Pdgfrb (platelet derived growth factor receptor beta) - Rat Genome Database

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Gene: Pdgfrb (platelet derived growth factor receptor beta) Rattus norvegicus
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Symbol: Pdgfrb
Name: platelet derived growth factor receptor beta
RGD ID: 3285
Description: Enables phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor receptor activity. Involved in several processes, including metanephros development; positive regulation of Rho protein signal transduction; and regulation of apoptotic process. Located in several cellular components, including apical plasma membrane; cell surface; and nucleus. Used to study extrahepatic cholestasis; middle cerebral artery infarction; and prostate cancer. Biomarker of hypertension; oligohydramnios; and sciatic neuropathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-dihydromyricetin; (-)-epigallocatechin 3-gallate; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; PDGF-R-beta; PDGFR-1; PDGFR-beta; platelet derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,770,348 - 56,809,228 (+)NCBIGRCr8
mRatBN7.21854,499,962 - 54,538,840 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,499,964 - 54,538,843 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,587,978 - 56,626,738 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,302,576 - 57,341,334 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,123,817 - 55,162,705 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,364,586 - 56,406,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,364,620 - 56,406,381 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,596,682 - 55,637,692 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,014,475 - 57,053,581 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,086,706 - 57,125,813 (+)NCBI
Celera1852,652,411 - 52,691,218 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
atherosclerosis  (ISO)
autism spectrum disorder  (ISS)
basal ganglia calcification  (ISS)
basal ganglia disease  (ISO)
Brain Injuries  (IEP)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cardiomegaly  (IEP)
cerebral palsy  (ISO)
choriocarcinoma  (ISO)
Chronic Allograft Nephropathy  (IEP)
Colonic Neoplasms  (ISO)
Dandy-Walker syndrome  (ISO)
Diabetic Nephropathies  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IMP,ISO)
extrahepatic cholestasis  (IMP)
familial adenomatous polyposis 1  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hydatidiform Mole  (ISO)
hydrocephalus  (ISO)
Hyperoxia  (IEP)
hypertension  (IEP)
Idiopathic Basal Ganglia Calcification 1  (ISO)
Idiopathic Basal Ganglia Calcification 4  (ISO)
infantile myofibromatosis  (ISO,ISS)
Infantile Myofibromatosis 1  (ISO)
Intimal Hyperplasia  (IMP)
Kidney Reperfusion Injury  (IEP,IMP)
Kosaki Overgrowth Syndrome  (ISO)
Kuhnt-Junius degeneration  (ISO)
Leydig cell tumor  (ISO)
Lung Neoplasms  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (IDA)
myeloproliferative disorder with eosinophilia  (ISO)
myeloproliferative neoplasm  (ISO,ISS)
Neointima  (IEP)
Neoplasm Metastasis  (ISO)
Neurodevelopmental Disorders  (ISO)
oligohydramnios  (IEP)
Ovarian Neoplasms  (ISO)
Parkinsonism  (ISO)
Penttinen-Aula Syndrome  (ISO)
prostate cancer  (IMP)
renal cell carcinoma  (ISO)
schizophrenia  (ISS)
sciatic neuropathy  (IEP)
severe nonproliferative diabetic retinopathy  (ISS)
Subarachnoid Hemorrhage  (IMP)
Transplant Rejection  (IMP)
Wounds and Injuries  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dihydromyricetin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP,ISO)
1,8-cineole  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6,7-dimethoxy-2-phenylquinoxaline  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allyl isothiocyanate  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
beta-carotene  (EXP)
beta-hexachlorocyclohexane  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
dermatan sulfate  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
Dimerumic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
endrin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fomepizole  (EXP)
furan  (EXP)
furosemide  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
glutathione  (ISO)
GW 4064  (ISO)
