Cdc25c (cell division cycle 25C) - Rat Genome Database

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Gene: Cdc25c (cell division cycle 25C) Rattus norvegicus
Analyze
Symbol: Cdc25c
Name: cell division cycle 25C
RGD ID: 1311875
Description: Predicted to enable WW domain binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Involved in spermatogenesis. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in endometrial cancer and prostate cancer. Orthologous to human CDC25C (cell division cycle 25C); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell division cycle 25 homolog C (S. cerevisiae); cell division cycle 25 homolog C (S. pombe); LOC307511; M-phase inducer phosphatase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,608,483 - 26,630,292 (-)NCBIGRCr8
mRatBN7.21826,335,156 - 26,356,199 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,335,834 - 26,356,185 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,463,197 - 26,483,545 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,226,843 - 27,247,181 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,561,743 - 26,582,080 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,528,768 - 27,550,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,528,354 - 27,550,224 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,242,318 - 27,263,503 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,206,537 - 27,225,811 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,233,399 - 27,252,447 (-)NCBI
Celera1826,073,642 - 26,093,887 (-)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(20R)-protopanaxadiol  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-palmitoylglycerol  (ISO)
3',4',5-trihydroxy-3,7-dimethoxyflavone  (ISO)
3,3'-diindolylmethane  (ISO)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-phenylbutyric acid  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-naphthoflavone  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arecoline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
azathioprine  (ISO)
bafilomycin A1  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cryptolepine  (ISO)
cucurbitacin I  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
ellipticine  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzalutamide  (ISO)
epoxiconazole  (ISO)
equol  (ISO)
etoposide  (ISO)
EUK-134  (ISO)
fisetin  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
geraniol  (ISO)
glutathione  (ISO)
Goe 6976  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
harmine  (ISO)
hellebrigenin  (ISO)
hydrogen peroxide  (ISO)
isosilybin A  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
leupeptin  (ISO)
levonorgestrel  (ISO)
lidocaine  (EXP)
lithium chloride  (ISO)
lucanthone  (ISO)
LY294002  (ISO)
mancozeb  (ISO)
manumycin A  (ISO)
MeIQx  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
monocrotaline  (ISO)
morin  (ISO)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (EXP)
NORCANTHARIDIN  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
Panduratin A  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
pifithrin-?  (ISO)
piperine  (ISO)
Pirarubicin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (ISO)
sunitinib  (ISO)
tanespimycin  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium dioxide  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Xanthatin  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia. Hashiguchi Y, etal., Oncol Rep. 2004 Sep;12(3):587-91.
4. Use of high-throughput protein array for profiling of differentially expressed proteins in normal and malignant breast tissue. Hudelist G, etal., Breast Cancer Res Treat. 2004 Aug;86(3):281-91.
5. HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor. Lokeshwar VB, etal., Cancer Res. 2005 Sep 1;65(17):7782-9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Expression of cdc25 phosphatases in the germ cells of the rat testis. Mizoguchi S and Kim KH, Biol Reprod. 1997 Jun;56(6):1474-81.
8. Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer. Ozen M and Ittmann M, Clin Cancer Res. 2005 Jul 1;11(13):4701-6.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Srivastava SK, etal., Carcinogenesis. 2003 Oct;24(10):1665-70. Epub 2003 Aug 1.
12. PKN activation via transforming growth factor-beta 1 (TGF-beta 1) receptor signaling delays G2/M phase transition in vascular smooth muscle cells. Su C, etal., Cell Cycle. 2007 Mar 15;6(6):739-49. Epub 2007 Mar 8.
13. Alteration of G2 cell cycle regulators occurs during carcinogenesis of the endometrium. Tsuda H, etal., Oncology. 2003;65(2):159-66.
14. Plant-derived MINA-05 inhibits human prostate cancer proliferation in vitro and lymph node spread in vivo. Vandyke K, etal., Neoplasia. 2007 Apr;9(4):322-31.
15. Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability. Vassileva V, etal., Cancer Res. 2002 Jul 15;62(14):4095-9.
16. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. Wang Z, etal., BMC Cancer. 2010 May 25;10:233.
Additional References at PubMed
PMID:2195549   PMID:9543386   PMID:10037602   PMID:12937170   PMID:14968113   PMID:22899714   PMID:36675024  


