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Gene: Pdgfrb (platelet derived growth factor receptor beta) Rattus norvegicus
Symbol: Pdgfrb
Name: platelet derived growth factor receptor beta
RGD ID: 3285
Description: Exhibits phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor-activated receptor activity. Involved in several processes, including animal organ development; positive regulation of Rho protein signal transduction; and regulation of apoptotic process. Localizes to several cellular components, including apical plasma membrane; cell surface; and nucleus. Used to study extrahepatic cholestasis; middle cerebral artery infarction; and prostate cancer. Biomarker of hypertension; oligohydramnios; and sciatic neuropathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma multiforme; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-dihydromyricetin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
Also known as: beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; PDGF-R-beta; PDGFR-1; PDGFR-beta; platelet derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta
Homo sapiens (human) : PDGFRB (platelet derived growth factor receptor beta)  HGNC  Alliance
Mus musculus (house mouse) : Pdgfrb (platelet derived growth factor receptor, beta polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfrb (platelet derived growth factor receptor beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFRB (platelet derived growth factor receptor beta)
Canis lupus familiaris (dog) : PDGFRB (platelet derived growth factor receptor beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfrb (platelet derived growth factor receptor beta)
Sus scrofa (pig) : PDGFRB (platelet derived growth factor receptor beta)
Chlorocebus sabaeus (African green monkey) : PDGFRB (platelet derived growth factor receptor beta)
Heterocephalus glaber (naked mole-rat) : Pdgfrb (platelet derived growth factor receptor beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01856,364,586 - 56,406,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,364,620 - 56,406,381 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,596,682 - 55,637,692 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,014,475 - 57,053,581 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11857,086,706 - 57,125,813 (+)NCBI
Celera1852,652,411 - 52,691,218 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pdgfrb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3285
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.