hemin  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indometacin  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (EXP)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lercanidipine  (EXP)
leukotriene D4  (ISO)
lipopolysaccharide  (ISO)
lipoxin A4  (ISO)
losartan  (EXP)
masitinib  (ISO)
melittin  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitrofen  (EXP)
Nonylphenol  (EXP)
olmesartan  (EXP)
orantinib  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sorafenib  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tanespimycin  (EXP,ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
Theaflavin 3,3'-digallate  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
Vitisin A  (EXP)
Y-27632  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
animal organ development  (IEA)
aorta morphogenesis  (ISO)
blood vessel development  (ISO)
cardiac myofibril assembly  (ISO,ISS)
cell chemotaxis  (IBA,IEA,ISO,ISS)
cell migration involved in coronary angiogenesis  (ISO,ISS)
cell migration involved in vasculogenesis  (ISO,ISS)
cellular response to growth factor stimulus  (IEA)
cellular response to hydrogen peroxide  (ISO)
cellular response to platelet-derived growth factor stimulus  (IEA)
chemotaxis  (IEA)
embryonic organ development  (ISO)
glycosaminoglycan biosynthetic process  (IMP)
hemopoiesis  (ISO,ISS)
in utero embryonic development  (ISO)
inner ear development  (IEP)
intracellular signal transduction  (IMP)
kidney development  (ISO)
lung growth  (IMP)
male gonad development  (IEP)
metanephric comma-shaped body morphogenesis  (IEP)
metanephric glomerular capillary formation  (ISO,ISS)
metanephric glomerular mesangial cell proliferation involved in metanephros development  (ISO,ISS)
metanephric glomerular mesangium development  (ISO)
metanephric glomerulus morphogenesis  (IEP)
metanephric mesenchymal cell migration  (IDA)
metanephric mesenchyme development  (IEP)
metanephric S-shaped body morphogenesis  (IEP)
negative regulation of apoptotic process  (IMP)
phosphatidylinositol metabolic process  (IEA,ISO,ISS)
platelet-derived growth factor receptor signaling pathway  (ISO)
platelet-derived growth factor receptor-beta signaling pathway  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of calcium ion import  (ISO,ISS)
positive regulation of calcium-mediated signaling  (IEA,ISO,ISS)
positive regulation of cell migration  (ISO,ISS)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of chemotaxis  (ISO,ISS)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of DNA biosynthetic process  (ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of hepatic stellate cell activation  (IMP)
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (ISO,ISS)
positive regulation of mitotic nuclear division  (ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO,ISS)
positive regulation of reactive oxygen species metabolic process  (ISO,ISS)
positive regulation of Rho protein signal transduction  (IMP)
positive regulation of smooth muscle cell migration  (IBA,IEA,ISO,ISS)
positive regulation of smooth muscle cell proliferation  (IEA,ISO,ISS)
regulation of actin cytoskeleton organization  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
response to ceramide  (ISO)
response to estradiol  (IEP)
response to estrogen  (IEP)
response to fluid shear stress  (IEP)
response to hydrogen peroxide  (IEP)
response to hyperoxia  (IEP)
response to lipid  (IEP)
response to organic cyclic compound  (IEP)
response to retinoic acid  (IEP)
response to toxic substance  (IEP)
retina vasculature development in camera-type eye  (ISO,ISS)
ruffle assembly  (ISO)
signal transduction  (ISO)
skeletal system morphogenesis  (ISO)
smooth muscle cell chemotaxis  (ISO)
smooth muscle tissue development  (ISO)
tissue homeostasis  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries: a link between angiotensin II and intimal thickening. Abe J, etal., Circulation. 1997 Sep 16;96(6):1906-13.
2. High glucose-induced upregulation of Rho/Rho-kinase via platelet-derived growth factor receptor-beta increases migration of aortic smooth muscle cells. Akiyama N, etal., J Mol Cell Cardiol. 2008 Aug;45(2):326-32. doi: 10.1016/j.yjmcc.2008.04.006. Epub 2008 Apr 25.
3. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. Apperley JF, etal., N Engl J Med. 2002 Aug 15;347(7):481-7.
4. Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells. Arar M, etal., J Biol Chem. 2000 Mar 31;275(13):9527-33.