Genomics

Comparative Map Data
Cdc25c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,608,483 - 26,630,292 (-)NCBIGRCr8
mRatBN7.21826,335,156 - 26,356,199 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,335,834 - 26,356,185 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,463,197 - 26,483,545 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,226,843 - 27,247,181 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,561,743 - 26,582,080 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,528,768 - 27,550,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,528,354 - 27,550,224 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,242,318 - 27,263,503 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,206,537 - 27,225,811 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,233,399 - 27,252,447 (-)NCBI
Celera1826,073,642 - 26,093,887 (-)NCBICelera
Cytogenetic Map18p12NCBI
CDC25C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,285,265 - 138,338,355 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,285,269 - 138,338,355 (-)EnsemblGRCh38hg38GRCh38
GRCh375137,620,954 - 137,674,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,648,858 - 137,695,415 (-)NCBINCBI36Build 36hg18NCBI36
Build 345137,648,857 - 137,695,415NCBI
Celera5133,741,791 - 133,788,347 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,811,846 - 132,858,438 (-)NCBIHuRef
CHM1_15137,053,552 - 137,100,241 (-)NCBICHM1_1
T2T-CHM13v2.05138,811,484 - 138,864,572 (-)NCBIT2T-CHM13v2.0
Cdc25c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,866,046 - 34,884,644 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,866,046 - 34,884,586 (-)EnsemblGRCm39 Ensembl
GRCm381834,732,993 - 34,751,564 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,732,993 - 34,751,533 (-)EnsemblGRCm38mm10GRCm38
MGSCv371834,892,651 - 34,911,187 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,858,971 - 34,877,482 (-)NCBIMGSCv36mm8
Celera1835,187,375 - 35,205,655 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.71NCBI
Cdc25c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554182,114,053 - 2,138,513 (+)NCBIChiLan1.0ChiLan1.0
CDC25C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,558,666 - 133,616,422 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,698,220 - 131,753,241 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,663,210 - 133,717,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,795,138 - 139,843,395 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,795,565 - 139,842,698 (-)Ensemblpanpan1.1panPan2
CDC25C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11125,904,152 - 25,940,754 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1125,904,144 - 25,935,744 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,673,724 - 24,710,763 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,760,225 - 26,797,581 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,760,283 - 26,795,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,467,428 - 25,504,608 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,289,991 - 25,327,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01125,954,590 - 25,991,631 (-)NCBIUU_Cfam_GSD_1.0
Cdc25c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213154,111,081 - 154,139,934 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,471,722 - 7,499,766 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,471,722 - 7,499,781 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC25C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,289,115 - 140,324,425 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,289,156 - 140,323,696 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22145,985,978 - 146,029,991 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC25C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12340,960,154 - 41,013,016 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2340,960,572 - 41,006,984 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603436,880,690 - 36,929,865 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc25c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474331,099,268 - 31,124,262 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474331,099,320 - 31,123,808 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdc25c
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:44
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000037368
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000037368   ⟹   ENSRNOP00000057498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1826,335,834 - 26,356,185 (-)Ensembl
Rnor_6.0 Ensembl1827,528,354 - 27,550,224 (-)Ensembl
RefSeq Acc Id: NM_001401323   ⟹   NP_001388252
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,609,945 - 26,630,292 (-)NCBI
mRatBN7.21826,335,825 - 26,356,175 (-)NCBI
RefSeq Acc Id: XM_039096871   ⟹   XP_038952799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,615,770 - 26,630,089 (-)NCBI
mRatBN7.21826,341,763 - 26,356,199 (-)NCBI
RefSeq Acc Id: XM_039096872   ⟹   XP_038952800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,612,133 - 26,630,089 (-)NCBI
mRatBN7.21826,338,013 - 26,356,198 (-)NCBI
RefSeq Acc Id: XM_039096873   ⟹   XP_038952801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,608,483 - 26,621,621 (-)NCBI
mRatBN7.21826,335,156 - 26,347,503 (-)NCBI
RefSeq Acc Id: XM_063277372   ⟹   XP_063133442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,608,483 - 26,630,082 (-)NCBI
RefSeq Acc Id: XM_063277373   ⟹   XP_063133443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,608,483 - 26,630,277 (-)NCBI
RefSeq Acc Id: XM_063277374   ⟹   XP_063133444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,608,483 - 26,629,665 (-)NCBI
RefSeq Acc Id: XR_005496040
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81826,612,053 - 26,630,089 (-)NCBI
mRatBN7.21826,337,929 - 26,356,198 (-)NCBI
Ensembl Acc Id: ENSRNOP00000057498   ⟸   ENSRNOT00000037368
RefSeq Acc Id: XP_038952801   ⟸   XM_039096873
- Peptide Label: isoform X5
- UniProtKB: A6J2V8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952800   ⟸   XM_039096872
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038952799   ⟸   XM_039096871
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001388252   ⟸   NM_001401323
- UniProtKB: D4ADT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133443   ⟸   XM_063277373
- Peptide Label: isoform X1
- UniProtKB: D4ADT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133442   ⟸   XM_063277372
- Peptide Label: isoform X1
- UniProtKB: D4ADT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133444   ⟸   XM_063277374
- Peptide Label: isoform X2
Protein Domains
Rhodanese

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADT2-F1-model_v2 AlphaFold D4ADT2 1-455 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700700
Promoter ID:EPDNEW_R11223
Type:multiple initiation site
Name:Cdc25c_1
Description:cell division cycle 25C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01827,550,309 - 27,550,369EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311875 AgrOrtholog
BioCyc Gene G2FUF-7949 BioCyc
Ensembl Genes ENSRNOG00000024008 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037368.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/TrEMBL
InterPro MPI_Phosphatase UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/TrEMBL
NCBI Gene 307511 ENTREZGENE
PANTHER M-PHASE INDUCER PHOSPHATASE 3 UniProtKB/TrEMBL
  M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 UniProtKB/TrEMBL
Pfam Rhodanese UniProtKB/TrEMBL
PhenoGen Cdc25c PhenoGen
PRINTS MPIPHPHTASE UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024008 RatGTEx
SMART RHOD UniProtKB/TrEMBL
Superfamily-SCOP Rhodanese-like UniProtKB/TrEMBL
UniProt A6J2V8 ENTREZGENE, UniProtKB/TrEMBL
  D4ADT2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Cdc25c  cell division cycle 25C  Cdc25c  cell division cycle 25 homolog C (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cdc25c  cell division cycle 25 homolog C (S. pombe)   Cdc25c_predicted  cell division cycle 25 homolog C (S. pombe) (predicted)  'predicted' is removed 2292626 APPROVED
2007-01-29 Bsnd  cell division cycle 25 homolog C (S. pombe) (predicted)  Cdc25c_predicted  cell division cycle 25 homolog C (S. cerevisiae) (predicted)  Name updated 1299863 APPROVED
2005-01-12 Cdc25c_predicted  cell division cycle 25 homolog C (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED