Pdgfrb (platelet derived growth factor receptor beta) - Rat Genome Database

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Gene: Pdgfrb (platelet derived growth factor receptor beta) Ictidomys tridecemlineatus
Analyze
Symbol: Pdgfrb
Name: platelet derived growth factor receptor beta
RGD ID: 12487612
Description: ENCODES a protein that exhibits kinase activity (ortholog); phosphatidylinositol 3-kinase binding (ortholog); platelet-derived growth factor receptor activity (ortholog); INVOLVED IN adrenal gland development (ortholog); aorta morphogenesis (ortholog); blood vessel development (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH atherosclerosis (ortholog); autism spectrum disorder (ortholog); basal ganglia calcification (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: platelet derived growth factor receptor beta, transcript variant X1; platelet derived growth factor receptor beta, transcript variant X2; platelet derived growth factor receptor beta, transcript variant X3; platelet-derived growth factor receptor beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,188,255 - 143,225,815 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,762,184 - 4,799,829 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,762,251 - 4,799,789 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
atherosclerosis  (ISO)
autism spectrum disorder  (ISO)
basal ganglia calcification  (ISO)
basal ganglia disease  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
cerebral palsy  (ISO)
choriocarcinoma  (ISO)
Chronic Allograft Nephropathy  (ISO)
Colonic Neoplasms  (ISO)
Dandy-Walker syndrome  (ISO)
Diabetic Nephropathies  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
familial adenomatous polyposis 1  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hydatidiform Mole  (ISO)
hydrocephalus  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
Idiopathic Basal Ganglia Calcification 1  (ISO)
Idiopathic Basal Ganglia Calcification 4  (ISO)
infantile myofibromatosis  (ISO)
Infantile Myofibromatosis 1  (ISO)
Intimal Hyperplasia  (ISO)
Kidney Reperfusion Injury  (ISO)
Kosaki Overgrowth Syndrome  (ISO)
Kuhnt-Junius degeneration  (ISO)
Leydig cell tumor  (ISO)
Lung Neoplasms  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
myeloproliferative disorder with eosinophilia  (ISO)
myeloproliferative neoplasm  (ISO)
Neointima  (ISO)
Neoplasm Metastasis  (ISO)
Neurodevelopmental Disorders  (ISO)
oligohydramnios  (ISO)
Ovarian Neoplasms  (ISO)
Parkinsonism  (ISO)
Penttinen-Aula Syndrome  (ISO)
prostate cancer  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
severe nonproliferative diabetic retinopathy  (ISO)
Subarachnoid Hemorrhage  (ISO)
Transplant Rejection  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
angiogenesis  (IEA)
animal organ development  (IEA)
aorta morphogenesis  (ISO)
blood vessel development  (ISO)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
cardiac myofibril assembly  (ISO)
cell chemotaxis  (IEA)
cell migration involved in coronary angiogenesis  (ISO)
cell migration involved in vasculogenesis  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to hydrogen peroxide  (ISO)
chemotaxis  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
embryonic organ development  (ISO)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
glycosaminoglycan biosynthetic process  (ISO)
hemopoiesis  (ISO)
hepatocyte growth factor receptor signaling pathway  (IEA)
in utero embryonic development  (ISO)
inner ear development  (ISO)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
intracellular signal transduction  (ISO)
kidney development  (ISO)
Kit signaling pathway  (IEA)
lung growth  (ISO)
macrophage colony-stimulating factor signaling pathway  (IEA)
male gonad development  (ISO)
metanephric comma-shaped body morphogenesis  (ISO)
metanephric glomerular capillary formation  (ISO)
metanephric glomerular mesangial cell proliferation involved in metanephros development  (ISO)
metanephric glomerular mesangium development  (ISO)
metanephric glomerulus morphogenesis  (ISO)
metanephric mesenchymal cell migration  (ISO)
metanephric mesenchyme development  (ISO)
metanephric S-shaped body morphogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium ion import  (ISO)
positive regulation of calcium-mediated signaling  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  (IEA)
positive regulation of chemotaxis  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of hepatic stellate cell activation  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of Rho protein signal transduction  (ISO)
positive regulation of smooth muscle cell migration  (IEA)
positive regulation of smooth muscle cell proliferation  (IEA)
protein autophosphorylation  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
response to ceramide  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to fluid shear stress  (ISO)
response to hydrogen peroxide  (ISO)
response to hyperoxia  (ISO)
response to lipid  (ISO)
response to retinoic acid  (ISO)
response to toxic substance  (ISO)
retina vasculature development in camera-type eye  (ISO)
ruffle assembly  (ISO)
signal transduction  (IEA,ISO)
skeletal system morphogenesis  (ISO)
smooth muscle cell chemotaxis  (ISO)
smooth muscle tissue development  (ISO)
tissue homeostasis  (ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pdgfrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,188,255 - 143,225,815 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,762,184 - 4,799,829 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,762,251 - 4,799,789 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,113,839 - 150,155,845 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,113,839 - 150,155,872 (-)EnsemblGRCh38hg38GRCh38
GRCh375149,493,402 - 149,535,408 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,473,595 - 149,515,615 (-)NCBINCBI36Build 36hg18NCBI36
Build 345149,473,595 - 149,515,503NCBI
Celera5145,574,776 - 145,616,798 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,641,381 - 144,683,476 (-)NCBIHuRef
