Il2rb (interleukin 2 receptor subunit beta) - Rat Genome Database

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Gene: Il2rb (interleukin 2 receptor subunit beta) Rattus norvegicus
Analyze
Symbol: Il2rb
Name: interleukin 2 receptor subunit beta
RGD ID: 2896
Description: Enables interleukin-2 binding activity and interleukin-2 receptor activity. Involved in cytokine-mediated signaling pathway. Located in cell surface. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 63; myasthenia gravis; and visceral leishmaniasis. Orthologous to human IL2RB (interleukin 2 receptor subunit beta); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: high affinity IL-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; IL2RBC; interleukin 2 receptor, beta; interleukin 2 receptor, beta chain; interleukin-2 receptor subunit beta; P70-75
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   MAMTS6_H   MAMTS5_H   MAMTS4_H  
Candidate Gene For: Cia4 Eau6
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,913,828 - 111,928,537 (-)NCBIGRCr8
mRatBN7.27110,033,341 - 110,048,054 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,033,341 - 110,048,054 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,783,773 - 111,798,546 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,007,308 - 114,022,077 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,975,130 - 113,989,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,701,338 - 119,716,238 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,701,251 - 119,716,238 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,690,375 - 119,705,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7106,371,243 - 106,385,925 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asperentin  (ISO)
barium sulfate  (EXP)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brevianamide A  (ISO)
carbon nanotube  (ISO)
ceric oxide  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
formaldehyde  (ISO)
graphite  (EXP)
hexachlorobenzene  (EXP)
ionomycin  (ISO)
Licochalcone B  (ISO)
mangiferin  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
microcystin-LR  (ISO)
mycophenolic acid  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis. Bucheton B, etal., Genes Immun. 2007 Jan;8(1):79-83. doi: 10.1038/sj.gene.6364355. Epub 2006 Nov 16.
2. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96
3. IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo. Doganci A, etal., J Immunol. 2008 Aug 1;181(3):1917-26.
4. Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats. Dracheva SV, etal., Immunogenetics 1999 Aug;49(9):787-91
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Decreased CD122 on CD56dim NK associated with its impairment in asymptomatic chronic HBV carriers with high levels of HBV DNA, HBsAg and HBeAg. Han W, etal., Life Sci. 2018 Feb 15;195:53-60. doi: 10.1016/j.lfs.2018.01.001. Epub 2018 Jan 4.
8. Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19. Liu Y, etal., Viral Immunol. 2020 Apr 10. doi: 10.1089/vim.2020.0062.
9. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Malek TR, etal., Immunity. 2002 Aug;17(2):167-78.
10. Decreased interleukin-2 receptor beta chain expression by peripheral blood lymphocytes in chronic liver disease. Masumoto T, etal., J Gastroenterol Hepatol. 1992 Jul-Aug;7(4):399-404. doi: 10.1111/j.1440-1746.1992.tb01008.x.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. A large-scale, consortium-based genomewide association study of asthma. Moffatt MF, etal., N Engl J Med. 2010 Sep 23;363(13):1211-21.
13. Enhanced protection against Heligmosomoides polygyrus in IL-2 receptor β-chain overexpressed transgenic mice with intestinal mastocytosis. Morimoto M and Utsumiya K, J Vet Med Sci. 2011 Jun;73(6):849-51. doi: 10.1292/jvms.10-0566. Epub 2011 Feb 3.
14. Role of innate immune cells in protection against Toxoplasma gondii at inflamed site. Nakano Y, etal., J Med Invest. 2001 Feb;48(1-2):73-80.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Roles of CD122+ cells in resistance against Neospora caninum infection in a murine model. Nishikawa Y, etal., J Vet Med Sci. 2010 Oct;72(10):1275-82. doi: 10.1292/jvms.10-0068. Epub 2010 May 7.
17. Expansion of intermediate T cell receptor cells expressing interleukin-2 receptor alpha- beta+, CD8alpha+ beta+, and lymphocyte function-associated antigen-1+ in the liver in association with intrahepatic islet xenograft rejection from rat to mouse: prevention of rejection with anti-interleukin-2 receptor beta monoclonal antibody treatment. Ohtsuka K, etal., Transplantation. 1997 Aug 27;64(4):633-9. doi: 10.1097/00007890-199708270-00015.
18. Molecular cloning of cDNAs for the rat interleukin 2 receptor alpha and beta chain genes: differentially regulated gene activity in response to mitogenic stimulation. Page TH and Dallman MJ, Eur J Immunol 1991 Sep;21(9):2133-8.
19. A novel galectin-1 and interleukin 2 receptor beta haplotype is associated with autoimmune myasthenia gravis. Pal Z, etal., J Neuroimmunol. 2010 Dec 15;229(1-2):107-11. Epub 2010 Aug 21.
20. Identification and cellular distribution of the rat interleukin-2 receptor beta chain: induction of the IL-2R alpha- beta+ phenotype by major histocompatibility complex class I recognition during T cell development in vivo and by T cell receptor stimulation of CD4+8+ immature thymocytes in vitro. Park JH, etal., Eur J Immunol. 1996 Oct;26(10):2371-5.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Effects of rat interleukin-2 and rat interferon on the natural killer cell activity of rat spleen cells after thermal injury. Singh H, etal., J Burn Care Rehabil. 1992 Nov-Dec;13(6):617-22.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. CD122 blockade restores immunological tolerance in autoimmune type 1 diabetes via multiple mechanisms. Yuan X, etal., JCI Insight. 2018 Jan 25;3(2). pii: 96600. doi: 10.1172/jci.insight.96600. eCollection 2018 Jan 25.
Additional References at PubMed
PMID:2467293   PMID:7736574   PMID:8262055   PMID:9841920   PMID:15123770   PMID:15345225   PMID:16227984   PMID:17082577   PMID:19723499   PMID:19946888   PMID:20818394   PMID:23034280  
PMID:31040184   PMID:31040185  


