyze
Symbol: Csnk1a1
Name: casein kinase 1, alpha 1
RGD ID: 71098
Description: Enables several functions, including ATP binding activity; magnesium ion binding activity; and phosphoprotein binding activity. Involved in peptidyl-serine phosphorylation and response to morphine. Located in cytosol and nuclear speck. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1); PARTICIPATES IN dopamine signaling pathway; Hedgehog signaling pathway; p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: casein kinase I; casein kinase I isoform alpha; CK1; CKI-alpha; MGC156603
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21855,017,049 - 55,050,184 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,017,055 - 55,049,271 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1857,110,855 - 57,142,124 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01857,825,472 - 57,856,741 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01855,640,937 - 55,672,070 (+)NCBIRnor_WKY
Rnor_6.01856,887,722 - 56,910,610 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,887,354 - 56,918,345 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,116,635 - 56,139,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,541,673 - 57,564,560 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,613,904 - 57,636,793 (+)NCBI
Celera1853,168,136 - 53,191,023 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
atrazine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbonyl sulfide  (EXP)
casticin  (ISO)
CGP 52608  (ISO)
chlormequat chloride  (EXP)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dibutyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lenalidomide  (ISO)
levonorgestrel  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
pentachlorophenol  (ISO)
piroxicam  (ISO)
pyrvinium  (ISO)
quinacrine  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone undecanoate  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: functional interactions with casein kinase Ialpha, Galpha(i) proteins, and ERK1/2 signaling. Garcia-Fuster MJ, etal., Neuropharmacology. 2008 Oct;55(5):886-99. doi: 10.1016/j.neuropharm.2008.06.071. Epub 2008 Jul 9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease. Ghoshal N, etal., Am J Pathol. 1999 Oct;155(4):1163-72.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. Gonzales ML, etal., J Biol Chem. 2008 May 2;283(18):12665-73. doi: 10.1074/jbc.M800656200. Epub 2008 Feb 27.
6. The casein kinase Ialpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism. Gross SD, etal., J Cell Sci. 1999 Aug;112 ( Pt 16):2647-56.
7. Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. Kannanayakal TJ, etal., Neurosci Lett. 2008 Jan 31;431(2):141-5. doi: 10.1016/j.neulet.2007.11.066. Epub 2007 Dec 15.
8. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
9. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Liu C, etal., Cell. 2002 Mar 22;108(6):837-47.
10. Gene Data Set MGD Curation, June 12, 2002
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
19. Casein kinase I alpha and alpha L: alternative splicing-generated kinases exhibit different catalytic properties. Zhang J, etal., Biochemistry 1996 Dec 17;35(50):16319-27.
Additional References at PubMed
PMID:12477932   PMID:14681019   PMID:15896722   PMID:17686994   PMID:19364825   PMID:19946888   PMID:20067794   PMID:21331045   PMID:21399614   PMID:21709260   PMID:21930935   PMID:22871113  
PMID:23902688   PMID:24760862   PMID:25500533   PMID:25644602  


Genomics

Comparative Map Data
Csnk1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21855,017,049 - 55,050,184 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,017,055 - 55,049,271 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1857,110,855 - 57,142,124 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01857,825,472 - 57,856,741 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01855,640,937 - 55,672,070 (+)NCBIRnor_WKY
Rnor_6.01856,887,722 - 56,910,610 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,887,354 - 56,918,345 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,116,635 - 56,139,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,541,673 - 57,564,560 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,613,904 - 57,636,793 (+)NCBI
Celera1853,168,136 - 53,191,023 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
CSNK1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,492,982 - 149,551,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5149,492,982 - 149,551,471 (-)EnsemblGRCh38hg38GRCh38
GRCh375148,872,545 - 148,931,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,855,038 - 148,911,200 (-)NCBINCBI36Build 36hg18NCBI36
Build 345148,855,741 - 148,910,850NCBI