5. Nilotinib-mediated mucosal healing in a rat model of colitis. Ataca P, etal., World J Gastroenterol. 2013 Oct 7;19(37):6237-44. doi: 10.3748/wjg.v19.i37.6237.
6. Expression of platelet-derived growth factor-A (PDGF-A), PDGF-B, and PDGF receptor-alpha and -beta during human testicular development and disease. Basciani S, etal., J Clin Endocrinol Metab. 2002 May;87(5):2310-9.
7. PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells. Biswas SK, etal., Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3687-98. Epub 2008 Apr 17.
8. Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis. Borkham-Kamphorst E, etal., Lab Invest. 2004 Jun;84(6):766-77.
9. Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC). Breitkopf K, etal., Cytokine. 2005 Sep 7;31(5):349-57.
10. Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRß aptamer. Camorani S, etal., Mol Ther. 2014 Apr;22(4):828-41. doi: 10.1038/mt.2013.300. Epub 2014 Jan 2.
11. PDGF-BB-mediated activation of p42(MAPK) is independent of PDGF beta-receptor tyrosine phosphorylation. Cartel NJ, etal., Am J Physiol Lung Cell Mol Physiol 2001 Oct;281(4):L786-98.
12. Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt. Cartel NJ, etal., Biochem J. 2002 Apr 1;363(Pt 1):19-28.
13. Oligohydramnios decreases platelet-derived growth factor expression in fetal rat lungs. Chen CM, etal., Neonatology. 2007;92(3):187-93. Epub 2007 May 21.
14. RNA interference targeting the platelet-derived growth factor receptor beta subunit ameliorates experimental hepatic fibrosis in rats. Chen SW, etal., Liver Int. 2008 Dec;28(10):1446-57. doi: 10.1111/j.1478-3231.2008.01759.x. Epub 2008 May 3.
15. Effects of ribozyme targeting platelet-derived growth factor receptor beta subunit gene on the proliferation and apoptosis of hepatic stellate cells in vitro. Chen YX, etal., Chin Med J (Engl). 2005 Jun 20;118(12):982-8.
16. c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells. Choudhury GG, etal., Cell Signal. 2006 Nov;18(11):1854-64.
17. Temporal changes in gene expression following cryogenic rat brain injury. Cook JL, etal., Brain Res Mol Brain Res. 1998 Mar 30;55(1):9-19.
18. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96
19. Comparative transcriptional and functional profiling of clear cell and papillary renal cell carcinoma. Diegmann J, etal., Int J Mol Med. 2006 Sep;18(3):395-403.
20. A high-potassium diet reduces infarct size and improves vascular structure in hypertensive rats. Dorrance AM, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R415-22. Epub 2006 Aug 17.
21. Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats. Dracheva SV, etal., Immunogenetics 1999 Aug;49(9):787-91
22. Sequential in-office vitreous aspirates demonstrate vitreous matrix metalloproteinase 9 levels correlate with the amount of subretinal fluid in eyes with wet age-related macular degeneration. Ecker SM, etal., Mol Vis. 2012;18:1658-67. Epub 2012 Jun 20.
23. Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2. Finlay GA, etal., J Biol Chem. 2004 May 28;279(22):23114-22. Epub 2004 Mar 23.
24. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
25. PDGFRB is overexpressed in metastatic medulloblastoma. Gilbertson RJ and Clifford SC, Nat Genet. 2003 Nov;35(3):197-8. doi: 10.1038/ng1103-197.
26. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
27. p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y. Hackzell A, etal., J Biol Chem 2002 Oct 18;277(42):39769-76.
28. Conservation in sequence and affinity of human and rodent PDGF ligands and receptors. Herren B, etal., Biochim Biophys Acta 1993 Jun 25;1173(3):294-302.
29. Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma. Holmgren L, etal., Cancer Res. 1993 Jun 15;53(12):2927-31.
30. A role for platelet-derived growth factor beta-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling. Jankov RP, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1162-70. Epub 2005 Feb 18.
