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Strain: BN/NHsdMcwi

Symbol: BN/NHsdMcwi
Strain: BN
Substrain: NHsdMcwi
RGD ID: 61498
RRID: RGD_61498
Ontology ID: RS:0000145
Also known as: MDC-03-05; BN/SsNHsdMcwi;BN/SsNHsdMcw; RRRC:00562; Eve; Brown Norway; BN/3NHsdMcwi
Type: inbred
Source: PhysGen, Rat Resource & Research Center
Origin: Inbred from a single pair of SsN line rats obtained from Harlan Sprague Dawley (Alabama colony). Maintained at the Medical College of Wisconsin since 1995. To confirm homozygosity, the strain was tested with 200 microsatellite markers (genome-wide scan at 20cM) all of which were homozygous for all regions tested (Cowley et al. 2000, Physiol. Genomics. 2:107-115)
Coat Color: Brown
Inbred Generations: F21, at MCW since 1995
Last Known Status: Live Animals; Cryorecovery





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Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma glucose level
plasma anion gap
heart wet weight
heart left ventricle wet weight
heart right ventricle wet weight
heart weight to body weight ratio
body length, nose to tail
body length, nose to rump
left kidney wet weight
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
urine creatinine level
urine potassium level
urine sodium level
minute ventilation
arterial blood flow rate
tidal volume
timed urine volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
plasma insulin level
serum triglyceride level
serum total cholesterol level
total white blood cell count
total serum bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
plasma triglyceride level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
plasma total cholesterol level
serum urea nitrogen level
single kidney wet weight to body weight ratio
plasma high density lipoprotein cholesterol level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine potassium excretion rate
urine creatinine excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
kidney glomerulus diameter
creatinine clearance to body weight ratio
ratio of change in renal blood flow rate to kidney weight
urine total protein excretion rate to body weight ratio
serum globulin level
urine sodium level to body weight ratio
urine sodium level to urine potassium level ratio

References


Region

Strain QTL Data
Symbol Name Trait
Bp349 Blood pressure QTL 349 arterial blood pressure trait   (VT:2000000)    
Bp350 Blood pressure QTL 350 arterial blood pressure trait   (VT:2000000)    
Bp351 Blood pressure QTL 351 arterial blood pressure trait   (VT:2000000)    
Bp352 Blood pressure QTL 352 arterial blood pressure trait   (VT:2000000)    
Bp353 Blood pressure QTL 353 arterial blood pressure trait   (VT:2000000)    
Bp354 Blood pressure QTL 354 arterial blood pressure trait   (VT:2000000)    
Bp355 Blood pressure QTL 355 arterial blood pressure trait   (VT:2000000)    
Gluco57 Glucose level QTL 57 blood glucose amount   (VT:0000188)    
Gluco58 Glucose level QTL 58 blood glucose amount   (VT:0000188)    
Gluco59 Glucose level QTL 59 blood glucose amount   (VT:0000188)    
Gluco60 Glucose level QTL 60 blood glucose amount   (VT:0000188)    
Pur21 Proteinuria QTL 21 urine protein amount   (VT:0005160)    
Pur22 Proteinuria QTL 22 urine protein amount   (VT:0005160)    
Rf57 Renal function QTL 57 kidney glomerulus morphology trait   (VT:0005325)    
Rf58 Renal function QTL 58 kidney glomerulus morphology trait   (VT:0005325)    
Scl66 Serum cholesterol level QTL 66 blood cholesterol amount   (VT:0000180)    
Stl24 Serum triglyceride level QTL 24 blood triglyceride amount   (VT:0002644)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
BN/NHsdMcwi (KNAW) 84
BN/NHsdMcwi (ICL) 10
BN/NHsdMcwi (2020) 894
BN/NHsdMcwi (2019) 986
BN/NHsdMcwi (2020)
BN/NHsdMcwi (2019)


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems The aortic rings of animals on low-salt diet and high salt-diet were less sensitive to phenylephrine as compared to the parental SS and less sensitive to acetylcholine when on high salt-diet. 1598768
strain_life_disease These are a suitable model for resistance to myocardial ischemia. 1342469
strain_other Mitochondrial DNA is 16,313 bp in size 2325144
strain_phys_biochem Cowley et al. reported the following arterial blood pressure measurements for this strain: Systolic arterial pressure (SAP) averaged 127 +/- 3 mmHg, and diastolic arterial pressure (DAP) averaged 94 +/- 2 mmHg. Mean arterial blood pressure determined during the inactive light cycle of male rats (n = 42) maintained for nearly 4 wk on 8% NaCl rat chow averaged 109 +/- 2 mmHg and ranged from 89 to 145 mmHg. Active MAP of rats on day 2 of recording averaged 114 +/- 4 mmHg, Inactive MAP on the same day averaged 109 +/- 3 mmHg. The reduction of MAP that occurs during the 36 h following sodium depletion averaged 14 +/- 2 mmHg. 629526
strain_reproduction The average generation is 49 days and the average litter size is 2.7 pups. 629526
strain_reproduction Cowley et al. maintained their stock on a 0.4% NaCl rat chow as a 0.1%NaCl diet impairs fertility in SS though it has not been tested in BN. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 BN/NHsdMcwi    BN/NHsdMcwi    Name updated 68913 APPROVED
2013-08-12 BN/NHsdMcwi    BN/NHsdMcwi    Name updated 68913 APPROVED
2013-04-15 BN/NHsdMcwi    BN/NHsdMcwi    Name updated 68913 APPROVED
2012-04-06 BN/NHsdMcwi    BN/NHsdMcwi    Name updated 68913 APPROVED
2012-04-06 BN/NHsdMcwi    BN/NHsdMcwi    Name updated 68913 APPROVED