Niddm19 QTL Report (Rattus norvegicus) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
QTL Registration

QTL: Niddm19 (Non-insulin dependent diabetes mellitus QTL 19) Rattus norvegicus

Symbol: Niddm19
Name: Non-insulin dependent diabetes mellitus QTL 19
RGD ID: 70173
Previously known as: Nidd1/of
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level area under curve (AUC)   (CMO:0000350)    
LOD Score: 4.33
P Value: 5.0E-5
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8785,497,398 - 130,497,398RGD_MAPPER_PIPELINE
mRatBN7.2764,002,457 - 135,012,528RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0771,448,715 - 145,729,302RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0771,619,460 - 143,501,887RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4768,162,496 - 143,002,779RGDRGSC3.4
RGSC_v3.1768,183,226 - 143,082,968RGD
Cross Type: F2
Strains Crossed: F344.OLETF-(D7Mgh16-D7Mgh20)/Tj 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm19Rattype 2 diabetes mellitus  IDA 69691 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm19Ratimpaired glucose tolerance  QTM 69691 RGD 
Niddm19Ratimpaired glucose tolerance  QTM 69696 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm19Ratblood glucose level area under curve (AUC)  IDA 625760 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm19Ratfasting  IDA 625760 RGD 
Niddm19Ratglucose solution, 2.8M  IDA 625760 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm19Ratoral glucose tolerance test  IDA 625760 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm19RatF344.OLETF-(D7Mgh16-D7Mgh20)/Tj  IEA 625760 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Niddm19Ratblood glucose amount  IDA 625760 RGD 


#
Reference Title
Reference Citation
1. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
2. Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat. Kose H, etal., Mamm Genome. 2007 Aug;18(8):609-15. Epub 2007 Aug 21.
3. Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka Long-Evans Tokushima Fatty rat. Moralejo DH, etal., Proc Assoc Am Physicians 1998 Nov-Dec;110(6):545-58.
4. QTL Data Transfer QTL data import from the RatMap database
5. Identification of genetic loci involved in diabetes using a rat model of depression. Solberg Woods LC, etal., Mamm Genome. 2009 Aug 22.
6. Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method. Sugiura K, etal., Mamm Genome 1999 Dec;10(12):1126-31.
7. Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat. Yamada T, etal., Exp Diabetes Res. 2012;2012:582546. doi: 10.1155/2012/582546. Epub 2012 Oct 15.
PMID:NIddm19  


Related QTL Description Reference
Gluco53 maps to same region RGD:2312611



1 to 20 of 1120 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1583261Limk2-ps1LIM domain kinase 2, pseudogene 176404610364047200Rat
3649Sdc2syndecan 276412718564239885Rat
628610Cpqcarboxypeptidase Q76426402564830867Rat
9336170LOC103692875translationally-controlled tumor protein pseudogene76436642264373306Rat
41192745LOC120094055U6 spliceosomal RNA76444494264445048Rat
1311262Tspyl5TSPY-like 576488150464885512Rat
1583210Spata1-ps1spermatogenesis associated 1, pseudogene 176498533164989584Rat
1597752Tpt1-ps9tumor protein, translationally-controlled 1 pseudogene 976512195965122559Rat
1562404Rps18l3ribosomal protein S18 like 376514312765143670Rat
41182883LOC120093916U6 spliceosomal RNA76517002665170131Rat
1591678Rps17-ps10ribosomal protein S17, pseudogene 1076523948265239890Rat
1591667Gltp-ps1glycolipid transfer protein, pseudogene 176524160465244954Rat
620992Mtdhmetadherin76530646465365647Rat
41364015LOC120093852uncharacterized LOC12009385276542170165423066Rat
1311853Laptm4blysosomal protein transmembrane 4 beta76543452565477386Rat
1305353Matn2matrilin 276549499665644613Rat
41226631LOC120093957small nucleolar RNA SNORA2876564737865647501Rat
621201Rpl30ribosomal protein L3076564826665651401Rat
41001841LOC120093944small nucleolar RNA SNORA7276564875865648889Rat
1590540Erich5glutamate-rich 576565582965682221Rat

1 to 20 of 1120 rows
1 to 20 of 1504 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10252D7Mit121367114727471114727581Ratregion
10253D7Wox201447114727449114727593Ratregion
10427D7Wox192577106839225106839474Ratregion
10431D7Wox182507106741074106741295Ratregion
10431D7Wox182507106773255106773476Ratregion
10447D7Wox212717113938271113938544Ratregion
10448D7Mgh32447113915925113916171Ratregion
10449D7Mit161627113886156113886318Ratregion
10472D7Wox301987114321734114321932Ratregion
10514D7Wox231157131786627131786744Ratregion
10515D7Mit262157131786600131786815Ratregion
10935D7Wox1413179359564793595780Ratregion
10936D7Arb520479359562793595833Ratregion
10937D7Wox1515979359562093595781Ratregion
10938D7Wox2911979359563393595754Ratregion
10939D7Mit2721079359563193595843Ratregion
11165D7Mit92767130221005130221281Ratregion
33798D7Mit242537121668493121668746Ratregion
33816D7Mit11947116738749116738842Ratregion
33838D3Mit181887116932605116932728Ratregion
1 to 20 of 1504 rows

Flank 1: (D7Mgh18) No map positions available.
Peak: (D7Wox6)
Rat AssemblyChrPosition (strand)Source
GRCr87107,997,327 - 107,997,469 (+)Marker Load Pipeline
mRatBN7.27106,108,321 - 106,108,463 (+)MAPPER
Rnor_6.07115,455,463 - 115,455,604NCBI
Rnor_5.07115,369,421 - 115,369,562UniSTS
RGSC_v3.47111,916,699 - 111,916,841RGD
RGSC_v3.47111,916,700 - 111,916,841UniSTS
RGSC_v3.17111,950,930 - 111,951,071RGD
Celera7102,513,236 - 102,513,377UniSTS
RH 3.4 Map7762.7UniSTS
RH 3.4 Map7762.7RGD
RH 2.0 Map7599.1RGD
Cytogenetic Map7 RGD
Flank 2: (D7Wox3)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2764,002,457 - 64,002,648 (+)MAPPER
Rnor_6.0771,448,715 - 71,448,905NCBI
Rnor_5.0771,619,460 - 71,619,650UniSTS
RGSC_v3.4768,162,496 - 68,162,687RGD
RGSC_v3.4768,162,497 - 68,162,687UniSTS
RGSC_v3.1768,183,226 - 68,183,417RGD
Celera761,127,880 - 61,128,070UniSTS
Cytogenetic Map7 RGD


1 to 10 of 79 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat

1 to 10 of 79 rows


Database
Acc Id
Source(s)
NCBI Gene Niddm19

Note Type Note Reference
qtl_general LOD reported is of glucose measured at 60 min in males which was confirmed in another experiment using the same strains 61021
qtl_general syntenic region in human has CA3, GAD3 and SSTR3 as candidate genes 7207431