RGD Reference Report - Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats. - Rat Genome Database

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Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats.

Authors: Dracheva, SV  Remmers, EF  Gulko, PS  Kawahito, Y  Longman, RE  Reese, VR  Cannon, GW  Griffiths, MM  Wilder, RL 
Citation: Dracheva SV, etal., Immunogenetics 1999 Aug;49(9):787-91
RGD ID: 61069
Web Url: http://link.springer-ny.com/link/service/journals/00251/bibs/49n9p787.html
Pubmed: PMID:10398805   (View Abstract at PubMed)

Autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, and multiple sclerosis, are regulated by multiple genes. Major histocompatibility complex (MHC) genes have the strongest effects, but non-MHC genes also contribute to disease susceptibility/severity. In this paper, we describe a new non-MHC quantitative trait locus, Cia8, on rat Chromosome (Chr) 7 that controls collagen-induced arthritis severity in F2 progeny of DA and F344 inbred rats, and present an updated localization of Cia4 on the same chromosome. We also describe the location of mouse and human genes, orthologous to the genes in the genomic intervals containing Cia4 and Cia8, and provide evidence that the segment of rat Chr 7 containing Cia4 and Cia8 is homologous to segments of mouse Chr 10 and 15 and human Chr 8, 12, and 19.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cia4RatExperimental Arthritis  IDA  RGD 
Cia8RatExperimental Arthritis  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cia4Ratjoint swelling  QTM  RGD 
Cia8Ratjoint swelling  QTM  RGD 
Objects Annotated

QTLs
Cia4  (Collagen induced arthritis QTL 4)
Cia8  (Collagen induced arthritis QTL 8)

Strains
DA/Bkl  (NA)
F344/NHsd  (F344/NHsd)

Objects referenced in this article
Marker D7Arb17 D7Arb17 Rattus norvegicus
Marker D7Rat44 D7Rat44 Rattus norvegicus
Marker D7Rat26 D7Rat26 Rattus norvegicus
Gene Il2rb interleukin 2 receptor subunit beta Rattus norvegicus
Gene Pdgfrb platelet derived growth factor receptor beta Rattus norvegicus

Additional Information