31. Autocrine PDGFR signaling promotes mammary cancer metastasis. Jechlinger M, etal., J Clin Invest. 2006 Jun;116(6):1561-70.
32. A stroma targeted therapy enhances castration effects in a transplantable rat prostate cancer model. Johansson A, etal., Prostate. 2007 Nov 1;67(15):1664-76.
33. A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma. Kaplan CD, etal., Vaccine. 2006 Nov 17;24(47-48):6994-7002. Epub 2006 Jun 5.
34. Inhibition of PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction in rat aortic vascular smooth muscle cells by kaempferol. Kim SY, etal., Planta Med. 2005 Jul;71(7):599-603.
35. Expression of platelet-derived growth factor in the developing cochlea of rats. Lee YW, etal., Acta Otolaryngol. 2004 Jun;124(5):558-62.
36. Role of platelet-derived growth factor receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats. Liu J, etal., Sheng Li Xue Bao. 2002 Apr 25;54(2):159-64.
37. Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: role of PDGF-beta receptor and Src. Liu SQ, etal., Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H1081-90. Epub 2003 May 8.
38. Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis. Liu X, etal., Mult Scler. 2005 Aug;11(4):381-9.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. Expansion of the phenotype of Kosaki overgrowth syndrome. Minatogawa M, etal., Am J Med Genet A. 2017 Sep;173(9):2422-2427. doi: 10.1002/ajmg.a.38310. Epub 2017 Jun 22.
41. Immunohistochemical characterization of glomerular PDGF B-chain and PDGF beta-receptor expression in diabetic rats. Nakagawa H, etal., Diabetes Res Clin Pract. 2000 May;48(2):87-98.
42. Role of PDGF B-chain and PDGF receptors in rat tubular regeneration after acute injury. Nakagawa T, etal., Am J Pathol. 1999 Nov;155(5):1689-99.
43. Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts. Nakatsuji T Tohoku J Exp Med. 1999 Mar;187(3):215-25.
44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. Bolus endovascular PDGFR-beta antisense treatment suppressed intimal hyperplasia in a rat carotid injury model. Noiseux N, etal., Circulation. 2000 Sep 12;102(11):1330-6.
46. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
49. Sodium butyrate inhibits platelet-derived growth factor-induced proliferation of vascular smooth muscle cells. Ranganna K, etal., Arterioscler Thromb Vasc Biol. 1995 Dec;15(12):2273-83.
50. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
51. GOA pipeline RGD automated data pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Comprehensive gene review and curation RGD comprehensive gene curation
55. Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells. Ricono JM, etal., Am J Physiol Renal Physiol. 2002 Feb;282(2):F211-9.
56. Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. Saito S, etal., J Biol Chem. 2002 Nov 22;277(47):44695-700. Epub 2002 Sep 10.
57. Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice. Sano H, etal., Circulation. 2001 Jun 19;103(24):2955-60.
58. Effects of hypertension and aging on platelet-derived growth factor and platelet-derived growth factor receptor expression in rat aorta and heart. Sarzani R, etal., Hypertension. 1991 Nov;18(5 Suppl):III93-9.
59. The effect of acute rejection and cyclosporin A-treatment on induction of platelet-derived growth factor and its receptors during the development of chronic rat renal allograft rejection. Savikko J, etal., Transplantation. 2002 Feb 27;73(4):506-11.
60. Melittin, a major bioactive component of bee venom toxin, inhibits PDGF receptor beta-tyrosine phosphorylation and downstream intracellular signal transduction in rat aortic vascular smooth muscle cells. Son DJ, etal., J Toxicol Environ Health A. 2007 Aug;70(15-16):1350-5.
61. Different roles for PDGF-alpha and -beta receptors in embryonic lung development. Souza P, etal., Am J Respir Cell Mol Biol. 1996 Oct;15(4):551-62.
62. Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury. Takikita-Suzuki M, etal., Am J Pathol. 2003 Jul;163(1):277-86.
63. Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Tanimoto T, etal., Circ Res. 2004 Apr 30;94(8):1050-8. Epub 2004 Mar 25.