Genomics

Comparative Map Data
Il2rb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,913,828 - 111,928,537 (-)NCBIGRCr8
mRatBN7.27110,033,341 - 110,048,054 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,033,341 - 110,048,054 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,783,773 - 111,798,546 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,007,308 - 114,022,077 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,975,130 - 113,989,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,701,338 - 119,716,238 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,701,251 - 119,716,238 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,690,375 - 119,705,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7106,371,243 - 106,385,925 (-)NCBICelera
Cytogenetic Map7q34NCBI
IL2RB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,125,838 - 37,175,118 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,118,666 - 37,175,118 (-)EnsemblGRCh38hg38GRCh38
GRCh372237,521,878 - 37,571,158 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,851,824 - 35,875,908 (-)NCBINCBI36Build 36hg18NCBI36
Build 342235,846,381 - 35,870,462NCBI
Celera2221,322,955 - 21,347,014 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2220,486,973 - 20,511,039 (-)NCBIHuRef
CHM1_12237,481,108 - 37,505,190 (-)NCBICHM1_1
T2T-CHM13v2.02237,585,773 - 37,635,037 (-)NCBIT2T-CHM13v2.0
Il2rb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,363,456 - 78,396,569 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,363,456 - 78,379,471 (-)EnsemblGRCm39 Ensembl
GRCm381578,479,256 - 78,511,621 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,479,256 - 78,495,271 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,310,978 - 78,325,496 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,307,803 - 78,322,277 (-)NCBIMGSCv36mm8
Celera1579,943,154 - 79,957,670 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.52NCBI
Il2rb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,623,154 - 23,640,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,623,567 - 23,640,245 (-)NCBIChiLan1.0ChiLan1.0
IL2RB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22346,981,923 - 47,006,008 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,670,496 - 49,694,590 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,039,469 - 18,069,952 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,874,889 - 35,899,038 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,874,898 - 35,899,038 (-)Ensemblpanpan1.1panPan2
IL2RB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,370,797 - 27,388,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,370,797 - 27,388,775 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,325,543 - 27,343,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01028,162,844 - 28,180,818 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1028,162,844 - 28,180,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,884,492 - 27,902,458 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,193,229 - 28,211,199 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,371,136 - 28,389,104 (+)NCBIUU_Cfam_GSD_1.0
Il2rb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,785,491 - 10,797,317 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,795,940 - 3,805,774 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,795,940 - 3,805,822 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL2RB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,628,962 - 10,650,314 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1510,610,094 - 10,650,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,223,970 - 8,247,389 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL2RB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,830,919 - 19,853,534 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,828,898 - 19,852,988 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045105,975,766 - 105,999,423 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il2rb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475210,672,432 - 10,683,045 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475210,662,053 - 10,682,891 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il2rb
92 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:52
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000075678
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH133980  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,033,585 - 110,033,786 (+)MAPPERmRatBN7.2
Rnor_6.07119,701,583 - 119,701,783NCBIRnor6.0
Rnor_5.07119,690,620 - 119,690,820UniSTSRnor5.0
Celera7106,371,459 - 106,371,659UniSTS
RH 3.4 Map7815.2UniSTS
RH94534  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,033,394 - 110,033,566 (+)MAPPERmRatBN7.2
Rnor_6.07119,701,392 - 119,701,563NCBIRnor6.0
Rnor_5.07119,690,429 - 119,690,600UniSTSRnor5.0
Celera7106,371,268 - 106,371,439UniSTS
Il2rb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27110,034,561 - 110,034,786 (+)MAPPERmRatBN7.2
Rnor_6.07119,702,559 - 119,702,783NCBIRnor6.0
Rnor_5.07119,691,596 - 119,691,820UniSTSRnor5.0
Celera7106,372,437 - 106,372,661UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 8 19 1 9
Low 1 17 35 27 27 5 7 3 25 25 2 5
Below cutoff 12 10 10 10 3 4 61 10 11 3