CHM1_15148,925,983 - 148,968,003 (-)NCBICHM1_1
T2T-CHM13v2.05150,650,431 - 150,692,448 (-)NCBIT2T-CHM13v2.0
Pdgfrb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,178,194 - 61,218,139 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,178,222 - 61,218,133 (+)EnsemblGRCm39 Ensembl
GRCm381861,045,127 - 61,085,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,045,150 - 61,085,061 (+)EnsemblGRCm38mm10GRCm38
MGSCv371861,204,804 - 61,244,721 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,170,810 - 61,210,428 (+)NCBIMGSCv36mm8
Celera1862,332,161 - 62,372,066 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
Pdgfrb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,770,348 - 56,809,228 (+)NCBIGRCr8
mRatBN7.21854,499,962 - 54,538,840 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,499,964 - 54,538,843 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,587,978 - 56,626,738 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,302,576 - 57,341,334 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,123,817 - 55,162,705 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,364,586 - 56,406,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,364,620 - 56,406,381 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,596,682 - 55,637,692 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,014,475 - 57,053,581 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11857,086,706 - 57,125,813 (+)NCBI
Celera1852,652,411 - 52,691,218 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Pdgfrb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,365,743 - 4,403,587 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,365,848 - 4,403,317 (+)NCBIChiLan1.0ChiLan1.0
PDGFRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,342,640 - 145,388,629 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,482,189 - 143,524,580 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,538,330 - 145,580,312 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,543,581 - 151,585,630 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,543,891 - 151,585,530 (-)Ensemblpanpan1.1panPan2
PDGFRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,925,922 - 58,963,639 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,926,351 - 58,962,283 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,692,327 - 58,728,259 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,406,388 - 59,444,135 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,406,430 - 59,444,130 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,195,608 - 59,231,543 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,310,188 - 59,346,130 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,841,270 - 59,877,207 (+)NCBIUU_Cfam_GSD_1.0
PDGFRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,155,756 - 151,192,647 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,155,753 - 151,192,818 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22158,113,430 - 158,121,798 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDGFRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,724,061 - 52,766,264 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,724,005 - 52,766,234 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603424,950,813 - 24,993,042 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdgfrb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,432,541 - 9,469,881 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,432,765 - 9,469,690 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000024810   ⟹   ENSSTOP00000023255
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365044,762,184 - 4,799,829 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000039357   ⟹   ENSSTOP00000025360
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365044,777,842 - 4,797,954 (+)Ensembl
RefSeq Acc Id: XM_005324167   ⟹   XP_005324224
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213143,188,255 - 143,225,815 (+)NCBI
SpeTri2.0NW_0049365044,762,251 - 4,797,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725680   ⟹   XP_021581355
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213143,202,843 - 143,225,815 (+)NCBI
SpeTri2.0NW_0049365044,776,854 - 4,799,789 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021725681   ⟹   XP_021581356
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213143,188,255 - 143,225,815 (+)NCBI
SpeTri2.0NW_0049365044,762,655 - 4,797,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040271876   ⟹   XP_040127810
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213143,206,390 - 143,225,815 (+)NCBI
RefSeq Acc Id: XP_005324224   ⟸   XM_005324167
- Peptide Label: isoform X2
- UniProtKB: I3NFV8 (UniProtKB/TrEMBL),   A0A287CVL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581356   ⟸   XM_021725681
- Peptide Label: isoform X3
- UniProtKB: A0A287CVL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021581355   ⟸   XM_021725680
- Peptide Label: isoform X1
- UniProtKB: A0A287CVL0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040127810   ⟸   XM_040271876
- Peptide Label: isoform X4
- UniProtKB: A0A287CVL0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000023255   ⟸   ENSSTOT00000024810
Ensembl Acc Id: ENSSTOP00000025360   ⟸   ENSSTOT00000039357
Protein Domains
Ig-like   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000025211 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000024810.2 UniProtKB/TrEMBL
  ENSSTOT00000039357.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PGFRB UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/TrEMBL
NCBI Gene Pdgfrb ENTREZGENE
PANTHER PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/TrEMBL
  PF00047 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PIRSF Beta-PDGF_receptor UniProtKB/TrEMBL
  TyrPK_CSF1-R UniProtKB/TrEMBL
PRINTS VEGFRECEPTOR UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A287CVL0 ENTREZGENE, UniProtKB/TrEMBL
  I3NFV8 ENTREZGENE, UniProtKB/TrEMBL