64. Prenatal exposure to estrogenic compounds alters the expression pattern of platelet-derived growth factor receptors alpha and beta in neonatal rat testis: identification of gonocytes as targets of estrogen exposure. Thuillier R, etal., Biol Reprod. 2003 Mar;68(3):867-80.
65. Glomerular expression of platelet-derived growth factor (PDGF)-A, -B chain and PDGF receptor-alpha, -beta in human diabetic nephropathy. Uehara G, etal., Clin Exp Nephrol. 2004 Mar;8(1):36-42.
66. Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphology. Uzumcu M, etal., Biol Reprod. 2002 Mar;66(3):745-53.
67. Expression of endothelial PDGF receptors alpha and beta in breast cancer: up-regulation of endothelial PDGF receptor beta. Vrekoussis T, etal., Oncol Rep. 2007 May;17(5):1115-9.
68. PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats. Wan W, etal., J Cereb Blood Flow Metab. 2019 Jul;39(7):1369-1380. doi: 10.1177/0271678X18760954. Epub 2018 Feb 26.
69. Crosstalk between angiotensin II and platelet derived growth factor-BB mediated signal pathways in cardiomyocytes. Wang C, etal., Chin Med J (Engl). 2008 Feb 5;121(3):236-40.
70. [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing] Wang HJ, etal., Fa Yi Xue Za Zhi. 2001 Nov;17(4):198-201, 204.
71. Identification and distribution of a novel platelet-derived growth factor receptor beta variant: effect of retinoic acid and involvement in cell differentiation. Wang Y and Culty M, Endocrinology. 2007 May;148(5):2233-50. Epub 2007 Feb 15.
72. Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers. Wilczynski SP, etal., Hum Pathol. 2005 Mar;36(3):242-9.
73. Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model. Xu L, etal., Cancer Res. 2005 Jul 1;65(13):5711-9.
74. Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves. Yamazaki T, etal., J Peripher Nerv Syst. 2009 Sep;14(3):165-76. doi: 10.1111/j.1529-8027.2009.00228.x.
75. Enhancement of glomerular platelet-derived growth factor beta-receptor tyrosine phosphorylation in hypertensive rats and its inhibition by calcium channel blocker. Zhan Y, etal., Hypertens Res. 2002 Mar;25(2):295-301.
Additional References at PubMed
PMID:1314164   PMID:1653029   PMID:2536956   PMID:2542288   PMID:2554309   PMID:2850496   PMID:7691811   PMID:9677323   PMID:9693135   PMID:10375497   PMID:10821867   PMID:11239463  
PMID:11264163   PMID:11346654   PMID:11940581   PMID:12808090   PMID:14624252   PMID:16456542   PMID:16477012   PMID:16479011   PMID:16569213   PMID:16971352   PMID:17143286   PMID:17335807  
PMID:17470632   PMID:17942966   PMID:17991872   PMID:18586678   PMID:19019919   PMID:19038866   PMID:19056881   PMID:19074160   PMID:19077273   PMID:19106110   PMID:19426150   PMID:19442606  
PMID:19494236   PMID:19691150   PMID:19742316   PMID:19946888   PMID:20036247   PMID:20686073   PMID:21423176   PMID:21679854   PMID:21929289   PMID:22027834   PMID:22166585   PMID:22272762  
PMID:22344297   PMID:22731705   PMID:22935817   PMID:23376485   PMID:23651497   PMID:23825366   PMID:23950935   PMID:24029230   PMID:24140598   PMID:24259663   PMID:24417820   PMID:24427322  
PMID:25159478   PMID:25380237   PMID:25866311   PMID:25882492   PMID:25899145   PMID:26315405   PMID:26437238   PMID:26599395   PMID:26896308   PMID:27038258   PMID:27379382   PMID:27400779  
PMID:28259995   PMID:28759157   PMID:28891521   PMID:32647179   PMID:33434537   PMID:33950542   PMID:34534604   PMID:35848503   PMID:36591929   PMID:37121121   PMID:38338969  


Genomics

Comparative Map Data
Pdgfrb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,770,348 - 56,809,228 (+)NCBIGRCr8
mRatBN7.21854,499,962 - 54,538,840 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,499,964 - 54,538,843 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,587,978 - 56,626,738 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,302,576 - 57,341,334 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,123,817 - 55,162,705 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,364,586 - 56,406,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,364,620 - 56,406,381 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,596,682 - 55,637,692 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,014,475 - 57,053,581 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,086,706 - 57,125,813 (+)NCBI
Celera1852,652,411 - 52,691,218 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
PDGFRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,113,839 - 150,155,845 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,113,839 - 150,155,872 (-)EnsemblGRCh38hg38GRCh38
GRCh375149,493,402 - 149,535,408 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,473,595 - 149,515,615 (-)NCBINCBI36Build 36hg18NCBI36
Build 345149,473,595 - 149,515,503NCBI
Celera5145,574,776 - 145,616,798 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,641,381 - 144,683,476 (-)NCBIHuRef
CHM1_15148,925,983 - 148,968,003 (-)NCBICHM1_1
T2T-CHM13v2.05150,650,431 - 150,692,448 (-)NCBIT2T-CHM13v2.0
Pdgfrb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,178,194 - 61,218,139 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,178,222 - 61,218,133 (+)EnsemblGRCm39 Ensembl
GRCm381861,045,127 - 61,085,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,045,150 - 61,085,061 (+)EnsemblGRCm38mm10GRCm38
MGSCv371861,204,804 - 61,244,721 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,170,810 - 61,210,428 (+)NCBIMGSCv36mm8
Celera1862,332,161 - 62,372,066 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
Pdgfrb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,365,743 - 4,403,587 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,365,848 - 4,403,317 (+)NCBIChiLan1.0ChiLan1.0
PDGFRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,342,640 - 145,388,629 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,482,189 - 143,524,580 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,538,330 - 145,580,312 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,543,581 - 151,585,630 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,543,891 - 151,585,530 (-)Ensemblpanpan1.1panPan2
PDGFRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,925,922 - 58,963,639 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,926,351 - 58,962,283 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,692,327 - 58,728,259 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,406,388 - 59,444,135 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,406,430 - 59,444,130 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,195,608 - 59,231,543 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,310,188 - 59,346,130 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,841,270 - 59,877,207 (+)NCBIUU_Cfam_GSD_1.0
Pdgfrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,188,255 - 143,225,815 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,762,184 - 4,799,829 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,762,251 - 4,799,789 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,155,756 - 151,192,647 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,155,753 - 151,192,818 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22158,113,430 - 158,121,798 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDGFRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,724,061 - 52,766,264 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,724,005 - 52,766,234 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603424,950,813 - 24,993,042 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdgfrb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,432,541 - 9,469,881 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,432,765 - 9,469,690 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdgfrb
230 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:153
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000068535
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876357867167Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671876359796643Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184671893559796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat

Markers in Region
D18Wox25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,498,329 - 54,498,481 (+)MAPPERmRatBN7.2
Rnor_6.01856,363,005 - 56,363,156NCBIRnor6.0
Rnor_5.01855,595,086 - 55,595,237UniSTSRnor5.0
RGSC_v3.41857,012,803 - 57,012,954UniSTSRGSC3.4
Celera1852,650,739 - 52,650,890UniSTS
Cytogenetic Map18q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 41 28 20 13 20 5 7 68 34 34 11 5
Low 2 2 29 21 6 21 3 4 6 1 7 3
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000068535   ⟹   ENSRNOP00000060534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,515,659 - 54,538,843 (+)Ensembl