Celera5144,956,788 - 145,012,931 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,021,796 - 144,077,664 (-)NCBIHuRef
CHM1_15148,307,871 - 148,363,537 (-)NCBICHM1_1
T2T-CHM13v2.05150,027,795 - 150,086,185 (-)NCBIT2T-CHM13v2.0
Csnk1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,687,307 - 61,723,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,688,345 - 61,723,132 (+)EnsemblGRCm39 Ensembl
GRCm381861,554,236 - 61,590,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,555,274 - 61,590,061 (+)EnsemblGRCm38mm10GRCm38
MGSCv371861,715,236 - 61,747,953 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,680,951 - 61,713,668 (+)NCBIMGSCv36mm8
Celera1862,838,154 - 62,870,841 (+)NCBICelera
Cytogenetic Map18E1NCBI
Csnk1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,921,852 - 4,966,705 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,921,356 - 4,966,705 (+)NCBIChiLan1.0ChiLan1.0
CSNK1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15150,929,397 - 150,985,930 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,929,420 - 150,985,912 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05144,919,775 - 144,977,105 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CSNK1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,435,530 - 59,485,591 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,435,764 - 59,483,475 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,200,573 - 59,251,121 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,917,581 - 59,968,297 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,917,668 - 59,968,538 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,704,847 - 59,755,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,818,995 - 59,869,549 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,349,721 - 60,400,321 (+)NCBIUU_Cfam_GSD_1.0
Csnk1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,777,433 - 143,820,877 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365045,351,029 - 5,396,034 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365045,351,354 - 5,394,856 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSNK1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,612,077 - 150,662,284 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,612,845 - 150,662,431 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,378,846 - 157,428,423 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSNK1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,111,500 - 52,169,043 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,114,053 - 52,168,998 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603425,552,342 - 25,611,260 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csnk1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247748,815,023 - 8,862,878 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247748,815,021 - 8,862,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Csnk1a1
130 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:637
Count of miRNA genes:258
Interacting mature miRNAs:329
Transcripts:ENSRNOT00000044346, ENSRNOT00000066133
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876357867167Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat

Markers in Region
X90945  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21855,047,422 - 55,047,578 (+)MAPPERmRatBN7.2
Rnor_6.01856,917,597 - 56,917,752NCBIRnor6.0
Rnor_5.01856,146,510 - 56,146,665UniSTSRnor5.0
RGSC_v3.41857,571,548 - 57,571,703UniSTSRGSC3.4
Celera1853,198,010 - 53,198,165UniSTS
Cytogenetic Map18q12.1UniSTS
RH144160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21855,042,536 - 55,042,744 (+)MAPPERmRatBN7.2
Rnor_6.01856,912,711 - 56,912,918NCBIRnor6.0
Rnor_5.01856,141,624 - 56,141,831UniSTSRnor5.0
RGSC_v3.41857,566,662 - 57,566,869UniSTSRGSC3.4
Celera1853,193,124 - 53,193,331UniSTS
RH 3.4 Map18540.3UniSTS
Cytogenetic Map18q12.1UniSTS
BE111197  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21855,045,347 - 55,045,525 (+)MAPPERmRatBN7.2
Rnor_6.01856,915,522 - 56,915,699NCBIRnor6.0
Rnor_5.01856,144,435 - 56,144,612UniSTSRnor5.0
RGSC_v3.41857,569,473 - 57,569,650UniSTSRGSC3.4
Celera1853,195,935 - 53,196,112UniSTS
RH 3.4 Map18543.8UniSTS
Cytogenetic Map18q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC127486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000044346   ⟹   ENSRNOP00000051516
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1855,017,055 - 55,049,271 (+)Ensembl
Rnor_6.0 Ensembl1856,887,354 - 56,917,711 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000066133   ⟹   ENSRNOP00000062327
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1856,887,496 - 56,918,345 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078783   ⟹   ENSRNOP00000072385