Sequence


Ensembl Acc Id: ENSRNOT00000075678   ⟹   ENSRNOP00000064699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7119,701,367 - 119,716,238 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077438   ⟹   ENSRNOP00000075262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7110,033,341 - 110,048,054 (-)Ensembl
Rnor_6.0 Ensembl7119,701,251 - 119,712,888 (-)Ensembl
RefSeq Acc Id: NM_013195   ⟹   NP_037327
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,913,828 - 111,928,537 (-)NCBI
mRatBN7.27110,033,341 - 110,048,054 (-)NCBI
Rnor_6.07119,701,367 - 119,716,238 (-)NCBI
Rnor_5.07119,690,375 - 119,705,275 (-)NCBI
Celera7106,371,243 - 106,385,925 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037327 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41429 (Get FASTA)   NCBI Sequence Viewer  
  EDM15864 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075262.1
GenBank Protein P26896 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037327   ⟸   NM_013195
- Peptide Label: precursor
- UniProtKB: P26896 (UniProtKB/Swiss-Prot),   A0A0G2KA53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064699   ⟸   ENSRNOT00000075678
Ensembl Acc Id: ENSRNOP00000075262   ⟸   ENSRNOT00000077438
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26896-F1-model_v2 AlphaFold P26896 1-537 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695476
Promoter ID:EPDNEW_R5988
Type:multiple initiation site
Name:Il2rb_1
Description:interleukin 2 receptor subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07119,716,279 - 119,716,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2896 AgrOrtholog
BioCyc Gene G2FUF-32813 BioCyc
Ensembl Genes ENSRNOG00000048636 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077438.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL2RB_N1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25746 UniProtKB/Swiss-Prot
NCBI Gene 25746 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN-2 RECEPTOR SUBUNIT BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL2RB_N1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il2rb PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048636 RatGTEx
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209594
UniProt A0A0G2KA53 ENTREZGENE, UniProtKB/TrEMBL
  A6HSK8_RAT UniProtKB/TrEMBL
  IL2RB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il2rb  interleukin 2 receptor subunit beta  Il2rb  interleukin 2 receptor, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Il2rb  interleukin 2 receptor, beta  Il2rb  interleukin 2 receptor, beta chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Il2rb  Interleukin 2 receptor, beta chain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is slowly upregulated (after 24 hours) by mitogen stimulation of lymphocytes 728928