Rnor_6.0 Ensembl1856,364,620 - 56,406,343 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078764   ⟹   ENSRNOP00000070561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,500,218 - 54,538,838 (+)Ensembl
Rnor_6.0 Ensembl1856,379,890 - 56,404,671 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086033   ⟹   ENSRNOP00000069485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1854,499,964 - 54,538,838 (+)Ensembl
Rnor_6.0 Ensembl1856,364,677 - 56,406,381 (+)Ensembl
RefSeq Acc Id: NM_031525   ⟹   NP_113713
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,770,348 - 56,809,228 (+)NCBI
mRatBN7.21854,499,962 - 54,538,838 (+)NCBI
Rnor_6.01856,364,677 - 56,406,381 (+)NCBI
Rnor_5.01855,596,682 - 55,637,692 (+)NCBI
RGSC_v3.41857,014,475 - 57,053,581 (+)RGD
Celera1852,652,411 - 52,691,218 (+)RGD
Sequence:
RefSeq Acc Id: XM_039096573   ⟹   XP_038952501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,776,593 - 56,809,228 (+)NCBI
mRatBN7.21854,506,207 - 54,538,840 (+)NCBI
RefSeq Acc Id: XM_063277094   ⟹   XP_063133164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81856,789,933 - 56,809,228 (+)NCBI
RefSeq Acc Id: NP_113713   ⟸   NM_031525
- Peptide Label: precursor
- UniProtKB: Q8R406 (UniProtKB/Swiss-Prot),   Q925F7 (UniProtKB/Swiss-Prot),   Q05030 (UniProtKB/Swiss-Prot),   A6IXF6 (UniProtKB/TrEMBL),   A0A8L2R1W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060534   ⟸   ENSRNOT00000068535
RefSeq Acc Id: ENSRNOP00000070561   ⟸   ENSRNOT00000078764
RefSeq Acc Id: ENSRNOP00000069485   ⟸   ENSRNOT00000086033
RefSeq Acc Id: XP_038952501   ⟸   XM_039096573
- Peptide Label: isoform X1
- UniProtKB: Q8R406 (UniProtKB/Swiss-Prot),   Q05030 (UniProtKB/Swiss-Prot),   Q925F7 (UniProtKB/Swiss-Prot),   A6IXF6 (UniProtKB/TrEMBL),   A0A8L2R1W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133164   ⟸   XM_063277094
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R2J5 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05030-F1-model_v2 AlphaFold Q05030 1-1097 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700815
Promoter ID:EPDNEW_R11335
Type:initiation region
Name:Pdgfrb_2
Description:platelet derived growth factor receptor beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11336  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01856,364,670 - 56,364,730EPDNEW
RGD ID:13700812
Promoter ID:EPDNEW_R11336
Type:initiation region
Name:Pdgfrb_1
Description:platelet derived growth factor receptor beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11335  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01856,364,898 - 56,364,958EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3285 AgrOrtholog
BioCyc Gene G2FUF-7348 BioCyc
Ensembl Genes ENSRNOG00000018461 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068535.4 UniProtKB/TrEMBL
  ENSRNOT00000078764.2 UniProtKB/TrEMBL
  ENSRNOT00000086033 ENTREZGENE
  ENSRNOT00000086033.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGFRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24629 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24629 ENTREZGENE
PANTHER PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PharmGKB PDGFRB RGD
PhenoGen Pdgfrb PhenoGen
PIRSF Beta-PDGF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrPK_CSF1-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS VEGFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018461 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QV39_RAT UniProtKB/TrEMBL
  A0A8L2R1W6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R2J5 ENTREZGENE, UniProtKB/TrEMBL
  A6IXF6 ENTREZGENE, UniProtKB/TrEMBL
  PGFRB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8R406 ENTREZGENE
  Q925F7 ENTREZGENE
UniProt Secondary Q8R406 UniProtKB/Swiss-Prot
  Q925F7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-25 Pdgfrb  platelet derived growth factor receptor beta  Pdgfrb  platelet derived growth factor receptor, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pdgfrb  Platelet-derived growth factor receptor, beta      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function ligand-activated tyrosine kinase 628442
gene_process autophosphorylates and binds to downstream proteins linking cell surface message to the nucleus, required for the activation of mitogen-activated protein kinases when mediated by platelet-derived growht factor -BB but not required during tyrosine phosphor 628442