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1856,887,722 - 56,910,901 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097100   ⟹   ENSRNOP00000085265
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1855,017,055 - 55,049,271 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103047   ⟹   ENSRNOP00000082592
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1855,017,055 - 55,049,271 (+)Ensembl
RefSeq Acc Id: NM_053615   ⟹   NP_446067
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21855,017,053 - 55,048,195 (+)NCBI
Rnor_6.01856,887,722 - 56,910,610 (+)NCBI
Rnor_5.01856,116,635 - 56,139,523 (+)NCBI
RGSC_v3.41857,541,673 - 57,564,560 (+)RGD
Celera1853,168,136 - 53,191,023 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096533   ⟹   XP_038952461
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21855,017,049 - 55,043,822 (+)NCBI
RefSeq Acc Id: XM_039096534   ⟹   XP_038952462
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21855,017,049 - 55,046,762 (+)NCBI
RefSeq Acc Id: XM_039096535   ⟹   XP_038952463
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21855,017,051 - 55,050,184 (+)NCBI
RefSeq Acc Id: XM_039096536   ⟹   XP_038952464
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21855,017,049 - 55,043,822 (+)NCBI
RefSeq Acc Id: XM_039096537   ⟹   XP_038952465
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21855,017,051 - 55,050,184 (+)NCBI
RefSeq Acc Id: XM_039096538   ⟹   XP_038952466
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21855,017,054 - 55,043,822 (+)NCBI
RefSeq Acc Id: XM_039096540   ⟹   XP_038952468
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21855,017,054 - 55,043,822 (+)NCBI
RefSeq Acc Id: XM_039096541   ⟹   XP_038952469
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21855,017,054 - 55,050,184 (+)NCBI
RefSeq Acc Id: XR_005495989
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21855,017,049 - 55,046,209 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_446067   ⟸   NM_053615
- UniProtKB: A0JPL2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062327   ⟸   ENSRNOT00000066133
RefSeq Acc Id: ENSRNOP00000051516   ⟸   ENSRNOT00000044346
RefSeq Acc Id: ENSRNOP00000072385   ⟸   ENSRNOT00000078783
RefSeq Acc Id: XP_038952462   ⟸   XM_039096534
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038952461   ⟸   XM_039096533
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952464   ⟸   XM_039096536
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038952463   ⟸   XM_039096535
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038952465   ⟸   XM_039096537
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038952469   ⟸   XM_039096541
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038952466   ⟸   XM_039096538
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038952468   ⟸   XM_039096540
- Peptide Label: isoform X7
- UniProtKB: D3ZRE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085265   ⟸   ENSRNOT00000097100
RefSeq Acc Id: ENSRNOP00000082592   ⟸   ENSRNOT00000103047
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97633-F1-model_v2 AlphaFold P97633 1-325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700823
Promoter ID:EPDNEW_R11341
Type:initiation region
Name:Csnk1a1_1
Description:casein kinase 1, alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01856,887,263 - 56,887,323EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71098 AgrOrtholog
BioCyc Gene G2FUF-7324 BioCyc
Ensembl Genes ENSRNOG00000017106 Ensembl
  ENSRNOG00000063313 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000051516 ENTREZGENE
  ENSRNOP00000051516.3 UniProtKB/TrEMBL
  ENSRNOP00000082592 ENTREZGENE
  ENSRNOP00000082592.1 UniProtKB/TrEMBL
  ENSRNOP00000085265 ENTREZGENE
  ENSRNOP00000085265.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044346 ENTREZGENE
  ENSRNOT00000044346.6 UniProtKB/TrEMBL
  ENSRNOT00000097100 ENTREZGENE
  ENSRNOT00000097100.1 UniProtKB/TrEMBL
  ENSRNOT00000103047 ENTREZGENE
  ENSRNOT00000103047.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8364080 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:113927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156603 IMAGE-MGC_LOAD
NCBI Gene 113927 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Csnk1a1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZV66_RAT UniProtKB/TrEMBL
  A0A8I6GCP2_RAT UniProtKB/TrEMBL
  A0JPL2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRE3 ENTREZGENE, UniProtKB/TrEMBL
  KC1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P97634 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Csnk1a1  casein kinase 1, alpha 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein splice variant CKI alpha L contains an insertion within the catalytic site 70700
gene_transcript CKI alpha and CKI alpha L are alternatively spliced isoforms 70700